Abstract：
:In this report data are summarized on changes in the quantity of proteolipid protein (PLP), its amino acid composition, and the lipid moiety of these lipid-protein complexes in rat brain during postnatal development. In all three parts of the central nervous system (CNS) studied (cerebral hemispheres, medulla oblongata and spinal cord) the main pattern of PLP accumulation is on the whole similar. PLP content is very low in the newborn, and it increased 12 to 20-fold during development. The highest rate of PLP accumulation is observed in the period from 10 to 30 days after birth. Against the background of general similarity the concentration of some amino acids such as lysine, proline, tyrosine in PLP somewhat increased during development, while that of aspartic acid, glutamic acid, glycine, and leucine decreased. Soluble proteolipid complexes, purified to various degree from lipids were isolated from brain of rats of different ages. As compared with the original lipid extracts from which they were obtained, the crude and especially purified proteolipids in all the animals studied were enriched in acidic phospholipids (PhL). This prevalence of acidic PhL increased with age. During the development in phospholipid moiety of proteolipids (PL) the content of phosphatidyl serine, sphingomyelin and mainly diphosphatidyl glycerol increases and that of phosphatidyl inositol and especially phosphatidyl choline decreases. The concentration of acidic PhL more tightly bound with PLP appreciably increases with age. Most of these changes occur mainly during the second decade after birth.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Manukian KH,Kirakosian LGsubject
Has Abstractpub_date
1985-11-01 00:00:00pages
1533-45issue
11eissn
0364-3190issn
1573-6903journal_volume
10pub_type
杂志文章abstract：:Antipsychotics represent high affinity for sigma receptors and sigma-like drugs often have the psychotomimetic properties. Besides, the receptors are unevenly distributed in human brain. These findings suggest that sigma receptors might be involved in the pathophysiology of schizophrenia. Sigma receptors in rat and hu...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966825
更新日期：1992-10-01 00:00:00
abstract：:The mitochondrial enzyme, pyruvate carboxylase (PC; EC 6.4.1.1) is considered to play a significant role in the intermediary metabolism of neural tissue. PC-catalyzed carboxylation of pyruvate to oxaloacetate is a major anaplerotic reaction in brain. Anaplerosis is essential for homeostasis of the members of the trica...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9806-6
更新日期：2009-03-01 00:00:00
abstract：:Caspase activation and apoptotic events may take place in terminal regions far removed from the cell body and contribute to synapse loss in neurodegenerative diseases. For examination of events in terminals, we have developed a cell-free assay using quantitative flow cytometric analysis (fluorescence-activated cell so...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1019840417796
更新日期：2002-06-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965941
更新日期：1986-08-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1011094728469
更新日期：2001-02-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-02975-7
更新日期：2020-04-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03002-5
更新日期：2020-05-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965100
更新日期：1983-04-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964435
更新日期：1979-10-01 00:00:00
abstract：:CNTF (ciliary neurotrophic factor) has been suggested to be an important survival factor for oligodendrocytes; however, this effect is inconsistently obtained and myelination appears normal in CNTF null animals. On the other hand, CNTF stimulates astrocytes to produce growth and trophic factors. Therefore, we tested t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9151-6
更新日期：2007-02-01 00:00:00
abstract：:In this review properties of lipid acetyltransferase enzymes are outlined. The three activities of interest are lyso PAF acetyltransferase (acetyl CoA: 1-alkyl-sn-glycero-3-phosphocholine acetyltransferase), AGP acetyltransferase (acetyl CoA: 1-alkyl sn-glycero-3-phosphate acetyltransferase) and a transacetylase activ...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1007567205078
更新日期：2000-05-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022889827195
更新日期：2003-04-01 00:00:00
abstract：:"Kindling" is a phenomenon of epileptogenesis, which has been widely used as an experimental model of temporal lobe epilepsy. At the present work we investigated the contribution of NMDA receptors in the Pentylenetetrazol-induced "kindling" model in the mouse brain, by using quantitative autoradiography and the radioa...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021143813935
更新日期：1999-12-01 00:00:00
abstract：:The exposure to hypobaric hypoxia increased lipid peroxidation as indicated by thiobarbituric acid-reactive substances [TBARS] in rat brain. Plasma lactate/pyruvate ratio was used as a marker of hypoxia. We compared the protective effect of alpha-tocopherol with the effect of L-carnitine or phosphocreatine. Rats pretr...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020339530924
