Peroxidative block of glucose utilization and survival in CNS neuronal cultures.

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder of dopaminergic, noradrenergic, and serotonergic systems, in which dopamine, noradrenaline, and serotonin levels are depleted and lead to the development of motor and non-motor symptoms such as tremor, bradykinesia, weight changes, fatigue, depression, and visua...

journal_title：Neurochemical research

authors： Parambi DGT,Saleem U,Shah MA,Anwar F,Ahmad B,Manzar A,Itzaz A,Harilal S,Uddin MS,Kim H,Mathew B

更新日期：2020-11-01 00:00:00

abstract：:Comparative structure-function studies have been carried out for alpha-conotoxin GI acting on nicotinic acetylcholine receptors (AChR) from mammalian muscles and from the electric organ of the Torpedo californica ray and for alpha-conotoxin ImI, which targets the neuronal alpha7 AChR. A series of analogs has been prep...

journal_title：Neurochemical research

authors： Kasheverov IE,Zhmak MN,Maslennikov IV,Utkin YN,Tsetlin VI

更新日期：2003-04-01 00:00:00

abstract：:Exposure of guinea pig brain slices to low concentrations (10 microM) of NMDA caused decreases in PCr and ATP within 30 min, with a slower decrease in NAA and increase in lactate, both detectable after 1 h. Exposure to NMDA for over 1 h or at higher concentrations caused further increases in lactate and decreases in N...

journal_title：Neurochemical research

authors： Thatcher NM,Badar-Goffer RS,Ben-Yoseph O,McLean MA,Morris PG,Prior MJ,Taylor A,Bachelard HS

更新日期：2002-02-01 00:00:00

abstract：:Deposition of amyloid beta peptide in human brain in the form of senile plaques is a neuropathological hallmark of Alzheimer's disease (AD). Levels of a phospholipid breakdown product, glycerophosphocholine (GPC), also increase in AD brain. The effect of GPC on amyloid beta(1-40) peptide (Abeta) aggregation in PBS buf...

journal_title：Neurochemical research

authors： Mandal PK,McClure RJ,Pettegrew JW

更新日期：2004-12-01 00:00:00

abstract：:We have previously showed that peptide neurotensin inhibits neuronal Na(+), K(+)-ATPase activity, an effect which involves high affinity neurotensin receptor. Nitric oxide (NO) acts as a neurotransmitter or as a neuromodulator when it is synthesized by neuronal nitric oxide synthase. Neurotensin effect on Na(+), K(+)-...

journal_title：Neurochemical research

authors： López Ordieres MG,Álvarez-Juliá A,Kemmling A,Rodríguez de Lores Arnaiz G

更新日期：2011-12-01 00:00:00

abstract：:The adaptation of cells to hyperosmotic conditions involves accumulation of organic osmolytes to achieve osmotic equilibrium and maintenance of cell volume. The Na+ and Cl(-)-coupled betaine/GABA transporter, designated BGT-1, is responsible for the cellular accumulation of betaine and has been proposed to play a role...

journal_title：Neurochemical research

authors： Olsen M,Sarup A,Larsson OM,Schousboe A

更新日期：2005-06-01 00:00:00

abstract：:We analyzed the impact of axonopathy-inducing agents 1,2-diacetylbenzene (1,2-DAB) and 2,5-hexanedione (2,5-HD) on membrane-bound protein disulfide isomerase (mPDI) versus soluble PDI (sPDI), or PDI-family member thioredoxin (THX), and asked whether changes in PDI/THX were associated with production of oxidative/nitro...

journal_title：Neurochemical research

authors： Tshala-Katumbay D,Desjardins P,Sabri M,Butterworth R,Spencer P

更新日期：2009-11-01 00:00:00

abstract：:Exercise increases both the consumption of oxygen and the production of reactive species in biological tissues, and this is counterbalanced by antioxidant adaptations to regular physical training. When the intensity of exercise fluctuates between mild and moderate, it improves the status of reduction-oxidation balance...

journal_title：Neurochemical research

authors： Speck AE,Tromm CB,Pozzi BG,Paganini CS,Tuon T,Silveira PC,Aguiar AS Jr,Pinho RA

更新日期：2014-08-01 00:00:00

abstract：:Neonatal hypoxia/ischemia (HI) is the most common cause of developmental neurological, cognitive and behavioral deficits in children, with hyperoxia (HHI) treatment being a clinical therapy for newborn resuscitation. Although cerebral edema is a common outcome after HI, the mechanisms leading to excessive fluid accumu...

