Abstract：
:As is known to all, neuroinflammation plays a vital role in early brain injury pathogenesis following subarachnoid hemorrhage (SAH). It has been shown that rutin have a property of inhibiting inflammation in many kinds of animal models. However, the effect of rutin on neuroinflammation after SAH remains uninvestigated. In this study, we investigated the potential effects of rutin on neuroinflammation and the underlying mechanism in an experimental rat model of SAH performed by endovascular perforation. Adult male SD rats were randomly divided into three groups, including sham group, SAH + vehicle group and SAH + rutin group (50 mg/kg) intraperitoneally (i.p.) administered at 30 min after SAH. After sacrificed at 24 h after SAH, all rats were examined by following tests, including neurologic scores, blood-brain barrier permeability, brain water content and neuronal cell death in cerebral cortex. The level of inflammation in brain was estimated by means of multiple molecules, including RAGE, NF-κB, and inflammation cytokines. Our results indicated that rutin could significantly downregulate the increased level of REGE, NF-κB and inflammatory cytokines in protein level. In addition, rutin could also ameliorate a series of secondary brain injuries such as brain edema, destruction of blood-brain barrier, neurological deficits and neuronal death. This study indicated that rutin administration had a neuroprotective effect in an experimental rat model of SAH, possibly through inhibiting RAGE-NF-κB mediated inflammation signaling pathway.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Hao G,Dong Y,Huo R,Wen K,Zhang Y,Liang Gdoi
10.1007/s11064-016-1863-7subject
Has Abstractpub_date
2016-06-01 00:00:00pages
1496-504issue
6eissn
0364-3190issn
1573-6903pii
10.1007/s11064-016-1863-7journal_volume
41pub_type
杂志文章abstract：:Glutamine synthetase (GS) from the chick brain was purified to apparent homogeneity by ammonium sulfate fractionation followed by affinity chromatography, electrofocusing and Sephadex G-150 chromatography. The purified enzyme showed a single band on sodium dodecyl sulfate analysis in polyacrylamide gel. By sedimentati...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00970934
更新日期：1987-11-01 00:00:00
abstract：:The search for neuronotrophic factors addressing CNS neurons requires CNS neuronal cell cultures to quantitate putative effects on neuronal survival. Investigation of neurons dissociated from several embryonic CNS tissues have shown that their short-term survival requires supplementation of the culture medium with eit...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973276
更新日期：1988-07-01 00:00:00
abstract：:The present study addressed the hypothesis that the DA transporter ligand, [3H]mazindol, labels multiple sites/states associated with the dopamine (DA) transporter in striatal membranes. Incubations with [3H]mazindol proceeded for 18-24 hr at 4 degrees C in 55.2 mM sodium phosphate buffer, pH 7.4, with a protease inhi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966817
更新日期：1994-02-01 00:00:00
abstract：:Metabolism of triacylglycerol (TAG) in developing brain has been examined. TAG is a relatively minor fraction of brain lipid in both suckling and adult rats and cannot be accounted for as entrapped blood. When glycerol tri[1-14C]oleate and [2-3H]glycerol trioleate were simultaneously injected intracerebrally into suck...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966679
更新日期：1981-11-01 00:00:00
abstract：:Chronic acrylamide (ACR) exposure induces peripheral-central axonopathy in occupational workers and laboratory animals, but the underlying mechanisms remain unclear. In this study, we first investigated the effects of ACR on slow axonal transport of neurofilaments in cultured rat dorsal root ganglia (DRG) neurons thro...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1782-z
更新日期：2016-05-01 00:00:00
abstract：:We have investigated gene expression changes produced by acute and chronic daily treatment with a prototypical antidepressant, imipramine, using DNA microarrays. The analysis of similarities in gene expression patterns among functionally related genes revealed four expression profile cluster areas that showed a highly...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/b:nere.0000023610.89631.d6
更新日期：2004-06-01 00:00:00
abstract：:Rabbits were immunized with the myelin-associated glycoprotein (MAG) that had been purified from isolated rat brain myelin by selective extraction with lithium diiodosalicylate (LIS) and phenol followed by preparative SDS gel electrophoresis. Antibodies to MAG were detected qualitatively by immunodiffusion and quantit...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964417