更新日期：2002-09-01 00:00:00
abstract：:Lewy bodies and Lewy neurites in the brain constitute the main histopathological features of Parkinson's disease (PD) and dementia with Lewy bodies. They comprise amyloid-like fibrils composed of α-synuclein (αS), a small protein (~14 kDa). Because the aggregation of αS in the brain has been implicated as a critical s...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-017-2382-x
更新日期：2017-12-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1014884504879
更新日期：2002-03-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964517
更新日期：1984-05-01 00:00:00
abstract：:Umbilical cord blood-derived marrow stromal cells (UCB-MSCs) with high proliferation capacity and immunomodulatory properties are considered to be a good candidate for cell-based therapies. But until now, little work has been focused on the differentiation of UCB-MSCs. In this work, UCB-MSCs were demonstrated to be ne...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1186-x
更新日期：2013-12-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0600-5
更新日期：2012-02-01 00:00:00
abstract：:Brain development is a highly orchestrated complex process. The developing brain utilizes many substrates including glucose, ketone bodies, lactate, fatty acids and amino acids for energy, cell division and the biosynthesis of nucleotides, proteins and lipids. Metabolism is crucial to provide energy for all cellular p...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-015-1600-7
更新日期：2015-12-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-6879-3
更新日期：2005-06-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963926
更新日期：1983-02-01 00:00:00
abstract：:Development of the central somatosensory system is profoundly modulated by the sensory periphery. Cauterization of facial whiskers alters the segregation pattern of barrels in rodents only during a few days just after birth (critical period). Although a molecular basis of the segregation of barrel neurons and the crit...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022075508176
更新日期：1997-07-01 00:00:00
abstract：:It is thought that changes in gene expression in the brain mediate chronic ethanol-induced complex behaviors such as tolerance, dependence, and sensitization, and also relate to ethanol-induced brain toxicity. Using high-density filter-based cDNA microarrays (GeneFilters), we analyzed the expression of over 5000 genes...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020937728506
更新日期：2002-10-01 00:00:00
abstract：:The selective vulnerability of specific neuronal subpopulations to trimethyltin (TMT), an organotin compound with neurotoxicant effects selectively involving the limbic system and especially marked in the hippocampus, makes it useful to obtain in vivo models of neurodegeneration associated with behavioural alterations...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-012-0932-9
更新日期：2013-02-01 00:00:00
abstract：:Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor that plays an important role in multiple sclerosis (MS). However, mechanisms by which CNTF expression could be increased in the brain are poorly understood. Recently we have discovered anti-inflammatory and immunomodulatory activities of sodium benz...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1723-x
更新日期：2015-11-01 00:00:00
abstract：:Adult rabbit brain contains the enzymatic machinery to convert deoxyuridine to deoxyuridine triphosphate (dUTP). Although dUTP as dUMP can be readily incorporated into DNA in place of thymidine monophosphate, we detected no (3H)dUMP in newly synthesized (3H)DNA in adult rabbit brain after the intraventricular injectio...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965201
更新日期：1983-08-01 00:00:00
abstract：:We have measured the postnatal development and GABA modulation of benzodiazepine receptors in neuronal membranes from vitamin B-6 deficient and normal rats. In rats fed vitamin B-6 adequate and deficient diets there were age-dependent changes in [3H]flunitrazepam binding site affinity and in the number of binding site...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00975043
更新日期：1993-12-01 00:00:00
abstract：:Implication of protein phosphatases in Alzheimer disease led us to a systemic investigation of the identification of these enzyme activities in human brain. Human brain phosphatases eluted from DEAE-Sephacel with 0.22 M NaCl were resolved into two main groups by affi-gel blue chromatography, namely affi-gel blue-bindi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1007547701518
更新日期：2000-01-01 00:00:00
abstract：:Single prolonged stress (SPS) rats is a rodent model of post traumatic stress disorder (PTSD). Abnormal hippocampal morphology and function were found in the PTSD patients. Our previous study has shown that SPS induce loss of hippocampal neurons. But the effects of SPS on glial cells in the hippocampus have not been e...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1549-6
更新日期：2015-05-01 00:00:00
