Acidosis-induced modifications of high-affinity choline uptake by synaptosomes: effects of pH readjustment.

abstract：:Methylphenidate is commonly used for the treatment of attention deficit/hyperactivity disorder. There are still few works regarding the effects of methylphenidate on brain energy metabolism. Thus, in the present study we evaluated the effect of chronic administration of methylphenidate on the activities of mitochondri...

journal_title：Neurochemical research

authors： Fagundes AO,Aguiar MR,Aguiar CS,Scaini G,Sachet MU,Bernhardt NM,Rezin GT,Valvassori SS,Quevedo J,Streck EL

更新日期：2010-11-01 00:00:00

abstract：:We investigated the distribution of serotonin (5-HT) receptors of type 3 (5-HT3) in human brain areas, by means of the the specific binding of [3H]GR65630. The brains were obtained during autoptic sessions from 6 subjects. Human brain membranes and the binding of [3H]GR65630 were carried out according to standardized ...

journal_title：Neurochemical research

authors： Marazziti D,Betti L,Giannaccini G,Rossi A,Masala I,Baroni S,Cassano GB,Lucacchini A

更新日期：2001-03-01 00:00:00

abstract：:The anterograde axonal transport of choline-phosphoglycerides was studied in sciatic nerve motoneurons of adult (3-month-old) and aged (24-month-old) rats. After the spinal cord injection of [2-3H]glycerol, choline-phosphoglycerides; the major phospholipid class was transported along the nerve. The axonal transport ra...

journal_title：Neurochemical research

authors： Brunetti M,Miscena A,Salviati A,Gaiti A

更新日期：1987-01-01 00:00:00

abstract：:It is well known that antioxidants containing sulfhydryl (-SH) groups are protective against the toxic effects of mercury. The current study was designed to elucidate the mechanism(s) of the cytoprotective effects of glutathione (GSH) and N-acetylcysteine (NAC) against the toxicity of inorganic mercury (HgCl(2)) in ne...

journal_title：Neurochemical research

authors： Becker A,Soliman KF

更新日期：2009-09-01 00:00:00

abstract：:Acetate is a two carbon intermediate in metabolism. It is an accepted marker of astrocytic metabolism, and a substrate for production of metabolites such as glutamine, glutamate and GABA. However, anomalies exist in the current explanations of compartmentation and metabolism of acetate. Here, we investigated these ano...

journal_title：Neurochemical research

authors： Rae C,Fekete AD,Kashem MA,Nasrallah FA,Bröer S

更新日期：2012-11-01 00:00:00

abstract：:In human pathology little is known about the activating enzymes for fatty acids of different carbon chain length. In order to have a better insight into disorders of lipid metabolism in human skeletal muscle, we studied the distribution of acyl-CoA synthetases in muscular subcellular fractions. We find that in muscle ...

journal_title：Neurochemical research

authors： Trevisan C,DiMauro S

更新日期：1983-05-01 00:00:00

abstract：:The Ca(2+)-dependent release of aspartate from hippocampal preparations was first reported 35 years ago, but the functional significance of this process remains uncertain. Aspartate satisfies all the criteria normally required for identification of a CNS transmitter. It is synthesized in nerve terminals, is accumulate...

journal_title：Neurochemical research

authors： Nadler JV

更新日期：2011-04-01 00:00:00

abstract：:Suspensions of rat brain microsomes, synaptosomes, and synaptic vesicles were able to convert adenosine to inosine by means of adenosine deaminase. Isosbestic points of this transformation, at 222, 250 and 281 nm, remained unchanged with time-course. This fact suggests that adenosine deaminase (ADA, E.C. 3.5.4.4) is l...

journal_title：Neurochemical research

authors： Centelles JJ,Franco R,Canela EI,Bozal J

更新日期：1986-04-01 00:00:00

abstract：:The cyclic GMP analog 8-bromo-cyclic GMP (8-Br-cGMP) protects differentiated murine oligodendrocytes (OLs) from caspase-mediated death initiated by staurosporine, thapsigargin or kainate. Caspase-independent death caused by high levels of NO is also partially prevented by 8-Br-cGMP. Inhibitors of protein kinase G (cGM...

journal_title：Neurochemical research

authors： Benjamins JA,Nedelkoska L

更新日期：2007-02-01 00:00:00

abstract：:In the present study, we evaluated the expression of some proliferation and differentiation markers in 15 DIV astrocyte cultures pretreated or not with 0.5 mM glutamate for 24 h and than maintained under chronic or acute treatment with 50 μM R(+)enantiomer or raceme alpha-lipoic acid (ALA). GFAP expression significant...

