Abstract:
:Antipsychotics represent high affinity for sigma receptors and sigma-like drugs often have the psychotomimetic properties. Besides, the receptors are unevenly distributed in human brain. These findings suggest that sigma receptors might be involved in the pathophysiology of schizophrenia. Sigma receptors in rat and human brain were measured with [3H]-1, 3, di-o-tolylguanidine (DTG) and non-specific binding of [3H]DTG was determined in the presence of 10(-5)M haloperidol. Monovalent and divalent cations strongly inhibited [3H]DTG binding. Glutamate, aspartate and glycine also decreased the binding to human cerebral membranes. With post-mortem brain samples from 12 schizophrenics and 10 controls, sigma receptors were measured in 17 areas of cerebral cortex. Sigma receptors binding showed the regional differences in the cortex, but no significant differences between schizophrenics and controls were observed except the superior parietal cortex where the binding significantly increased in the schizophrenic group. These results suggest that sigma receptors in cerebral cortices might not be directly concerned with the pathophysiological role in schizophrenia.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Shibuya H,Mori H,Toru Mdoi
10.1007/BF00966825keywords:
subject
Has Abstractpub_date
1992-10-01 00:00:00pages
983-90issue
10eissn
0364-3190issn
1573-6903journal_volume
17pub_type
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更新日期:2014-08-01 00:00:00
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更新日期:2014-10-01 00:00:00
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更新日期:1995-04-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-07-01 00:00:00
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更新日期:1996-01-01 00:00:00
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更新日期:1996-11-01 00:00:00
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