journal_title：Neurochemical research

authors： Ferrari DC,Nesic O,Perez-Polo JR

更新日期：2010-12-01 00:00:00

abstract：:The phosphoinositide signal transduction system, and particularly, phospholipase Cbeta isozymes, are relevant in the etiopathogeny of human neuropsychiatric pathologies such as depression. Stimulation of phospholipase Cbeta activity by muscarinic receptors and G proteins was determined in crude and synaptosomal membra...

journal_title：Neurochemical research

authors： Garro MA,López de Jesús M,Ruíz de Azúa I,Callado LF,Meana JJ,Sallés J

更新日期：2004-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common type of neurodegenerative dementia that affects the elderly population. Nerve growth factor (NGF) contributes to the survival, regeneration and death of neurons during aging and in neurodegenerative diseases. Recently, research has shown that NGF is related to the pathology,...

journal_title：Neurochemical research

authors： Xu CJ,Wang JL,Jin WL

更新日期：2016-06-01 00:00:00

abstract：:The secretion of fluid and electrolytes by salivary gland acinar cells requires the coordinated regulation of multiple ion channel and transporter proteins, signaling components, and water transport. Importantly, neurotransmitter stimulated increase in the cytosolic free [Ca(2+)] ([Ca(2+)](i)) is critical for the regu...

journal_title：Neurochemical research

authors： Ambudkar IS

更新日期：2011-07-01 00:00:00

abstract：:A study of separate and combined actions of cobra venom (CV) and a new hypothalamic proline-rich polypeptide (PRP) isolated from magnocellular cells (NPV and NSO) on intoxication- and trauma-induced neuronal injury (during 3-4 weeks after hemisection with and without PRP treatment) was carried out. The registration of...

journal_title：Neurochemical research

authors： Galoyan AA,Sarkissian JS,Kipriyan TK,Sarkissian EJ,Chavushyan EA,Sulkhanyan RM,Meliksetyan IB,Abrahamyan SS,Grigorian YKh,Avetisyan ZA,Otieva NA

更新日期：2001-09-01 00:00:00

abstract：:Oligodendrocytes (OL) are the only myelinating cells of the central nervous system thus interferences, either environmental or genetic, with their maturation or function have devastating consequences. Albeit so far neglected, one of the less appreciated, nevertheless possible, regulators of OL maturation and function ...

journal_title：Neurochemical research

authors： Colwell CS,Ghiani CA

更新日期：2020-03-01 00:00:00

abstract：:Omega-conotoxin GVIA (omega-CTX), as a selective blocker for an N-type Ca2+ channel, has been conveniently used in many molecular biochemical and pharmacological experiments. There has been little elucidation of 125I-omega-CTX binding sites (mainly the 135-kDa band) in the crude membranes from chick brain, although th...

journal_title：Neurochemical research

authors： Wada T,Abe J,Minami T,Masuko T,Ichida S

更新日期：2003-05-01 00:00:00

abstract：:The neuropathy associated with diabetes includes well documented impairment of axonal transport, a reduction in axon calibre and a reduced capacity for nerve regeneration. All of those aspects of nerve function rely on the integrity of the axonal cytoskeleton. Alterations in the axonal cytoskeleton in experimental dia...

journal_title：Neurochemical research

authors： McLean WG

更新日期：1997-08-01 00:00:00

abstract：:We estimated catecholamine levels in CSF of 15 epileptics and 75 non-neurological patients utilizing a high performance liquid chromatograph with a highly sensitive fluorometer and found the following results: The dopamine (DA) levels in males were significantly higher than those in females, while norepinephrine (NE) ...

journal_title：Neurochemical research

authors： Hiramatsu M,Fujimoto N,Mori A

更新日期：1982-10-01 00:00:00

abstract：:The amyloid peptide (Abeta) deposited in Alzheimer's disease (AD) is generated by beta- and gamma-secretase processing of a larger integral membrane protein precursor (APP). Intramembrane processing of APP by gamma-secretase also yields an intracellular fragment, CTFgamma (a.k.a. AICD), which is highly conserved and i...

journal_title：Neurochemical research

authors： Venugopal C,Pappolla MA,Sambamurti K

更新日期：2007-12-01 00:00:00

abstract：:The concept of exosomes has been progressively changed from the status of cellular trashcans to multitasking organelles involved in many processes, including internalization, transport and transfer of macromolecules such as proteins, lipids and nucleic acids. While underpinning the mechanisms behind neurodegeneration ...

journal_title：Neurochemical research

authors： Lakshmi S,Essa MM,Hartman RE,Guillemin GJ,Sivan S,Elumalai P

更新日期：2020-11-01 00:00:00

abstract：:The features of neuronal damage induced by the mitochondrial toxin NaN(3) were investigated in rat primary cortical neuron cultures. Cell viability (MTT colorimetric determination) and transmembrane mitochondrial potential (J-C1 fluorescence) were concentration-dependently reduced 24 h after NaN(3); neither nuclear fr...