journal_title：Neurochemical research

authors： Bramanti V,Tomassoni D,Bronzi D,Grasso S,Currò M,Avitabile M,Li Volsi G,Renis M,Ientile R,Amenta F,Avola R

更新日期：2010-12-01 00:00:00

abstract：:Recent evidence indicates that mechanisms involved in reward and mechanisms involved in learning interact, in that reward includes learning processes and learning includes reward processes. In spite of such interactions, reward and learning represent distinct functions. In the present study, as part of an examination ...

journal_title：Neurochemical research

authors： Fallon S,Shearman E,Sershen H,Lajtha A

更新日期：2007-10-01 00:00:00

abstract：:Somatostatin (SS) is an inhibitory regulator of secretory and proliferative responses that activates a group of receptors in the plasma membrane termed SSR1-5. SSR2 is one of the most abundant SSR, which also is expressed in high numbers in many neuroendocrine tumor types. Here, we describe a study of the presence and...

journal_title：Neurochemical research

authors： Hashemi SH,Li JY,Ahlman H,Dahlström A

更新日期：2003-04-01 00:00:00

abstract：:Regional and developmental changes in metabolite concentrations were measured by 1H NMR spectroscopy and HPLC of perchloric acid extracts from rat brain and eye. The highest concentrations of N-acetylaspartate were found in grey matter as opposed to white matter with concentration increasing with age from neonate to a...

journal_title：Neurochemical research

authors： Florian CL,Williams SR,Bhakoo KK,Noble MD

更新日期：1996-09-01 00:00:00

abstract：:Calpains, cathepsins and caspases play crucial role in mediating cell death. In the present study we observed a cascade of events involving the three proteases during middle cerebral artery occlusion (MCAo) in Wistar rats. The rats were MCA occluded and reperfused at various time points. We observed a maximal increase...

journal_title：Neurochemical research

authors： Chaitanya GV,Babu PP

更新日期：2008-11-01 00:00:00

abstract：:Pyroptosis is a newly identified lytic form of programmed cell death which is characterized by plasma membrane blebbing and rupture. Pyroptosis occurs in cerebral ischemia injury, and contributes to the activation and secretion of the inflammatory cytokines interleukin (IL)-1β, IL-18, and IL-6. Previous reports have f...

journal_title：Neurochemical research

authors： Liu D,Dong Z,Xiang F,Liu H,Wang Y,Wang Q,Rao J

更新日期：2020-02-01 00:00:00

abstract：:A previously described inhibitor of the UDP-N-acetylgalactosamine: GM3, N-acetylgalactosaminyltransferase (GalNAc-T) (Quiroga et al., 1, 2), was purified from chicken blood serum by a new procedure. When subjected to SDS-PAGE, two major polypeptides of 27 and 70 kDa were observed. When tested in vitro, only the 27 kDa...

journal_title：Neurochemical research

authors： Conde CB,Grabois VR,Deza SN,Caputto BL

更新日期：1997-04-01 00:00:00

abstract：:The aim of this study was to determine the anticancer potential of Leonurus sibiricus extract derived from in vitro transgenic roots transformed by Agrobacetrium rhizogenes with AtPAP1 transcriptional factor, and that of transformed roots without construct, on grade IV human glioma cells and the U87MG cell line, and a...

journal_title：Neurochemical research

authors： Sitarek P,Kowalczyk T,Santangelo S,Białas AJ,Toma M,Wieczfinska J,Śliwiński T,Skała E

更新日期：2018-07-01 00:00:00

abstract：:Neuronal perikarya were isolated, using bulk preparative procedures, from bovine brains. Synaptosomes, neuronal perikarya, and brain homogenates had similar ganglioside patterns, with the synaptosomes containing at least four times more total ganglioside per mg protein than the neuronal perikarya and twice that of the...

journal_title：Neurochemical research

authors： Schengrund CL,Nelson JT

更新日期：1976-04-01 00:00:00

abstract：:Trans-caryophyllene (TC), a component of essential oil found in many flowering plants, has shown its neuroprotective effects in various neurological disorders. However, the effects of TC on epilepsy haven't been reported before. In this study, we investigated the effect of TC on kainic acid-induced seizure activity ca...

journal_title：Neurochemical research

authors： Liu H,Song Z,Liao D,Zhang T,Liu F,Zhuang K,Luo K,Yang L

更新日期：2015-01-01 00:00:00

abstract：:Bilateral injection of 6-hydroxydopamine into the medial forebrain bundle (MFB) significantly decreased monoamine concentrations in the hypothalamus. The noradrenaline and serotonin content of the paraventricular nucleus (PVN) was also significantly reduced. These drastic decreases in neurotransmitter concentration di...

