Abstract：
:Serotonin (5HT) synthesis in brain is influenced by precursor (tryptophan (TRP)) concentrations, which are modified by food ingestion. Hence, in rats, a carbohydrate meal raises brain TRP and 5HT; a protein-containing meal does not, but little attention has focused on differences among dietary proteins. Recently, single meals containing different proteins have been shown to produce marked changes in TRP and 5HT. The present studies evaluate if such differences persist when rats ingest such diets chronically. Male rats were studied that ingested diets for 9 days containing zein, wheat gluten, soy protein, casein, or α-lactalbumin (17% dry weight). Brain TRP varied up to eightfold, and 5HT synthesis fivefold among the different protein groups. TYR and LEU concentrations, and catecholamine synthesis rate in brain varied much less. The effects of dietary protein on brain TRP and 5HT previously noted after single meals thus continue undiminished when such diets are consumed chronically.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Choi S,DiSilvio B,Fernstrom MH,Fernstrom JDdoi
10.1007/s11064-010-0382-1subject
Has Abstractpub_date
2011-03-01 00:00:00pages
559-65issue
3eissn
0364-3190issn
1573-6903journal_volume
36pub_type
杂志文章abstract：:Folic acid plays an important role in neuroplasticity and acts as a neuroprotective agent, as observed in experimental brain ischemia studies. The aim of this study was to investigate the effects of folic acid on locomotor activity, aversive memory and Na(+),K(+)-ATPase activity in the frontal cortex and striatum in a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0757-6
更新日期：2012-08-01 00:00:00
abstract：:Quantitative measurements were made of choline acetyltransferase (CAT) activity, acetylcholinesterase (AChE) activity and cholinergic muscarinic receptor binding ([3H]QNB) in eight areas of a cross-section of the rat medulla oblongata. A fourth cholinergic parameter, high-affinity choline uptake, was measured in three...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964389
更新日期：1981-05-01 00:00:00
abstract：:Correct timing and spatial location of growth factor expression is critical for undisturbed brain development and functioning. In terminally differentiated cells distinct biological responses to growth factors may depend on cell type specific activation of signalling cascades. We show that the hematopoietic growth fac...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9149-0
更新日期：2006-10-01 00:00:00
abstract：:To clarify the molecular basis of the cytoprotective properties of immunophilin ligands (IPLs), the anti-apoptotic effects of IPLs were determined in human glioma U251 cells. GPI1046 and V10367, non-immunosuppressive IPLs (NI-IPLs), as well as FK506, an immunosuppressive IPL (I-IPL), had cytoprotective effects against...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/b:nere.0000029565.92587.25
更新日期：2004-08-01 00:00:00
abstract：:Bovine brain synaptic membranes which were frozen and then extensively washed showed low affinity [3H]muscimol binding. These membranes contained GABA and calmodulin, apparently tightly bound within the membrane fraction. Membranes which were additionally treated with the detergent Triton X-100 showed high affinity [3...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00970756
更新日期：1988-09-01 00:00:00
abstract：:2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) was phosphorylated in vivo, in brain slices and in a cell free system. Phosphoamino acid analysis of immunoprecipitated CNP labeled in vivo and in brain slices revealed phosphorylation of phosphoserine (94%) and phosphothreonine (5%) residues. Phosphorylation of CNP in...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967712
更新日期：1994-06-01 00:00:00
abstract：:The present work describes the kinetics of enkephalin hydrolysis by plasma enzymes and the fragmentation pattern of both the parent peptide and of the first hydrolysis by-products. The degradation kinetics were followed by positive identification of the hydrolysis fragments by chromatographic methods, by amino acid an...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964980
更新日期：1985-10-01 00:00:00
abstract：:The present study examined the potential membrane retention of desipramine (DMI) following exposures of 293-hNET cells to DMI, and its effect on [3H]NE uptake. Incubation of cells with 500 nM DMI for 1 h or 1 day persistently inhibited the uptake of [3H]NE up to 7 days, despite daily repeated washing of cells with dru...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/b:nere.0000013747.04964.46
