Special Issue in Honor of Dr. Elias K. Michaelis.

abstract：:Amyotrophic lateral sclerosis (ALS) is a degenerative disorder caused by motor neuron loss. T-cell intracellular antigen-1 (TIA-1), a cytotoxic T lymphocyte granule-associated RNA binding protein, is a key component of stress granules. However, it remains uncertain whether ALS-causing superoxide dismutase-1 (SOD1) tox...

journal_title：Neurochemical research

authors： Lee DY,Jeon GS,Sung JJ

更新日期：2020-12-01 00:00:00

abstract：:Hydroxysafflor yellow A (HSYA) is a component of the flower Carthamus tinctorius L. that elicits neuroprotective effects in vivo and in vitro. The purpose of this study was to investigate pharmacological properties of HSYA on neurotoxicity of glutamate in primary cultured rat cortical neurons along with its possible m...

journal_title：Neurochemical research

authors： Yang Q,Yang ZF,Liu SB,Zhang XN,Hou Y,Li XQ,Wu YM,Wen AD,Zhao MG

更新日期：2010-09-01 00:00:00

abstract：:The study examined (a) whether there is sex difference in spinal cord and plasma oxidative stress profiles in Dark Agouti rats immunised for experimental autoimmune encephalomyelitis (EAE), the principal experimental model of multiple sclerosis, and (b) whether there is correlation between the oxidative stress in spin...

journal_title：Neurochemical research

authors： Dimitrijević M,Kotur-Stevuljević J,Stojić-Vukanić Z,Vujnović I,Pilipović I,Nacka-Aleksić M,Leposavić G

更新日期：2017-02-01 00:00:00

abstract：:Memory impairment is a major problem afflicting mankind. The association between memory functions and neurotransmitter functions is of great interest for understanding brain function. Serotonergic pathways play an important role in the modulation of memory functions but the importance of its receptor types and subtype...

journal_title：Neurochemical research

authors： Haider S,Khaliq S,Tabassum S,Haleem DJ

更新日期：2012-10-01 00:00:00

abstract：:Proteasome inhibition has been observed in many neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Here, the effect of proteasome inhibition on the morphology of cultured rat cortical astrocytes was investigated. Increasing evidence suggests that the function of astrocytes is related close...

journal_title：Neurochemical research

authors： Ren QG,Yu Y,Pan DJ,Luo X,Wang XZ,Wang W

更新日期：2009-05-01 00:00:00

abstract：:A previously described inhibitor of the UDP-N-acetylgalactosamine: GM3, N-acetylgalactosaminyltransferase (GalNAc-T) (Quiroga et al., 1, 2), was purified from chicken blood serum by a new procedure. When subjected to SDS-PAGE, two major polypeptides of 27 and 70 kDa were observed. When tested in vitro, only the 27 kDa...

journal_title：Neurochemical research

authors： Conde CB,Grabois VR,Deza SN,Caputto BL

更新日期：1997-04-01 00:00:00

abstract：:Recently we have demonstrated that extracellular ATP acts as an excitatory neurotransmitter and enhances cell death in the presence of ferrous ions. By using a newly developed cis-parinaric acid fluorescence technique, we demonstrated that ATP, in a dose dependent manner, enhanced the increased membrane lipid peroxida...

journal_title：Neurochemical research

authors： Cheng Y,Chen M,James-Kracke M,Wixom P,Sun AY

更新日期：1996-01-01 00:00:00

abstract：:The release of the inhibitory neurotransmitter GABA is generally enhanced under potentially cell-damaging conditions. The properties and regulation of preloaded [3H]GABA release from mouse hippocampal slices were now studied in free radical-containing medium in a superfusion system. Free radical production was induced...

journal_title：Neurochemical research

authors： Saransaari P,Oja SS

更新日期：2008-03-01 00:00:00

abstract：:The importance of astrocytic K(+) uptake for extracellular K(+) ([K(+)](e)) clearance during neuronal stimulation or pathophysiological conditions is increasingly acknowledged. It occurs by preferential stimulation of the astrocytic Na(+),K(+)-ATPase, which has higher K(m) and V(max) values than its neuronal counterpa...

journal_title：Neurochemical research

authors： Xu J,Song D,Xue Z,Gu L,Hertz L,Peng L

更新日期：2013-03-01 00:00:00

abstract：:Developing cellular models of sporadic Alzheimer's disease (sAD) is challenging due to the unknown initiator of disease onset and the slow disease progression that takes many years to develop in vivo. The use of human induced pluripotent stem cells (iPSCs) has revolutionised the opportunities to model AD pathology, in...

