Histone Acetylation Regulation in Sleep Deprivation-Induced Spatial Memory Impairment.


:Sleep disorders negatively affect cognition and health. Recent evidence has indicated that chromatin remodeling via histone acetylation regulates cognitive function. This study aimed to investigate the possible roles of histone acetylation in sleep deprivation (SD)-induced cognitive impairment. Results of the Morris water maze test showed that 3 days of SD can cause spatial memory impairment in Wistar rats. SD can also decrease histone acetylation levels, increase histone deacetylase 2 (HDAC2) expression, and decrease histone acetyltransferase (CBP) expression. Furthermore, SD can reduce H3 and H4 acetylation levels in the promoters of the brain-derived neurotrophic factor (Bdnf) gene and thus significantly downregulate BDNF expression and impair the activity of key BDNF signaling pathways (pCaMKII, pErk2, and pCREB). However, treatment with the HDAC inhibitor trichostatin A attenuated all the negative effects induced by SD. Therefore, BDNF and its histone acetylation regulation may play important roles in SD-induced spatial memory impairment, whereas HDAC inhibition possibly confers protection against SD-induced impairment in spatial memory and hippocampal functions.


Neurochem Res


Neurochemical research


Duan R,Liu X,Wang T,Wu L,Gao X,Zhang Z




Has Abstract


2016-09-01 00:00:00














  • Environmental light-darkness conditions induce changes in brain and peripheral pyroglutamyl-peptidase I activity.

    abstract::To evaluate the influence of light and darkness on brain pyroglutamyl-peptidase I (pGluPI) activity, four experimental groups of rats were compared at the same time-point (10.00 h). Two groups were designed with a standard 12-12 h light-dark cycle: In group A, the lights were on from 7.00 h to 19.00 h, and the experim...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Ramírez M,Arechaga G,Martínez JM,Prieto I,Ramírez-Expósito MJ,Sánchez B,Alba F

    更新日期:2001-05-01 00:00:00

  • Possible involvement of folate cycle in the pathogenesis of amyotrophic lateral sclerosis.

    abstract::The folate cycle, which has a close correlation with nucleic acid synthesis as well as with sulfur amino acid metabolism, may have some bearing on the pathogenesis of amyotrophic lateral sclerosis. The folate cycle hypothesis offers a unified explanation of the reduction of RNA and the elevation of taurine in nervous ...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Yoshino Y

    更新日期:1984-03-01 00:00:00

  • Aberrant cAMP metabolism in NF1 malignant peripheral nerve sheath tumor cells.

    abstract::Malignant peripheral nerve sheath (MPNST) cell lines derived from patients with neurofibromatosis type 1 (NF!) were found to have basal cAMP levels which are two-fold higher than cAMP levels in normal human adult Schwann cells (nHSC). PCR analysis also revealed that normal adult human Schwann cells express mRNA for ty...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Dang I,De Vries GH

    更新日期:2011-09-01 00:00:00

  • [35S]GTP gamma S binding: a tool to evaluate functional activity of a cloned opioid receptor transiently expressed in COS cells.

    abstract::In this paper we propose a powerful procedure to measure functional activation of the mouse delta-opioid receptor transiently expressed in mammalian cells. Receptor stimulation was assessed using a population of electroporated COS cells, transfected at a 50% efficiency. Under those conditions, agonist-promoted activat...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Befort K,Tabbara L,Kieffer BL

    更新日期:1996-11-01 00:00:00

  • Special Issue in Honor of Dr. Elias K. Michaelis.

    abstract:: ...

    journal_title:Neurochemical research

    pub_type: 传,社论,历史文章


    authors: Choi IY,Schousboe A

    更新日期:2019-01-01 00:00:00

  • Combination of Omega 3 and Coenzyme Q10 Exerts Neuroprotective Potential Against Hypercholesterolemia-Induced Alzheimer's-Like Disease in Rats.

    abstract::Alzheimer's disease (AD) is the most common form of dementia that progressively disrupts neurocognitive function, which has neither cure nor effective treatment. Hypercholesterolemia might be involved in brain alterations that could evolve into AD. The present study aims to evaluate the potential of omega-3, Co-enzyme...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Ibrahim Fouad G

    更新日期:2020-05-01 00:00:00

  • Involvement of brain trace amines in the behavioural effects of phenelzine.

