Abstract:
:Cloned fragments of members of the Drosophila and mouse major heat shock (hsp70) gene family were used to demonstrate that homologous sequences are present in the rabbit genome. After a physiologically relevant increase in body temperature of 3 degrees C, transcription of inducible hsp70 genes is detected in both the fetal and maternal brain and kidney. The induced hsp70 gene transcripts decay rapidly after whole body hyperthermia subsides. Transcripts of constitutively expressed member(s) of the hsp70 gene family, the heat shock cognate genes (hsc70), are detected in unstressed fetal and maternal rabbit tissues.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Brown IR,Lowe DG,Moran LAdoi
10.1007/BF00964846subject
Has Abstractpub_date
1985-09-01 00:00:00pages
1277-84issue
9eissn
0364-3190issn
1573-6903journal_volume
10pub_type
杂志文章abstract::The 12/15-lipoxygenase(s) (LOX), poly(ADP-ribose) polymerase (PARP-1) activity and mitochondrial apoptosis inducing factor (AIF) protein in the amyloid β (Aβ) toxicity were investigated in PC12 cells that express either wild-type (APPwt) or double Swedish mutation (APPsw) forms of human Aβ precursor protein. Different...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0412-7
更新日期:2011-05-01 00:00:00
abstract::Zonisamide (ZNS), an antiepileptic drug having beneficial effects also against Parkinson's disease symptoms, has proven to display an antioxidant effects in different experimental models. In the present study, the effects of ZNS on rotenone-induced cell injury were investigated in human neuroblastoma SH-SY5Y cells dif...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1181-2
更新日期:2013-12-01 00:00:00
abstract::Emerging data suggests that mitochondrial dysfunction is prominently involved in Alzheimer disease (AD) progression. Sirtuin-3 (Sirt3) is a member of the sirtuin family of nicotinamide adenine dinucleotide dependent deacetylases that regulates a variety of mitochondrial functions and suppresses mitochondria-related ph...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1630-1
更新日期:2015-08-01 00:00:00
abstract::Myelinating cells of both the peripheral and central nervous systems (CNSs) undergo dramatic cytoskeletal reorganization in order to differentiate and produce myelin. Myelinating oligodendrocytes in the CNS show a periodic actin pattern, demonstrating tight regulation of actin. Furthermore, recent data demonstrate tha...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-019-02753-0
更新日期:2020-03-01 00:00:00
abstract::Release of endogenous dopamine (DA) and gamma-aminobutyric acid (GABA) from superfused rat caudate synaptosomes was monitored with liquid chromatography with electrochemical detection. Dopamine was analyzed by oxidative detection following alumina extraction while GABA was analyzed with reductive detection following p...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964602
更新日期:1985-03-01 00:00:00
abstract::Cell surface β-Amyloid precursor protein (APP) is known to have a functional role in iron homeostasis through stabilising the iron export protein ferroportin (FPN). Mechanistic evidence of this role has previously only been provided through transcriptional or translational depletion of total APP levels. However, numer...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02747-y
更新日期:2019-06-01 00:00:00
abstract::The hippocampus-derived neuroestradiol plays a major role in neuroplasticity, independent of circulating estradiol that originates from gonads. The response of hypothalamus-pituitary regions towards the synthesis of neuroestradiol in the hippocampus is an emerging scientific concept in cognitive neuroscience. Hippocam...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-019-02833-1
更新日期:2019-08-01 00:00:00
abstract::Prion diseases are conformational diseases, many factors are involved in altering the conformation of prion, such as RNA, DNA, pH, and copper etc. However the neurotoxic mechanism of prion diseases is not clear yet. The aim of this study is to investigate the effect of the nucleoprotein complex of RNA and recombinant ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0506-2
更新日期:2011-10-01 00:00:00
abstract::Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutritio...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1025678510480
更新日期:2003-10-01 00:00:00
abstract::The preventive effect of dietary taurine supplementation on glial alterations in retina of streptozotocin-induced diabetic rats was examined in this study. Blood glucose content, content of taurine, glutamate and
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9763-0
更新日期:2009-02-01 00:00:00
abstract::The concept of exosomes has been progressively changed from the status of cellular trashcans to multitasking organelles involved in many processes, including internalization, transport and transfer of macromolecules such as proteins, lipids and nucleic acids. While underpinning the mechanisms behind neurodegeneration ...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-020-03111-1
更新日期:2020-11-01 00:00:00
abstract::The particulars regarding the amine precursor therapy for treatment of neuropsychiatric disorders and their neurochemical background are described historically. Furthermore, peculiar or artificial amino acids which are metabolized into the brain amine or their derivatives and promised their clinical application are al...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/BF02529142
更新日期:1996-02-01 00:00:00
abstract::We previously reported that vanilloid receptor type 1 (VR1, or TRPV1) was up-regulated in dorsal root ganglion (DRG) and the spinal dorsal horn after chronic inflammatory pain produced by complete Freund's adjuvant (CFA) injection into the plantar of rat hind paw. In the present study, we found that subcutaneous or in...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9751-4
更新日期:2008-10-01 00:00:00
abstract::The mitochondrial enzyme, pyruvate carboxylase (PC; EC 6.4.1.1) is considered to play a significant role in the intermediary metabolism of neural tissue. PC-catalyzed carboxylation of pyruvate to oxaloacetate is a major anaplerotic reaction in brain. Anaplerosis is essential for homeostasis of the members of the trica...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9806-6
更新日期:2009-03-01 00:00:00