journal_title：Neurochemical research

authors： Rowland HA,Hooper NM,Kellett KAB

更新日期：2018-12-01 00:00:00

abstract：:The release of endogenous amino acids from depolarized rat hippocampal mossy fiber synaptosomes was investigated to assess the possible role(s) of glutamate and aspartate in mediating the excitatory mossy fiber synaptic input. The relative proportions of prodynorphin-derived peptides concomitantly released with amino ...

journal_title：Neurochemical research

authors： Terrian DM,Gannon RL,Rea MA

更新日期：1990-01-01 00:00:00

abstract：:As is known to all, neuroinflammation plays a vital role in early brain injury pathogenesis following subarachnoid hemorrhage (SAH). It has been shown that rutin have a property of inhibiting inflammation in many kinds of animal models. However, the effect of rutin on neuroinflammation after SAH remains uninvestigated...

journal_title：Neurochemical research

authors： Hao G,Dong Y,Huo R,Wen K,Zhang Y,Liang G

更新日期：2016-06-01 00:00:00

abstract：:Two major glycoproteins, P0 and PASII/PMP22, are specifically expressed in peripheral myelin. Point mutations of these proteins and over or under expression of PASII/PMP22 cause various hereditary peripheral neuropathies. P0 is well characterized as a major adhesion molecule in PNS myelin, but the function of PASII/PM...

journal_title：Neurochemical research

authors： Takeda Y,Notsu T,Kitamura K,Uyemura K

更新日期：2001-06-01 00:00:00

abstract：:Oligodendrocytes (OL) are the only myelinating cells of the central nervous system thus interferences, either environmental or genetic, with their maturation or function have devastating consequences. Albeit so far neglected, one of the less appreciated, nevertheless possible, regulators of OL maturation and function ...

journal_title：Neurochemical research

authors： Colwell CS,Ghiani CA

更新日期：2020-03-01 00:00:00

abstract：:Correct timing and spatial location of growth factor expression is critical for undisturbed brain development and functioning. In terminally differentiated cells distinct biological responses to growth factors may depend on cell type specific activation of signalling cascades. We show that the hematopoietic growth fac...

journal_title：Neurochemical research

authors： Byts N,Samoylenko A,Woldt H,Ehrenreich H,Sirén AL

更新日期：2006-10-01 00:00:00

abstract：:Methylphenidate is commonly used for the treatment of attention deficit/hyperactivity disorder. There are still few works regarding the effects of methylphenidate on brain energy metabolism. Thus, in the present study we evaluated the effect of chronic administration of methylphenidate on the activities of mitochondri...

journal_title：Neurochemical research

authors： Fagundes AO,Aguiar MR,Aguiar CS,Scaini G,Sachet MU,Bernhardt NM,Rezin GT,Valvassori SS,Quevedo J,Streck EL

更新日期：2010-11-01 00:00:00

abstract：:It has been reported that electrical stimulation (ES) can promote nerve regeneration. One of the key factors leading to the promotion is calcium, which plays a vital role in the regulation on electrical activity of neurons, but the detailed mechanism is still an open question. In this study, ES was used to stimulate c...

journal_title：Neurochemical research

authors： Yan X,Liu J,Huang J,Huang M,He F,Ye Z,Xiao W,Hu X,Luo Z

更新日期：2014-01-01 00:00:00

abstract：:The mitochondrial enzyme, pyruvate carboxylase (PC; EC 6.4.1.1) is considered to play a significant role in the intermediary metabolism of neural tissue. PC-catalyzed carboxylation of pyruvate to oxaloacetate is a major anaplerotic reaction in brain. Anaplerosis is essential for homeostasis of the members of the trica...

journal_title：Neurochemical research

authors： Murin R,Cesar M,Kowtharapu BS,Verleysdonk S,Hamprecht B

更新日期：2009-03-01 00:00:00

abstract：:Donepezil is a selective inhibitor of acetylcholinesterase (AChE) clinically used for treating Alzheimer's disease. Cholinergic effects after short-term exposure of donepezil (up to 12 h) have been extensively studied in rats, but few have addressed the potential long-term effects. After 14 days administration (1x3 mg...

journal_title：Neurochemical research

authors： Haug KH,Bogen IL,Osmundsen H,Walaas I,Fonnum F

更新日期：2005-12-01 00:00:00

abstract：:Despite the consensus that activation of TWIK-related spinal cord K+ (TRESK) might contribute to the pathogenesis of chronic pain, the specific mechanisms underlying the transfer and development of pain signals still remain obscure. In the present study, we validated that TRESK was expressed in neurons instead of glia...

journal_title：Neurochemical research

authors： Zhou J,Chen H,Yang C,Zhong J,He W,Xiong Q

更新日期：2017-05-01 00:00:00

abstract：:A role for protein phosphorylation in the process of neurite outgrowth has been inferred from many studies of the effects of protein kinase inhibitors and activators on cultured neurotumor cells and primary neuronal cells from developing brain or ganglia. Here we re-examine this issue, using a culture system derived f...

