Beneficial Effect of Metformin on Nerve Regeneration and Functional Recovery After Sciatic Nerve Crush Injury in Diabetic Rats.

abstract：:Neonatal hypoxia/ischemia (HI) is the most common cause of developmental neurological, cognitive and behavioral deficits in children, with hyperoxia (HHI) treatment being a clinical therapy for newborn resuscitation. Although cerebral edema is a common outcome after HI, the mechanisms leading to excessive fluid accumu...

journal_title：Neurochemical research

authors： Ferrari DC,Nesic O,Perez-Polo JR

更新日期：2010-12-01 00:00:00

abstract：:Increasing evidence indicates that adhesion molecules are critically involved in the regulation of mechanisms of synaptic plasticity including synapse formation, but also synaptic remodeling associated to changes in synaptic strength. Among these, the Neural Cell Adhesion Molecule (NCAM) and its polysialylated form PS...

journal_title：Neurochemical research

authors： Muller D,Mendez P,De Roo M,Klauser P,Steen S,Poglia L

更新日期：2008-03-20 00:00:00

abstract：:Protein kinase C has recently attracted considerable attention because of its importance in the control of cell division, cell differentiation, and signal transduction across the cell membrane. The activity of this enzyme is altered by several lipids such as diacylglycerol, free fatty acids, lipoxins, gangliosides, an...

journal_title：Neurochemical research

authors： Farooqui AA,Farooqui T,Yates AJ,Horrocks LA

更新日期：1988-06-01 00:00:00

abstract：:The axonal transport of tRNA has been investigated in the chick optic system. Chicks were injected with [3H]uridine intraocularly or intracranially and the RNA of the retina, nerve complex, and tecta separated by polyacrylamide gel electrophoresis and then counted. The ratio of tRNA to rRNA specific activities increas...

journal_title：Neurochemical research

authors： Por S,Gunning PW,Jeffrey PL,Austin L

更新日期：1978-08-01 00:00:00

abstract：:The oxidation of pyruvate is mediated by the pyruvate dehydrogenase complex (PDHC; EC 1.2.4.1, EC 2.3.1.12 and EC 1.6.4.3) whose catalytic activity is influenced by phosphorylation and by product inhibition. 2-Oxoglutarate and 3-hydroxybutyrate are readily utilized by brain mitochondria and inhibit pyruvate oxidation....

journal_title：Neurochemical research

authors： Lai JC,Sheu KF

更新日期：1987-08-01 00:00:00

abstract：:Adaptive changes in serotonergic 5HT1 receptor signalling are believed to underlie the therapeutic effectiveness of antidepressant drugs. Since cells are continuously exposed to neurotransmitters/neuromodulators, spatially and temporally integrated, the responsiveness of a receptor system is dependent upon the physio-...

journal_title：Neurochemical research

authors： Trincavelli ML,Cuboni S,Montali M,Santaguida S,Lucacchini A,Martini C

更新日期：2008-07-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the presence of insoluble protein clusters containing α-synuclein. Impairment of mitochondria, endoplasmic reticulum, autophagy and intracellular trafficking proper function has been suggested to be caused by α-synuclein toxicity, which is also associated with the higher le...

journal_title：Neurochemical research

authors： Melo TQ,Copray SJCVM,Ferrari MFR

更新日期：2018-12-01 00:00:00

abstract：:Postmortem cerebral neocortical and hippocampal samples were taken from patients who died with dementia of the Alzheimer type (DAT) and individuals without diagnoses of neurological or psychiatric disease (control). Nicotinic binding was assayed with 20 nM [3H]acetylcholine [( 3H]ACh) in the presence of atropine, or w...

journal_title：Neurochemical research

authors： London ED,Ball MJ,Waller SB

更新日期：1989-08-01 00:00:00

abstract：:The number of c-Fos protein-like immunoreactive (c-Fos-IR) neurons in the spinal dorsal horn evoked by noxious stimulation was previously shown to be increased following peripheral nerve injury, and this increase was proposed to reflect the neuropathic pain state. The aim of this study was to investigate whether anoma...

journal_title：Neurochemical research

authors： Terayama R,Kishimoto N,Yamamoto Y,Maruhama K,Tsuchiya H,Mizutani M,Iida S,Sugimoto T

更新日期：2015-03-01 00:00:00

abstract：:Plasmalogens are ether-linked phospholipids that are abundant in nervous tissues. Their biological role is unclear, but may involve membrane structure/function and antioxidant activities. This study further investigates a recent report that chronic administration of myo-inositol in rats increased brain phosphatidyleth...

