Levels and uptake of taurine in various brain regions after drug-induced generalized convulsions.

abstract：:The phosphoinositide signal transduction system, and particularly, phospholipase Cbeta isozymes, are relevant in the etiopathogeny of human neuropsychiatric pathologies such as depression. Stimulation of phospholipase Cbeta activity by muscarinic receptors and G proteins was determined in crude and synaptosomal membra...

journal_title：Neurochemical research

authors： Garro MA,López de Jesús M,Ruíz de Azúa I,Callado LF,Meana JJ,Sallés J

更新日期：2004-07-01 00:00:00

abstract：:Several studies showed that the up-regulation of glial glutamate transporter-1 (GLT-1) participates in the acquisition of brain ischemic tolerance induced by cerebral ischemic preconditioning or ceftriaxone pretreatment in rats. To explore whether GLT-1 plays a role in the acquisition of brain ischemic tolerance induc...

journal_title：Neurochemical research

authors： Gong SJ,Chen LY,Zhang M,Gong JX,Ma YX,Zhang JM,Wang YJ,Hu YY,Sun XC,Li WB,Zhang Y

更新日期：2012-03-01 00:00:00

abstract：:cDNA microarray analysis of 1-methyl-4-phenyl-pyridinium (MPP+) toxicity (1 mM, 72 h) in undifferentiated SH-SY5Y cells identified 48 genes that displayed a signal intensity greater than the mean of all differentially expressed genes and a two-fold or greater difference in normalized expression. RT-PCR analysis of a s...

journal_title：Neurochemical research

authors： Conn KJ,Ullman MD,Larned MJ,Eisenhauer PB,Fine RE,Wells JM

更新日期：2003-12-01 00:00:00

abstract：:An in vitro procedure for labeling of RNA in the excised rat nodose ganglion was used to evaluate the changes in incorporation of [3H]uridine into ganglionic RNA following transection of the abdominal vagus nerves. Significant increases in the incorporation into 28S, 18S and 4S RNA were observed at 1 day after injury,...

journal_title：Neurochemical research

authors： Bates DJ,Sirkos S,Moses EK,Austin L

更新日期：1983-03-01 00:00:00

abstract：:Implication of protein phosphatases in Alzheimer disease led us to a systemic investigation of the identification of these enzyme activities in human brain. Human brain phosphatases eluted from DEAE-Sephacel with 0.22 M NaCl were resolved into two main groups by affi-gel blue chromatography, namely affi-gel blue-bindi...

journal_title：Neurochemical research

authors： Cheng LY,Wang JZ,Gong CX,Pei JJ,Zaidi T,Grundke-Iqbal I,Iqbal K

更新日期：2000-01-01 00:00:00

abstract：:The objective of the present study was to investigate the effects of preincubation of hippocampus homogenates in the presence of homocysteine or methionine on Na+, K+-ATPase and Mg2+-ATPase activities in synaptic membranes of rats. Homocysteine significantly inhibited Na+, K+-ATPase activity, whereas methionine had no...

journal_title：Neurochemical research

authors： Streck EL,Zugno AI,Tagliari B,Franzon R,Wannmacher CM,Wajner M,Wyse AT

更新日期：2001-11-01 00:00:00

abstract：:Isozyme patterns of cholinesterase (ChE) from heart, tongue, and skeletal muscle of normal and dystrophic hamsters are presented. Two principal bands, bands 1 and 2, were evaluated. Band 1 migrates faster towards the anode than does band 2. While bands 1 and 2 stain for AChE and were found in control muscles, only ban...

journal_title：Neurochemical research

authors： Henderson NS,Tweedle CD,Kabara JJ

更新日期：1980-12-01 00:00:00

abstract：:The wobbler mouse suffers an autosomal recessive mutation producing severe neurodegeneration and astrogliosis in spinal cord. It has been considered a model for amyotrophic lateral sclerosis. We have studied in these animals the expression of two proteins, the growth-associated protein (GAP-43) and the NADPH-diaphoras...

journal_title：Neurochemical research

authors： González Deniselle MC,González SL,Lima AE,Wilkin G,De Nicola AF

更新日期：1999-01-01 00:00:00

abstract：:Changes in oxygen consumption, body temperature and energy metabolism were studied while mice were repeatedly exposed to a sealed environment. The average tolerance limits of environmental oxygen level (vol%) and the average oxygen consumption rates (ml/g x min) were exponentially decreased and the average body rectal...

journal_title：Neurochemical research

authors： Lu GW,Cui XY,Zhao BM

更新日期：1999-05-01 00:00:00

abstract：:In this review article, we summarize recently accumulated knowledge regarding the molecular mechanisms, which control retinal development. Retinal neurons are born in two waves of cytogenesis. In the first wave, neurons of cone circuitry are generated, whereas in the second wave, rod circuitry is added. Neurons genera...

