Possible role of "prenervous" neurotransmitters in cellular interactions of early embryogenesis: a hypothesis.

abstract：:Several previous studies utilizing selective pharmacological antagonists have demonstrated that type 5 metabotropic glutamate receptors (mGluR5) are potential therapeutic targets for the treatment of numerous disorders of the central nervous system, but the role of mGluR5 activation in traumatic brain injury (TBI) is ...

journal_title：Neurochemical research

authors： Chen T,Cao L,Dong W,Luo P,Liu W,Qu Y,Fei Z

更新日期：2012-05-01 00:00:00

abstract：:Evidence has suggested that cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) is correlated with the development and recurrence of pain. A recent research showed that the CSF-contacting nucleus acts as a component of the descending 5-hydroxytryptamine (5-HT) system and plays a role in descending pain inh...

journal_title：Neurochemical research

authors： Fei Y,Wang X,Chen S,Zhou Q,Zhang C,Li Y,Sun L,Zhang L

更新日期：2016-07-01 00:00:00

abstract：:Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. The glycolytic inhibitor 2-deoxy-D-glucose (2-DG) has been reported to exert antiepileptic effects by upregulating KATP subunits (kir6.1 and kir6.2). We evaluated whether 2-DG exhibits anti-seizure effect by...

journal_title：Neurochemical research

authors： Long Y,Zhuang K,Ji Z,Han Y,Fei Y,Zheng W,Song Z,Yang H

更新日期：2019-04-01 00:00:00

abstract：:A hemagglutinating activity was detected in a synaptic vesicle-enriched fraction prepared from adult rat brain, using trypsinized glutaraldehyde-fixed rabbit erythrocytes. The specific activity of the fraction, in two series of experiments, was 7.5 and 16-fold higher than in the other subcellular fractions. The activi...

journal_title：Neurochemical research

authors： Popoli M,Mengano A

更新日期：1988-01-01 00:00:00

abstract：:This work evaluated the in vitro effect of thiazolidin-4-ones on the activity of AChE (total and isoforms) isolated from the cerebral cortex, hippocampus, and lymphocytes. Kinetic parameters were evaluated and molecular docking was performed. Our results showed that thiazolidinones derived from 4-(methylthio)benzaldeh...

journal_title：Neurochemical research

authors： da Silva DS,Soares MSP,Martini F,Pesarico AP,de Mattos BDS,de Souza AA,da Silva CEH,Scaini JLR,Machado KDS,Wayne Nogueira C,Spanevello RM,Cunico W

更新日期：2020-02-01 00:00:00

abstract：:Treatment for epilepsy, particularly temporal lobe epilepsy, is challenging. Baicalein has multiple effects, including anti-inflammatory action. However, little is known about its efficacy in treatment of epilepsy. In this study, we established a pilocarpine-induced rat model and used it for assessment of baicalein ef...

journal_title：Neurochemical research

authors： Fu P,Yuan Q,Sun Y,Wu X,Du Z,Li Z,Yu J,Lv K,Hu J

更新日期：2020-12-01 00:00:00

abstract：:Rat tissues were tested for their ability to inhibit the binding of [3H]dihydromorphine or [3H]naloxone to membrane-bound opiate receptors. By this criterion, morphine-like substances were found in lung, heart, liver, and kidney as well as in brain. The relative activity of the extracts, based on initial tissue weight...

journal_title：Neurochemical research

authors： Neidle A,Manigault I,Wajda IJ

更新日期：1979-06-01 00:00:00

abstract：:Methamphetamine (MA), an amphetamine-type psychostimulant, is associated with dopaminergic toxicity and has a high abuse potential. Numerous in vivo and in vitro studies have suggested that impaired mitochondria are critical in dopaminergic toxicity induced by MA. Mitochondria are important energy-producing organelles...

journal_title：Neurochemical research

authors： Shin EJ,Tran HQ,Nguyen PT,Jeong JH,Nah SY,Jang CG,Nabeshima T,Kim HC

更新日期：2018-01-01 00:00:00

abstract：:Evidence was accumulated indicating that cyclic nucleotides are involved in regulation of growth, differentiation and function of lymphoid cells. It was previously shown that the N-fragment (1-4) of thymosin beta 4 (Ac-Ser-Asp-Lys-Pro-OH) inhibits in vivo the entry of cell populations into S-phase. In the course of th...

journal_title：Neurochemical research

authors： Voelter W,Kapuzniotu A,Mihelic M,Gurvits B,Abrahamian G,Galoyan A

更新日期：1995-01-01 00:00:00

abstract：:Specific [3H]MK801 binding to rat brain NMDA receptors after the administration of the convulsant drug 3-mercaptopropionic acid (MP) and the adenosine analogue cyclopentyladenosine (CPA) was studied by means of a quantitative autoradiographic method. MP administration (150 mg/kg, i.p.) caused significant decreases in ...

