Abstract：
:Antibodies to synthetic myelin basic protein peptide S82 (TTHYG-SLPQKAQGHRPQDEG) did not react with synthetic peptide S8 (GSLPQKAQGHRPQDENG) and only partially so with synthetic peptide S79 (AQGHRPQDEG); however, the antibodies did react to a considerable extent with an equimolar mixture of S8 and S79. Since the anti-S82 antibodies had previously been shown to be directed to a non-sequential format determinant dependent on the conformation of secondary structure, it seems probable that the mixture of S8 and S79 assumed a format that neither one individually possessed to any great degree.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Day ED,Hashim GAdoi
10.1007/BF00964671subject
Has Abstractpub_date
1984-10-01 00:00:00pages
1445-52issue
10eissn
0364-3190issn
1573-6903journal_volume
9pub_type
杂志文章abstract：:Direct evidence for the excitotoxicity of 3-N-oxalyl-L-alpha,beta-diaminopropionic acid (ODAP), the Lathyrus sativus neurotoxin has been studied by examining the binding of chemically synthesized [2,3 3H]ODAP ([3H]ODAP) to synaptic membranes. [3H]ODAP binding to membranes was mostly nonspecific, with only a very low s...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020782119057
更新日期：1998-09-01 00:00:00
abstract：:A previously described inhibitor of the UDP-N-acetylgalactosamine: GM3, N-acetylgalactosaminyltransferase (GalNAc-T) (Quiroga et al., 1, 2), was purified from chicken blood serum by a new procedure. When subjected to SDS-PAGE, two major polypeptides of 27 and 70 kDa were observed. When tested in vitro, only the 27 kDa...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1027320113151
更新日期：1997-04-01 00:00:00
abstract：:Ethylcholine mustard aziridinium ion (ECMA) was infused intracerebroventricularly (icv) to rats followed by measurement of two markers of presynaptic cholinergic neurons, choline acetyltransferase (ChAT) activity and high affinity choline transport (HAChT), in the hippocampus and cortex. Bilateral icv administration o...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971589
更新日期：1988-08-01 00:00:00
abstract：:The interactions of S-nitrosoglutathione (GSNO) with the ionotropic glutamate receptors were studied on synaptic membranes isolated from the pig cerebral cortex. GSNO displaced the binding of [3H]glutamate, 3-[(R)-2-carboxypiperazin-4-yl] [3H]propyl-1-phosphonate ([3H]CPP), a competitive N-methyl-D-aspartate (NMDA) an...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1007626230278
更新日期：2000-08-01 00:00:00
abstract：:The primary objective of this investigation was to assess the neuroprotective efficacy of spice active principles namely Eugenol (Eug) and isoeugenol (IE) in an acrylamide (ACR) neuropathy model in rats. In the present study, ACR administration (50 mg/kg bw, i.p. 3 times/week) for 5 weeks to growing rats caused typica...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0924-9
更新日期：2013-02-01 00:00:00
abstract：:After rapid inactivation of the enzymes responsible for glucose metabolism by microwave irradiation, concentrations of glucose in 20 regions of the mouse brain were estimated with combined gas chromatography-mass spectrometry (GC-MS). The highest concentrations of glucose were found in the periventricular nuclei of th...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963774
更新日期：1977-12-01 00:00:00
abstract：:The exposure to hypobaric hypoxia increased lipid peroxidation as indicated by thiobarbituric acid-reactive substances [TBARS] in rat brain. Plasma lactate/pyruvate ratio was used as a marker of hypoxia. We compared the protective effect of alpha-tocopherol with the effect of L-carnitine or phosphocreatine. Rats pretr...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020339530924
更新日期：2002-09-01 00:00:00
abstract：:Sex differences exist in the functioning of the two brain corticosteroid receptor systems. Ovarian steroid replacement alters receptor mRNA expression, receptor binding capacities, and receptor affinity. The abundance of both mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) message can be reduced by es...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1022023207326
更新日期：1997-11-01 00:00:00
abstract：:Germline mutations in genes encoding succinate dehydrogenase subunits are associated with the development of familial pheochromocytomas and paragangliomas [hereditary paraganglioma/pheochromocytoma syndrome (HPPS)]. In particular, a mutation in succinate dehydrogenase subunit B (SDHB) is highly associated with abdomin...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1738-3
