Abstract：
:Protein kinase C has recently attracted considerable attention because of its importance in the control of cell division, cell differentiation, and signal transduction across the cell membrane. The activity of this enzyme is altered by several lipids such as diacylglycerol, free fatty acids, lipoxins, gangliosides, and sulfatides. These lipids may interact with protein kinase C either directly or through calcium ions and produce their regulatory effect (activation or inhibition) on the activities of the enzymes phosphorylated by this kinase. These processes widen our perspective of the regulation of intercellular and intracellular communication.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Farooqui AA,Farooqui T,Yates AJ,Horrocks LAdoi
10.1007/BF00973288subject
Has Abstractpub_date
1988-06-01 00:00:00pages
499-511issue
6eissn
0364-3190issn
1573-6903journal_volume
13pub_type
杂志文章,评审abstract：:The primary objective of this investigation was to assess the neuroprotective efficacy of spice active principles namely Eugenol (Eug) and isoeugenol (IE) in an acrylamide (ACR) neuropathy model in rats. In the present study, ACR administration (50 mg/kg bw, i.p. 3 times/week) for 5 weeks to growing rats caused typica...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0924-9
更新日期：2013-02-01 00:00:00
abstract：:Levels of free amino acids were determined quantitatively in whole ocular tissues of the rat eye with aid of a sensitive amino acid analyzer. The tissues studied were the retina, vitreous, lens, iris-ciliary body, and cornea. The retina and lens contained a more concentrated free amino acid pool than other tissues. Th...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965323
更新日期：1986-04-01 00:00:00
abstract：:The hippocampus-derived neuroestradiol plays a major role in neuroplasticity, independent of circulating estradiol that originates from gonads. The response of hypothalamus-pituitary regions towards the synthesis of neuroestradiol in the hippocampus is an emerging scientific concept in cognitive neuroscience. Hippocam...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-019-02833-1
更新日期：2019-08-01 00:00:00
abstract：:A simple, rapid method for determining depolarization-induced 45Ca influx into synaptosomes is described. Synaptosomes which had been depolarized in the presence of 45Ca were applied to a small column of Chelex-100 resin to separate free Ca2+ from that taken up by the tissue. Approximately 70% of the synaptosomal prot...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965062
更新日期：1982-02-01 00:00:00
abstract：:Serotonin (5HT) synthesis in brain is influenced by precursor (tryptophan (TRP)) concentrations, which are modified by food ingestion. Hence, in rats, a carbohydrate meal raises brain TRP and 5HT; a protein-containing meal does not, but little attention has focused on differences among dietary proteins. Recently, sing...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0382-1
更新日期：2011-03-01 00:00:00
abstract：:Oxidative stress-induced neuronal cell death requires opening of the mitochondrial permeability transition pore. P53 mitochondrial translocation and association with Cyclophilin D (Cyp-D) is required for the pore opening. Here we tested this signaling axis in oxygen glucose deprivation (OGD)/re-oxygenation-induced in ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-0968-5
更新日期：2013-04-01 00:00:00
abstract：:Antibodies to synthetic myelin basic protein peptide S82 (TTHYG-SLPQKAQGHRPQDEG) did not react with synthetic peptide S8 (GSLPQKAQGHRPQDENG) and only partially so with synthetic peptide S79 (AQGHRPQDEG); however, the antibodies did react to a considerable extent with an equimolar mixture of S8 and S79. Since the anti-...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964671
更新日期：1984-10-01 00:00:00
abstract：:Repeated electroconvulsive shock is an effective treatment for affective disorders. Striatum, hippocampus and brainstem are involved in affective disorders. Sodium-potassium/ATPase is of paramount importance for the proper functioning of the brain and its involvement in the affective disorders has been claimed for a l...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9046-6
更新日期：2006-04-01 00:00:00
abstract：:Age related changes in brain cortex NO metabolism were investigated in mitochondria and cytosolic extracts from youth to adulthood. Decreases of 19%, 40% and 71% in NO production were observed in mitochondrial fractions from 3, 7, and 14 months old rats, respectively, as compared with 1-month-old rats. Decreased nNOS ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9570-z
更新日期：2008-07-01 00:00:00
abstract：:Chronic administration to rats of mood-stabilizers that are effective against mania in bipolar disorder, is reported to downregulate markers of the brain arachidonic acid cascade. We hypothesized that chronic administration of lamotrigine, which is used to treat depression and rapid cycling in bipolar disorder, might ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9526-3
更新日期：2008-05-01 00:00:00
abstract：:In this paper we propose a powerful procedure to measure functional activation of the mouse delta-opioid receptor transiently expressed in mammalian cells. Receptor stimulation was assessed using a population of electroporated COS cells, transfected at a 50% efficiency. Under those conditions, agonist-promoted activat...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02532371
更新日期：1996-11-01 00:00:00
abstract：:We observed that AP-3, an antagonist of metabotropic glutamate receptors, reduced carbachol-induced hydrolysis of phospholipids in hippocampal slices. This inhibition could be explained in different ways, e.g.: 1) AP-3 acts also as antagonist of muscarinic receptors mediating the hydrolysis of phospholipids induced by...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022423415238
更新日期：1998-06-01 00:00:00
abstract：:The frontal cortex, hippocampus, and cerebellum of the Fischer 344 rat were examined for an age-dependent change in neuronal and non-neuronal binding. Clonazepam and Ro5-6669 displaceable [3H]diazepam binding were used as indicators of [3H]diazepam binding on neuronal and non-neuronal membranes, respectively. In both ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964927
更新日期：1983-09-01 00:00:00
abstract：:The release of endogenous amino acids from depolarized rat hippocampal mossy fiber synaptosomes was investigated to assess the possible role(s) of glutamate and aspartate in mediating the excitatory mossy fiber synaptic input. The relative proportions of prodynorphin-derived peptides concomitantly released with amino ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969176