journal_title：Neurochemical research

authors： Hoffman-Kuczynski B,Reo NV

更新日期：2004-04-01 00:00:00

abstract：:We measured the activity of several acid hydrolases in oligodendrocyte and mixed glial (predominantly astrocytic) cell cultures prepared from neonatal rat cerebra. When compared with the mixed glial cultures, the cultured oligodendrocytes exhibited higher levels for all the hydrolases when activities were normalized t...

journal_title：Neurochemical research

authors： Bradel EJ,Sloan HR

更新日期：1988-10-01 00:00:00

abstract：:Mycobacterium leprae, the causative agent of leprosy, specifically invades and destroys the peripheral nerve, which results in the main clinical manifestation of the disease. Little is known about the bacteria-nerve protein interaction. We show in the present work that M leprae binds to a 25 kDa glycoprotein from huma...

journal_title：Neurochemical research

authors： Suneetha LM,Satish PR,Korula RJ,Suneetha SK,Job CK,Balasubramanian AS

更新日期：1998-06-01 00:00:00

abstract：:In human pathology little is known about the activating enzymes for fatty acids of different carbon chain length. In order to have a better insight into disorders of lipid metabolism in human skeletal muscle, we studied the distribution of acyl-CoA synthetases in muscular subcellular fractions. We find that in muscle ...

journal_title：Neurochemical research

authors： Trevisan C,DiMauro S

更新日期：1983-05-01 00:00:00

abstract：:Antiretroviral protease inhibitors are a class of important drugs that are used for the treatment of human immunodeficiency virus infections. Among those compounds, ritonavir is applied frequently in combination with other antiretroviral protease inhibitors, as it has been reported to boost their therapeutic efficienc...

journal_title：Neurochemical research

authors： Arend C,Brandmann M,Dringen R

更新日期：2013-04-01 00:00:00

abstract：:Single prolonged stress (SPS) is one of the preclinical models of posttraumatic stress disorder (PTSD) in humans. Not every traumatized person develops PTSD and the onset of the disease varies from months to many years after exposure to life-threatening events. The pathogenetic neurometabolites in PTSD have not been i...

journal_title：Neurochemical research

authors： Lim SI,Song KH,Yoo CH,Woo DC,Choe BY

更新日期：2017-08-01 00:00:00

abstract：:The δ subunit of the GABAAR is highly expressed in the dentate gyrus of the hippocampus where it mediates a tonic extrasynaptic inhibitory current that is sensitive to neurosteroids. In female mice, the expression level of the δ subunit within the dentate gyrus is elevated in the diestrous relative to estrous phase of...

journal_title：Neurochemical research

authors： Cushman JD,Moore MD,Olsen RW,Fanselow MS

更新日期：2014-06-01 00:00:00

abstract：:A number of recent findings support the notion of mechanistic parallels between Alzheimer disease (AD) and oncogenic processes, specifically, that neurons in AD, like cancer cells, display aberrant mitotic cell cycle re-entry. However, the mechanism that drives postmitotic neurons to reenter cell cycle remains elusive...

journal_title：Neurochemical research

authors： Previll LA,Crosby ME,Castellani RJ,Bowser R,Perry G,Smith MA,Zhu X

更新日期：2007-04-01 00:00:00

abstract：:Neuronal MHC class I proteins have been previously reported to regulate synaptic plasticity. Several reports indicate MHC class I proteins are expressed early during development of the nervous system, suggesting they may also play a role in neuronal development. Using cultured cortical neurons, we show MHC class I pro...

journal_title：Neurochemical research

authors： Shen Y,Zhao H,Li P,Peng Y,Cui P,Miao F,Zhang Y,Zhang A,Zhang J

更新日期：2019-02-01 00:00:00

abstract：:We have utilized quantitative autoradiography with the GABA(A) receptor chloride channel blocker [35S]t-butylbicyclophosphorothionate ([35S]TBPS) in rodent brain sections to investigate if differential proton modulation of various GABA(A) receptor subtypes expressed in various brain regions are differentially sensitiv...

journal_title：Neurochemical research

authors： Uusi-Oukari M,Kosonen P,Homanics GE,Korpi ER

更新日期：2004-04-01 00:00:00

abstract：:Cognitive impairment in diabetes (CID) is a severe chronic complication of diabetes mellitus (DM). It has been hypothesized that diabetes can lead to cognitive dysfunction due to expression changes of excitatory neurotransmission mediated by N-methyl-D-aspartate receptors (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxa...

journal_title：Neurochemical research

authors： Wang XP,Ye P,Lv J,Zhou L,Qian ZY,Huang YJ,Mu ZH,Wang X,Liu XJ,Wan Q,Yang ZH,Wang F,Zou YY

更新日期：2019-04-01 00:00:00

abstract：:Enolase is a glycolytic enzyme whose amino acid sequence is highly conserved across a wide range of animal species. In mammals, enolase is known to be a dimeric protein composed of distinct but closely related subunits: alpha (non-neuronal), beta (muscle-specific), and gamma (neuron-specific). However, little informat...

