Three TRH-like molecules are released from rat hypothalamus in vitro.

abstract：:Cerebral deposition of amyloid β-peptide (Aβ), a fundamental feature of Alzheimer's disease (AD), damages the neurocytes and impairs the cognition functions and associative learning memory of AD patients. A series of novel 2-arylethenylquinoline derivatives were synthesized and evaluated in our previous study, which i...

journal_title：Neurochemical research

authors： He Q,Huang G,Chen Y,Wang X,Huang Z,Chen Z

更新日期：2017-11-01 00:00:00

abstract：:Mycobacterium leprae, the causative agent of leprosy, specifically invades and destroys the peripheral nerve, which results in the main clinical manifestation of the disease. Little is known about the bacteria-nerve protein interaction. We show in the present work that M leprae binds to a 25 kDa glycoprotein from huma...

journal_title：Neurochemical research

authors： Suneetha LM,Satish PR,Korula RJ,Suneetha SK,Job CK,Balasubramanian AS

更新日期：1998-06-01 00:00:00

abstract：:Due to the biological importance of sodium and its relative scarcity within many natural environments, 'salt appetite' has evolved whereby dietary salt is highly sought after and palatable when tasted. In addition to peripheral responses, salt depletion is detected within the brain via circumventricular organs and 11β...

journal_title：Neurochemical research

authors： Smith CM,Lawrence AJ

更新日期：2018-01-01 00:00:00

abstract：:The potassium A-current (IK(A)) is important in regulating the membrane potential between action potentials. The whole-cell patch-clamp technique was applied to cultured Drosophila neurons derived from embryonic neuroblasts. IK(A) was measured from neurons before and after application of 0.1 mM lanthanum to the extern...

journal_title：Neurochemical research

authors： Alshuaib WB,Mathew MV

更新日期：2005-09-01 00:00:00

abstract：:The effect of isoproterenol, norepinephrine, dopamine, and serotonin on the accumulation of adenosine 3',5'-monophosphate (cAMP) was studied in homogeneous neuronal cultures from 8-day chick embryo hemispheres. Among the catecholamines, isoproterenol had a more pronounced effect on the accumulation of cAMP. Norepineph...

journal_title：Neurochemical research

authors： Ciesielski-Treska J,Ulrich G

更新日期：1980-10-01 00:00:00

abstract：:DNase I sensitivity experiments were performed utilizing DNA probes to genes which are either transcribed in rat cortical neurons (the 68 kDa neurofilament gene and the neuron-specific enolase gene) or are transcriptionally silent (albumin). Results suggest that unlike liver, in which a hierarchy in chromatin conforma...

journal_title：Neurochemical research

authors： Ivanov TR,Brown IR

更新日期：1989-02-01 00:00:00

abstract：:Astrocytes occupy a strategic position in the brain where they can act as an interface between neurones and blood vessels, and neurones and the cerebro-spinal fluid. This location is ideal for functioning as interoceptors, as they may sense changes in brain microenvironment and contribute to the adaptive homeostatic r...

journal_title：Neurochemical research

authors： Teschemacher AG,Gourine AV,Kasparov S

更新日期：2015-12-01 00:00:00

abstract：:The developmental profiles of acetylcholinesterase and choline acetyltransferase in chick optic tectum and retina cell aggregates, over a 30-day period, have been determined and compared with the corresponding developmental curves obtained in vivo. Both acetylcholinesterase and choline acetyltransferase activities in ...

journal_title：Neurochemical research

authors： Ramirez G

更新日期：1977-08-01 00:00:00

abstract：:The long-acting opiate antagonist naltrexone hydrochloride was administered by intraperitoneal injection, in a dose response protocol, to adult rats. The drug was used to observe effects of opiate receptor blockade on cells of the pituitary gland and adjacent hypothalamus. At higher drug doses (5 mg/kg or 10 mg/kg), n...

journal_title：Neurochemical research

authors： Saland LC,Reyes E,Ortiz E

更新日期：1984-02-01 00:00:00

abstract：:Mice infected with the Venezuelan equine encephalomyelitis virus showed a significant decrease in the GABA content of cerebral hemispheres. Activity of the enzyme which synthetizes GABA, glutamate decarboxylase, is also reduced in whole cerebral hemispheres, neostriatum, and frontal cortex of infected animals, as comp...

journal_title：Neurochemical research

authors： Bonilla E,Ryder E,Ryder S

更新日期：1980-02-01 00:00:00

abstract：:Several models for the transmission and progression of prion diseases have arisen, evolving with the acquisition of new experimental results. It is generally accepted that the PrP(Sc) protein is at least part of the infectious particle and the major protein component of the scrapie-associated fibrils (SAFs) that chara...

