Abstract：
:The enzymes degrading leucine enkephalin in human plasma and the inhibitors active on these enzymes were studied by kinetic and chromatographic techniques. Data obtained evidence the existence of complex kinetics of leu-enkephalin hydrolysis and of formation of its hydrolysis by-products. These appear to originate from the combined effect of further hydrolysis of the enkephalin's fragments after their release and of competition between the different enzymes present in plasma. Chromatographic separation of plasma proteolysis inhibitors indicates the existence of several pools of substances acting on all three enzyme groups that degrade leu-enkephalin. The partial specificity of these substances induces competition effects: consequently, the actual protection over leu-enkephalin is considerably lower that the total inhibitory activity. That notwithstanding, plasma inhibitors control enkephalin hydrolysis to a relevant extent, while they modify only slightly the ratio of hydrolysis between the different enzymes. This latter parameter--and specifically the large prevalence of aminopeptidases over dipeptidylaminopeptidases and dipeptidylcarboxypeptidases--appears controlled mainly by kinetic factors.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Bolacchi F,Marini M,Urbani A,Roda LGdoi
10.1007/BF00995551subject
Has Abstractpub_date
1995-09-01 00:00:00pages
991-9issue
9eissn
0364-3190issn
1573-6903journal_volume
20pub_type
杂志文章abstract：:Many studies have demonstrated that apoptosis play an important role in cerebral ischemic pathogenesis and may represent a target for treatment. Neuroprotective effect of quercetin has been shown in a variety of brain injury models including ischemia/reperfusion. It is not clear whether BDNF-TrkB-PI3K/Akt signaling pa...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0871-5
更新日期：2012-12-01 00:00:00
abstract：:Exposure of guinea pig brain slices to low concentrations (10 microM) of NMDA caused decreases in PCr and ATP within 30 min, with a slower decrease in NAA and increase in lactate, both detectable after 1 h. Exposure to NMDA for over 1 h or at higher concentrations caused further increases in lactate and decreases in N...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1014898421330
更新日期：2002-02-01 00:00:00
abstract：:Malformations of cortical development (MCD) are critical brain development disorders associated with varied abnormalities in both anatomic structures and neural functioning. It is also a very common etiology to the epilepsy, in which the alteration on excitability of cortical neurons is hypothesized as one of importan...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1936-7
更新日期：2016-09-01 00:00:00
abstract：:Quantitative measurements were made of choline acetyltransferase (CAT) activity, acetylcholinesterase (AChE) activity and cholinergic muscarinic receptor binding ([3H]QNB) in eight areas of a cross-section of the rat medulla oblongata. A fourth cholinergic parameter, high-affinity choline uptake, was measured in three...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964389
更新日期：1981-05-01 00:00:00
abstract：:The pineal gland is a neuroendocrine gland responsible for nocturnal synthesis of melatonin. During early development of the rodent pineal gland from the roof of the diencephalon, homeobox genes of the orthodenticle homeobox (Otx)- and paired box (Pax)-families are expressed and are essential for normal pineal develop...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-012-0906-y
更新日期：2013-06-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章,评审
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journal_title：Neurochemical research
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doi：10.1007/s11064-019-02935-w
更新日期：2020-02-01 00:00:00
abstract：:Factors secreted by C6 glioma cells which induce electrical resistances across endothelial monolayers in an in vitro blood-brain barrier model have been partially characterised for the first time. These transendothelial electrical resistances (TEERs) were only evident when cell-free conditioned medium derived from C6 ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020932121378
更新日期：1998-12-01 00:00:00
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journal_title：Neurochemical research
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doi：10.1007/s11064-016-2063-1
更新日期：2016-12-01 00:00:00
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journal_title：Neurochemical research
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更新日期：1999-12-01 00:00:00
abstract：:Spinal cord injury (SCI) is a functional impairment of the spinal cord caused by external forces, accompanied by limb movement disorders and permanent paralysis, which seriously lowers the life quality of SCI patients. Secondary injury caused by inflammation attenuated the therapeutic effects of SCI. Therefore, the ex...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03211-y
更新日期：2021-01-13 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02527725
更新日期：1996-06-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1007517524179
更新日期：2000-06-01 00:00:00
abstract：:The developmental profiles of acetylcholinesterase and choline acetyltransferase in chick optic tectum and retina cell aggregates, over a 30-day period, have been determined and compared with the corresponding developmental curves obtained in vivo. Both acetylcholinesterase and choline acetyltransferase activities in ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965466
更新日期：1977-08-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00970934
更新日期：1987-11-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-2081-z
更新日期：2017-02-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965018
更新日期：1986-03-01 00:00:00
abstract：:The elevated plus maze (EPM) is an animal model of anxiety used to test the effects of anxioselective drugs. The loss of the anxiolytic effect of drugs during the second exposure to the EPM is called the "one trial tolerance" (OTT) phenomenon. The present study was designed to investigate the relationship between the ...
journal_title：Neurochemical research
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doi：10.1007/s11064-013-1051-y
更新日期：2013-07-01 00:00:00
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journal_title：Neurochemical research
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doi：10.1007/BF00963906
更新日期：1981-01-01 00:00:00
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journal_title：Neurochemical research
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更新日期：2017-08-01 00:00:00
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更新日期：1993-06-01 00:00:00
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更新日期：2006-09-01 00:00:00
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journal_title：Neurochemical research
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doi：10.1007/BF01474683
更新日期：1993-02-01 00:00:00
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更新日期：2015-08-01 00:00:00
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journal_title：Neurochemical research
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更新日期：1998-03-01 00:00:00
abstract：:Disturbance in cholesterol homeostasis appears to be an important factor in the pathogenesis of neurodegenerative disorders. The aim of the present study was to investigate sterol regulatory element binding protein (SREBP) levels in the nuclear extracts of human neuroblastoma cells and the possible interaction of beta...
journal_title：Neurochemical research
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更新日期：2009-05-01 00:00:00
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journal_title：Neurochemical research
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更新日期：2012-10-01 00:00:00
abstract：:Ethyl pyruvate (EP) has recently been reported to afford protection against neurodegenerative disorders. However, the mechanism underlying EP-mediated neuroprotection remains to be elucidated. Because peroxynitrite has been extensively implicated in the pathogenesis of various forms of neurodegenerative disorders via ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-0059-9
更新日期：2010-02-01 00:00:00
abstract：:Uridine, a pyrimidine nucleoside, has been proposed to be a potential signaling molecule in the central nervous system. The understanding of uridine release in the brain is therefore of fundamental importance. The present study was performed to determine the characteristics of basal and morphine-induced uridine releas...
journal_title：Neurochemical research
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doi：10.1007/s11064-012-0903-1
更新日期：2013-01-01 00:00:00
