Expression and regulation of kainate and AMPA receptors in uncommitted and committed neural progenitors.

abstract：:The objective of the present study was to investigate the effects of preincubation of hippocampus homogenates in the presence of homocysteine or methionine on Na+, K+-ATPase and Mg2+-ATPase activities in synaptic membranes of rats. Homocysteine significantly inhibited Na+, K+-ATPase activity, whereas methionine had no...

journal_title：Neurochemical research

authors： Streck EL,Zugno AI,Tagliari B,Franzon R,Wannmacher CM,Wajner M,Wyse AT

更新日期：2001-11-01 00:00:00

abstract：:We report further analysis of axonally transported proteoglycans in soluble and membranous subfractions of goldfish optic tectum. Distribution of transported 35SO4 radioactivity was 35.2% soluble, 63.4% Triton-NaCl extractable and 1.4% unextracted. Proteoglycans isolated on DEAE cellulose were treated with chondroitin...

journal_title：Neurochemical research

authors： Elam JS

更新日期：1995-02-01 00:00:00

abstract：:Oxidative stress can induce neuronal apoptosis via the production of superoxide and hydroxyl radicals. This process is as a major pathogenic mechanism in neurodegenerative disorders. In this study, we aimed to clarify whether theaflavins protect PC12 cells from oxidative stress damage induced by H2O2. A cell model of ...

journal_title：Neurochemical research

authors： Zhang J,Cai S,Li J,Xiong L,Tian L,Liu J,Huang J,Liu Z

更新日期：2016-12-01 00:00:00

abstract：:VGF nerve growth factor inducible (VGF) is a neuropeptide precursor induced by brain-derived neurotrophic factor and nerve growth factor. VGF is increased in the prefrontal cortex and cerebrospinal fluid in schizophrenia patients. In our previous study, VGF-overexpressing mice exhibited schizophrenia-like behaviors an...

journal_title：Neurochemical research

authors： Mizoguchi T,Shimazawa M,Ohuchi K,Kuse Y,Nakamura S,Hara H

更新日期：2019-02-01 00:00:00

abstract：:Several models for the transmission and progression of prion diseases have arisen, evolving with the acquisition of new experimental results. It is generally accepted that the PrP(Sc) protein is at least part of the infectious particle and the major protein component of the scrapie-associated fibrils (SAFs) that chara...

journal_title：Neurochemical research

authors： Grossman A,Zeiler B,Sapirstein V

更新日期：2003-06-01 00:00:00

abstract：:Phosphate activated glutaminase (PAG) was assayed in whole homogenate and synaptosomes of cerebral cortex from normal or fasted for 120 h rats. The specific activity (s.a.) of PAG was found diminished by 25% in the whole homogenate from the fasted animals compared to the normal. On the contrary, fasting did not affect...

journal_title：Neurochemical research

authors： Lellos V,Tselentis V,Galanopoulos E,Philippidis H,Palaiologos G

更新日期：1991-01-01 00:00:00

abstract：:Cyclin-dependent kinase 5 (Cdk5) plays a pivotal role in neuronal migration and differentiation, and in axonal elongation. Although many studies have been conducted to analyze neuronal functions of Cdk5, its kinase activity has also been reported during oligodendrocyte differentiation, which suggests Cdk5 may play an ...

journal_title：Neurochemical research

authors： He X,Takahashi S,Suzuki H,Hashikawa T,Kulkarni AB,Mikoshiba K,Ohshima T

更新日期：2011-07-01 00:00:00

abstract：:Metabolism of triacylglycerol (TAG) in developing brain has been examined. TAG is a relatively minor fraction of brain lipid in both suckling and adult rats and cannot be accounted for as entrapped blood. When glycerol tri[1-14C]oleate and [2-3H]glycerol trioleate were simultaneously injected intracerebrally into suck...

