Abstract：
:Apoptosis can be defined as the regulated death of a cell and is conducted by conserved pathways. Apoptosis of neurons after injury or disease differs from programed cell death, in the sense that neurons in an adult brain are not "meant" to die and results in a loss of function. Thus apoptosis is an honorable process by a neuron, a cell with limited potential to replace itself, choosing instead to commit suicide to save neighboring cells from release of cellular components that cause injury directly or trigger secondary injury resulting from inflammatory reactions. The excess of apoptosis of neuronal cells underlies the progressive loss of neuronal populations in neurodegenerative disorders and thus is harmful. Mitochondria are the primary source for energy in neurons but are also poised, through the "mitochondrial apoptosis pathway," to signal the demise of cells. This duplicity of mitochondria is discussed, with particular attention given to the specialized case of pathological neuronal cell death.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Haeberlein SLdoi
10.1023/b:nere.0000014823.74782.b7keywords:
subject
Has Abstractpub_date
2004-03-01 00:00:00pages
521-30issue
3eissn
0364-3190issn
1573-6903journal_volume
29pub_type
杂志文章,评审abstract：:Cortical spreading depression (CSD) enhances ischemic tolerance to temporary focal ischemia. Although this effect most likely requires the expression or activation of neuroprotective factors, their identity remains relatively unknown. One important factor involved in neuroprotection is adenosine monophosphate-dependen...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1447-3
更新日期：2014-12-01 00:00:00
abstract：:Incubation of [3H]-tyrosine methionine5-enkephalin (MET) with human brain preparations (100,000g supernatant; sections of the limbic system, thalamus, basal ganglia, cerebellum, and cortex) results in its rapid and complete degradation; over 95% of the initial labeled tyrosine is recovered as the free aminoacid within...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9418-6
更新日期：2008-01-01 00:00:00
abstract：:The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcriptional factor that belongs to the nuclear hormone receptor superfamily. PPARγ was initially identified through its role in the regulation of glucose and lipid metabolism and cell differentiation. It also influences the expressi...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-014-1377-0
更新日期：2015-02-01 00:00:00
abstract：:The Fatty Acid method was used to determine whether incorporation of plasma radiolabeled arachidonic acid into brain phospholipids is controlled by phospholipase A2. Awake rats received an i.v. injection of a phospholipase A2 inhibitor, manoalide (10 mg/kg), and then were infused i.v. with [1-(14)C]arachidonate or [3H...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020788031720
更新日期：1998-10-01 00:00:00
abstract：:Malignant peripheral nerve sheath (MPNST) cell lines derived from patients with neurofibromatosis type 1 (NF!) were found to have basal cAMP levels which are two-fold higher than cAMP levels in normal human adult Schwann cells (nHSC). PCR analysis also revealed that normal adult human Schwann cells express mRNA for ty...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0433-2
更新日期：2011-09-01 00:00:00
abstract：:We investigated the ability of hydrogen peroxide (H2O2) to cause apoptotic cell death in cultured rat forebrain neurons and the potential mechanisms by which oxidative stress triggers delayed neuronal death. H2O2 (25 microM for 5 min) reduced cell viability to 34.5 +/- 8.3% of untreated controls 20 h after exposure, a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022403224901
更新日期：1997-03-01 00:00:00
abstract：:Nerve growth factor (NGF) has been isolated from human placental tissue. Using the chicken embryo dorsal root ganglia assay, we determined levels of NGF activity for the amnion, placental cotyledons, cord serum, fetal serum, and maternal serum. The highest levels of NGF activity were measured in placental cotyledons. ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964058
更新日期：1978-04-01 00:00:00
abstract：:Heme oxygenase-1 (HO-1) plays a crucial role in oxidative stress processes, apoptosis and cell differentiation. Further, some proteins related to cell cycle including cyclins and p21 are important markers of astrocyte cultures. Aim of investigation was to study the effects of cholinergic precursors (choline, CDP-choli...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0873-3
