Abstract:
:The labeling of RNA in young and adult rat brain has been studied by measuring in vitro (tissue slices incubation) the incorporation of labeled uridine into RNA of total tissue and of the various subcellular fractions purified from cerebral hemispheres of 1- and 10-month-old rats. Gel electrophoretic analysis of the newly synthesized nuclear and microsomal RNA was also accomplished. An active metabolism of RNA in adult animals was found; moreover, distinct differences in ribosomal RNA processing in cerebral hemispheres of 1- and 10-month-old rats, with a more rapid processing in the brain of adult animals, were obtained.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Serra I,Cupello A,Gadaleta MN,Viola M,Ragonese P,Giuffrida AMdoi
10.1007/BF00965100subject
Has Abstractpub_date
1983-04-01 00:00:00pages
433-47issue
4eissn
0364-3190issn
1573-6903journal_volume
8pub_type
杂志文章abstract::Alzheimer's disease (AD) is a devastative neurodegenerative disorder with complex etiology. Apoptosis, a biological process that plays an essential role in normal physiology to oust a few cells and contribute to the normal growth, when impaired or influenced by various factors such as Bcl2, Bax, caspases, amyloid beta...
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journal_title:Neurochemical research
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更新日期:2016-10-01 00:00:00
abstract::Glioblastoma is one of the most frequent and aggressive primary tumor of glial brain tumors. Long non-coding RNA Prostate cancer-associated ncRNA transcript 6 (PCAT6) has been identified to influence the progression of many cancers, but its expression and functions in glioblastoma remain unclear. In this study, we int...
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journal_title:Neurochemical research
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更新日期:1999-06-01 00:00:00
abstract::Human amniotic membrane mesenchymal stem cells (hAMSCs) are considered ideal candidate stem cells for cell-based therapy. In this study, we assessed whether hAMSCs transplantation promotes neurological functional recovery in rats after traumatic spinal cord injury (SCI). In addition, the potential mechanisms underlyin...
journal_title:Neurochemical research
pub_type: 杂志文章
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journal_title:Neurochemical research
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更新日期:2019-08-01 00:00:00
abstract::Seizures are accompanied by an exacerbated activation of cerebral ion channels. 4-aminopyridine (4-AP) is a pro-convulsive agent which mechanism of action involves activation of Na(+) and Ca(2+) channels, and several antiepileptic drugs control seizures by reducing these channels permeability. The antidepressant, sert...
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更新日期:2016-06-01 00:00:00
abstract::Precise control of the proliferation and differentiation of multipotent neural stem cells (NSCs) is crucial for the proper development of the nervous system. Although cyclinD1 has been implicated as a cause of cancer in many studies, its roles in NSCs remain elusive. In this study, we examined the over-expression of c...
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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