更新日期：1981-10-01 00:00:00
abstract：:Rats were long-term morphine-intoxicated by a fluid-diet model ensuring an equal nutrient intake in morphinized and control rats. Uptake of neurotransmitters and D-ala2-met5-enkephalinamide (Enk) was studied in the particulate fractions (obtained at 10,000 g) from well defined brain regions of long-term intoxicated an...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967978
更新日期：1986-02-01 00:00:00
abstract：:2,5-Hexanedione (2,5-HD) induces central-peripheral axonpathy characterized by the accumulation of 10-nm neurofilaments proximal to the nodes of Ranvier and a Wallerian-type degeneration. It has been postulated that neurofilament crosslinking may be involved in the production of this axonopathy. A potential initiating...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965151
更新日期：1994-09-01 00:00:00
abstract：:The serotoninergic system modulates nociceptive and locomotor spinal cord circuits. Exercise improves motor function and changes dopaminergic, noradrenergic, and serotonergic central systems. However, the direct relationship between serotonin, peripheral nerve lesion and aerobic treadmill exercise has not been studied...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-0066-x
更新日期：2010-03-01 00:00:00
abstract：:The synaptic glutamate level homeostasis is mainly maintained by the astrocytes membrane bound glutamate transporter type-1 (GLT-1/EAAT2). Alterations in its expression during development and aging and the underlying mechanisms are not well studied. Here, we report that NF-κB interaction was highest in both cerebral a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1200-3
更新日期：2014-01-01 00:00:00
abstract：:Trigeminal neuralgia (TN) is a type of chronic neuropathic pain that is caused by peripheral nerve lesions that result from various conditions, including the compression of vessels, tumors and viral infections. MicroRNAs (miRs) are increasingly recognized as potential regulators of neuropathic pain. Previous evidence ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02797-2
更新日期：2019-07-01 00:00:00
abstract：:Probenecid inhibits the transport of the small monocarboxylic acids lactate and propionate from blood to brain but does not affect the transport of 5HIAA or HVA. Neither lactate, 5HIAA, HVA, nor probenecid itself inhibits probenecid uptake into brain from blood and neither lactate nor 5HIAA itself inhibits 5HIAA uptak...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965898
更新日期：1982-10-01 00:00:00
abstract：:The potent parkinsonian neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is known to cause dopaminergic neurodegeneration in nigrostriatal system. In the present study we investigated the nuclear morphology of cells in the substantia nigra pars compacta (SNpc) region of rats following unilateral intra...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9299-8
更新日期：2007-07-01 00:00:00
abstract：:Schwann cell biosynthesis of glycolipids was studied by in vitro incorporation of [3H]galactose into neonatal rat sciatic nerves before and after endoneurial explant culture and in culture of purified Schwann cells. In neonatal nerves prior to culture, [3H]galactose was actively incorporated into galactocerebrosides (...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00968672
更新日期：1990-03-01 00:00:00
abstract：:Methylguanidine (MG) is known as not only a nephrotoxin but also as a neurotoxine. We have previously showed that MG itself generates hydroxyl radicals (*OH) in an in vitro study. In this study, we examined the inhibitory effects of ascorbate, EPC-K(1) (alpha-tocopheryl-L-ascorbate-2-O-phosphate diester), Trolox (wate...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9811-9
更新日期：2009-04-01 00:00:00
abstract：:The neurotoxic effects of aluminum are generally associated with reduced antioxidant capacity, increased oxidative stress and apoptosis, which lead to the induction of neurodegenerative processes. Curcumin has a lipophilic polyphenol character and effects of antioxidant and anti-apoptotic. The present study was undert...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02839-9
更新日期：2019-08-01 00:00:00
abstract：:The secretion of fluid and electrolytes by salivary gland acinar cells requires the coordinated regulation of multiple ion channel and transporter proteins, signaling components, and water transport. Importantly, neurotransmitter stimulated increase in the cytosolic free [Ca(2+)] ([Ca(2+)](i)) is critical for the regu...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-011-0465-7
更新日期：2011-07-01 00:00:00
