Abstract：
:Changes in oxygen consumption, body temperature and energy metabolism were studied while mice were repeatedly exposed to a sealed environment. The average tolerance limits of environmental oxygen level (vol%) and the average oxygen consumption rates (ml/g x min) were exponentially decreased and the average body rectal temperatures (degrees C) were linearly declined while the average tolerable times (min) to hypoxia were linearly increased as animals were repeatedly exposed to hypoxia for 5 runs. The average survival times (min) in sealed environments after administration of normal saline, iodoacetic acid, malonic acid, potassium cyanide, and potassium cyanide plus iodoacetic acid in group exposed repeatedly to hypoxia for three runs were, respectively, 3.1, 3.9, 1.4, 2.6, and 2.8 times those of the control groups that had corresponding administration of the different chemicals, but no exposure to hypoxia. The results indicate that progressive increase in hypoxia tolerance is related to progressively lower rate of oxygen consumption and heat production, and the lowered energy requirement during repetitive exposure to hypoxia is achieved mainly via pathways of the respiratory chain and glycolysis.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Lu GW,Cui XY,Zhao BMdoi
10.1023/a:1021092023253keywords:
subject
Has Abstractpub_date
1999-05-01 00:00:00pages
625-8issue
5eissn
0364-3190issn
1573-6903journal_volume
24pub_type
杂志文章abstract：:TRH-like immunoreactivity distinct from TRH is present in various tissues and fluids. In order to determine whether TRH-like molecules are secreted by the hypothalamus, we analyzed tissues and media from hypothalamic slices incubated in Krebs Ringer bicarbonate. Media from basal or high KCl conditions contained 3 TRH-...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020993527602
更新日期：1999-07-01 00:00:00
abstract：:Ethyl pyruvate (EP) has recently been reported to afford protection against neurodegenerative disorders. However, the mechanism underlying EP-mediated neuroprotection remains to be elucidated. Because peroxynitrite has been extensively implicated in the pathogenesis of various forms of neurodegenerative disorders via ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-0059-9
更新日期：2010-02-01 00:00:00
abstract：:Brain regional 5-HT (5-hydroxytryptamine) and 5-HIAA (5-hydroxyindole-3-acetic acid) concentrations in male LE rats at three times were measured by a fluorescence method, to evaluate effects of intracranial surgery and administration of melatonin on the changes in these compounds during the first part of the dark phas...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965929
更新日期：1989-10-01 00:00:00
abstract：:In human pathology little is known about the activating enzymes for fatty acids of different carbon chain length. In order to have a better insight into disorders of lipid metabolism in human skeletal muscle, we studied the distribution of acyl-CoA synthetases in muscular subcellular fractions. We find that in muscle ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964696
更新日期：1983-05-01 00:00:00
abstract：:A very large body of evidence from in vivo studies has been accumulated on a link between the change of energy and cell survival/apoptosis. Using an in vitro ischemia model, we have previously shown that ischemia could induce apoptosis in astrocytes. In this study, we utilized the same in vitro model to investigate ch...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021691112190
更新日期：2002-12-01 00:00:00
abstract：:Phosphate activated glutaminase (PAG) was assayed in whole homogenate and synaptosomes of cerebral cortex from normal or fasted for 120 h rats. The specific activity (s.a.) of PAG was found diminished by 25% in the whole homogenate from the fasted animals compared to the normal. On the contrary, fasting did not affect...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965830
更新日期：1991-01-01 00:00:00
abstract：:A simple, rapid method for determining depolarization-induced 45Ca influx into synaptosomes is described. Synaptosomes which had been depolarized in the presence of 45Ca were applied to a small column of Chelex-100 resin to separate free Ca2+ from that taken up by the tissue. Approximately 70% of the synaptosomal prot...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965062
更新日期：1982-02-01 00:00:00
abstract：:We have previously showed that peptide neurotensin inhibits neuronal Na(+), K(+)-ATPase activity, an effect which involves high affinity neurotensin receptor. Nitric oxide (NO) acts as a neurotransmitter or as a neuromodulator when it is synthesized by neuronal nitric oxide synthase. Neurotensin effect on Na(+), K(+)-...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0552-9