journal_title：Neurochemical research

authors： Grossman A,Zeiler B,Sapirstein V

更新日期：2003-06-01 00:00:00

abstract：:We have attempted to show eventual modifications in the brain protein synthesis apparatus of rat during the first three weeks after birth. Through this time we noted a steady decrease (about 60%) in the free polysomes, when expressed relative to tissue weight. This decrease does not correlate with changes in the polys...

journal_title：Neurochemical research

authors： Gauthier D,Ven Murthy MR

更新日期：1986-09-01 00:00:00

abstract：:Mouse isolated vas deferens preincubated with [3-H]noradrenaline was superfused and the effect of alpha 1-adrenoceptor agonists was studied on the release of total radioactivity ([3H]noradrenaline + 3H-metabolites) and [3H]noradrenaline. Reverse phase high pressure liquid chromatography (HPLC) combined with scintillat...

journal_title：Neurochemical research

authors： Vizi ES,Somogyi GT,Harsing LG Jr,Zimanyi I

更新日期：1986-01-01 00:00:00

abstract：:Planarians are rapidly developing into very useful research subjects in pharmacology and neuroscience research. Here we report that curare, a cholinergic nicotinic receptor antagonist, alleviates the nicotine-induced planarian seizure-like movements (pSLM) by up to 50 % at equimolar concentrations of nicotine and cura...

journal_title：Neurochemical research

authors： Pagán OR,Montgomery E,Deats S,Bach D,Baker D

更新日期：2015-10-01 00:00:00

abstract：:We studied the dose-response characteristics and the temporal profile of inhibition of brain nitric oxide (NO) synthase (NOS) elicited by i.v. administration of the NOS inhibitor nitro-L-arginine methyl ester (L-NAME). L-NAME was administered i.v. in awake rats equipped with a venous cannula. L-NAME was injected in cu...

journal_title：Neurochemical research

authors： Iadecola C,Xu X,Zhang F,Hu J,el-Fakahany EE

更新日期：1994-04-01 00:00:00

abstract：:We have developed a coupled Xenopus oocyte expression system for evaluating the functional effects of mutations in known or suspected adhesion molecules, which allows for a very rapid assessment of intercellular adhesion. As a model protein, we first used Protein zero (Po), an adhesion molecule that mediates self-adhe...

journal_title：Neurochemical research

authors： Yoshida M,Colma DR

更新日期：2001-06-01 00:00:00

abstract：:The cellular uptake of the GABA-transaminase inhibitors gamma-vinyl GABA (GVG) and gamma-acetylenic GABA (GAG) was studied in cultured neurons and astrocytes. By the use of the individual enantiomers R- and S-GVG and R- and S-GAG it could be shown that in both cell types only the S-enantiomers could be actively transp...

journal_title：Neurochemical research

authors： Schousboe A,Larsson OM,Seiler N

更新日期：1986-11-01 00:00:00

abstract：:Umbilical cord blood-derived marrow stromal cells (UCB-MSCs) with high proliferation capacity and immunomodulatory properties are considered to be a good candidate for cell-based therapies. But until now, little work has been focused on the differentiation of UCB-MSCs. In this work, UCB-MSCs were demonstrated to be ne...

journal_title：Neurochemical research

authors： Zeng Y,Rong M,Liu Y,Liu J,Lu M,Tao X,Li Z,Chen X,Yang K,Li C,Liu Z

更新日期：2013-12-01 00:00:00

abstract：:Trigeminal neuralgia (TN) is a type of chronic neuropathic pain that is caused by peripheral nerve lesions that result from various conditions, including the compression of vessels, tumors and viral infections. MicroRNAs (miRs) are increasingly recognized as potential regulators of neuropathic pain. Previous evidence ...

journal_title：Neurochemical research

authors： Wang X,Wang H,Zhang T,He M,Liang H,Wang H,Xu L,Chen S,Xu M

更新日期：2019-07-01 00:00:00

abstract：:Amphiphile dependency, solubility in aqueous solutions, and sensitivity to proteolysis of acetylcholinesterase (AChE) and nonspecific cholinesterase (nsChE) in the rat superior cervical ganglion were studied and compared to properties of soluble plasma cholinesterases. Ganglion AChE shows strong amphiphile dependency:...

journal_title：Neurochemical research

authors： Klinar B,Kamarić L,Sketelj J,Brzin M

更新日期：1985-06-01 00:00:00

abstract：:This review summarizes the recent research development on mammalian sialidase molecular cloning. Sialic acid-containing compounds are involved in several physiological processes, and sialidases, as glycohydrolytic enzymes that remove sialic acid residues, play a pivotal role as well. Sialidases hydrolyze the nonreduci...

