Abstract:
:We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathione (GSH) content and antioxidative enzymes activities. The treatment with TMS reverted towards normality the biomarkers indicative of oxidative stress and apoptosis. In conclusion, our data show that TMS induced a protection against cell and oxidative damage induced by OBX, as well as they support the hypothesis that oxidative stress may play an important role in depression.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Tasset I,Drucker-Colín R,Peña J,Jimena I,Montilla P,Medina FJ,Túnez Idoi
10.1007/s11064-010-0172-9subject
Has Abstractpub_date
2010-08-01 00:00:00pages
1182-7issue
8eissn
0364-3190issn
1573-6903journal_volume
35pub_type
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