    abstract::The MAO inhibitor phenelzine (PLZ) at a dose of 25 mg/kg does not affect the behavior of rats. In contrast, the equivalent dose of a deuterated analog (alpha, alpha, beta, beta-tetradeutero-PLZ, d4PLZ) elicits a biphasic behavioral syndrome in rats. In an attempt to correlate changes in cerebral monoamines with behavi...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Dewar KM,Dyck LE,Durden DA,Boulton AA

    更新日期:1988-02-01 00:00:00

  • (4S)-4-amino-5,6-heptadienoic acid (MDL 72483): a potent anticonvulsant GABA-T inhibitor.

    abstract::(4S)-4-Amino-5,6-heptadienoic acid [S)-gamma-allenyl-GABA; MDL 72483) is a potent inactivator of brain GABA-T in mice; (ED50 (i.p.) = 60 mg.kg-1; ED50 (oral) = 70 mg.kg-1). Its anticonvulsant effects against 3-mercaptopropionic acid (MPA)-induced seizures in mice is related to the elevation of whole brain GABA concent...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Sarhan S,Casara P,Knödgen B,Seiler N

    更新日期:1991-03-01 00:00:00

  • Reduction of Na(+),K(+)-ATPase activity in hippocampus of rats subjected to chemically induced hyperhomocysteinemia.

    abstract::Hyperhomocysteinemia occurs in homocystinuria, an inherited metabolic disease clinically characterized by thromboembolic episodes and a variable degree of neurological dysfunction whose pathophysiology is poorly known. In this study, we induced elevated levels of homocysteine (Hcy) in blood (500 microM), comparable to...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Streck EL,Matte C,Vieira PS,Rombaldi F,Wannmacher CM,Wajner M,Wyse AT

    更新日期:2002-12-01 00:00:00

  • Differential response of neural cells to trauma-induced free radical production in vitro.

    abstract::CNS trauma has been associated with an increase in free radical production, but the cellular sources of this increase or the mechanism involved in the production of free radicals are not known. We, therefore, investigated the effects of trauma on free radical production in cultured neurons, astrocytes and BV-2 microgl...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Panickar KS,Jayakumar AR,Norenberg MD

    更新日期:2002-02-01 00:00:00

  • 2-Phenylethylamine-induced changes in catecholamine receptor density: implications for antidepressant drug action.

    abstract::It is now established that (1) concentrations of 2-phenylethylamine (PEA) are greatly increased in brain following administration of monoamine oxidase inhibitor (MAOI) antidepressants; (2) PEA is a metabolite of the MAOI antidepressant phenelzine; and (3) PEA may be a neuromodulator of catecholamine activity. On the b...

    journal_title:Neurochemical research

    pub_type: 杂志文章,评审


    authors: Paetsch PR,Greenshaw AJ

    更新日期:1993-09-01 00:00:00

  • Influence of blood sera from dogs subjected to ischemia and recirculation on incorporation of 14C-amino acids in vitro.

    abstract::Incomplete ischemia of the spinal cord was produced in dogs by 40 min occlusion of the abdominal aorta that was followed by 5-40 min of recirculation. Amino acid incorporation into ribosomes in vitro in the presence of venous blood sera was estimated. The most significant reduction in incorporation was produced by ser...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Chavko M,Burda J,Marsala J

    更新日期:1986-06-01 00:00:00

  • Leucine: effector of phosphate activated glutaminase in rat cerebral cortex.

    abstract::Phosphate activated glutaminase (PAG) was assayed in whole homogenate and synaptosomes of cerebral cortex from normal or fasted for 120 h rats. The specific activity (s.a.) of PAG was found diminished by 25% in the whole homogenate from the fasted animals compared to the normal. On the contrary, fasting did not affect...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Lellos V,Tselentis V,Galanopoulos E,Philippidis H,Palaiologos G

    更新日期:1991-01-01 00:00:00

  • Tissue and regional distribution of cysteic acid decarboxylase. A new assay method.

    abstract::A sensitive and rapid assay method method for cysteic acid decarboxylase was develped which combined the selectivity of ion exchange resin (a complete retention of the substrate, cysteic acid, and exclusion of the product, taurine) with the speed of a vacuum filtration. The synthesis and purification of 35S-labeled cy...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Wu JY,Moss LG,Chen MS