更新日期：2016-04-01 00:00:00
abstract：:A case-control study was undertaken to investigate the status of platelet monoamine oxidase-B (MAO-B) activity in Indian cases of idiopathic Parkinson's disease. A significant increase in the activity of platelet MAO-B was observed in Parkinson's cases (n = 26) as compared to controls (n = 26). No significant change i...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-9929-4
更新日期：2009-08-01 00:00:00
abstract：:Cloned fragments of members of the Drosophila and mouse major heat shock (hsp70) gene family were used to demonstrate that homologous sequences are present in the rabbit genome. After a physiologically relevant increase in body temperature of 3 degrees C, transcription of inducible hsp70 genes is detected in both the ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964846
更新日期：1985-09-01 00:00:00
abstract：:The incubation of neuronal nitric oxide synthase with the five amyloid peptide fragments [Aβ17-21; Aβ25-29; Aβ29-33; Aβ33-37; Aβ25-37] catalyzed the formation of fibrils. The role of neuronal isomer (nNOS) involved the entrapment of free monomers and seed aggregates to initiate the events of nucleation and elongation,...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1206-x
更新日期：2014-01-01 00:00:00
abstract：:To study the early effects of neonatal 5,7-dihydroxytryptamine lesions on 5-hydroxytryptamine1A (5-HT1A) receptors, we measured regional [3H]8-OH-DPAT-labeled 5-HT1A sites in binding assays and compared them to our previous studies of [3H]paroxetine-labeled 5-HT transporter sites during the first month in the same rat...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971579
更新日期：1994-03-01 00:00:00
abstract：:Staurosporine was found to bring about complete growth inhibition of human glioma cell lines. U87 MG cells were arrested in S phase while U373 MG cells in G2/M phase on staurosporine treatment. Consistent with this observation, no change in G1 phase regulators viz., Cyclin D1, D3 and CDK4 was seen on staurosporine tre...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9068-0
更新日期：2006-05-01 00:00:00
abstract：:Incomplete ischemia of the spinal cord was produced in dogs by 40 min occlusion of the abdominal aorta that was followed by 5-40 min of recirculation. Amino acid incorporation into ribosomes in vitro in the presence of venous blood sera was estimated. The most significant reduction in incorporation was produced by ser...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965210
更新日期：1986-06-01 00:00:00
abstract：:Mutations in genes for Alzheimer's disease (AD) result in a modulating of gene expressions in the brains of patients with AD. The aim of this study was to identify genes whose expression is modulated due to the over-expression of human mutant presenilin-2 (N141I) (hPS2m) in transgenic mice, which has previously been p...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-6787-6
更新日期：2005-08-01 00:00:00
abstract：:Guanine nucleotides (GN) have been implicated in many intracellular mechanisms. Extracellular actions, probably as glutamate receptor antagonists, have also been recently attributed to these compounds. GN may have a neuroprotective role by inhibiting excitotoxic events evoked by glutamate. Effects of extracellular GN ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1007557600687
更新日期：2000-02-01 00:00:00
abstract：:Social isolation is one of the most potent stressors in the prepubertal period and may influence disease susceptibility or resilience in adulthood. The glucocorticoid response and, consequently, the adaptive response to stress involve important changes in mitochondrial functions and apoptotic signaling. Previous studi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0915-x
更新日期：2013-02-01 00:00:00
abstract：:Tetrahydrobiopterin and the folate coenzymes can reciprocally interact in ways that would be useful to the metabolic pathways subserved by both of these coenzymes. Thus, through one of the reactions catalyzed by methylene tetrahydrofolate reductase, 5-CH3-H4-folate can regenerate BH4 from q-BH2 and q-BH2 can provide a...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/BF00965847
更新日期：1991-09-01 00:00:00