journal_title：Neurochemical research

authors： Daniels WM,Jaffer A,Russell VA,Taljaard JJ

更新日期：1993-02-01 00:00:00

abstract：:2,5-Hexanedione (2,5-HD) induces central-peripheral axonpathy characterized by the accumulation of 10-nm neurofilaments proximal to the nodes of Ranvier and a Wallerian-type degeneration. It has been postulated that neurofilament crosslinking may be involved in the production of this axonopathy. A potential initiating...

journal_title：Neurochemical research

authors： Lanning CL,Wilmarth KR,Abou-Donia MB

更新日期：1994-09-01 00:00:00

abstract：:Tumor Necrosis Factor Receptor Super Family 6 gene (TNFRSF6), also known as FAS, encodes the Fas antigen, a cell surface receptor mediating cell apoptosis, situated on chromosome 10q located near the region of linkage to sporadic Alzheimer's disease (sAD). FAS levels have been reported elevated in the brain of AD pati...

journal_title：Neurochemical research

authors： Andreoli V,Nicoletti G,Romeo N,Condino F,La Russa A,Liguori M,Manna I,Spadafora P,Quattrone A,Cittadella R

更新日期：2007-09-01 00:00:00

abstract：:In this paper, we show that caveolin-1 is abundantly present in a cell line of immortalized gonadotropin-releasing hormone-expressing neurons (GN11). In contrast to GN11, caveolin is undetectable in a cognate cell line of immortalized gonadotropin-releasing hormone-secreting neurons (GT1-7). These two cell lines are c...

journal_title：Neurochemical research

authors： Prioni S,Loberto N,Prinetti A,Chigorno V,Guzzi F,Maggi R,Parenti M,Sonnino S

更新日期：2002-08-01 00:00:00

abstract：:Evidence is presented in support of the working hypothesis that "prenervous" neurotransmitters directly participate in cell-cell interactions occurring during the first several cleavage divisions of sea urchin embryos, a function which may occur during the early development of higher animals as well. This intercellula...

journal_title：Neurochemical research

authors： Buznikov GA,Shmukler YB

更新日期：1981-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a severe neurodegenerative disease characterized by selective loss of dopaminergic neurons, which reduces quality of life of patients and poses a heavy burden to the society. The pathological mechanism of PD remains unclear, and increasing efforts are aimed to solve this problem. MiRNAs are...

journal_title：Neurochemical research

authors： Dong Y,Xiong J,Ji L,Xue X

更新日期：2020-11-12 00:00:00

abstract：:Convulsions and brain levels of amino acids and 5-hydroxytryptamine (5-HT) in E1 mice were examined after oral administration of a 1% guanidinoethane sulfonate (GES) solution. The incidence of convulsions increased 3 days after starting GES administration, and this effect continued throughout the 6 months of drug admi...

journal_title：Neurochemical research

authors： Hiramatsu M,Edamatsu R,Kabuto H,Higashihara Y,Mori A

更新日期：1989-01-01 00:00:00

abstract：:ESR spin trapping technique was used to detect and analyze free radical formation. When 6-hydroxydopamine (6-OHDA) was incubated alone or in the presence of a free radical generating system (H2O2 and FeSO4), hydroxyl free radicals were observed in a concentration-dependent manner. Glutathione was found to be the most ...

journal_title：Neurochemical research

authors： Oldfield FF,Cowan DL,Sun AY

更新日期：1991-01-01 00:00:00

abstract：:Metabolism of triacylglycerol (TAG) in developing brain has been examined. TAG is a relatively minor fraction of brain lipid in both suckling and adult rats and cannot be accounted for as entrapped blood. When glycerol tri[1-14C]oleate and [2-3H]glycerol trioleate were simultaneously injected intracerebrally into suck...

journal_title：Neurochemical research

authors： Cook HW

更新日期：1981-11-01 00:00:00

abstract：:Previous studies suggest that alterations of brain glutamate synthesis and release occur in experimental thiamine deficiency. In order to assess the integrity of post-synaptic glutamatergic receptors in thiamine deficiency, binding sites for [3H]glutamate (displaced by NMDA), [3H]-kainate, and [3H]quisqualate (AMPA si...

journal_title：Neurochemical research

authors： Peterson C,Héroux M,Lavoie J,Butterworth RF

更新日期：1995-10-01 00:00:00

abstract：:In our previous study vesamicol, an inhibitor of the acetylcholine transporter of the cholinergic vesicles, inhibited veratridine-evoked external Ca(2+)-dependent acetylcholine release from striatal slices but did not influence acetylcholine release observed in Ca(2+)-free medium (4). Here we examined if the effect of...

journal_title：Neurochemical research

authors： Deri Z,Adam-Vizi V

更新日期：1992-06-01 00:00:00