The involvement of ethanol in the free radical reaction of 6-hydroxydopamine.

abstract：:Amphiphile dependency, solubility in aqueous solutions, and sensitivity to proteolysis of acetylcholinesterase (AChE) and nonspecific cholinesterase (nsChE) in the rat superior cervical ganglion were studied and compared to properties of soluble plasma cholinesterases. Ganglion AChE shows strong amphiphile dependency:...

journal_title：Neurochemical research

authors： Klinar B,Kamarić L,Sketelj J,Brzin M

更新日期：1985-06-01 00:00:00

abstract：:Any spinal cord injury carries the potential for persistent disability affecting motor, sensory and autonomic functions. To prevent this outcome, it is highly desirable to block a chain of deleterious reactions developing in the spinal areas immediately around the primary lesion. Thus, early timing of pharmacological ...

journal_title：Neurochemical research

authors： Sámano C,Nistri A

更新日期：2019-01-01 00:00:00

abstract：:Diisopropylfluorophosphate (DFP) is an irreversible inhibitor of acetylcholine esterase and a surrogate of the organophosphorus (OP) nerve agent sarin. The neurotoxicity of DFP was assessed as a reduction of population spike (PS) area elicited by synaptic stimulation in acute hippocampal slices. Two classical antidote...

journal_title：Neurochemical research

authors： Ferchmin PA,Pérez D,Cuadrado BL,Carrasco M,Martins AH,Eterović VA

更新日期：2015-10-01 00:00:00

abstract：:Discrete populations of anti-S49 antibodies were found in the antisera of Lewis rats recovered from S49-induced experimental allergic encephalomyelitis (EAE). A potent inducer of EAE in Lewis rats, S49 is a synthetic peptide representing residues 69-84 of bovine myelin basic protein but with deletions at Gly-77 and Hi...

journal_title：Neurochemical research

authors： Day ED,Hashim GA,Potter NT,Lazarus KJ

更新日期：1985-12-01 00:00:00

abstract：:Systemic inflammation triggered by lipopolysaccharide (LPS) administration disrupts blood-brain barrier (BBB) homeostasis in animal models. This event leads to increased susceptibility of several encephalic structures to potential neurotoxicants present in the bloodstream. In this study, we investigated the effects of...

journal_title：Neurochemical research

authors： Gonçalves C,Dos Santos DB,Portilho SS,Lopes MW,Ghizoni H,de Souza V,Mack JM,Naime AA,Dafre AL,de Souza Brocardo P,Prediger RD,Farina M

更新日期：2018-03-01 00:00:00

abstract：:Apoptosis can be defined as the regulated death of a cell and is conducted by conserved pathways. Apoptosis of neurons after injury or disease differs from programed cell death, in the sense that neurons in an adult brain are not "meant" to die and results in a loss of function. Thus apoptosis is an honorable process ...

journal_title：Neurochemical research

authors： Haeberlein SL

更新日期：2004-03-01 00:00:00

abstract：:In this report data are summarized on changes in the quantity of proteolipid protein (PLP), its amino acid composition, and the lipid moiety of these lipid-protein complexes in rat brain during postnatal development. In all three parts of the central nervous system (CNS) studied (cerebral hemispheres, medulla oblongat...

journal_title：Neurochemical research

authors： Manukian KH,Kirakosian LG

更新日期：1985-11-01 00:00:00

abstract：:Cold restraint stress (CRS) model exerts similar effect as physiological stress because it combines emotional stress (escape reaction) and physical stress (muscle work). It is well established that various responses to stress are regulated by sympathoadrenal system, brain monoaminergic systems and oxidative processes....

journal_title：Neurochemical research

authors： Lyle N,Chakrabarti S,Sur T,Gomes A,Bhattacharyya D

更新日期：2012-12-01 00:00:00

abstract：:The influence of phosphatidylserine (PS) on the isoniazid-induced convulsions has been studied in mice. Sonicated dispersions of this phospholipid given intravenously do not show anticonvulsant activity but they do so when gamma-aminobutyric acid (GABA) is simultaneously injected. GABA alone is inactive. The synergism...

journal_title：Neurochemical research

authors： Toffano G,Mazzari S,Zanotti A,Bruni A

更新日期：1984-08-01 00:00:00

abstract：:Calpains, cathepsins and caspases play crucial role in mediating cell death. In the present study we observed a cascade of events involving the three proteases during middle cerebral artery occlusion (MCAo) in Wistar rats. The rats were MCA occluded and reperfused at various time points. We observed a maximal increase...

