Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics.

abstract：:The extracellular amino acid content was measured in the parietal cortex in portacaval and sham operated rats, using the brain dialysis technique. The amino acid content of the perfusate was determined for 10 min before and during stimulation with potassium chloride. Basal levels of aspartate, glutamine, glycine, meth...

journal_title：Neurochemical research

authors： Tossman U,Delin A,Eriksson LS,Ungerstedt U

更新日期：1987-03-01 00:00:00

abstract：:Transgenic therapy for central neuralgia faces the problems of low expression and weak targeting and affects superficial but not deep neurons. In this study, we generated a lentivirus vector with human preproenkephalin gene (hPPE) expression driven by the transcriptional amplification strategy system (TAS) and establi...

journal_title：Neurochemical research

authors： Yang J,Zhang L,Xie P,Pan M,Ma G

更新日期：2020-09-01 00:00:00

abstract：:The vesicular hypothesis has stimulated fruitful investigations on many secreting systems. In the case of rapid synaptic transmission, however, the hypothesis has been found difficult to reconcile with a number of well established observations. Brief impulses of transmitter molecules (quanta) are emitted from nerve te...

journal_title：Neurochemical research

authors： Dunant Y,Israël M

更新日期：1998-05-01 00:00:00

abstract：:Isoleucine, together with leucine and valine, constitutes the group of branched-chain amino acids (BCAAs). BCAAs are transported from the blood into the brain parenchyma, where they can serve several distinct functions. Since brain tissue is known to oxidatively metabolize BCAAs to CO(2), they are considered as fuel m...

journal_title：Neurochemical research

authors： Murín R,Mohammadi G,Leibfritz D,Hamprecht B

更新日期：2009-01-01 00:00:00

abstract：:CNS trauma has been associated with an increase in free radical production, but the cellular sources of this increase or the mechanism involved in the production of free radicals are not known. We, therefore, investigated the effects of trauma on free radical production in cultured neurons, astrocytes and BV-2 microgl...

journal_title：Neurochemical research

authors： Panickar KS,Jayakumar AR,Norenberg MD

更新日期：2002-02-01 00:00:00

abstract：:Glutamine synthetase (GS) is the key enzyme in cerebral glutamine production. Understanding the regulation of the expression of GS is important for definition of the control of glutamine metabolism in brain. Therefore, we studied the control of GS expression by 8-bromo cyclic AMP in primary cultures of astrocytes prep...

journal_title：Neurochemical research

authors： Max SR,Landry ME,Zielke HR

更新日期：1990-06-01 00:00:00

abstract：:The immediate and long-term effects of the selective serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) on rat striatal serotonergic neurons were examined after its intracerebroventricular administration using in vivo voltammetry. Extracellular concentration of 5-hydroxyindoles increased immediately following i...

journal_title：Neurochemical research

authors： Nakazato T,Akiyama A

更新日期：1998-01-01 00:00:00

abstract：:Detergents Triton X-100, sodium deoxycholate, and octyl-beta-D-glucopyranoside, and proteinase papain proved to be excellent agents solubilizing the gamma-glutamyltransferase (gamma-GT) from human brain cortex microvessels. Ficin also solubilized gamma-GT but to a lesser extent than papain. The relative molecular mass...

journal_title：Neurochemical research

authors： Veselý J,Cernoch M

更新日期：1984-07-01 00:00:00

abstract：:The inflammatory response mediated by microglia in the central nervous system is closely related to epilepsy. Notch signaling plays an important role in the microglial activation during hypoxia. This study aimed to investigate whether Notch signaling is involved in microglial activation and subsequent inflammation-rel...

journal_title：Neurochemical research

authors： Wu L,Li Y,Yu M,Yang F,Tu M,Xu H

更新日期：2018-06-01 00:00:00

abstract：:The neurotoxic effects of aluminum are generally associated with reduced antioxidant capacity, increased oxidative stress and apoptosis, which lead to the induction of neurodegenerative processes. Curcumin has a lipophilic polyphenol character and effects of antioxidant and anti-apoptotic. The present study was undert...

journal_title：Neurochemical research

authors： Kar F,Hacioglu C,Uslu S,Kanbak G

更新日期：2019-08-01 00:00:00

abstract：:Complementary DNA (cDNA) clones containing the entire coding sequence for Diazepam Binding Inhibitor (DBI) peptide, a 10-kDa precursor of putative natural ligands of benzodiazepine recognition sites, were isolated from rat, human and cow libraries. The sequence of all these clones is highly conserved; however, the N-t...