更新日期：1990-01-01 00:00:00
abstract：:It is well known that antioxidants containing sulfhydryl (-SH) groups are protective against the toxic effects of mercury. The current study was designed to elucidate the mechanism(s) of the cytoprotective effects of glutathione (GSH) and N-acetylcysteine (NAC) against the toxicity of inorganic mercury (HgCl(2)) in ne...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-9962-3
更新日期：2009-09-01 00:00:00
abstract：:The objective of the present study was to investigate the effects of preincubation of hippocampus homogenates in the presence of homocysteine or methionine on Na+, K+-ATPase and Mg2+-ATPase activities in synaptic membranes of rats. Homocysteine significantly inhibited Na+, K+-ATPase activity, whereas methionine had no...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1013907104585
更新日期：2001-11-01 00:00:00
abstract：:We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0172-9
更新日期：2010-08-01 00:00:00
abstract：:Disruptive effects of calcium upon neurofilaments and glial filaments were studied in white matter of rat optic nerve and spinal cord and in rat peripheral nerve. Filament ultrastructure and tissue protein composition were compared following a calcium influx into excised tissues. A calcium influx was induced by freeze...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964040
更新日期：1981-03-01 00:00:00
abstract：:Aneurysmal subarachnoid hemorrhage still has a high mortality and morbidity despite notable advances in surgical approaches to cerebral aneurysm (CA). We examined the role of aspirin in vascular inflammation and degeneration. CA was induced in male Sprague-Dawley rats by ligating left common carotid artery and bilater...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1603-4
更新日期：2015-07-01 00:00:00
abstract：:The diversification of neuronal subtypes during corticogenesis is fundamental to the establishment of the complex cortical structure. Although subtype specification has been assumed to occur in neural progenitor cells, increasing evidence has begun to reveal the plasticity of subtype determination in immature neurons....
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-017-2441-3
更新日期：2018-01-01 00:00:00
abstract：:Recent evidence has linked striatal amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor function to the adverse effects of long-term dopaminergic treatment in Parkinson's disease. The phosphorylation of AMPA subunit, GluR1, reflects AMPA receptor activity. To determine whether serine phosphorylation of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9177-9
更新日期：2006-11-01 00:00:00
abstract：:The effects of carbachol (CCh) on the frequency (f) of the miniature endplate potentials were tested at temperatures between 5 and 30 degrees C. Higher CCh concentrations, 1 x 10(-5) and 5 x 10(-6) M, reduced the f to 60% and the temperature dependence was negligible. However, an inverse temperature dependence was fou...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1012372115058
更新日期：2001-09-01 00:00:00
abstract：:Neuroprotectin D1 (NPD1), a docosahexaenoic acid (DHA)-derived lipid mediator, promotes survival in cells exposed to oxidative stress by inducing the activity of anti-inflammatory mediators and suppressing the expression of pro-inflammatory genes. Though retinal pigment epithelial (RPE) cells naturally produce NPD1 fr...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0351-8
更新日期：2010-12-01 00:00:00
abstract：:Hypothalamic and plasma dopamine-beta-hydroxylase [DBH, EC 1.14.2.1] activites were measured by a coupled radioenzymatic method. Animals representing five experimental groups [intact controls, adrenalectomized, pinealectomized, adrenalectomized pinealectomized, doubly sham-operated] were killed and sampled at 8 times ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965575
更新日期：1978-06-01 00:00:00
abstract：:(E)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeine (HOEC), a naturally caffeic ester isolated from Incarvillea mairei, has been reported to possess anti-inflammatory activity by targeting 5-lipoxygenase. However, its other potential activities have yet to be explored. In this study, we measured antioxidant activity of ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1498-5
更新日期：2015-03-01 00:00:00
abstract：:This study aimed at comparing the binding characteristics of [3H]ketanserin, a high-affinity serotonin 2A (5-HT2A) receptor antagonist, in the prefrontal cortex, hippocampus and striatum of human brain post-mortem. The results indicated the presence of a single population of binding sites in all the regions investigat...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1027366413289
更新日期：1997-06-01 00:00:00
abstract：:Glutamate, the primary excitatory neurotransmitter in the central nervous system (CNS), exerts neuromodulatory actions via the activation of metabotropic glutamate (mGlu) receptors. There are eight known mGlu receptor subtypes (mGlu1-8), which are widely expressed throughout the brain, and are divided into three group...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-014-1415-y
更新日期：2014-10-01 00:00:00
abstract：:The adaptation of cells to hyperosmotic conditions involves accumulation of organic osmolytes to achieve osmotic equilibrium and maintenance of cell volume. The Na+ and Cl(-)-coupled betaine/GABA transporter, designated BGT-1, is responsible for the cellular accumulation of betaine and has been proposed to play a role...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-6879-3
更新日期：2005-06-01 00:00:00
abstract：:We have synthesized the tertiary amines of pyridostigmine and neostigmine, 3-pyridinol dimethylcarbamate (norpyridostigmine) and 3-dimethylaminophenol dimethylcarbamate (norneostigmine) respectively, and we have tested their abilities to cross the blood-brain barrier and inhibit mouse brain AChE activity. The in vivo ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973747
更新日期：1990-06-01 00:00:00
abstract：:The role of protein phosphorylation in catecholamine secretion from bovine adrenomedullary chromaffin cells was studied using different protein kinase inhibitors. Naphthalenesulfonamide derivatives as ML9 and ML7, more specific for the myosin light chain kinase, and the calmodulin antagonist W7 inhibited catecholamine...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969089
更新日期：1993-03-01 00:00:00
