A direct chemical interaction between dynorphin and excitatory amino acids.

abstract：:The effects of the following drugs: nimodipine (1 mg/kg b.w., i.p.), 2-amino-5-phosphonovaleric acid (4 mg/kg b.w., i.p.) and propentofylline (25 mg/kg b.w., i.p.), administered (alone or in combination) at the end of 15 min bilateral ischemia in gerbils were evaluated on mitochondrial superoxide dismutase (SOD), glut...

journal_title：Neurochemical research

authors： Stanimirovic DB,Micic DV,Markovic M,Spatz M,Mrsulja BB

更新日期：1994-02-01 00:00:00

abstract：:Studies on primary astrocytes cultured in vitro have shown that process formation involves changes in cytoskeletal proteins and release of tension on the substratum. Actin filament reorganization has previously been found to be the major cytoskeletal change occurring during process formation. These changes are relativ...

journal_title：Neurochemical research

authors： Padmanabhan J,Shelanski ML

更新日期：1998-03-01 00:00:00

abstract：:The tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) is not only a protein, but also a lipid phosphatase that can negatively regulate the serine/threonine kinase Akt. It has been reported that PTEN can be regulated by means of phosphorylation. However, whether PTEN can be regulated by an...

journal_title：Neurochemical research

authors： Pei DS,Sun YF,Song YJ

更新日期：2009-08-01 00:00:00

abstract：:Activation of glial cells has been observed in neurodegenerative diseases including Alzheimer's disease (AD). Aggregation of amyloid β (Aβ) is profusely observed as characteristic pathology in AD brain. In our previous study using microglial cell line BV-2, tissue-type transglutaminase (TG2) was found to be involved i...

journal_title：Neurochemical research

authors： Kawabe K,Takano K,Moriyama M,Nakamura Y

更新日期：2018-01-01 00:00:00

abstract：:Three peptides overlapping the tryptophan region of bovine CNS myelin basic protein were synthesized by the solid phase procedure of Merrifield. These were the nonapeptide H-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Lys-OH, the octapeptide H-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Lys-OH, and the heptapeptide H-Trp-Gly-Ala-Glu-Gly-Gln-Lys-...

journal_title：Neurochemical research

authors： Levit S,Powers JM,Milek D,Brostoff SW

更新日期：1980-01-01 00:00:00

abstract：:Incomplete ischemia of the spinal cord was produced in dogs by 40 min occlusion of the abdominal aorta that was followed by 5-40 min of recirculation. Amino acid incorporation into ribosomes in vitro in the presence of venous blood sera was estimated. The most significant reduction in incorporation was produced by ser...

journal_title：Neurochemical research

authors： Chavko M,Burda J,Marsala J

更新日期：1986-06-01 00:00:00

abstract：:The effects of vinpocetine on internal Na+ (Na(i)), cAMP accumulation, internal Ca2+ (Ca(i)) and excitatory amino acid neurotransmitters release, under resting and under depolarized conditions, was investigated in rat striatum synaptosomes. Veratridine (20 microM) or high K+ (30 mM) were used as depolarizing agents. R...

journal_title：Neurochemical research

authors： Sitges M,Nekrassov V

更新日期：1999-12-01 00:00:00

abstract：:Neuroprotective effects of metformin have been increasingly recognized in both diabetic and non-diabetic conditions. Thus far, no information has been available on the potential beneficial effects of metformin on peripheral nerve regeneration in diabetes mellitus. The present study was designed to investigate such a p...

journal_title：Neurochemical research

authors： Ma J,Liu J,Yu H,Chen Y,Wang Q,Xiang L

更新日期：2016-05-01 00:00:00

abstract：:Ferulago angulata (Apiaceae) is a shrub indigenous to western Iran, Turkey and Iraq. In traditional medicine, F. angulata is recommended for treating digestive pains, hemorrhoids, snake bite, ulcers and as sedative. In the present study, the effects of inhaled F. angulata essential oil (1 and 3%, daily, for 21 days) o...

journal_title：Neurochemical research

authors： Hritcu L,Bagci E,Aydin E,Mihasan M

更新日期：2015-09-01 00:00:00

abstract：:Memory impairment is the most common symptom in patients with Alzheimer's disease. The purpose of this study is to evaluate the memory enhancing effects of P7C3, a recently identified compound with robust proneurogenic and neuroprotective effects, on the cognitive impairment induced by scopolamine, a muscarinic acetyl...