abstract：:It is reported that chitinase1 increases in Alzheimer's disease (AD). However, the alteration of chitinase1 in the progress of AD is still unclear. Thus, we designed the present study to detect chitinase1 level in different stages of APP/PS1 double transgenic mice. Experimental models were APP/PS1 double transgenic mi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1874-4
更新日期：2016-07-01 00:00:00
abstract：:The maximal rate of some cerebral enzymatic activities related to energy transduction (hexokinase; phosphofructokinase; lactate dehydrogenase; citrate synthase; malate dehydrogenase; total NADH-cytochrome c reductase; cytochrome oxidase), amino acid metabolism (glutamate decarboxylase; glutamate dehydrogenase) and cho...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963926
更新日期：1983-02-01 00:00:00
abstract：:"Kindling" is a phenomenon of epileptogenesis, which has been widely used as an experimental model of temporal lobe epilepsy. At the present work we investigated the contribution of NMDA receptors in the Pentylenetetrazol-induced "kindling" model in the mouse brain, by using quantitative autoradiography and the radioa...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021143813935
更新日期：1999-12-01 00:00:00
abstract：:(4S)-4-Amino-5,6-heptadienoic acid [S)-gamma-allenyl-GABA; MDL 72483) is a potent inactivator of brain GABA-T in mice; (ED50 (i.p.) = 60 mg.kg-1; ED50 (oral) = 70 mg.kg-1). Its anticonvulsant effects against 3-mercaptopropionic acid (MPA)-induced seizures in mice is related to the elevation of whole brain GABA concent...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966092
更新日期：1991-03-01 00:00:00
abstract：:Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutritio...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1025678510480
更新日期：2003-10-01 00:00:00
abstract：:Single prolonged stress (SPS) is one of the preclinical models of posttraumatic stress disorder (PTSD) in humans. Not every traumatized person develops PTSD and the onset of the disease varies from months to many years after exposure to life-threatening events. The pathogenetic neurometabolites in PTSD have not been i...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-017-2232-x
更新日期：2017-08-01 00:00:00
abstract：:Intracerebral hemorrhage (ICH) is an important public health problem in neurology, which is not only associated with high mortality but also leading to disability. Yet no satisfactory treatment has been developed. The secondary injury that resulted from a number of self-destructive processes such as neuroinflammation,...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-017-2179-y
更新日期：2017-05-01 00:00:00
abstract：:One of the many pharmacological targets of ethanol is the GABA inhibitory system, and chronic ethanol (CE) is known to alter the polypeptide levels of the GABA(A )receptor subunits in rat brain regions. In the present study, we investigated the regulation of the tyrosine kinase phosphorylation of the GABA(A) receptor ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9288-y
更新日期：2007-07-01 00:00:00
abstract：:The hypothalamic paraventricular nucleus (PVN) is a key site for regulating neuroendocrine functions in the magnocellular part and autonomic activities in the parvocellular part. Its anatomical proximity to the third ventricle could be a good target for intrathecal injection of baclofen. We investigated the correlatio...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0621-0
更新日期：2012-02-01 00:00:00
abstract：:Recent evidence indicates that mechanisms involved in reward and mechanisms involved in learning interact, in that reward includes learning processes and learning includes reward processes. In spite of such interactions, reward and learning represent distinct functions. In the present study, as part of an examination ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9343-8
更新日期：2007-10-01 00:00:00
abstract：:Zinc oxide nanoparticles (ZnO NPs) have diverse utility these days ranging from being part of nanosensors to be ingredient of cosmetics. Present study was designed to report the effect of variable doses of ZnO NPs on selected aspects of male albino mice behavior. Nano particles were synthesized by sol-gel auto-combust...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-2090-y
更新日期：2017-02-01 00:00:00
abstract：:The present study investigated the expression patterns of glial cells and interleukin-1beta (IL-1beta) in the rat spinal cord after a surgical incision, which is closely related with clinical postoperative pain. Microglia and astrocytes became activated in the spinal cord following incision. Real-time polymerase chain...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-9032-4
更新日期：2006-03-01 00:00:00