journal_title：Neurochemical research

authors： Selvatici R,Previati M,Marino S,Marani L,Falzarano S,Lanzoni I,Siniscalchi A

更新日期：2009-05-01 00:00:00

abstract：:Neuronal perikarya were isolated, using bulk preparative procedures, from bovine brains. Synaptosomes, neuronal perikarya, and brain homogenates had similar ganglioside patterns, with the synaptosomes containing at least four times more total ganglioside per mg protein than the neuronal perikarya and twice that of the...

journal_title：Neurochemical research

authors： Schengrund CL,Nelson JT

更新日期：1976-04-01 00:00:00

abstract：:BCL-2-associated athanogene-1(BAG-1) is a multifunctional and anti-apoptotic protein that was first identified as a binding partner of BCL-2. But the effects and mechanisms for BAG-1 against hypoxic damage is unclear up to now. Whether BAG-1 could protect the human brain against hypoxic damage through up-regulating 70...

journal_title：Neurochemical research

authors： Wang Y,Jia C,Li QS,Xie CY,Zhang N,Qu Y

更新日期：2017-10-01 00:00:00

abstract：:Overactivation of glutamate receptors results in neurodegeneration in a variety of brain pathologies, including ischemia, epilepsy, traumatic brain injury and slow-progressing neurodegenerative disorders. In all these pathologies, it is well accepted that the calcium-dependent cysteine proteases calpains are key playe...

journal_title：Neurochemical research

authors： Araújo IM,Carreira BP,Carvalho CM,Carvalho AP

更新日期：2010-12-01 00:00:00

abstract：:Changes in oxygen consumption, body temperature and energy metabolism were studied while mice were repeatedly exposed to a sealed environment. The average tolerance limits of environmental oxygen level (vol%) and the average oxygen consumption rates (ml/g x min) were exponentially decreased and the average body rectal...

journal_title：Neurochemical research

authors： Lu GW,Cui XY,Zhao BM

更新日期：1999-05-01 00:00:00

abstract：:The pathogenesis of sepsis associated encephalopathy (SAE) is not yet clear: the blood-brain barrier (BBB) disruption has been indicated among the possible causative mechanisms. S100B, a calcium binding protein, originates in the central nervous system but it can be also produced by extra-cerebral sources; it is passi...

journal_title：Neurochemical research

authors： Piazza O,Cotena S,De Robertis E,Caranci F,Tufano R

更新日期：2009-07-01 00:00:00

abstract：:The Fatty Acid method was used to determine whether incorporation of plasma radiolabeled arachidonic acid into brain phospholipids is controlled by phospholipase A2. Awake rats received an i.v. injection of a phospholipase A2 inhibitor, manoalide (10 mg/kg), and then were infused i.v. with [1-(14)C]arachidonate or [3H...

journal_title：Neurochemical research

authors： Grange E,Rabin O,Bell J,Chang MC

更新日期：1998-10-01 00:00:00

abstract：:Tau is a protein involved in regulation of microtubule stability, axonal differentiation and transport. Alteration of retrograde transport may lead to motor neuron degeneration. Thus alternative mRNA splicing and expression of tau isoforms were studied in a transgenic mouse model harboring the human SOD1 G93A mutation...

journal_title：Neurochemical research

authors： Usarek E,Kuźma-Kozakiewicz M,Schwalenstöcker B,Kaźmierczak B,Münch C,Ludolph AC,Barańczyk-Kuźma A

更新日期：2006-05-01 00:00:00

abstract：:Sex differences exist in the functioning of the two brain corticosteroid receptor systems. Ovarian steroid replacement alters receptor mRNA expression, receptor binding capacities, and receptor affinity. The abundance of both mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) message can be reduced by es...

journal_title：Neurochemical research

authors： Turner BB

更新日期：1997-11-01 00:00:00

abstract：:Exposure to Hg2+ below 10 micrometer destroys synaptosomal membrane-associated sialidase of bovine brain in situ. Inhibition by Cu2+ occurs only at relatively higher concentrations, and is demonstrable after the synaptosomal membrane preparation has been presaturated with Cu2+ . Pb2+ does not inhibit enzymatic activit...

journal_title：Neurochemical research

authors： Yohe HC,Rosenberg A

更新日期：1978-02-01 00:00:00

abstract：:Acupuncture and moxibustion are traditional medical treatments that have come to play important roles in complementary and alternative medicines. Moxibustion also has a long history as a folk remedy in Japan, particularly due to the technical simplicity and selective efficacy on certain types of disease and distress. ...

journal_title：Neurochemical research

authors： Fukuda F,Shinbara H,Yoshimoto K,Yano T,Kuriyama K

更新日期：2005-12-01 00:00:00