journal_title：Neurochemical research

authors： Chaitanya GV,Babu PP

更新日期：2008-11-01 00:00:00

abstract：:The action of electroacupuncture (EA) may be similar to analgesia by electrode stimulation or transcutaneous nerve stimulation. Since EA may directly stimulate nerve activity or indirectly enhance the release of opiate peptides and other neurotransmitter substances, we have used (Na+ + K+)-ATPase as a model to study t...

journal_title：Neurochemical research

authors： Lee DZ,Sun AY

更新日期：1984-05-01 00:00:00

abstract：:Chronic thiamine deprivation in the rat leads to ataxia, loss of righting reflex and neuropathological damage to lateral vestibular nucleus. Before onset of neurological symptoms, transketolase (TK) activities were found to be selectively reduced by 25% in lateral vestibular nucleus and surrounding pons. Further progr...

journal_title：Neurochemical research

authors： Giguère JF,Butterworth RF

更新日期：1987-03-01 00:00:00

abstract：:In human pathology little is known about the activating enzymes for fatty acids of different carbon chain length. In order to have a better insight into disorders of lipid metabolism in human skeletal muscle, we studied the distribution of acyl-CoA synthetases in muscular subcellular fractions. We find that in muscle ...

journal_title：Neurochemical research

authors： Trevisan C,DiMauro S

更新日期：1983-05-01 00:00:00

abstract：:We have investigated gene expression changes produced by acute and chronic daily treatment with a prototypical antidepressant, imipramine, using DNA microarrays. The analysis of similarities in gene expression patterns among functionally related genes revealed four expression profile cluster areas that showed a highly...

journal_title：Neurochemical research

authors： Knuuttila JE,Törönen P,Castrén E

更新日期：2004-06-01 00:00:00

abstract：:Numerous studies have demonstrated that the Acetyl Coenzyme A-dependent arylamine NAT enzyme exist in many tissues of experimental animals including humans, and that NAT has been shown to be exist in mouse brain tissue. Increased NAT activity levels are associated with increased sensitivity to the mutagenic effects of...

journal_title：Neurochemical research

authors： Lin SS,Hung CF,Ho CC,Liu YH,Ho HC,Chung JG

更新日期：2000-11-01 00:00:00

abstract：:TRH-like immunoreactivity distinct from TRH is present in various tissues and fluids. In order to determine whether TRH-like molecules are secreted by the hypothalamus, we analyzed tissues and media from hypothalamic slices incubated in Krebs Ringer bicarbonate. Media from basal or high KCl conditions contained 3 TRH-...

journal_title：Neurochemical research

authors： Méndez M,Cisneros M,Baez A,Joseph-Bravo P,Charli JL

更新日期：1999-07-01 00:00:00

abstract：:Mutations in genes for Alzheimer's disease (AD) result in a modulating of gene expressions in the brains of patients with AD. The aim of this study was to identify genes whose expression is modulated due to the over-expression of human mutant presenilin-2 (N141I) (hPS2m) in transgenic mice, which has previously been p...

journal_title：Neurochemical research

authors： Hwang DY,Cho JS,Oh JH,Shim SB,Jee SW,Lee SH,Seo SJ,Lee SK,Lee SH,Kim YK

更新日期：2005-08-01 00:00:00

abstract：:Brain regional 5-HT (5-hydroxytryptamine) and 5-HIAA (5-hydroxyindole-3-acetic acid) concentrations in male LE rats at three times were measured by a fluorescence method, to evaluate effects of intracranial surgery and administration of melatonin on the changes in these compounds during the first part of the dark phas...

journal_title：Neurochemical research

authors： Quay WB

更新日期：1989-10-01 00:00:00

abstract：:Studies on primary astrocytes cultured in vitro have shown that process formation involves changes in cytoskeletal proteins and release of tension on the substratum. Actin filament reorganization has previously been found to be the major cytoskeletal change occurring during process formation. These changes are relativ...

journal_title：Neurochemical research

authors： Padmanabhan J,Shelanski ML

更新日期：1998-03-01 00:00:00

abstract：:Deciphering what governs inflammation and its effects on tissues is vital for understanding many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes inflammation reveals a new component of its well-documented actions in several prevalent diseases which involve inflammation, including mood...

journal_title：Neurochemical research

authors： Jope RS,Yuskaitis CJ,Beurel E

更新日期：2007-04-01 00:00:00

abstract：:The modulation of intracellular GABA activated 36Cl- in-->out permeation across single Deiters' neuron membranes has been studied in a microchamber system. Addition of Mg2+/ATP on the membrane cytoplasmic side reduces strongly the GABA effect as does ATP alone. However, the greatest inhibition of the GABA effect is gi...

