Abstract:
:The selective vulnerability of specific neuronal subpopulations to trimethyltin (TMT), an organotin compound with neurotoxicant effects selectively involving the limbic system and especially marked in the hippocampus, makes it useful to obtain in vivo models of neurodegeneration associated with behavioural alterations, such as hyperactivity and aggression, cognitive impairment as well as temporal lobe epilepsy. TMT has been widely used to study neuronal and glial factors involved in selective neuronal death, as well as the molecular mechanisms leading to hippocampal neurodegeneration (including neuroinflammation, excitotoxicity, intracellular calcium overload, mitochondrial dysfunction and oxidative stress). It also offers a valuable instrument to study the cell-cell interactions and signalling pathways that modulate injury-induced neurogenesis, including the involvement of newly generated neurons in the possible repair processes. Since TMT appears to be a useful tool to damage the brain and study the various responses to damage, this review summarises current data from in vivo and in vitro studies on neuroprotective strategies to counteract TMT-induced neuronal death, that may be useful to elucidate the role of putative candidates for translational medical research on neurodegenerative diseases.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Corvino V,Marchese E,Michetti F,Geloso MCdoi
10.1007/s11064-012-0932-9subject
Has Abstractpub_date
2013-02-01 00:00:00pages
240-53issue
2eissn
0364-3190issn
1573-6903journal_volume
38pub_type
杂志文章,评审abstract::Cerebral deposition of amyloid β-peptide (Aβ), a fundamental feature of Alzheimer's disease (AD), damages the neurocytes and impairs the cognition functions and associative learning memory of AD patients. A series of novel 2-arylethenylquinoline derivatives were synthesized and evaluated in our previous study, which i...
journal_title:Neurochemical research
pub_type: 杂志文章
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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journal_title:Neurochemical research
pub_type: 杂志文章
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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doi:10.1007/BF00973747
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journal_title:Neurochemical research
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journal_title:Neurochemical research
pub_type: 杂志文章,评审
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journal_title:Neurochemical research
pub_type: 杂志文章
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journal_title:Neurochemical research
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1023/a:1026670620633
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00963918
更新日期:1983-02-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:1978-06-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0316-y
更新日期:2011-02-01 00:00:00
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更新日期:2020-04-01 00:00:00
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journal_title:Neurochemical research
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journal_title:Neurochemical research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-07-01 00:00:00
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journal_title:Neurochemical research
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journal_title:Neurochemical research
pub_type: 杂志文章,评审
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更新日期:2012-04-01 00:00:00
abstract::Microdissection of selected regions of central nervous system (CNS) has provided the basis of modern chemoarchitectonics. Laser microdissection is a modern variant of the "Palkovits punch" technique and used together with gene array analysis has revolutionalized CNS molecular analysis. Here we describe the use of such...
journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:2006-02-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章,评审
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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更新日期:2009-07-01 00:00:00
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