    更新日期:1979-04-01 00:00:00

  • Modulation of potassium evoked secretory function in rat cerebellar slices measured by real time monitoring: evidence of a possible role for methylfolate in cerebral tissue.

    abstract::The real time dynamics of K+ evoked neurosecretion in cerebellar slices has been monitored electrochemically. In the presence of 5-methyltetrahydrofolate a statistically significant diminution in secretory response occurs. Agonists to probe the pharmacological basis for this indicate it is not due to voltage sensitive...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Lucock MD,Levene MI,Hartley R

    更新日期:1993-05-01 00:00:00

  • Ethyl pyruvate inhibits peroxynitrite-induced DNA damage and hydroxyl radical generation: implications for neuroprotection.

    abstract::Ethyl pyruvate (EP) has recently been reported to afford protection against neurodegenerative disorders. However, the mechanism underlying EP-mediated neuroprotection remains to be elucidated. Because peroxynitrite has been extensively implicated in the pathogenesis of various forms of neurodegenerative disorders via ...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Chen W,Jia Z,Zhu H,Zhou K,Li Y,Misra HP

    更新日期:2010-02-01 00:00:00

  • Ether lipid composition and molecular species alterations in carp brain (Cyprinus carpio L.) during normoxic temperature acclimation.

    abstract::Carp (Cyprinus carpio L.) whole brain was used to investigate the thermal acclimation changes under normoxic conditions of three-subclasses (alkenylacyl-, alkylacyl- and diacyl-subclasses) of choline glycerophospholipids (CGP), ethanolamine glycerophospholipids (EGP) and inositol glycerophospholipids (IGP) as well as ...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Yeo YK,Park EJ,Lee CW,Joo HT,Farkas T

    更新日期:1997-10-01 00:00:00

  • Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway.

    abstract::Many studies have demonstrated that apoptosis play an important role in cerebral ischemic pathogenesis and may represent a target for treatment. Neuroprotective effect of quercetin has been shown in a variety of brain injury models including ischemia/reperfusion. It is not clear whether BDNF-TrkB-PI3K/Akt signaling pa...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Yao RQ,Qi DS,Yu HL,Liu J,Yang LH,Wu XX

    更新日期:2012-12-01 00:00:00

  • Transport of 2-deoxy-D-[3H]glucose in microvessels isolated from bovine cerebral cortex.

    abstract::Microvessels were isolated from a bovine cortex and the transport of glucose was investigated by using 2-deoxy-D-[3H]glucose (2-DG). The apparent Km for 2-DG transport was 118 microM and therefore indicates a significant high affinity for the substrate. The inhibition of 2-DG uptake by D-glucose showed an apparent Ki ...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Stefanovich V,Gojowczyk G

    更新日期:1981-04-01 00:00:00

  • Oxidative stress and S100B protein in cirrhotic children.

    abstract:UNLABELLED:Cirrhosis represents the terminal stage of a number of chronic liver diseases. Consequences include accumulation of toxic metabolic wastes, reduced synthesis of key proteins, increased portal venous pressure, and portosystemic shunting. We conducted a case-control study to assess the serum levels of S100B pr...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Ribeiro L,Andreazza AC,Salvador M,da Silveira TR,Vieira S,Nora DB,Bosa C,Di Napoli F,Schaf DV,Souza DO,Portela LV,Kapczinski F

    更新日期:2007-09-01 00:00:00

  • Peroxidative block of glucose utilization and survival in CNS neuronal cultures.

    abstract::The search for neuronotrophic factors addressing CNS neurons requires CNS neuronal cell cultures to quantitate putative effects on neuronal survival. Investigation of neurons dissociated from several embryonic CNS tissues have shown that their short-term survival requires supplementation of the culture medium with eit...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Chau RM,Skaper SD,Varon S

    更新日期:1988-07-01 00:00:00

  • Characterization of endogenous amino acid efflux from hippocampal slices during chemically-induced ischemia.

    abstract::Using sodium (NaN3)-induced anoxia plus aglycaemia as a model of chemically-induced ischemia, we have characterized the endogenous release of excitatory and inhibitory amino acids from superfused hippocampal slices. Chemical ischemia produced an azide (1-30 mM) dose-dependent increase in the efflux of glutamate, aspar...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Djali S,Dawson LA

    更新日期:2001-02-01 00:00:00

  • Involvement of brain stem noradrenergic neurons in the development of hypertension in spontaneously hypertensive rats.

