Abstract:
:The exposure to hypobaric hypoxia increased lipid peroxidation as indicated by thiobarbituric acid-reactive substances [TBARS] in rat brain. Plasma lactate/pyruvate ratio was used as a marker of hypoxia. We compared the protective effect of alpha-tocopherol with the effect of L-carnitine or phosphocreatine. Rats pretreated with alpha-tocopherol, L-carnitine, or phosphocreatine had lower TBARS levels after the exposure to hypobaric hypoxia. However, lactate/ pyruvate ratio was improved only in rats pretreated with L-carnitine or phosphocreatine. We conclude from our data that, contrary to alpha-tocopherol, protective effects of L-carnitine and phosphocreatine administrations are due to their regulation of metabolic reactions during hypobaric hypoxia rather than to their scavenger activity.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Rauchová H,Koudelová J,Drahota Z,Mourek Jdoi
10.1023/a:1020339530924keywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
899-904issue
9eissn
0364-3190issn
1573-6903journal_volume
27pub_type
杂志文章abstract::Metabolic turnover of axonally transported glycoproteins has been examined in membranous and soluble subfractions of goldfish optic tectum following intraocular injection of [3H]fucose. Radioactivity in total transported glycoproteins reached a maximum in the tectum after 24-30 hr, then declined with a half-life of ap...
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pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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