journal_title：Neurochemical research

authors： Sharma RK,Johnson DA

更新日期：2000-10-01 00:00:00

abstract：:Protocatechuic acid (PA), a major metabolite of anthocyanins, has been reported to possess antioxidant and anti-inflammatory activities. However, the effects of PA on LPS-induced inflammatory responses in microglia have not been reported. The aim of this study was to investigate the anti-inflammatory effects and molec...

journal_title：Neurochemical research

authors： Wang HY,Wang H,Wang JH,Wang Q,Ma QF,Chen YY

更新日期：2015-08-01 00:00:00

abstract：:Lipid peroxides, quantitated as lipid conjugated dienes, and (Na+, K+)-ATPase activity were assayed concurrently in brains of control rats and in three groups subjected to 30 min of reversible forebrain ischemia followed by 0, 1, and 4 hr of recirculation. Multiple small samples were taken from lateral, dorsolateral a...

journal_title：Neurochemical research

authors： Goldberg WJ,Watson BD,Busto R,Kurchner H,Santiso M,Ginsberg MD

更新日期：1984-12-01 00:00:00

abstract：:Excitotoxicity has been associated with the loss of medium spiny neurons (MSN) in Huntington's disease (HD). We have previously observed that the content of the glial glutamate transporters, glutamate transporter 1 (GLT-1) and glutamate-aspartate transporter (GLAST), diminishes in R6/2 mice at 14 weeks of age but not ...

journal_title：Neurochemical research

authors： Estrada-Sánchez AM,Montiel T,Massieu L

更新日期：2010-08-01 00:00:00

abstract：:The aim of this study was to determine whether neurotrophin-4/5 (NT-4/5) treatment alters infarction volume following permanent focal cerebral ischemia in the rat. Permanent focal cerebral ischemia was produced in adult male rats by intraluminal occlusion of the right middle cerebral artery. NT-4/5 was administered in...

journal_title：Neurochemical research

authors： Chan KM,Lam DT,Pong K,Widmer HR,Hefti F

更新日期：1996-07-01 00:00:00

abstract：:We recently presented evidence that distinct morphine and enkephalin receptors coexist in an opioid receptor complex (Mol. Pharmacol. 21:548-557, 1982). In this paper, we present data which demonstrate that in the presence of sodium leucine enkephalin noncompetitively inhibits the binding of [3H]naloxone to a crude pa...

journal_title：Neurochemical research

authors： Rothman RB,Westfall TC

更新日期：1983-07-01 00:00:00

abstract：:The cellular uptake of the GABA-transaminase inhibitors gamma-vinyl GABA (GVG) and gamma-acetylenic GABA (GAG) was studied in cultured neurons and astrocytes. By the use of the individual enantiomers R- and S-GVG and R- and S-GAG it could be shown that in both cell types only the S-enantiomers could be actively transp...

journal_title：Neurochemical research

authors： Schousboe A,Larsson OM,Seiler N

更新日期：1986-11-01 00:00:00

abstract：:Several epidemiological studies have shown that consumption of large quantities of vegetables especially cruciferous vegetables (Broccoli and Brussels sprouts) can protect against chronic diseases. Sulforaphane, an isothiocynate found in cruciferous vegetables has been demonstrated to have neuroprotective effects in s...

journal_title：Neurochemical research

authors： Rajesh V,Ilanthalir S

更新日期：2016-10-01 00:00:00

abstract：:The binding of the enkephalin dimer [D-Ala2, Leu5-NH-CH2-]2 (DPE2) is characterized by its high affinity for receptors on NG108-15 hybrid cells, the affinity constant K = 4.7 X 10(9) M-1 is up to 8-fold that of monomers (0.6 to 1.0 X 10(9) M-1), and a maximal binding capacity equal to one half that of the monomers. Ki...

journal_title：Neurochemical research

authors： Krumins SA,Lutz RA,Costa T,Rodbard D

更新日期：1986-06-01 00:00:00

abstract：:The present study was designed to evaluate the potential role of miR-93 in cerebral ischemic/reperfusion (I/R) injury in mice. The stroke model was produced in C57BL/6 J mice via middle cerebral artery occlusion (MCAO) for 1 h followed by reperfusion. And miR-93 antagomir was transfected to down-regulate the miR-93 le...

journal_title：Neurochemical research

authors： Wang P,Liang X,Lu Y,Zhao X,Liang J

更新日期：2016-10-01 00:00:00

abstract：:In the unrestrained rat, the hyperphagic-like ingestion of food evoked by the sustained elevation of neuropeptide-Y (NPY) in the hypothalamus was correlated with the release and turnover of monoaminergic transmitters in this structure. A single guide tube was implanted stereotaxically in the perifornical region of the...