journal_title：Neurochemical research

authors： Rapallino MV,Cupello A,Hydén H

更新日期：1999-08-01 00:00:00

abstract：:One of the many pharmacological targets of ethanol is the GABA inhibitory system, and chronic ethanol (CE) is known to alter the polypeptide levels of the GABA(A )receptor subunits in rat brain regions. In the present study, we investigated the regulation of the tyrosine kinase phosphorylation of the GABA(A) receptor ...

journal_title：Neurochemical research

authors： Marutha Ravindran CR,Mehta AK,Ticku MK

更新日期：2007-07-01 00:00:00

abstract：:The oxidation of pyruvate is mediated by the pyruvate dehydrogenase complex (PDHC; EC 1.2.4.1, EC 2.3.1.12 and EC 1.6.4.3) whose catalytic activity is influenced by phosphorylation and by product inhibition. 2-Oxoglutarate and 3-hydroxybutyrate are readily utilized by brain mitochondria and inhibit pyruvate oxidation....

journal_title：Neurochemical research

authors： Lai JC,Sheu KF

更新日期：1987-08-01 00:00:00

abstract：:Ménière's disease (MD) is characterized by the triad of fluctuating hearing loss, episodic vertigo and tinnitus, and by endolymphatic hydrops found on post-mortem examination. Increasing evidence suggests that oxidative stress is involved in the development of endolymphatic hydrops and that cellular damage and apoptot...

journal_title：Neurochemical research

authors： Calabrese V,Cornelius C,Maiolino L,Luca M,Chiaramonte R,Toscano MA,Serra A

更新日期：2010-12-01 00:00:00

abstract：:We have previously reported that angiotensin receptor blockade reduces reperfusion hemorrhage in a suture occlusion model of stroke, despite increasing matrix metalloproteinase (MMP-9) activity. We hypothesized that candesartan will also decrease hemorrhage associated with delayed (6 h) tissue plasminogen activator (t...

journal_title：Neurochemical research

authors： Ishrat T,Pillai B,Ergul A,Hafez S,Fagan SC

更新日期：2013-12-01 00:00:00

abstract：:Synaptosomes isolated from mouse brain were incubated with [14C]glutamate and [3H]gamma-amino-butyric acid ([3H]GABA), and then [14C]GABA (newly synthesized GABA) and [3H]GABA (newly captured GABA) in the synaptosomes were analysed. (1) the [3H]GABA was rapidly degraded in the synaptosomes, (2) when the synaptosomes w...

journal_title：Neurochemical research

authors： Asakura T,Matsuda M

更新日期：1990-03-01 00:00:00

abstract：:Lewy bodies and Lewy neurites in the brain constitute the main histopathological features of Parkinson's disease (PD) and dementia with Lewy bodies. They comprise amyloid-like fibrils composed of α-synuclein (αS), a small protein (~14 kDa). Because the aggregation of αS in the brain has been implicated as a critical s...

journal_title：Neurochemical research

authors： Ono K

更新日期：2017-12-01 00:00:00

abstract：:Ethyl pyruvate (EP) has recently been reported to afford protection against neurodegenerative disorders. However, the mechanism underlying EP-mediated neuroprotection remains to be elucidated. Because peroxynitrite has been extensively implicated in the pathogenesis of various forms of neurodegenerative disorders via ...

journal_title：Neurochemical research

authors： Chen W,Jia Z,Zhu H,Zhou K,Li Y,Misra HP

更新日期：2010-02-01 00:00:00

abstract：:One of the main pathological symptoms of early diabetic retinal neuropathy is retina neuronal apoptosis. In the present work we investigated the effects of indoleamine hormone melatonin, a powerful free radical scavenger, on streptozotocin-induced retina neuronal cell apoptosis in high blood glucose rat. After melaton...

journal_title：Neurochemical research

authors： Li X,Zhang M,Tang W

更新日期：2013-03-01 00:00:00

abstract：:Paclitaxel (PTX) is an antineoplastic agent commonly used in the treatment of solid tumors and is known to cause dose-limiting peripheral neurotoxicity. This study was performed to evaluate the protective effect of curcumin (CUR) against PTX-induced spinal cord and sciatic nerve injuries in rats. The rats were adminis...

journal_title：Neurochemical research

authors： Yardım A,Kandemir FM,Çomaklı S,Özdemir S,Caglayan C,Kucukler S,Çelik H

更新日期：2020-11-17 00:00:00