Abstract:
:Planarians are rapidly developing into very useful research subjects in pharmacology and neuroscience research. Here we report that curare, a cholinergic nicotinic receptor antagonist, alleviates the nicotine-induced planarian seizure-like movements (pSLM) by up to 50 % at equimolar concentrations of nicotine and curare (1 mM), while curare alone does not induce significant pSLMs. The simplest interpretation of our data is that there are nicotine induced behaviors insensitive to curare in our experimental organism. To the best of our knowledge, this is the first report on curare-insensitive, nicotine-induced effects in any organism.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Pagán OR,Montgomery E,Deats S,Bach D,Baker Ddoi
10.1007/s11064-015-1512-6subject
Has Abstractpub_date
2015-10-01 00:00:00pages
2087-90issue
10eissn
0364-3190issn
1573-6903pii
10.1007/s11064-015-1512-6journal_volume
40pub_type
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