Abstract:
:The effects of acute lorazepam challenges on plasma (p) HVA, MHPG, and 5-HIAA, and their relationship to drug-induced cognitive and motor deficits and the apolipoprotein (APOE)-epsilon4 allele were examined. Eighteen healthy elderly (8 epsilon4 carriers) received placebo or acute oral lorazepam doses (0.5 mg or 1 mg) in random sequence, 1-week apart. Cognitive assessment and plasma levels of pHVA, pMHPG, and p5-HIAA were determined at baseline and at 1, 2.5, and 5 h postchallenge. There was no drug-to-placebo difference in monoamine levels and no consistent relationship between changes in monoamine levels and cognitive performance, regardless of epsilon4 status. However, the 1.0 mg dose increased p5-HIAA in epsilon4 carriers, whereas it caused a reduction in noncarriers. Higher baseline pMHPG and p5-HIAA levels were associated with better baseline memory. The epsilon4 allele may modulate the effect of lorazepam on p5-HIAA, but further studies are needed to confirm this finding and elucidate its possible significance.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Pomara N,Willoughby LM,Hashim A,Sershen H,Sidtis JJ,Wesnes K,Greenblatt DJ,Lajtha Adoi
10.1023/b:nere.0000026402.09466.54keywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
1391-8issue
7eissn
0364-3190issn
1573-6903journal_volume
29pub_type
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