journal_title：Neurochemical research

authors： Giraldez L,Girardi E

更新日期：1998-10-01 00:00:00

abstract：:cDNA microarray analysis of 1-methyl-4-phenyl-pyridinium (MPP+) toxicity (1 mM, 72 h) in undifferentiated SH-SY5Y cells identified 48 genes that displayed a signal intensity greater than the mean of all differentially expressed genes and a two-fold or greater difference in normalized expression. RT-PCR analysis of a s...

journal_title：Neurochemical research

authors： Conn KJ,Ullman MD,Larned MJ,Eisenhauer PB,Fine RE,Wells JM

更新日期：2003-12-01 00:00:00

abstract：:Lewy bodies and Lewy neurites in the brain constitute the main histopathological features of Parkinson's disease (PD) and dementia with Lewy bodies. They comprise amyloid-like fibrils composed of α-synuclein (αS), a small protein (~14 kDa). Because the aggregation of αS in the brain has been implicated as a critical s...

journal_title：Neurochemical research

authors： Ono K

更新日期：2017-12-01 00:00:00

abstract：:Calcium-naive synaptosomes were used to assess the effects of divalent cations on [3H]acetylcholine release from rat hippocampal homogenates. Following equilibration with calcium-free buffer (containing 10 microM EGTA), calcium reversibly increased [3H]acetylcholine efflux (up to five-fold) while causing no measurable...

journal_title：Neurochemical research

authors： Vickroy TW,Schneider CJ

更新日期：1991-10-01 00:00:00

abstract：:Ochratoxin A (OA) is a mycotoxin produced by several storage fungi, such as Aspergillus ochraceus and several Penicillium species. OA (3 mg/kg) was given intraperitoneally to pregnant mice on day 11 of gestation (day 1 = day of insemination), and neurochemical changes in brains of their offspring were examined at feta...

journal_title：Neurochemical research

authors： Tamaru M,Hirata Y,Matsutani T

更新日期：1988-12-01 00:00:00

abstract：:Hypoglycemia is the major problem to blood glucose homeostasis in treatment of diabetes and is associated with severe irreversible consequences including seizures, coma and death. GABAergic inhibitory function in the cerebral cortex plays an important role in controlling the excitability and responsiveness of cortical...

journal_title：Neurochemical research

authors： Antony S,Kumar TP,Kuruvilla KP,George N,Paulose CS

更新日期：2010-10-01 00:00:00

abstract：:A Zn(2+)-glycerophosphocholine cholinephosphodiesterase was purified with a specific activity of 4.6 mumole/min.mg protein from bovine brain membranes by procedures involving PI-PLC solubilization, concanavalin A affinity chromatography, CM-sephadex chromatography and Sephadex G-150 chromatography. Based on molecular ...

journal_title：Neurochemical research

authors： Sok DE

更新日期：1996-10-01 00:00:00

abstract：:Overactivation of glutamate receptors results in neurodegeneration in a variety of brain pathologies, including ischemia, epilepsy, traumatic brain injury and slow-progressing neurodegenerative disorders. In all these pathologies, it is well accepted that the calcium-dependent cysteine proteases calpains are key playe...

journal_title：Neurochemical research

authors： Araújo IM,Carreira BP,Carvalho CM,Carvalho AP

更新日期：2010-12-01 00:00:00

abstract：:The serotoninergic system modulates nociceptive and locomotor spinal cord circuits. Exercise improves motor function and changes dopaminergic, noradrenergic, and serotonergic central systems. However, the direct relationship between serotonin, peripheral nerve lesion and aerobic treadmill exercise has not been studied...

journal_title：Neurochemical research

authors： Korb A,Bonetti LV,da Silva SA,Marcuzzo S,Ilha J,Bertagnolli M,Partata WA,Faccioni-Heuser MC

更新日期：2010-03-01 00:00:00

abstract：:The oxidation of pyruvate is mediated by the pyruvate dehydrogenase complex (PDHC; EC 1.2.4.1, EC 2.3.1.12 and EC 1.6.4.3) whose catalytic activity is influenced by phosphorylation and by product inhibition. 2-Oxoglutarate and 3-hydroxybutyrate are readily utilized by brain mitochondria and inhibit pyruvate oxidation....

journal_title：Neurochemical research

authors： Lai JC,Sheu KF

更新日期：1987-08-01 00:00:00

abstract：:There is increasing evidence to suggest that hepatic encephalopathy in acute liver failure is the result of altered glutamatergic function. In particular, the high affinity uptake of glutamate is decreased in brain slices and synaptosomes from rats with acute liver failure as well as by exposure of cultured astrocytes...

