Abstract:
:In this review we examine successively: 1) the major effects of thyroid hormone deficiency seen during brain development with special emphasis on the changes in neuronal morphology and migration occurring postnatally in the cerebellum. 2) The effects of this hormone on microtubule assembly during neurite outgrowth and acquisition of neuronal polarity. 3) The changes in expression of the different tubulin isoforms occurring during development in the normal and hypothyroid rat brain. 4) The regulation by thyroid hormone of the transition occurring during development between the juvenile and adult microtubule-associated protein Tau.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Nunez J,Couchie D,Aniello F,Bridoux AMdoi
10.1007/BF00965840subject
Has Abstractpub_date
1991-09-01 00:00:00pages
975-82issue
9eissn
0364-3190issn
1573-6903journal_volume
16pub_type
杂志文章,评审abstract::The selective vulnerability of specific neuronal subpopulations to trimethyltin (TMT), an organotin compound with neurotoxicant effects selectively involving the limbic system and especially marked in the hippocampus, makes it useful to obtain in vivo models of neurodegeneration associated with behavioural alterations...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-012-0932-9
更新日期:2013-02-01 00:00:00
abstract::Astrocytes have been considered to be transformed from radial glial cells that appear at early stage of development and play a scaffold-role for neuronal cell migration. Recent studies indicate that neuroepithelial cells in the spinal cord also give rise to astrocytes. However, the mode of astroglial generation and mi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9590-3
更新日期:2008-07-01 00:00:00
abstract::Methylphenidate is commonly used for the treatment of attention deficit/hyperactivity disorder. There are still few works regarding the effects of methylphenidate on brain energy metabolism. Thus, in the present study we evaluated the effect of chronic administration of methylphenidate on the activities of mitochondri...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0229-9
更新日期:2010-11-01 00:00:00
abstract::The tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) is not only a protein, but also a lipid phosphatase that can negatively regulate the serine/threonine kinase Akt. It has been reported that PTEN can be regulated by means of phosphorylation. However, whether PTEN can be regulated by an...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-009-9938-3
更新日期:2009-08-01 00:00:00
abstract::Focal epileptic seizures can in some patients be managed by inhibiting γ-aminobutyric acid (GABA) uptake via the GABA transporter 1 (GAT1) using tiagabine (Gabitril®). Synergistic anti-seizure effects achieved by inhibition of both GAT1 and the betaine/GABA transporter (BGT1) by tiagabine and EF1502, compared to tiaga...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03017-y
更新日期:2020-07-01 00:00:00
abstract::Lipid peroxides, quantitated as lipid conjugated dienes, and (Na+, K+)-ATPase activity were assayed concurrently in brains of control rats and in three groups subjected to 30 min of reversible forebrain ischemia followed by 0, 1, and 4 hr of recirculation. Multiple small samples were taken from lateral, dorsolateral a...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00968084
更新日期:1984-12-01 00:00:00
abstract::Some crustacean axons remain functional for months after injury. This unusual property may require stress proteins synthesized by those neurons or provided to them by glial cells. To begin to explore this hypothesis, we examined the conditions that stimulated stress protein synthesis by crayfish CNS tissue in vitro. I...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00974871
更新日期:1991-05-01 00:00:00
abstract::In this communication, the effect of acute treatment with lamotrigine (LTG) was investigated on release of main excitatory amino acids (EAA) such as glutamate (Glu) and aspartate (Asp) in the hippocampus of pentylenetetrazol (PTZ)-induced and PTZ-kindled freely moving rats using micro dialysis. The results show that, ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-012-0942-7
更新日期:2013-03-01 00:00:00
abstract::Caspase activation and apoptotic events may take place in terminal regions far removed from the cell body and contribute to synapse loss in neurodegenerative diseases. For examination of events in terminals, we have developed a cell-free assay using quantitative flow cytometric analysis (fluorescence-activated cell so...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1019840417796
更新日期:2002-06-01 00:00:00
abstract::Intracerebral hemorrhage (ICH) is an important public health problem in neurology, which is not only associated with high mortality but also leading to disability. Yet no satisfactory treatment has been developed. The secondary injury that resulted from a number of self-destructive processes such as neuroinflammation,...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2179-y
更新日期:2017-05-01 00:00:00
abstract::Suspensions of rat brain microsomes, synaptosomes, and synaptic vesicles were able to convert adenosine to inosine by means of adenosine deaminase. Isosbestic points of this transformation, at 222, 250 and 281 nm, remained unchanged with time-course. This fact suggests that adenosine deaminase (ADA, E.C. 3.5.4.4) is l...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965316
更新日期:1986-04-01 00:00:00
abstract::Pathogens such as bacterial lipopolysaccharide (LPS) play an important role in promoting the production of the inflammatory cytokines interleukin-1 beta (IL-1β) and tumour necrosis factor-α (TNF-α) in response to infection or damage in microglia. However, whether different signalling pathways regulate these two inflam...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02895-1
更新日期:2019-12-01 00:00:00
abstract::Disturbance in cholesterol homeostasis appears to be an important factor in the pathogenesis of neurodegenerative disorders. The aim of the present study was to investigate sterol regulatory element binding protein (SREBP) levels in the nuclear extracts of human neuroblastoma cells and the possible interaction of beta...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9832-4
更新日期:2009-05-01 00:00:00
abstract::During neural activity, neurotransmitters released at synapses reach neighbouring cells, such as astrocytes. These get excited via numerous mechanisms, including the G protein coupled receptors that regulate the cytosolic concentration of second messengers, such as Ca(2+) and cAMP. The stimulation of these pathways le...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-015-1545-x