更新日期：2004-02-01 00:00:00
abstract：:Diurnal changes in Chordc1 mRNA were recently described in mouse hypothalamus. This report shows that Chordc1 mRNA changes rhythmically throughout the entire adult brain with highest expression levels occurring around the dark-light transition. The rhythmic cycling pattern of Chordc1 was retained under various light-d...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9271-z
更新日期：2007-02-01 00:00:00
abstract：:Enolase is a glycolytic enzyme whose amino acid sequence is highly conserved across a wide range of animal species. In mammals, enolase is known to be a dimeric protein composed of distinct but closely related subunits: alpha (non-neuronal), beta (muscle-specific), and gamma (neuron-specific). However, little informat...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00970738
更新日期：1995-08-01 00:00:00
abstract：:The binding of the enkephalin dimer [D-Ala2, Leu5-NH-CH2-]2 (DPE2) is characterized by its high affinity for receptors on NG108-15 hybrid cells, the affinity constant K = 4.7 X 10(9) M-1 is up to 8-fold that of monomers (0.6 to 1.0 X 10(9) M-1), and a maximal binding capacity equal to one half that of the monomers. Ki...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965208
更新日期：1986-06-01 00:00:00
abstract：:Metformin is the most frequently used drug for the treatment of type 2 diabetes in humans. However, only little is known about effects of metformin on brain metabolism. To investigate potential metabolic consequences of an exposure of brain cells to metformin, we incubated rat astrocyte-rich primary cultures with this...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1733-8
更新日期：2017-01-01 00:00:00
abstract：:Thiamine deficiency (TD) produces severe neurodegenerative lesions. Studies have suggested that primary neurodegenerative events are associated with both oxidative stress and inflammation. Very little is known about the downstream effects on intracellular signaling pathways involved in neuronal death. The primary aim ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-02975-7
更新日期：2020-04-01 00:00:00
abstract：:Somatostatin contents of striatum, hippocampus, and pons medulla have been followed in two inbred strains of mice (C57B1/6J and Balb/cJ) with aging and long term alcohol exposure (over a 25 month period of intoxication). Marked strain dependent differences in basic levels of somatostatin and genotypic variations in re...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965332
更新日期：1986-05-01 00:00:00
abstract：:The Ca(2+)-dependent release of aspartate from hippocampal preparations was first reported 35 years ago, but the functional significance of this process remains uncertain. Aspartate satisfies all the criteria normally required for identification of a CNS transmitter. It is synthesized in nerve terminals, is accumulate...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-010-0291-3
更新日期：2011-04-01 00:00:00
abstract：:Ursolic acid (UA) is a plant derived compound which is also a component of the standard human diet. It possesses a wide range of pharmacological properties, i.e., antioxidant, anti-inflammatory, antimicrobial and antitumor, which have been used in folk medicine for centuries. Moreover, influence of UA on central nervo...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2505-z
更新日期：2018-05-01 00:00:00
abstract：:A cortical cup model with continuous perfusion of artificial cerebrospinal fluid (containing 134 mM NaCl) was used to investigate the effects of anion channel blockers on the hyposmotically-induced release of amino acids from the in vivo rat cerebral cortex. The hyposmotic stimulus (25 mM NaCl) evoked a release of tau...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020902104056
更新日期：1999-03-01 00:00:00
abstract：:Endogenous phosphorylation of proteins from rat brain synaptosomal plasma membranes was studied in vitro. Cyclic AMP (cAMP) markedly stimulated(32)P incorporation in three protein bands with molecular weights of 75,000, 57,000, and 54,000, respectively. The effect of the behaviorally active peptide ACTH1-24 on this en...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965607
更新日期：1976-12-01 00:00:00
abstract：:Neonatal hypoxia/ischemia (HI) is the most common cause of developmental neurological, cognitive and behavioral deficits in children, with hyperoxia (HHI) treatment being a clinical therapy for newborn resuscitation. Although cerebral edema is a common outcome after HI, the mechanisms leading to excessive fluid accumu...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0308-y