journal_title：Neurochemical research

authors： Chan H,Butterworth RF

更新日期：1999-11-01 00:00:00

abstract：:Schwann cell biosynthesis of glycolipids was studied by in vitro incorporation of [3H]galactose into neonatal rat sciatic nerves before and after endoneurial explant culture and in culture of purified Schwann cells. In neonatal nerves prior to culture, [3H]galactose was actively incorporated into galactocerebrosides (...

journal_title：Neurochemical research

authors： Yao JK,Windebank AJ,Poduslo JF,Yoshino JE

更新日期：1990-03-01 00:00:00

abstract：:NMDA, the specific agonist of glutamate gated ion channels permeable to calcium, is implicated as a causal factor in the pathogenesis of several neurobiological disorders such as stroke, seizures, ischemia, and chronic neurodegenerative diseases. On the other hand, evidence on the roles of oxidative mechanisms involve...

journal_title：Neurochemical research

authors： Küçükkaya B,Haklar G,Yalçin AS

更新日期：1996-12-01 00:00:00

abstract：:Deciphering what governs inflammation and its effects on tissues is vital for understanding many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes inflammation reveals a new component of its well-documented actions in several prevalent diseases which involve inflammation, including mood...

journal_title：Neurochemical research

authors： Jope RS,Yuskaitis CJ,Beurel E

更新日期：2007-04-01 00:00:00

abstract：:To study the early effects of neonatal 5,7-dihydroxytryptamine lesions on 5-hydroxytryptamine1A (5-HT1A) receptors, we measured regional [3H]8-OH-DPAT-labeled 5-HT1A sites in binding assays and compared them to our previous studies of [3H]paroxetine-labeled 5-HT transporter sites during the first month in the same rat...

journal_title：Neurochemical research

authors： Pranzatelli MR

更新日期：1994-03-01 00:00:00

abstract：:A simple, rapid method for determining depolarization-induced 45Ca influx into synaptosomes is described. Synaptosomes which had been depolarized in the presence of 45Ca were applied to a small column of Chelex-100 resin to separate free Ca2+ from that taken up by the tissue. Approximately 70% of the synaptosomal prot...

journal_title：Neurochemical research

authors： Michaelis ML,Michaelis EK,Simpson AE

更新日期：1982-02-01 00:00:00

abstract：:The maximal rate of some cerebral enzymatic activities related to energy transduction (hexokinase; phosphofructokinase; lactate dehydrogenase; citrate synthase; malate dehydrogenase; total NADH-cytochrome c reductase; cytochrome oxidase), amino acid metabolism (glutamate decarboxylase; glutamate dehydrogenase) and cho...

journal_title：Neurochemical research

authors： Villa RF,Marzatico F,Benzi G

更新日期：1983-02-01 00:00:00

abstract：:Comparative structure-function studies have been carried out for alpha-conotoxin GI acting on nicotinic acetylcholine receptors (AChR) from mammalian muscles and from the electric organ of the Torpedo californica ray and for alpha-conotoxin ImI, which targets the neuronal alpha7 AChR. A series of analogs has been prep...

journal_title：Neurochemical research

authors： Kasheverov IE,Zhmak MN,Maslennikov IV,Utkin YN,Tsetlin VI

更新日期：2003-04-01 00:00:00

abstract：:The activity, properties, and developmental pattern of cysteine sulfinate transaminase (CSA-T) were studied in chick retina and compared with the activity, properties, and developmental pattern of glutamate oxaloacetate transaminase (GOT). Their optimum pH is identical whereas the effect of pyridoxal phosphate seems t...

journal_title：Neurochemical research

authors： Recasens M,Gabellec MM,Mack G,Mandel P

更新日期：1978-02-01 00:00:00

abstract：:We have shown that acute ammonia toxicity is mediated by activation of the NMDA type of glutamate receptors. Although it is well known that L-carnitine prevents acute ammonia toxicity, the underlying molecular mechanism is not clear. We suspected that L-carnitine would prevent ammonia toxicity by preventing the toxic ...

journal_title：Neurochemical research

authors： Felipo V,Miñana MD,Cabedo H,Grisolía S

更新日期：1994-03-01 00:00:00

abstract：:Serotonin-synthesizing raphé/parapyramidal neurons (5-HT neurons) may function as sympathetic premotor neurons regulating sympathetic outflow to the cutaneous vascular bed. In the present study a genetically engineered pseudorabies virus (PRV) expressing green fluorescent protein (GFP) was injected into the rat tail. ...

journal_title：Neurochemical research

authors： Tóth IE,Tóth DE,Boldogkoi Z,Hornyák A,Palkovits M,Blessing WW

更新日期：2006-02-01 00:00:00