更新日期:2015-12-01 00:00:00
abstract::Exposure chronically to n-hexane produces peripheral-central axonopathy mediated by 2,5-hexanedione (HD). Previous studies have demonstrated decreases in neurofilament (NF) contents of peripheral and central nervous regions from rats intoxicated with HD, and recent analysis has demonstrated that axonal atrophy, instea...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-004-2439-5
更新日期:2005-02-01 00:00:00
abstract::Heme oxygenase-1 (HO-1) plays a crucial role in oxidative stress processes, apoptosis and cell differentiation. Further, some proteins related to cell cycle including cyclins and p21 are important markers of astrocyte cultures. Aim of investigation was to study the effects of cholinergic precursors (choline, CDP-choli...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-012-0873-3
更新日期:2012-12-01 00:00:00
abstract::Antidepressive drugs offer considerable symptomatic relief in mood disorders and, although commonly discovered by screening with single biological targets, most interact with multiple receptors and signaling pathways. Antidepressants require a treatment regimen of several weeks before clinical efficacy is achieved in ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-005-8513-9
更新日期:2005-11-01 00:00:00
abstract::Analysis of gene expression in the brain is a valuable tool to study the function of the brain under normal and pathological conditions. Although there are many techniques used to measure gene expression the validity of any such experiment is directly related to the quality of the RNA in the samples. The most readily ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020996519419
更新日期:2002-10-01 00:00:00
abstract::Plasmalogens are ether-linked phospholipids that are abundant in nervous tissues. Their biological role is unclear, but may involve membrane structure/function and antioxidant activities. This study further investigates a recent report that chronic administration of myo-inositol in rats increased brain phosphatidyleth...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000018859.23881.f9
更新日期:2004-04-01 00:00:00
abstract::The amyloid peptide (Abeta) deposited in Alzheimer's disease (AD) is generated by beta- and gamma-secretase processing of a larger integral membrane protein precursor (APP). Intramembrane processing of APP by gamma-secretase also yields an intracellular fragment, CTFgamma (a.k.a. AICD), which is highly conserved and i...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9449-z
更新日期:2007-12-01 00:00:00
abstract::Ion channels are targets of various antiepileptic drugs. In cerebral presynaptic nerve endings Na(+) and Ca(2+) channels are particularly abundant, as they control neurotransmitter release, including the release of glutamate (Glu), the most concentrated excitatory amino acid neurotransmitter in the brain. Several pre-...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1749-0
更新日期:2016-04-01 00:00:00
abstract::Here we review experimental evidence of non-NMDA glutamate receptor expression in the embryonic central nervous system. AMPA- and kainate-preferring glutamate receptor subunit mRNA transcripts are detected in embryonic neurons, glia and neural progenitors. Functional assays demonstrate that in some cell subpopulations...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/BF01694536
更新日期:1995-05-01 00:00:00
abstract::Oxidative stress is a long-hypothesized cause of diverse neurological and psychiatric disorders but the pathways by which physiological redox perturbations may detour healthy brain development and aging are unknown. We reported recently (Foley et al., Neurochem Res 39:2030-2039, 2014) that two-electron oxidations, to ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1991-0
更新日期:2016-10-01 00:00:00
abstract::Effects of single and repeated doses of acrylamide on fast and slow axonal transport of radio labeled proteins following the injection of L-[4,5-3H] leucine have been studied in the optic system of male Sprague-Dawley rats. A single dose of acrylamide (100 mg/kg) had no effect, but higher concentrations (200-300 mg/kg...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00973750
更新日期:1990-06-01 00:00:00
abstract::One of the many pharmacological targets of ethanol is the GABA inhibitory system, and chronic ethanol (CE) is known to alter the polypeptide levels of the GABA(A )receptor subunits in rat brain regions. In the present study, we investigated the regulation of the tyrosine kinase phosphorylation of the GABA(A) receptor ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9288-y
更新日期:2007-07-01 00:00:00
abstract::Glioblastoma is one of the most frequent and aggressive primary tumor of glial brain tumors. Long non-coding RNA Prostate cancer-associated ncRNA transcript 6 (PCAT6) has been identified to influence the progression of many cancers, but its expression and functions in glioblastoma remain unclear. In this study, we int...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03138-4
更新日期:2020-12-01 00:00:00
abstract::Cloned fragments of members of the Drosophila and mouse major heat shock (hsp70) gene family were used to demonstrate that homologous sequences are present in the rabbit genome. After a physiologically relevant increase in body temperature of 3 degrees C, transcription of inducible hsp70 genes is detected in both the ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964846
更新日期:1985-09-01 00:00:00
abstract::Ingestion of ammonium induces hyperammonemia which increases tubulin content in cerebrum but not in cerebellum. We have dissected 11 discrete areas of cerebrum and quantified the tubulin content in control and hyperammonemic rats. An heterogeneity in the induction of tubulin is shown. The areas more affected are ventr...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965516
更新日期:1989-12-01 00:00:00
abstract::It was found that acute ethanol intoxication caused an imbalance of the neurotransmitters in the CNS: accumulation of GABA and serotonin and depletion of catecholamines. Alcohol depression was characterized by suppression of the evoked potentials of the various rat brain structures. Under chronic ethanol intoxication ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966062
更新日期:1982-11-01 00:00:00
abstract::The role of protein phosphorylation in catecholamine secretion from bovine adrenomedullary chromaffin cells was studied using different protein kinase inhibitors. Naphthalenesulfonamide derivatives as ML9 and ML7, more specific for the myosin light chain kinase, and the calmodulin antagonist W7 inhibited catecholamine...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00969089
更新日期:1993-03-01 00:00:00