更新日期：2010-12-01 00:00:00
abstract：:The changes in both the levels of some free amino acids and their metabolism in the rat brain during the first 24 hr of postnatal life were studied. The content of glutamic acid decreased for the first 2 hr; it remained at the lowest level for the next 4 hr, when it began to increase. The content of alanine decreased ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966169
更新日期：1980-10-01 00:00:00
abstract：:A panel of mouse monoclonal antibodies to rat and human myelin-associated glycoprotein (MAG) was developed. Normal mice were unresponsive to rat MAG, and successful immunization with rat MAG was only achieved in autoimmune NZB mice. By contrast, all strains of mice were responsive to human MAG. The monoclonal antibodi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964654
更新日期：1985-04-01 00:00:00
abstract：:Factors secreted by C6 glioma cells which induce electrical resistances across endothelial monolayers in an in vitro blood-brain barrier model have been partially characterised for the first time. These transendothelial electrical resistances (TEERs) were only evident when cell-free conditioned medium derived from C6 ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020932121378
更新日期：1998-12-01 00:00:00
abstract：:It has been reported that central dopaminergic system is implicated in the mechanism underlying general anesthesia. Whether dopamine (DA) neurons in midbrain ventral periaqueductal gray (vPAG) are involved in general anesthesia and how general anesthetics affect these neurons remain sparsely documented. To determine t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2486-y
更新日期：2018-04-01 00:00:00
abstract：:Cell surface β-Amyloid precursor protein (APP) is known to have a functional role in iron homeostasis through stabilising the iron export protein ferroportin (FPN). Mechanistic evidence of this role has previously only been provided through transcriptional or translational depletion of total APP levels. However, numer...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02747-y
更新日期：2019-06-01 00:00:00
abstract：:Analysis of gene expression in the brain is a valuable tool to study the function of the brain under normal and pathological conditions. Although there are many techniques used to measure gene expression the validity of any such experiment is directly related to the quality of the RNA in the samples. The most readily ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020996519419
更新日期：2002-10-01 00:00:00
abstract：:The NG 108-15 (neuroblastoma X glioma hybrid) cell line was used as an in vitro neuronal model to evaluate potential antagonists of the Na+-selective carboxylic ionophore monensin. Changes in membrane electrical characteristics induced by monensin with and without the simultaneous administration of antagonists were me...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1007548307554
更新日期：2000-07-01 00:00:00
abstract：:The ability of Sendai virosomes or Lipofectin to introduce an AAV vector into primary rat brain astroglial cultures was characterized. The pJDT95npy vector was constructed by inserting rat NPY cDNA downstream from the indigenous AAV p5, p19 and p40 promoters in pJDT95. Lipofectin-mediated transfection with pJDT95npy (...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967701
更新日期：1994-06-01 00:00:00
abstract：:Overactivation of glutamate receptors results in neurodegeneration in a variety of brain pathologies, including ischemia, epilepsy, traumatic brain injury and slow-progressing neurodegenerative disorders. In all these pathologies, it is well accepted that the calcium-dependent cysteine proteases calpains are key playe...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0323-z
更新日期：2010-12-01 00:00:00
abstract：:Turmeric has been in use since ancient times as a condiment and due to its medicinal properties. Curcumin, the yellow colouring principle in turmeric, is polyphenolic and major active constituent. Besides anti-inflammatory, thrombolytic and anticarcinogenic activities, curcumin also possesses strong antioxidant proper...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9547-y
更新日期：2008-06-01 00:00:00
abstract：:Diisopropylfluorophosphate (DFP) is an irreversible inhibitor of acetylcholine esterase and a surrogate of the organophosphorus (OP) nerve agent sarin. The neurotoxicity of DFP was assessed as a reduction of population spike (PS) area elicited by synaptic stimulation in acute hippocampal slices. Two classical antidote...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1729-4
更新日期：2015-10-01 00:00:00