abstract：:Ménière's disease (MD) is characterized by the triad of fluctuating hearing loss, episodic vertigo and tinnitus, and by endolymphatic hydrops found on post-mortem examination. Increasing evidence suggests that oxidative stress is involved in the development of endolymphatic hydrops and that cellular damage and apoptot...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0304-2
更新日期：2010-12-01 00:00:00
abstract：:In this review we examine successively: 1) the major effects of thyroid hormone deficiency seen during brain development with special emphasis on the changes in neuronal morphology and migration occurring postnatally in the cerebellum. 2) The effects of this hormone on microtubule assembly during neurite outgrowth and...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/BF00965840
更新日期：1991-09-01 00:00:00
abstract：:Glutamine synthetase (GS) from the chick brain was purified to apparent homogeneity by ammonium sulfate fractionation followed by affinity chromatography, electrofocusing and Sephadex G-150 chromatography. The purified enzyme showed a single band on sodium dodecyl sulfate analysis in polyacrylamide gel. By sedimentati...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00970934
更新日期：1987-11-01 00:00:00
abstract：:Experimental hyperphenylalaninemia has been induced in 5-day-old chicks by dietary treatments with phenylalanine and alpha-methylphenylalanine. An increase of nearly 8-fold in plasma Phe/Tyr ratio was found after 4 days of supplementation the standard diet with 5% phenylalanine plus 0.4% alpha-methylphenylalanine. The...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973296
更新日期：1988-06-01 00:00:00
abstract：:Crayfish glutamic acid decarboxylase (GAD), like the homologous enzymes from other species, is inhibited by carbonyl-trapping agents (e.g. aminooxyacetic acid; AOAA) and sulfhydryl reagents (e.g. 5,5'-dithiobis-(2-nitrobenzoic acid); DTNB). It also is inhibited by the product GABA, many anions (e.g. SCN- and Cl-), and...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964526
更新日期：1984-07-01 00:00:00
abstract：:The cellular effects of eleven compounds including chalcone glycosides isolated from Brassica rapa L. 'hidabeni' and their synthetic derivatives were studied in rat pheochromocytoma PC12 cells. Of the compounds tested, 4'-O-β-D-glucopyranosyl-3',4-dimethoxychalcone (A2) significantly increased the levels of the phosph...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1152-7
更新日期：2013-11-01 00:00:00
abstract：:Glutamate and its receptors are expressed very early during development and may play important roles in neurogenesis, synapse formation and brain wiring. The levels of glutamate and activity of its receptors can be influenced by exogenous factors, leading to neurodevelopmental disorders. To investigate the role of NMD...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9213-9
更新日期：2007-02-01 00:00:00
abstract：:The pineal gland is a neuroendocrine gland responsible for nocturnal synthesis of melatonin. During early development of the rodent pineal gland from the roof of the diencephalon, homeobox genes of the orthodenticle homeobox (Otx)- and paired box (Pax)-families are expressed and are essential for normal pineal develop...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-012-0906-y
更新日期：2013-06-01 00:00:00
abstract：:The present study examined the potential membrane retention of desipramine (DMI) following exposures of 293-hNET cells to DMI, and its effect on [3H]NE uptake. Incubation of cells with 500 nM DMI for 1 h or 1 day persistently inhibited the uptake of [3H]NE up to 7 days, despite daily repeated washing of cells with dru...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/b:nere.0000013747.04964.46
更新日期：2004-02-01 00:00:00
abstract：:Examination of the cytoskeleton has demonstrated the pivotal role of regulatory proteins governing cytoskeletal dynamics. Most work has focused on cell cycle and cell migration regarding cancer. However, these studies have yielded tremendous insight for development, particularly in the nervous system where all major c...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9127-6
更新日期：2007-02-01 00:00:00
abstract：:We examined the impact of peroxiredoxin-I (Prx-I) and peroxiredoxin-II (Prx-II) stable transduction on oxidative stress in PC12 neurons and NIH3T3 fibroblasts and found variability depending on cell type and Prx subtype. In PC12 neurons, Prx-II suppressed reactive oxygen species (ROS) generation by 36% (p < 0.01) rela...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1026670620633
更新日期：2000-12-01 00:00:00