journal_title：Neurochemical research

authors： Jiang B,Song L,Huang C,Zhang W

更新日期：2016-05-01 00:00:00

abstract：:There is growing evidence that ketone bodies (KB)-derived from fatty acid oxidation and produced during fasting or consumption of high-fat diets-can exert broad neuroprotective effects. With respect to epilepsy, KB (such as β-hydroxybutyrate or BHB, acetoacetate and acetone) have been shown to block acutely induced an...

journal_title：Neurochemical research

authors： Simeone TA,Simeone KA,Rho JM

更新日期：2017-07-01 00:00:00

abstract：:We examined the effects of small unilamellar vesicles composed of dipalmitoylphosphatidylcholine on rat cerebral cortical [3H]acetylcholine release. Synaptosomes from this region were loaded with the labeled transmitter, and then incubated with the lipid (0-6 mg/ml) for specified intervals before adding various secret...

journal_title：Neurochemical research

authors： Bottiglieri DF,Meyer EM

更新日期：1987-08-01 00:00:00

abstract：:Myelinating cells of both the peripheral and central nervous systems (CNSs) undergo dramatic cytoskeletal reorganization in order to differentiate and produce myelin. Myelinating oligodendrocytes in the CNS show a periodic actin pattern, demonstrating tight regulation of actin. Furthermore, recent data demonstrate tha...

journal_title：Neurochemical research

authors： Brown TL,Macklin WB

更新日期：2020-03-01 00:00:00

abstract：:We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathi...

journal_title：Neurochemical research

authors： Tasset I,Drucker-Colín R,Peña J,Jimena I,Montilla P,Medina FJ,Túnez I

更新日期：2010-08-01 00:00:00

abstract：:Oxidative stress is a long-hypothesized cause of diverse neurological and psychiatric disorders but the pathways by which physiological redox perturbations may detour healthy brain development and aging are unknown. We reported recently (Foley et al., Neurochem Res 39:2030-2039, 2014) that two-electron oxidations, to ...

journal_title：Neurochemical research

authors： Foley TD,Katchur KM,Gillespie PF

更新日期：2016-10-01 00:00:00

abstract：:Despite immense advances in the treatment strategies, the effective treatment of patients suffering from neuropathic pain remains challenging. Saikosaponin a possesses anti-inflammatory activity. However, the role of saikosaponin a in neuropathic pain is still unclear. Therefore, the objective of this study was to inv...

journal_title：Neurochemical research

authors： Zhou X,Cheng H,Xu D,Yin Q,Cheng L,Wang L,Song S,Zhang M

更新日期：2014-11-01 00:00:00

abstract：:Glutamine synthetase (GS) is the key enzyme in cerebral glutamine production. Understanding the regulation of the expression of GS is important for definition of the control of glutamine metabolism in brain. Therefore, we studied the control of GS expression by 8-bromo cyclic AMP in primary cultures of astrocytes prep...

journal_title：Neurochemical research

authors： Max SR,Landry ME,Zielke HR

更新日期：1990-06-01 00:00:00

abstract：:The experiments reported in this paper address the hypothesis that [3H]leucine enkephalin labels both mu and delta receptors. As reported by other workers, this peptide dissociates from rat brain membranes in a biphasic manner. This is consistent with a two site binding model which hypothesizes that the peptide labels...

journal_title：Neurochemical research

authors： Rothman RB,Westfall TC

更新日期：1983-02-01 00:00:00

abstract：:Some crustacean axons remain functional for months after injury. This unusual property may require stress proteins synthesized by those neurons or provided to them by glial cells. To begin to explore this hypothesis, we examined the conditions that stimulated stress protein synthesis by crayfish CNS tissue in vitro. I...

journal_title：Neurochemical research

authors： Rochelle JM,Grossfeld RM,Bunting DL,Tytell M,Dwyer BE,Xue ZY

更新日期：1991-05-01 00:00:00

abstract：:The cerebellar cortical circuit of mammals develops via a series of magnificent cellular events in the postnatal stage of development to accomplish the formation of functional circuit architectures. The contribution of genetic factors is thought to be crucial to cerebellar development. Therefore, it is essential to an...

journal_title：Neurochemical research

authors： Furuichi T,Shiraishi-Yamaguchi Y,Sato A,Sadakata T,Huang J,Shinoda Y,Hayashi K,Mishima Y,Tomomura M,Nishibe H,Yoshikawa F