更新日期：2011-12-01 00:00:00
abstract：:Aneurysmal subarachnoid hemorrhage still has a high mortality and morbidity despite notable advances in surgical approaches to cerebral aneurysm (CA). We examined the role of aspirin in vascular inflammation and degeneration. CA was induced in male Sprague-Dawley rats by ligating left common carotid artery and bilater...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1603-4
更新日期：2015-07-01 00:00:00
abstract：:Release of endogenous dopamine (DA) and gamma-aminobutyric acid (GABA) from superfused rat caudate synaptosomes was monitored with liquid chromatography with electrochemical detection. Dopamine was analyzed by oxidative detection following alumina extraction while GABA was analyzed with reductive detection following p...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964602
更新日期：1985-03-01 00:00:00
abstract：:There is growing evidence that ketone bodies (KB)-derived from fatty acid oxidation and produced during fasting or consumption of high-fat diets-can exert broad neuroprotective effects. With respect to epilepsy, KB (such as β-hydroxybutyrate or BHB, acetoacetate and acetone) have been shown to block acutely induced an...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-017-2253-5
更新日期：2017-07-01 00:00:00
abstract：:Neurons, purified by bulk-isolation procedures from 10 day-old rat brain, are 80-90% homogeneous. Contaminants are primarily blood vessels and occasional oligodendroglia. All sizes and shapes of neurons are obtained, as they are isolated from all areas of the brain, except the cerebellum. Neurotransmitter enzyme activ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971368
更新日期：1987-01-01 00:00:00
abstract：:We investigated the effects of H(2)O(2)-induced oxidative stress on the delayed-rectifier current (IK(DR)), neuronal physiological and morphological properties. Measurements were obtained from hippocampal CA1 neurons in control solution and from the same neurons after exposure to oxidative stress (short- and long-term...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9287-z
更新日期：2007-07-01 00:00:00
abstract：:Trans-caryophyllene (TC), a component of essential oil found in many flowering plants, has shown its neuroprotective effects in various neurological disorders. However, the effects of TC on epilepsy haven't been reported before. In this study, we investigated the effect of TC on kainic acid-induced seizure activity ca...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1474-0
更新日期：2015-01-01 00:00:00
abstract：:Age related changes in brain cortex NO metabolism were investigated in mitochondria and cytosolic extracts from youth to adulthood. Decreases of 19%, 40% and 71% in NO production were observed in mitochondrial fractions from 3, 7, and 14 months old rats, respectively, as compared with 1-month-old rats. Decreased nNOS ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9570-z
更新日期：2008-07-01 00:00:00
abstract：:The role of protein phosphorylation in catecholamine secretion from bovine adrenomedullary chromaffin cells was studied using different protein kinase inhibitors. Naphthalenesulfonamide derivatives as ML9 and ML7, more specific for the myosin light chain kinase, and the calmodulin antagonist W7 inhibited catecholamine...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969089
更新日期：1993-03-01 00:00:00
abstract：:Protein kinase A (PKA) plays a crucial role in tau hyperphosphorylation, an early event of Alzheimer disease (AD), and 17beta-estradiol replacement in aging women forestalls the onset of AD. However, the role of estradiol in PKA-induced tau hyperphosphorylation is not known. Here, we investigated the effect of 17beta-...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9638-4
更新日期：2008-09-01 00:00:00
abstract：:28-O-caffeoyl betulin (B-CA) has been demonstrated to reduce the cerebral infarct volume caused by transient middle cerebral artery occlusion (MCAO) injury. B-CA is a novel derivative of naturally occurring caffeoyl triterpene with little information associated with its pharmacological target(s). To date no data is av...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03202-z
更新日期：2021-01-03 00:00:00
abstract：:We have adopted the PC12 cell line as in vitro cell model for studying Dp71 function in neuronal cells. These cells express a cytoplasmic (Dp71f) and a nuclear (Dp71d) isoform of Dp71 as well as various dystrophin-associated proteins (DAPs). In this study, we revealed by confocal microscopy analysis and Western blotti...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-0064-z
