Abstract:
:Zinc (Zn2+) was shown to invariably inhibit muscimol-stimulated 36Cl- uptake by synaptoneurosomes in the cerebral cortex, hippocampus and cerebellum. The Zn2+ sensitivity of the GABAA receptor-gated 36Cl- uptake in the cerebral cortex was comparable to that in the hippocampus, whereas the uptake in the cerebellum was less sensitive to Zn2+. Although diazepam-potentiation of muscimol-stimulated 36Cl- uptake was unaltered by 100 microM Zn2+ in the cerebral cortex and hippocampus, diazepam caused no enhancement in the presence of Zn2+ in the cerebellum. Zn2+ inhibited [3H]diazepam binding significantly at 1 mM in the cerebral cortex and cerebellum, whereas Ni2+ increased the binding in a concentration-dependent manner in both regions. Although lower concentrations of Zn2+ did not affect [3H]Ro 15-4513 binding to diazepam-sensitive sites, higher concentrations of ZN2+ increased the binding in both regions. Unlike the diazepam-sensitive sites, the diazepam-insensitive [3H]Ro 15-4513 binding was not affected by Zn2+ or Ni2+ at any of the tested concentrations. These results suggest that the GABAA ligand-gated Cl- flux and its diazepam-potentiation are heterogeneously modulated in various brain regions. It is also suggested that cerebellar diazepam-insensitive [3H]Ro 15-4513 binding sites are insensitive to Zn2+ and Ni2+.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Ito Y,Segawa K,Kobayashi M,Fukuda Hdoi
10.1007/BF02532346subject
Has Abstractpub_date
1996-08-01 00:00:00pages
955-61issue
8eissn
0364-3190issn
1573-6903journal_volume
21pub_type
杂志文章abstract::Experimental allergic encephalomyelitis (EAE) is an experimentally induced autoallergic demyelinating disease which is caused by immunization with a particular neuroantigen, such as myelin basic protein (MBP). Results have suggested that protease inhibitors might be useful therapeutically. Leupeptin (acetyl-L-leucyl-L...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964667
更新日期:1984-10-01 00:00:00
abstract::The study provides detailed biochemical correlates to the common histopathological diagnoses in epilepsy. A dot immunobinding procedure was used for quantification of NSE, GFA, S-100, NCAM, NF 68 and NF 200. The material consisted of samples from 48 patients either selected for surgical treatment of partial epilepsy o...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00967255
更新日期:1993-04-01 00:00:00
abstract::Omega-conotoxin GVIA (omega-CTX), as a selective blocker for an N-type Ca2+ channel, has been conveniently used in many molecular biochemical and pharmacological experiments. There has been little elucidation of 125I-omega-CTX binding sites (mainly the 135-kDa band) in the crude membranes from chick brain, although th...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022805615926
更新日期:2003-05-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1083-3
更新日期:2013-09-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
abstract::Some crustacean axons remain functional for months after injury. This unusual property may require stress proteins synthesized by those neurons or provided to them by glial cells. To begin to explore this hypothesis, we examined the conditions that stimulated stress protein synthesis by crayfish CNS tissue in vitro. I...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00974871
更新日期:1991-05-01 00:00:00
abstract::In vitro aggregation and fibrillization of synthetic amyloid beta-protein Abeta 1-40 was assessed in the conditioned media from rhabdomyosarcoma (CRL 1598, HTB 82, HTB 153, CCL 136), adenocarcinoma (CCL 218), neuroblastoma (SY5Y), and COS cells cultured in the absence and presence of 10% heat-inactivated fetal bovine ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1027379926976
更新日期:1997-02-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000014833.54481.1d
更新日期:2004-03-01 00:00:00
abstract::The incidence of acute and chronic spinal cord injury (SCI) in the United States is more than 10,000 per year, resulting in 720 cases per million persons enduring permanent disability each year. The economic impact of SCI is estimated to be more than 4 billion dollars annually. Preclinical studies, case reports, and s...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-013-0991-6
更新日期:2013-05-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0649-1
更新日期:2012-03-01 00:00:00
abstract::Cloned fragments of members of the Drosophila and mouse major heat shock (hsp70) gene family were used to demonstrate that homologous sequences are present in the rabbit genome. After a physiologically relevant increase in body temperature of 3 degrees C, transcription of inducible hsp70 genes is detected in both the ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964846
更新日期:1985-09-01 00:00:00
abstract::Sleep disorders negatively affect cognition and health. Recent evidence has indicated that chromatin remodeling via histone acetylation regulates cognitive function. This study aimed to investigate the possible roles of histone acetylation in sleep deprivation (SD)-induced cognitive impairment. Results of the Morris w...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1937-6
更新日期:2016-09-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00971007
更新日期:1987-07-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00993245
更新日期:1987-04-01 00:00:00
abstract::Mice with a heterozygous knock-out of the myelin protein P0 gene (P0+/-) develop a neuropathy similar to human Charcot-Marie-Tooth disease. They are indistinguishable from wild-types (WT) at birth and develop a slowly progressing demyelinating neuropathy. The aim of this study was to investigate whether the regenerati...