abstract::Alzheimer's disease (AD) is a devastative neurodegenerative disorder with complex etiology. Apoptosis, a biological process that plays an essential role in normal physiology to oust a few cells and contribute to the normal growth, when impaired or influenced by various factors such as Bcl2, Bax, caspases, amyloid beta...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-014-1454-4
更新日期:2014-12-01 00:00:00
abstract::The levels of selected neuroregulatory proteins that inhibit or promote apoptotic cell death were measured in the striatum of piglets subjected to precisely controlled 1 h hypoxic insult followed by 0, 2 and 4 h recovery and compared to sham operated animals. The anti-apoptotic proteins: there were increases in Surviv...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0394-x
更新日期:2011-05-01 00:00:00
abstract::We found that chronic lithium diet affects the sensitivity of neuroleptic receptors and the content of amino acids in the brain, and that the changes in adult animals differ from those in young rats. Pregnant rats were kept on lithium diet (pellets with 0.21% Li2CO3 and 0.21% NaCl) during the gestation period and the ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964703
更新日期:1983-05-01 00:00:00
abstract::Cationic lipid formulations consisting of 3beta [N-(N', N'-dimethylaminoethane)-carbamoyl] cholesterol (DC-Chol) and the helper lipid dioleoylphosphatidylethanolamine (DOPE) (1.5: 1 molar ratio) were prepared by solvent evaporation and sized by high pressure extrusion. Liposomes made of 1:1 molar ratio 1 ,2-dioleoyl-3...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021012727796
更新日期:1999-05-01 00:00:00
abstract::Despite immense advances in the treatment strategies, the effective treatment of patients suffering from neuropathic pain remains challenging. Saikosaponin a possesses anti-inflammatory activity. However, the role of saikosaponin a in neuropathic pain is still unclear. Therefore, the objective of this study was to inv...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1407-y
更新日期:2014-11-01 00:00:00
abstract::Previous work from this laboratory and others has shown that neurotransmitters can activate phospholipase D. Unlike the phospholipase C that specifically hydrolyzes inositol-containing phospholipids, phospholipase D in neuronal tissue specifically hydrolyzes phosphatidylcholine. One route for the synthesis of phosphat...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020716304520
更新日期:1998-08-01 00:00:00
abstract::The immediate and long-term effects of the selective serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) on rat striatal serotonergic neurons were examined after its intracerebroventricular administration using in vivo voltammetry. Extracellular concentration of 5-hydroxyindoles increased immediately following i...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022460216822
更新日期:1998-01-01 00:00:00
abstract::Brain regional 5-HT (5-hydroxytryptamine) and 5-HIAA (5-hydroxyindole-3-acetic acid) concentrations in male LE rats at three times were measured by a fluorescence method, to evaluate effects of intracranial surgery and administration of melatonin on the changes in these compounds during the first part of the dark phas...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965929
更新日期:1989-10-01 00:00:00
abstract::Mutations in genes for Alzheimer's disease (AD) result in a modulating of gene expressions in the brains of patients with AD. The aim of this study was to identify genes whose expression is modulated due to the over-expression of human mutant presenilin-2 (N141I) (hPS2m) in transgenic mice, which has previously been p...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-005-6787-6
更新日期:2005-08-01 00:00:00
abstract::Amyloidogenic proteins (Abeta peptide) in Alzheimer's disease (AD) and alpha-synuclein (alpha-Syn) in Parkinson's disease (PD) are typically soluble monomeric precursors, which undergo remarkable conformational changes and culminate in the form of aggregates in diseased condition. Overlap of clinical and neuropatholog...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9140-9
更新日期:2006-09-01 00:00:00
abstract::The synaptic glutamate level homeostasis is mainly maintained by the astrocytes membrane bound glutamate transporter type-1 (GLT-1/EAAT2). Alterations in its expression during development and aging and the underlying mechanisms are not well studied. Here, we report that NF-κB interaction was highest in both cerebral a...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1200-3
更新日期:2014-01-01 00:00:00
abstract::Age-related increase of reactive oxygen species (ROS) is particularly detrimental in postmitotic tissues. Calorie restriction (CR) has been shown to exert beneficial effects, consistent with reduced ROS generation by mitochondria. Many antioxidant compounds also mimic such effects. N-acetyl cysteine (NAC) provides thi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-005-6867-7
更新日期:2005-06-01 00:00:00
abstract::Over the past two decades the techniques associated with the manipulation of the mouse genome have provided a powerful approach toward the better understanding of gene function. Conventional transgenic and gene targeting approaches have been used extensively, and these techniques have been particularly rewarding for n...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1020772706279
更新日期:1999-09-01 00:00:00
abstract::We have shown that acute ammonia toxicity is mediated by activation of the NMDA type of glutamate receptors. Although it is well known that L-carnitine prevents acute ammonia toxicity, the underlying molecular mechanism is not clear. We suspected that L-carnitine would prevent ammonia toxicity by preventing the toxic ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00971588
更新日期:1994-03-01 00:00:00
abstract::The monoclonal antibody 14E immunocytochemically stains the nuclear membrane of oligodendrocytes but not myelin in tissue sections of adult normal human white matter. The nuclear membranes of Schwann cells in human peripheral nerve and cerebellar Bergmann glia were also visualized with this antibody. In actively demye...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00993270
更新日期:1992-09-01 00:00:00
abstract::Diisopropylfluorophosphate (DFP) is an irreversible inhibitor of acetylcholine esterase and a surrogate of the organophosphorus (OP) nerve agent sarin. The neurotoxicity of DFP was assessed as a reduction of population spike (PS) area elicited by synaptic stimulation in acute hippocampal slices. Two classical antidote...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1729-4
更新日期:2015-10-01 00:00:00