更新日期：2010-03-01 00:00:00
abstract：:Docosahexaenoic acid (DHA) is verified to have neuroprotective effects on traumatic brain injury (TBI) rats by activating Nrf2 signaling pathway, but the role of NOX2 in this effect has not been illuminated. So this study explored the role of NOX2 in TBI models treated with DHA, aiming to complete the mechanism of DHA...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03078-z
更新日期：2020-08-01 00:00:00
abstract：:Growth-promoting macroglia (aldynoglia) with growth properties and immunological markers similar to Schwann cells, are found in loci of the mammalian CNS where axon regeneration occurs throughout life, like the olfactory sytem, hypothalamus-hypophysis and the pineal gland. Contrary to Schwann cells, aldynoglia mingle ...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1026056921037
更新日期：2003-11-01 00:00:00
abstract：:Bilateral injection of 6-hydroxydopamine into the medial forebrain bundle (MFB) significantly decreased monoamine concentrations in the hypothalamus. The noradrenaline and serotonin content of the paraventricular nucleus (PVN) was also significantly reduced. These drastic decreases in neurotransmitter concentration di...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF01474679
更新日期：1993-02-01 00:00:00
abstract：:Mutations in genes for Alzheimer's disease (AD) result in a modulating of gene expressions in the brains of patients with AD. The aim of this study was to identify genes whose expression is modulated due to the over-expression of human mutant presenilin-2 (N141I) (hPS2m) in transgenic mice, which has previously been p...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-6787-6
更新日期：2005-08-01 00:00:00
abstract：:Ochratoxin A (OA) is a mycotoxin produced by several storage fungi, such as Aspergillus ochraceus and several Penicillium species. OA (3 mg/kg) was given intraperitoneally to pregnant mice on day 11 of gestation (day 1 = day of insemination), and neurochemical changes in brains of their offspring were examined at feta...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971631
更新日期：1988-12-01 00:00:00
abstract：:The action of electroacupuncture (EA) may be similar to analgesia by electrode stimulation or transcutaneous nerve stimulation. Since EA may directly stimulate nerve activity or indirectly enhance the release of opiate peptides and other neurotransmitter substances, we have used (Na+ + K+)-ATPase as a model to study t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964513
更新日期：1984-05-01 00:00:00
abstract：:The effects of 1 min of acute hypoxic treatment (1% O2 in N2) on incorporation of [1-14C]arachidonic acid into brain lipids of 16-day-old rats were investigated at 3, 6, and 12 min after intracerebral injection of the labeled fatty acid. The hypoxic-hypoxia condition associated with convulsive seizures caused a decrea...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965474
更新日期：1981-07-01 00:00:00
abstract：:We have synthesized the tertiary amines of pyridostigmine and neostigmine, 3-pyridinol dimethylcarbamate (norpyridostigmine) and 3-dimethylaminophenol dimethylcarbamate (norneostigmine) respectively, and we have tested their abilities to cross the blood-brain barrier and inhibit mouse brain AChE activity. The in vivo ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973747
更新日期：1990-06-01 00:00:00
abstract：:Two major glycoproteins, P0 and PASII/PMP22, are specifically expressed in peripheral myelin. Point mutations of these proteins and over or under expression of PASII/PMP22 cause various hereditary peripheral neuropathies. P0 is well characterized as a major adhesion molecule in PNS myelin, but the function of PASII/PM...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1010927001378
更新日期：2001-06-01 00:00:00
abstract：:Amphiphile dependency, solubility in aqueous solutions, and sensitivity to proteolysis of acetylcholinesterase (AChE) and nonspecific cholinesterase (nsChE) in the rat superior cervical ganglion were studied and compared to properties of soluble plasma cholinesterases. Ganglion AChE shows strong amphiphile dependency:...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964537
更新日期：1985-06-01 00:00:00
abstract：:The effect of maternal hypoxia on the modification of the fetal brain cell membrane N-methyl-D-aspartate (NMDA) receptor and its modulatory sites was investigated. Experiments were conducted in pregnant guinea pigs of 60 days of gestation. Guinea pig fetuses were exposed to maternal hypoxia (FiO2 = 7%) for 60 minutes....
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00968402
更新日期：1992-12-01 00:00:00