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pub_type: 杂志文章
doi:10.1007/s11064-013-1030-3
更新日期:2013-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s11064-010-0327-8
更新日期:2011-02-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965512
更新日期:1989-12-01 00:00:00
abstract::Proteasome inhibition has been observed in many neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Here, the effect of proteasome inhibition on the morphology of cultured rat cortical astrocytes was investigated. Increasing evidence suggests that the function of astrocytes is related close...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9830-6
更新日期:2009-05-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00970540
更新日期:1995-02-01 00:00:00
abstract::Exercise has been regarded as an effective rehabilitation strategy to facilitate motor and cognitive functional recovery after stroke, even though the complex effects associated with exercise-induced repair of cerebral ischemic injury are not fully elucidated. The enhancement of angiogenesis and neurogenesis, and the ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02728-1
更新日期:2019-04-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00970770
更新日期:1988-10-01 00:00:00
abstract::Myelinating cells of both the peripheral and central nervous systems (CNSs) undergo dramatic cytoskeletal reorganization in order to differentiate and produce myelin. Myelinating oligodendrocytes in the CNS show a periodic actin pattern, demonstrating tight regulation of actin. Furthermore, recent data demonstrate tha...
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更新日期:2020-03-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022471331168
更新日期:1998-06-01 00:00:00
abstract::The dorsal raphe nucleus (DRN) has been suggested playing an important role in the pathophysiology of post-traumatic stress disorder (PTSD), however the underlying cellular mechanisms are not fully understood. The endoplasmic reticulum (ER) is a critical organelle for synthesis of membrane and secretory proteins, and ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1262-x
更新日期:2014-04-01 00:00:00
abstract::Danhong injection, a Chinese Materia Medica standardized product extracted from Radix Salviae miltiorrhizae and Flos Carthami tinctorii, is used extensively for the treatment of cerebrovascular diseases such as acutely cerebral infarction in clinic. In this study, we further investigated the mechanisms of Danhong inje...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1384-1
更新日期:2014-09-01 00:00:00
abstract::Glutamate, the primary excitatory neurotransmitter in the central nervous system (CNS), exerts neuromodulatory actions via the activation of metabotropic glutamate (mGlu) receptors. There are eight known mGlu receptor subtypes (mGlu1-8), which are widely expressed throughout the brain, and are divided into three group...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
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更新日期:2014-10-01 00:00:00
abstract::We investigated the effects of H(2)O(2)-induced oxidative stress on the delayed-rectifier current (IK(DR)), neuronal physiological and morphological properties. Measurements were obtained from hippocampal CA1 neurons in control solution and from the same neurons after exposure to oxidative stress (short- and long-term...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9287-z
更新日期:2007-07-01 00:00:00
abstract::The concentrations of taurine in a number of brain regions and in other tissues of rhesus monkeys fed a taurine-free human infant formula for 3 months are substantially lower than in similar monkeys fed the same formula supplemented with taurine. Activities of enzymes involved in taurine biosynthesis were not differen...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00972479
更新日期:1988-04-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/BF00966318
更新日期:1987-10-01 00:00:00
abstract::5- and 6-Hydroxydopamine, which we had earlier identified as naturally occurring amines in human urine, were quantified in Parkinson's patients treated with L-DOPA, Parkinson's patients whose treatment did not include L-DOPA and in age matched controls. Analysis was carried out by GC-MS of the ditrifluoromethylbenzoyl...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00978370
更新日期:1993-11-01 00:00:00