journal_title：Neurochemical research

authors： Myers RD,Lankford MF,Paez X

更新日期：1992-11-01 00:00:00

abstract：:Nicotine has been reported to exert certain protective effect in the Parkinson's and Alzheimer's diseases. Whether it has a similar action in focal cerebral ischemia was unclear. In the present study, rats received either an injection of (-)-nicotine hydrogen tartrate salt (1.2 mg/kg, i.p.) or the vehicle 2 h before t...

journal_title：Neurochemical research

authors： Chen Y,Nie H,Tian L,Tong L,Yang L,Lao N,Dong H,Sang H,Xiong L

更新日期：2013-02-01 00:00:00

abstract：:The present work describes the kinetics of enkephalin hydrolysis by plasma enzymes and the fragmentation pattern of both the parent peptide and of the first hydrolysis by-products. The degradation kinetics were followed by positive identification of the hydrolysis fragments by chromatographic methods, by amino acid an...

journal_title：Neurochemical research

authors： Roscetti G,Possenti R,Bassano E,Roda LG

更新日期：1985-10-01 00:00:00

abstract：:It has been established that oligodendrocytes, the myelin forming cells, participate in iron homeostasis through the synthesis and secretion of transferrin. Here we investigated whether a correlation exists between myelination, the commonly studied function of oligodendrocytes, and that of transferrin synthesis and se...

journal_title：Neurochemical research

authors： Espinosa de los Monteros A,Kumar S,Zhao P,Huang CJ,Nazarian R,Pan T,Scully S,Chang R,de Vellis J

更新日期：1999-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia in the aged population. Early-onset familial AD (FAD) involves mutations in a gene on chromosome 21 encoding the amyloid protein precursor or on chromosomes 14 or 1 encoding genes known as presenilins. All mutations examined have been found to increase the p...

journal_title：Neurochemical research

authors： Small DH

更新日期：1998-05-01 00:00:00

abstract：:The present study reports inhibition of taurine uptake in the rat retina in vitro to 49% of control by 1 mM guanidinoethyl sulfonate. No efflux of preloaded [14C]taurine was observed by incubation in the presence of guanidinoethyl sulfonate. The in vivo depletion of retinal taurine by guanidinoethyl sulfonate treatmen...

journal_title：Neurochemical research

authors： Lake N,Cocker SE

更新日期：1983-12-01 00:00:00

abstract：:The labeling of RNA in young and adult rat brain has been studied by measuring in vitro (tissue slices incubation) the incorporation of labeled uridine into RNA of total tissue and of the various subcellular fractions purified from cerebral hemispheres of 1- and 10-month-old rats. Gel electrophoretic analysis of the n...

journal_title：Neurochemical research

authors： Serra I,Cupello A,Gadaleta MN,Viola M,Ragonese P,Giuffrida AM

更新日期：1983-04-01 00:00:00

abstract：:C-6 glial cells were studied in culture with respect to morphological and biochemical changes under several experimental conditions. Doubling time was 33 hr for cells plated at either 0.5 or 1.0×10(6) cells per flask. Markedly reduced cell growth and astrocyte-like appearance were observed following dibutyryl cyclic A...

journal_title：Neurochemical research

authors： Vernadakis A,Nidess R

更新日期：1976-08-01 00:00:00

abstract：:This study attempted to investigate the possible involvement of the brain stem noradrenergic system in the development of hypertension in spontaneously hypertensive rats. Steady-state norepinephrine, dopamine, serotonin and 5-hydroxyindoleacetic acid concentrations and norepinephrine turnover were determined in the in...

journal_title：Neurochemical research

authors： Yao H,Matsumoto T,Hirano M,Kuroki T,Tsutsumi T,Uchimura H,Nakamura K,Nakahara T,Fujishima M

更新日期：1989-01-01 00:00:00

abstract：:The purpose of this study was to investigate whether the kappa-opioid receptor (KOR) agonist, BRL52537, has a neuroprotective effect against cerebral ischemia/reperfusion (I/R) injury in rats and further explore the underlying mechanisms. Adult male Sprague-Dawley rats were randomly assigned into sham (group A), I/R (...

journal_title：Neurochemical research

authors： Fang S,Xu H,Lu J,Zhu Y,Jiang H

更新日期：2013-11-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset, irreversible neurodegenerative disease that leads to progressive paralysis and inevitable death 3-5 years after diagnosis. The mechanisms underlying this process remain unknown, but new evidence indicates that accumulating levels of D-serine result from the downre...

journal_title：Neurochemical research

authors： Wang W,Duan W,Wang Y,Wen D,Liu Y,Li Z,Hu H,Cui H,Cui C,Lin H,Li C

更新日期：2017-04-01 00:00:00