更新日期：2012-12-01 00:00:00
abstract：:The aim of this study was to determine the anticancer potential of Leonurus sibiricus extract derived from in vitro transgenic roots transformed by Agrobacetrium rhizogenes with AtPAP1 transcriptional factor, and that of transformed roots without construct, on grade IV human glioma cells and the U87MG cell line, and a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2551-6
更新日期：2018-07-01 00:00:00
abstract：:We describe an attempt to incorporate a metabolically inert phospholipid analog into animal membranes, especially myelin, in vivo, with the view of eventual long-term membrane modification or membrane engineering. A sonicated suspension of a mixture of [14C]phosphatidylcholine and its dialkyl analog, [3H] tetradecylo...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964783
更新日期：1980-06-01 00:00:00
abstract：:Emerging data suggests that mitochondrial dysfunction is prominently involved in Alzheimer disease (AD) progression. Sirtuin-3 (Sirt3) is a member of the sirtuin family of nicotinamide adenine dinucleotide dependent deacetylases that regulates a variety of mitochondrial functions and suppresses mitochondria-related ph...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1630-1
更新日期：2015-08-01 00:00:00
abstract：:Microglia can exacerbate central nervous system disorders, including stroke and chronic progressive neurodegenerative diseases such as Alzheimer disease. Mounting evidence points to ion channels expressed by microglia as contributing to these neuropathologies. The Chloride Intracellular Channel (CLIC) family represent...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1084-2
更新日期：2013-09-01 00:00:00
abstract：:The tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) is not only a protein, but also a lipid phosphatase that can negatively regulate the serine/threonine kinase Akt. It has been reported that PTEN can be regulated by means of phosphorylation. However, whether PTEN can be regulated by an...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-9938-3
更新日期：2009-08-01 00:00:00
abstract：:We identify and characterize two classes of immediate-early genes: (i) genes, induced by depolarization in neurons, that play a role in depolarization-induced neuronal plasticity and (ii) genes, induced in neuronal precursors by neurotrophins, that play a causal role in neurotrophin-directed neuronal differentiation. ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1007546600535
更新日期：2000-05-01 00:00:00
abstract：:Blood-brain barrier formed by brain capillary endothelial cells, being in contact with astrocytes endfeet and pericytes, separates extracellular fluid from plasma. Supply of necessary nutrients and removal of certain metabolites takes place due to the activity of transporting proteins from ABC (ATP binding cassette) a...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-016-2030-x
更新日期：2017-03-01 00:00:00
abstract：:We recently presented evidence that distinct morphine and enkephalin receptors coexist in an opioid receptor complex (Mol. Pharmacol. 21:548-557, 1982). In this paper, we present data which demonstrate that in the presence of sodium leucine enkephalin noncompetitively inhibits the binding of [3H]naloxone to a crude pa...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964552
更新日期：1983-07-01 00:00:00
abstract：:A number of recent findings support the notion of mechanistic parallels between Alzheimer disease (AD) and oncogenic processes, specifically, that neurons in AD, like cancer cells, display aberrant mitotic cell cycle re-entry. However, the mechanism that drives postmitotic neurons to reenter cell cycle remains elusive...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9146-3
更新日期：2007-04-01 00:00:00
abstract：:The frontal cortex, hippocampus, and cerebellum of the Fischer 344 rat were examined for an age-dependent change in neuronal and non-neuronal binding. Clonazepam and Ro5-6669 displaceable [3H]diazepam binding were used as indicators of [3H]diazepam binding on neuronal and non-neuronal membranes, respectively. In both ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964927
更新日期：1983-09-01 00:00:00
abstract：:In this report data are summarized on changes in the quantity of proteolipid protein (PLP), its amino acid composition, and the lipid moiety of these lipid-protein complexes in rat brain during postnatal development. In all three parts of the central nervous system (CNS) studied (cerebral hemispheres, medulla oblongat...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：