更新日期：2011-07-01 00:00:00

abstract：:Radioactive azide derivatives of tetrodotoxin (TTX) were synthesized using 2-nitro-4-azidephenyl-[3H]beta alanine for the purpose of photolabeling of the Na channel. Three azide derivatives, N1, N2 and N3, were separated by ion exchange chromatography on Bio-Rex 70 resin and reversed phase high performance liquid chro...

journal_title：Neurochemical research

authors： Uehara S,Uyemura K

更新日期：1985-08-01 00:00:00

abstract：:Docosahexaenoic acid (DHA) is verified to have neuroprotective effects on traumatic brain injury (TBI) rats by activating Nrf2 signaling pathway, but the role of NOX2 in this effect has not been illuminated. So this study explored the role of NOX2 in TBI models treated with DHA, aiming to complete the mechanism of DHA...

journal_title：Neurochemical research

authors： Zhu W,Cui G,Li T,Chen H,Zhu J,Ding Y,Zhao L

更新日期：2020-08-01 00:00:00

abstract：:The pineal gland is a neuroendocrine gland responsible for nocturnal synthesis of melatonin. During early development of the rodent pineal gland from the roof of the diencephalon, homeobox genes of the orthodenticle homeobox (Otx)- and paired box (Pax)-families are expressed and are essential for normal pineal develop...

journal_title：Neurochemical research

authors： Rath MF,Rohde K,Klein DC,Møller M

更新日期：2013-06-01 00:00:00

abstract：:Exposure of guinea pig brain slices to low concentrations (10 microM) of NMDA caused decreases in PCr and ATP within 30 min, with a slower decrease in NAA and increase in lactate, both detectable after 1 h. Exposure to NMDA for over 1 h or at higher concentrations caused further increases in lactate and decreases in N...

journal_title：Neurochemical research

authors： Thatcher NM,Badar-Goffer RS,Ben-Yoseph O,McLean MA,Morris PG,Prior MJ,Taylor A,Bachelard HS

更新日期：2002-02-01 00:00:00

abstract：:The volume-regulated anion channel, VRAC, plays an important role in cell volume regulation. This channel is permeable for a wide variety of anions, amino acids, and organic osmolytes, including taurine. However, nothing is known about possible water permeability of this channel. Water permeability of endothelial cell...

journal_title：Neurochemical research

authors： Nilius B

更新日期：2004-01-01 00:00:00

abstract：:A very large body of evidence from in vivo studies has been accumulated on a link between the change of energy and cell survival/apoptosis. Using an in vitro ischemia model, we have previously shown that ischemia could induce apoptosis in astrocytes. In this study, we utilized the same in vitro model to investigate ch...

journal_title：Neurochemical research

authors： Yu AC,Lau AM,Fu AW,Lau LT,Lam PY,Chen XQ,Xu ZY

更新日期：2002-12-01 00:00:00

abstract：:Brief limb ischemia was reported to protect neurons against injury induced by subsequent cerebral ischemia-reperfusion, and this phenomenon is known as limb ischemic preconditioning (LIP). To explore the role of nitric oxide (NO) in neuroprotection of LIP in rats, we observed changes in the content of nitric oxide (NO...

journal_title：Neurochemical research

authors： Zhao HG,Sun XC,Xian XH,Li WB,Zhang M,Li QJ

更新日期：2007-11-01 00:00:00

abstract：:The dorsal raphe nucleus (DRN) has been suggested playing an important role in the pathophysiology of post-traumatic stress disorder (PTSD), however the underlying cellular mechanisms are not fully understood. The endoplasmic reticulum (ER) is a critical organelle for synthesis of membrane and secretory proteins, and ...

journal_title：Neurochemical research

authors： Xie J,Han F,Shi Y

更新日期：2014-04-01 00:00:00

abstract：:The diversification of neuronal subtypes during corticogenesis is fundamental to the establishment of the complex cortical structure. Although subtype specification has been assumed to occur in neural progenitor cells, increasing evidence has begun to reveal the plasticity of subtype determination in immature neurons....

journal_title：Neurochemical research

authors： Oishi K,Nakajima K

更新日期：2018-01-01 00:00:00

abstract：:In the unrestrained rat, the hyperphagic-like ingestion of food evoked by the sustained elevation of neuropeptide-Y (NPY) in the hypothalamus was correlated with the release and turnover of monoaminergic transmitters in this structure. A single guide tube was implanted stereotaxically in the perifornical region of the...

journal_title：Neurochemical research

authors： Myers RD,Lankford MF,Paez X

更新日期：1992-11-01 00:00:00