journal_title：Neurochemical research

authors： Chun JT,Gioio AE,Crispino M,Giuditta A,Kaplan BB

更新日期：1995-08-01 00:00:00

abstract：:The expression and localization of syntaxin isoforms 1A and 1B in adrenergic and noradrenergic chromaffin cells were examined by both immunoblot analysis and confocal immunofluorescence microscopy. Syntaxin 1A was found in higher levels in noradrenergic cells, whereas syntaxin 1B was similarly expressed in most noradr...

journal_title：Neurochemical research

authors： Baltazar G,Carvalho AP,Duarte EP

更新日期：2003-10-01 00:00:00

abstract：:Nicotine is the principal psychoactive ingredient in cigarette smoke, and has been associated with health problems in humans. However, the pure form of nicotine may prove to be a valuable pharmaceutical agent for the treatment of AD. However, the beneficial effects of nicotine remain a matter of much controversy. In o...

journal_title：Neurochemical research

authors： Shim SB,Lee SH,Chae KR,Kim CK,Hwang DY,Kim BG,Jee SW,Lee SH,Sin JS,Bae CJ,Lee BC,Lee HH,Kim YK

更新日期：2008-09-01 00:00:00

abstract：:Abnormally high levels of iron are observed in the brain of patients suffering from neurodegenerative disorders. The mechanisms involved in iron accumulation in neurodegenerative disorders remain poorly understood. In the present study we investigated the effects of aging and neonatal iron overload on the mRNA express...

journal_title：Neurochemical research

authors： Dornelles AS,Garcia VA,de Lima MN,Vedana G,Alcalde LA,Bogo MR,Schröder N

更新日期：2010-04-01 00:00:00

abstract：:Gelsolin is an actin regulatory protein that generally distributed in a wide variety of body tissues, especially the brain tissues and cerebrospinal fluid. In this study we found that lumbar CSF-gelsolin concentrations markedly decreased in epileptic patients by enzyme linked immunosorbent assay. In order to help judg...

journal_title：Neurochemical research

authors： Peng X,Zhang X,Wang L,Zhu Q,Luo J,Wang W,Wang X

更新日期：2011-12-01 00:00:00

abstract：:Systemic inflammation triggered by lipopolysaccharide (LPS) administration disrupts blood-brain barrier (BBB) homeostasis in animal models. This event leads to increased susceptibility of several encephalic structures to potential neurotoxicants present in the bloodstream. In this study, we investigated the effects of...

journal_title：Neurochemical research

authors： Gonçalves C,Dos Santos DB,Portilho SS,Lopes MW,Ghizoni H,de Souza V,Mack JM,Naime AA,Dafre AL,de Souza Brocardo P,Prediger RD,Farina M

更新日期：2018-03-01 00:00:00

abstract：:Clinical studies have demonstrated that decreased adiponectin is associated with the development of Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). We focused on determining the neuroprotective effect offered by adiponectin against streptozotocin-induced brain damage in ICV-STZ rat model. We found that a...

journal_title：Neurochemical research

authors： Xu ZP,Gan GS,Liu YM,Xiao JS,Liu HX,Mei B,Zhang JJ

更新日期：2018-02-01 00:00:00

abstract：:Regional and developmental changes in metabolite concentrations were measured by 1H NMR spectroscopy and HPLC of perchloric acid extracts from rat brain and eye. The highest concentrations of N-acetylaspartate were found in grey matter as opposed to white matter with concentration increasing with age from neonate to a...

journal_title：Neurochemical research

authors： Florian CL,Williams SR,Bhakoo KK,Noble MD

更新日期：1996-09-01 00:00:00

abstract：:Triptolide (T10), an extract from the traditional Chinese herb, Tripterygium wilfordii Hook F (TWHF), has been shown to attenuate the rotational behavior induced by D: -amphetamine and prevent the loss of dopaminergic neurons in the substantia nigra in rat models of Parkinson's disease. To examine if the neuroprotecti...

journal_title：Neurochemical research

authors： Xue B,Jiao J,Zhang L,Li KR,Gong YT,Xie JX,Wang XM

更新日期：2007-07-01 00:00:00

abstract：:Parkinson's disease (PD) is a severe neurodegenerative disease characterized by selective loss of dopaminergic neurons, which reduces quality of life of patients and poses a heavy burden to the society. The pathological mechanism of PD remains unclear, and increasing efforts are aimed to solve this problem. MiRNAs are...

journal_title：Neurochemical research

authors： Dong Y,Xiong J,Ji L,Xue X

更新日期：2020-11-12 00:00:00