journal_title：Neurochemical research

authors： Mocchetti I

更新日期：1990-02-01 00:00:00

abstract：:The potassium A-current (IK(A)) is important in regulating the membrane potential between action potentials. The whole-cell patch-clamp technique was applied to cultured Drosophila neurons derived from embryonic neuroblasts. IK(A) was measured from neurons before and after application of 0.1 mM lanthanum to the extern...

journal_title：Neurochemical research

authors： Alshuaib WB,Mathew MV

更新日期：2005-09-01 00:00:00

abstract：:Nicotinic agonists stimulate 22Na flux in rat pheochromocytoma PC12 cells. The stimulatory effect of carbamylcholine is maximal at 1 mM, while the stimulatory effect of nicotine and anatoxin maximize at the same level at 100 microM and 10 microM, respectively. The tertiary amines arecolone and isoarecolone have no eff...

journal_title：Neurochemical research

authors： Daly JW,Nishizawa Y,Edwards MW,Waters JA,Aronstam RS

更新日期：1991-04-01 00:00:00

abstract：:Alcohol abuse affects several neurological pathways and causes significant alterations in the brain. Abstention from alcohol causes only a marginal decrease in oxidative stress and neuro inflammation. Our previous studies had shown that an active metabolite of vitamin A, all trans retinoic acid (ATRA), ameliorates alc...

journal_title：Neurochemical research

authors： Priyanka SH,Syam Das S,Thushara AJ,Rauf AA,Indira M

更新日期：2018-09-01 00:00:00

abstract：:Growth-promoting macroglia (aldynoglia) with growth properties and immunological markers similar to Schwann cells, are found in loci of the mammalian CNS where axon regeneration occurs throughout life, like the olfactory sytem, hypothalamus-hypophysis and the pineal gland. Contrary to Schwann cells, aldynoglia mingle ...

journal_title：Neurochemical research

authors： Nieto-Sampedro M

更新日期：2003-11-01 00:00:00

abstract：: ...

journal_title：Neurochemical research

authors： Choi IY,Schousboe A

更新日期：2019-01-01 00:00:00

abstract：:The oxidation of pyruvate is mediated by the pyruvate dehydrogenase complex (PDHC; EC 1.2.4.1, EC 2.3.1.12 and EC 1.6.4.3) whose catalytic activity is influenced by phosphorylation and by product inhibition. 2-Oxoglutarate and 3-hydroxybutyrate are readily utilized by brain mitochondria and inhibit pyruvate oxidation....

journal_title：Neurochemical research

authors： Lai JC,Sheu KF

更新日期：1987-08-01 00:00:00

abstract：:Evidence suggests that apoptosis contributes significantly to cell death after cerebral ischemia. Our recent studies that utilized human umbilical cord blood-derived mesenchymal stem cells (hUCBSCs) demonstrated the potential of hUCBSCs to inhibit neuronal apoptosis in a rat model of CNS injury. Therefore, we hypothes...

journal_title：Neurochemical research

authors： Chelluboina B,Klopfenstein JD,Pinson DM,Wang DZ,Veeravalli KK

更新日期：2014-08-01 00:00:00

abstract：:This study examined the relationship between the distance of axotomy and the death of injured retinal ganglion cells (RGCs) in adult hamsters and the relationship of cytochrome c and caspase-3 on the death pathway of RGCs. The left optic nerve (ON) of adult hamsters was transected either at 1 or 3 mm away from the opt...

journal_title：Neurochemical research

authors： He MH,Cheung ZH,Yu EH,Tay DK,So KF

更新日期：2004-11-01 00:00:00

abstract：:We have measured the postnatal development and GABA modulation of benzodiazepine receptors in neuronal membranes from vitamin B-6 deficient and normal rats. In rats fed vitamin B-6 adequate and deficient diets there were age-dependent changes in [3H]flunitrazepam binding site affinity and in the number of binding site...

journal_title：Neurochemical research

authors： Pilachowski J,Guilarte TR

更新日期：1993-12-01 00:00:00

abstract：:We have investigated gene expression changes produced by acute and chronic daily treatment with a prototypical antidepressant, imipramine, using DNA microarrays. The analysis of similarities in gene expression patterns among functionally related genes revealed four expression profile cluster areas that showed a highly...