journal_title：Neurochemical research

authors： Monti E,Preti A,Venerando B,Borsani G

更新日期：2002-08-01 00:00:00

abstract：:Gelsolin is an actin regulatory protein that generally distributed in a wide variety of body tissues, especially the brain tissues and cerebrospinal fluid. In this study we found that lumbar CSF-gelsolin concentrations markedly decreased in epileptic patients by enzyme linked immunosorbent assay. In order to help judg...

journal_title：Neurochemical research

authors： Peng X,Zhang X,Wang L,Zhu Q,Luo J,Wang W,Wang X

更新日期：2011-12-01 00:00:00

abstract：:Changes in serotonin (5-HT) and 5-hydroxy indole acetic acid (5-HIAA), its major metabolite, in cerebral cortex, corpus striatum and hippocampus were investigated at 10th and 21st days of chronic ethanol ingestion in Wistar rats. Ethanol (7.2% v/v) was given to rats in a modified liquid diet. Biochemical analysis was ...

journal_title：Neurochemical research

authors： Uzbay IT,Usanmaz SE,Akarsu ES

更新日期：2000-02-01 00:00:00

abstract：:Previous studies have shown that early life stress induced by maternal separation or non-handling can lead to behavioural deficits in rats and that these deficits can be alleviated by providing palatable cafeteria high-fat diet (HFD). In these studies we investigated the effects of maternal separation or non-handling ...

journal_title：Neurochemical research

authors： Bobrovskaya L,Maniam J,Ong LK,Dunkley PR,Morris MJ

更新日期：2013-04-01 00:00:00

abstract：:The central control of growth hormone (GH) secretion from the pituitary gland is ultimately achieved by the interaction between two hypothalamic neurohormones, somatostatin which inhibits and growth hormone-releasing hormone (GHRH) which stimulates GH release. The regulation of the somatostatin and GHRH release from t...

journal_title：Neurochemical research

authors： Fodor M,Kordon C,Epelbaum J

更新日期：2006-02-01 00:00:00

abstract：:Acetylcholinesterase (AChE) inhibition has been described as the main mechanism of organophosphate (OP)-evoked toxicity. OPs represent a human health threat, because chronic exposure to low doses can damage the developing brain, and acute exposure can produce long-lasting damage to adult brains, despite post-exposure ...

journal_title：Neurochemical research

authors： Berríos VO,Boukli NM,Rodriguez JW,Negraes PD,Schwindt TT,Trujillo CA,Oliveira SL,Cubano LA,Ferchmin PA,Eterović VA,Ulrich H,Martins AH

更新日期：2015-10-01 00:00:00

abstract：:Ciliary ganglion neurons and nonneurons can be separated from each other, based on the greater adhesivity of the nonneurons to untreated tissue culture plastic in the presence of serum. When the separation was carried out in the presence of Serum Plus (a commercially available supplemented serum), two populations of n...

journal_title：Neurochemical research

authors： Needels DL,Nieto-Sampedro M,Cotman CW

更新日期：1987-10-01 00:00:00

abstract：:The overlapping distribution of opioid and cholecystokinin (CCK) peptides and their receptors (mu and delta opioid receptors; CCK-A and CCK-B receptors) in the central nervous system have led to a large number of studies aimed at clarifying the functional relationships between these two neuropeptides. Most of the phar...

journal_title：Neurochemical research

authors： Roques BP,Noble F

更新日期：1996-11-01 00:00:00

abstract：:Despite immense advances in the treatment strategies, the effective treatment of patients suffering from neuropathic pain remains challenging. Saikosaponin a possesses anti-inflammatory activity. However, the role of saikosaponin a in neuropathic pain is still unclear. Therefore, the objective of this study was to inv...

journal_title：Neurochemical research

authors： Zhou X,Cheng H,Xu D,Yin Q,Cheng L,Wang L,Song S,Zhang M

更新日期：2014-11-01 00:00:00

abstract：:Because it appears that oxidative stress and inflammation are implicated with disease pathogenesis in the diabetic brain, many researchers have used streptozotocin (STZ)-induced diabetic animals to study superoxide production and the effects of superoxide scavengers like Cu,Zn-superoxide dismutase (SOD1). However, man...

journal_title：Neurochemical research

authors： Yi SS,Hwang IK,Kim DW,Shin JH,Nam SM,Choi JH,Lee CH,Won MH,Seong JK,Yoon YS

更新日期：2011-01-01 00:00:00