    abstract::This study attempted to investigate the possible involvement of the brain stem noradrenergic system in the development of hypertension in spontaneously hypertensive rats. Steady-state norepinephrine, dopamine, serotonin and 5-hydroxyindoleacetic acid concentrations and norepinephrine turnover were determined in the in...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Yao H,Matsumoto T,Hirano M,Kuroki T,Tsutsumi T,Uchimura H,Nakamura K,Nakahara T,Fujishima M

    更新日期:1989-01-01 00:00:00

  • Extracellular superoxide dismutase induced by dopamine in cultured astrocytes.

    abstract::Under some pathological conditions in brain, a large amount of superoxide anion (O(2)(-)) is produced, causing various cellular damages. Among three isozymes of superoxide dismutase (SOD), extracellular (EC)-SOD should play a role to detoxify O(2)(-) in extracellular space; however, a little is known about EC-SOD in b...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Takano K,Tanaka N,Kawabe K,Moriyama M,Nakamura Y

    更新日期:2013-01-01 00:00:00

  • Isolation and characterization of cathepsin B from bovine brain.

    abstract::Cathepsin B (EC was purified 746-fold with a 21% recovery from bovine brain by autolysis, fractional precipitation with acetone, carboxy-methyl-Sephadex chromatography, affinity chromatography on a cystamine containing column and gel filtration chromatography. The purified cathepsin B eluted on gel filtratio...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Bradley JD,Whitaker JN

    更新日期:1986-06-01 00:00:00

  • Effect of moxibustion on dopaminergic and serotonergic systems of rat nucleus accumbens.

    abstract::Acupuncture and moxibustion are traditional medical treatments that have come to play important roles in complementary and alternative medicines. Moxibustion also has a long history as a folk remedy in Japan, particularly due to the technical simplicity and selective efficacy on certain types of disease and distress. ...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Fukuda F,Shinbara H,Yoshimoto K,Yano T,Kuriyama K

    更新日期:2005-12-01 00:00:00

  • Stem cell treatment after cerebral ischemia regulates the gene expression of apoptotic molecules.

    abstract::Evidence suggests that apoptosis contributes significantly to cell death after cerebral ischemia. Our recent studies that utilized human umbilical cord blood-derived mesenchymal stem cells (hUCBSCs) demonstrated the potential of hUCBSCs to inhibit neuronal apoptosis in a rat model of CNS injury. Therefore, we hypothes...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Chelluboina B,Klopfenstein JD,Pinson DM,Wang DZ,Veeravalli KK

    更新日期:2014-08-01 00:00:00

  • Selective alteration of neurotransmitter release by low oxygen in vitro.

    abstract::The potassium-stimulated release of acetylcholine, norepinephrine, serotonin, glutamate, and 4-aminobutyrate from superfused rat cortical slices was studied during hypoxia. A reduction in oxygen tensions from 603 +/- 6 to 22 +/- 2 mm Hg selectively altered the calcium-dependent efflux of these neurotransmitters, but d...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Hirsch JA,Gibson GE

    更新日期:1984-08-01 00:00:00

  • Recombinant DNA vaccine against inhibition of neurite outgrowth promotes functional recovery associated with endogeous NGF expression in spinal cord hemisected adult rats.

    abstract::Axonal regeneration across the site of spinal cord lesion is often aborted in adult mammalian species. The use of DNA vaccine to nullify the inhibitory molecules has been shown to be effective in promoting axonal regeneration in injured spinal cord. The possible molecular mechanisms, however, remain to be elucidated. ...

    journal_title:Neurochemical research

    pub_type: 杂志文章


    authors: Zhang Y,Hao CG,Hu LQ,Dong J,Wei P,Xu D,Xiao ZC,Wang TH

    更新日期:2009-09-01 00:00:00

  • D-Serine, the Shape-Shifting NMDA Receptor Co-agonist.

    abstract::Shape-shifting, a phenomenon wide-spread in folklore, refers to the ability to physically change from one identity to another, typically from an innocuous entity to a destructive one. The amino acid D-serine over the last 25 years has "shape-shifted" into several identities: a purported glial transmitter activating N-...

    journal_title:Neurochemical research

    pub_type: 杂志文章,评审


    authors: Coyle JT,Balu D,Wolosker H

    更新日期:2020-06-01 00:00:00