journal_title：Neurochemical research

authors： Knuuttila JE,Törönen P,Castrén E

更新日期：2004-06-01 00:00:00

abstract：:Parecoxib is a recently described novel COX-2 inhibitor whose functional significance and neuroprotective mechanisms remain elusive. Therefore, in this study, we aimed to investigate whether delayed administration of parecoxib inhibited mitochondria-mediated neuronal apoptosis induced by ischemic reperfusion injury vi...

journal_title：Neurochemical research

authors： Ye Z,Wang N,Xia P,Wang E,Yuan Y,Guo Q

更新日期：2012-02-01 00:00:00

abstract：:The concept of exosomes has been progressively changed from the status of cellular trashcans to multitasking organelles involved in many processes, including internalization, transport and transfer of macromolecules such as proteins, lipids and nucleic acids. While underpinning the mechanisms behind neurodegeneration ...

journal_title：Neurochemical research

authors： Lakshmi S,Essa MM,Hartman RE,Guillemin GJ,Sivan S,Elumalai P

更新日期：2020-11-01 00:00:00

abstract：:The antibodies against omega-conotoxin GVIA (omega-CTX GVIA; N-type voltage-dependent calcium channel [VDCC] blocker) and B1Nt (N-terminal segment [residues 1-13] of BI alpha1 subunits of VDCCs) were prepared, and the selectivity for each antigen omega-CTX GVIA and B1Nt was investigated. For the antigen selectivity of...

journal_title：Neurochemical research

authors： Ichida S,Abe J,Sugimoto W,Uematsu M,Komoike K,Imoto K,Mori M,Wada T,Minami T,Kakutani K

更新日期：2003-06-01 00:00:00

abstract：:There is evidence that many of the GABA(A) receptor subunits contain consensus sequence for tyrosine kinase, and phosphorylation may play a key role in ethanol's regulation of GABA(A) receptors. Recently, we investigated the effect of chronic exposure of ethanol (CE) on tyrosine kinase phosphorylation and reported tha...

journal_title：Neurochemical research

authors： Ravindran CR,Ticku MK

更新日期：2006-09-01 00:00:00

abstract：:The p53 tumor suppressor gene is a sequence-specific transcription factor that activates the expression of genes engaged in promoting growth arrest or cell death in response to multiple forms of cellular stress. p53 expression is elevated in damaged neurons in acute models of injury such as ischemia and epilepsy and i...

journal_title：Neurochemical research

authors： Morrison RS,Kinoshita Y,Johnson MD,Guo W,Garden GA

更新日期：2003-01-01 00:00:00

abstract：:A variety of naturally occurring amino acids, their isomers, and synthetic analogs were tested for their ability to inhibit uptake of [3H]glutamate into presynaptic vesicles from bovine cerebral cortex. Strongest inhibition (Ki < 1mM) was observed for trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and erythr...

journal_title：Neurochemical research

authors： Winter HC,Ueda T

更新日期：1993-01-01 00:00:00

abstract：:We measured the activity of several acid hydrolases in oligodendrocyte and mixed glial (predominantly astrocytic) cell cultures prepared from neonatal rat cerebra. When compared with the mixed glial cultures, the cultured oligodendrocytes exhibited higher levels for all the hydrolases when activities were normalized t...

journal_title：Neurochemical research

authors： Bradel EJ,Sloan HR

更新日期：1988-10-01 00:00:00

abstract：:Rhesus macaque monkey brain microvessel endothelial cells (BMECs) were isolated and grown in culture in an effort to establish an appropriate primate in vitro model of the endothelial component of the blood-brain barrier. The presence of Factor VIII antigen, alkaline phosphatase, gamma-glutamyl transpeptidase, lactate...

journal_title：Neurochemical research

authors： Shi F,Audus KL

更新日期：1994-04-01 00:00:00

abstract：:We review here the possible mechanisms of neuronal degeneration caused by L-cysteine, an odd excitotoxin. L-Cysteine lacks the omega carboxyl group required for excitotoxic actions via excitatory amino acid receptors, yet it evokes N-methyl-D-aspartate (NMDA) -like excitotoxic neuronal death and potentiates the Ca2+ i...

journal_title：Neurochemical research

authors： Janáky R,Varga V,Hermann A,Saransaari P,Oja SS

更新日期：2000-10-01 00:00:00