更新日期：1985-11-01 00:00:00
abstract：:Acupuncture and moxibustion are traditional medical treatments that have come to play important roles in complementary and alternative medicines. Moxibustion also has a long history as a folk remedy in Japan, particularly due to the technical simplicity and selective efficacy on certain types of disease and distress. ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-8839-3
更新日期：2005-12-01 00:00:00
abstract：:A simple, rapid method for determining depolarization-induced 45Ca influx into synaptosomes is described. Synaptosomes which had been depolarized in the presence of 45Ca were applied to a small column of Chelex-100 resin to separate free Ca2+ from that taken up by the tissue. Approximately 70% of the synaptosomal prot...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965062
更新日期：1982-02-01 00:00:00
abstract：:The antibodies against omega-conotoxin GVIA (omega-CTX GVIA; N-type voltage-dependent calcium channel [VDCC] blocker) and B1Nt (N-terminal segment [residues 1-13] of BI alpha1 subunits of VDCCs) were prepared, and the selectivity for each antigen omega-CTX GVIA and B1Nt was investigated. For the antigen selectivity of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1023208103438
更新日期：2003-06-01 00:00:00
abstract：:6-Hydroxydopamine (6-OHDA) induces the production of reactive oxygen species (ROS) that are associated with various neurodegenerative diseases such as Parkinson's disease. 3,3',4',7-Tetrahydroxyflavone (fisetin), a plant flavonoid has a variety of physiological effects such as antioxidant activity. In this study, we i...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-017-2445-z
更新日期：2018-02-01 00:00:00
abstract：:Tau is a protein involved in regulation of microtubule stability, axonal differentiation and transport. Alteration of retrograde transport may lead to motor neuron degeneration. Thus alternative mRNA splicing and expression of tau isoforms were studied in a transgenic mouse model harboring the human SOD1 G93A mutation...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9057-3
更新日期：2006-05-01 00:00:00
abstract：:The synaptic glutamate level homeostasis is mainly maintained by the astrocytes membrane bound glutamate transporter type-1 (GLT-1/EAAT2). Alterations in its expression during development and aging and the underlying mechanisms are not well studied. Here, we report that NF-κB interaction was highest in both cerebral a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1200-3
更新日期：2014-01-01 00:00:00
abstract：:We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0172-9
更新日期：2010-08-01 00:00:00
abstract：:It is known that the NMDA-R NR1 subunit is needed for the receptor activity and that under hypoxia the evolution toward apoptosis or neuronal survival depends on the balance NR2A/NR2B subunits. This paper analyzes the effect of acute hypoxia on the above mentioned subunits mRNAs during development. The mean percentage...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0221-4
更新日期：2010-10-01 00:00:00
abstract：:The cerebellar cortical circuit of mammals develops via a series of magnificent cellular events in the postnatal stage of development to accomplish the formation of functional circuit architectures. The contribution of genetic factors is thought to be crucial to cerebellar development. Therefore, it is essential to an...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-011-0398-1
更新日期：2011-07-01 00:00:00
abstract：:Mevalonate phosphorylation was studied in neonatal chick brain. Formation of phosphorylated derivatives of mevalonic acid increased with the pH in the range assays (5.5-9.5). Phosphomevalonate kinase was completely inactivated after treatment at 50 degree C for 5-10 min, whereas mevalonate kinase was found to retain i...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965047
更新日期：1981-08-01 00:00:00
abstract：:The present investigation evaluates the anti-stress activity of risperidone (RIS) in the cold restraint stress (CRS) model and related stress pathways. Rats were pretreated with RIS (0.1 and 1.0 mg/kg) for 21 days before subjecting to CRS. Ultra low dose of RIS (ULD; 0.1 mg/kg) in contrast to higher dose (1.0 mg/kg) s...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0490-6
更新日期：2011-10-01 00:00:00