journal_title：Neurochemical research

authors： Heacock AM,Agranoff BW

更新日期：1997-10-01 00:00:00

abstract：:A study of separate and combined actions of cobra venom (CV) and a new hypothalamic proline-rich polypeptide (PRP) isolated from magnocellular cells (NPV and NSO) on intoxication- and trauma-induced neuronal injury (during 3-4 weeks after hemisection with and without PRP treatment) was carried out. The registration of...

journal_title：Neurochemical research

authors： Galoyan AA,Sarkissian JS,Kipriyan TK,Sarkissian EJ,Chavushyan EA,Sulkhanyan RM,Meliksetyan IB,Abrahamyan SS,Grigorian YKh,Avetisyan ZA,Otieva NA

更新日期：2001-09-01 00:00:00

abstract：:This study examined changes in neuropeptide Y (NPY) Y2 receptor binding in the brains of C57BL/6 mice in response to different levels of high-fat diets via three dietary intervention methods: high-fat diet, switching from high- to low-fat diet and finally, energy restricted high-fat diet. Forty-five C57Bl/6 male mice ...

journal_title：Neurochemical research

authors： Huang XF,Yu Y,Li Y,Tim S,Deng C,Wang Q

更新日期：2008-09-01 00:00:00

abstract：:The microdialysis technique was used to study the effect of nitric oxide synthase (NOS) activity on taurine release. Taurine release was characterized in rat striatum that was excitotoxically lesioned compared to normal conditions. The basal taurine level of the dialysate decreased during quinolinate (QUIN) lesion in ...

journal_title：Neurochemical research

authors： Böckelmann R,Reiser M,Wolf G

更新日期：1998-04-01 00:00:00

abstract：:Rat posterior eyecups containing the retina were prepared, loaded with [(3)H]glycine and superfused in order to determine its release originated from glycinergic amacrine cells and/or glial cells. Deprivation of oxygen and glucose from the Krebs-bicarbonate buffer used for superfusion evoked a marked increase of [(3)H...

journal_title：Neurochemical research

authors： Hanuska A,Szénási G,Albert M,Koles L,Varga A,Szabo A,Matyus P,Harsing LG Jr

更新日期：2016-02-01 00:00:00

abstract：:In vitro synthesis of myelin proteolipid protein (PLP) was explored at different ages using rat brain total homogenates, incubated for 30 min with [3H]glycine. Total proteolipids, extracted from the incubated samples, were separated by SDS-PAGE and the radioactivity was measured in the band corresponding to myelin PLP...

journal_title：Neurochemical research

authors： Bizzozero OA,Pasquini JM

更新日期：1984-09-01 00:00:00

abstract：:The acetylcholinesterase from synaptosomal membranes is inhibited by anesthetics: Nembutal, brietal, and thiopental. Nembutal and brietal decrease the Km for acetylthiocholine, without changes in Vmas. A noncompetitive type of inhibition is produced by thiopental. This anesthetic decreases Arrhenius plot discontinuity...

journal_title：Neurochemical research

authors： Pastuszko A

更新日期：1980-07-01 00:00:00

abstract：:The wobbler mouse suffers an autosomal recessive mutation producing severe neurodegeneration and astrogliosis in spinal cord. It has been considered a model for amyotrophic lateral sclerosis. We have studied in these animals the expression of two proteins, the growth-associated protein (GAP-43) and the NADPH-diaphoras...

journal_title：Neurochemical research

authors： González Deniselle MC,González SL,Lima AE,Wilkin G,De Nicola AF

更新日期：1999-01-01 00:00:00

abstract：:The characteristics and properties of the increase in cytosolic [Ca2+] that occurs in bovine adrenal medullary chromaffin cells on exposure to angiotensin 11 have been investigated. In fura-2 loaded cells exposure to a maximally effective concentration of angiotensin II (100 nM) caused a rapid, but transient increase ...

journal_title：Neurochemical research

authors： Powis DA,Zerbes M,Herd LM,Dunkley PR

更新日期：2003-09-01 00:00:00

abstract：:Poly(A)-RNA prepared from the brains of 30-day-old male rats has been shown to direct the synthesis of neuron-specific enolase (NSE) in a cell-free system derived from rabbit reticulocytes. The newly synthesized polypeptides were immunoprecipitated and analyzed on SDS-polyacrylamide slab gels. Autoradiography indicate...

journal_title：Neurochemical research

authors： Walker WA,Zomzely-Neurath C

更新日期：1980-04-01 00:00:00