Abstract：
:The presynaptic dopamine (DA) D2 receptor-mediated regulation of ATP-sensitive potassium (K+ATP) channels was examined in slices of the rat caudate-putamen. When slices were incubated with the specific D2 receptor antagonist (-)-sulpiride (SLP), a concentration-dependent increase of extracellular DA release was observed. SLP-induced enhancement was completely antagonized by coincubation with the K+ATP channel opener diazoxide (DIA). Treatment of slices with the D2 receptor agonist quinpirole (QUI) almost completely inhibited DA outflow induced by the K+ATP channel blocker butanedione-monoxime (BDM). Coincubation of SLP and guanosine triphosphate (GTP) or its non-hydrolizable analogue guanylyl-5'-imidodiphosphate [Gpp(NH)p], significantly reduced the SLP-induced effect on DA levels. Furthermore, we observed that BDM-induced DA outflow was markedly inhibited by G protein activators suggesting an additional receptor-independent regulation of K+ATP channel gating. Our results suggest that PTX-sensitive G proteins are involved in the signal transduction between D2 receptors and K+ATP channels. Furthermore, K+ATP channels can be modulated in a receptor-independent mechanism by G protein activators.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Neusch C,Runde D,Moser Adoi
10.1023/a:1026620316090keywords:
subject
Has Abstractpub_date
2000-12-01 00:00:00pages
1521-6issue
12eissn
0364-3190issn
1573-6903journal_volume
25pub_type
杂志文章abstract：:Isozyme patterns of cholinesterase (ChE) from heart, tongue, and skeletal muscle of normal and dystrophic hamsters are presented. Two principal bands, bands 1 and 2, were evaluated. Band 1 migrates faster towards the anode than does band 2. While bands 1 and 2 stain for AChE and were found in control muscles, only ban...
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pub_type： 杂志文章
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更新日期：1982-02-01 00:00:00
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更新日期：2002-08-01 00:00:00
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更新日期：2013-03-01 00:00:00
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更新日期：2005-10-01 00:00:00
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journal_title：Neurochemical research
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更新日期：2016-04-01 00:00:00
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pub_type： 杂志文章
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