journal_title：Neurochemical research

authors： Cook HW

更新日期：1981-11-01 00:00:00

abstract：:There is increasing evidence to suggest that hepatic encephalopathy in acute liver failure is the result of altered glutamatergic function. In particular, the high affinity uptake of glutamate is decreased in brain slices and synaptosomes from rats with acute liver failure as well as by exposure of cultured astrocytes...

journal_title：Neurochemical research

authors： Chan H,Butterworth RF

更新日期：1999-11-01 00:00:00

abstract：:Ingestion of ammonium induces hyperammonemia which increases tubulin content in cerebrum but not in cerebellum. We have dissected 11 discrete areas of cerebrum and quantified the tubulin content in control and hyperammonemic rats. An heterogeneity in the induction of tubulin is shown. The areas more affected are ventr...

journal_title：Neurochemical research

authors： Miñana MD,Felipo V,Quel A,Pallardó F,Grisolía S

更新日期：1989-12-01 00:00:00

abstract：:The study aimed to directly measure in vivo superoxide radical (O*2) a direct indicator of oxidative stress, in the brain of rats with experimentally induced obstructive jaundice by employing a new quantitative ultrasensitive fluorescent assay requiring minimum sample. O*2 anion is specific for dihydroethidine (DHE) a...

journal_title：Neurochemical research

authors： Konstantinou D,Mavrakis A,Grintzalis K,Papapostolou I,Assimakopoulos SF,Chroni E,Georgiou C

更新日期：2008-06-01 00:00:00

abstract：:Previous studies have demonstrated that the c-Jun N-terminal kinase (JNK) pathway plays an important role in inducing neuronal apoptosis following cerebral ischemic injury. JNK signaling pathway in activated during cerebral ischemic injury. It participates in ischemia-induced neuronal apoptosis. However, whether JNK s...

journal_title：Neurochemical research

authors： Ma Y,Sun S,Zhang J,Chen Z,Guo F,Du Y,Zhang J

更新日期：2016-04-01 00:00:00

abstract：:Several epidemiological studies have shown that consumption of large quantities of vegetables especially cruciferous vegetables (Broccoli and Brussels sprouts) can protect against chronic diseases. Sulforaphane, an isothiocynate found in cruciferous vegetables has been demonstrated to have neuroprotective effects in s...

journal_title：Neurochemical research

authors： Rajesh V,Ilanthalir S

更新日期：2016-10-01 00:00:00

abstract：:The presence and specificity of insulin receptors was investigated in culture cells obtained from 15-16 days old embryonic mouse cerebra. Developmental studies suggested that the maximum insulin binding occurred at about 11 days in vitro (DIV). Scatchard analysis of binding data revealed two types of binding sites. On...

journal_title：Neurochemical research

authors： Shanker G,Pieringer RA

更新日期：1988-05-01 00:00:00

abstract：:Many studies have demonstrated that apoptosis play an important role in cerebral ischemic pathogenesis and may represent a target for treatment. Neuroprotective effect of quercetin has been shown in a variety of brain injury models including ischemia/reperfusion. It is not clear whether BDNF-TrkB-PI3K/Akt signaling pa...

journal_title：Neurochemical research

authors： Yao RQ,Qi DS,Yu HL,Liu J,Yang LH,Wu XX

更新日期：2012-12-01 00:00:00

abstract：:Plasmalogens are ether-linked phospholipids that are abundant in nervous tissues. Their biological role is unclear, but may involve membrane structure/function and antioxidant activities. This study further investigates a recent report that chronic administration of myo-inositol in rats increased brain phosphatidyleth...

journal_title：Neurochemical research

authors： Hoffman-Kuczynski B,Reo NV

更新日期：2004-04-01 00:00:00

abstract：:To assess RNAi mediated inhibition of the expression of wt-DYT1 on H(2)O(2)-induced toxicity in NIH 3T3 cells and primary cortical neurons. To detect the function of wild-type Torsin A and the effect of SiRNA on the wt-DYT1 gene. The shRNA expression vector was constructed by ligating annealed complementary shRNA olig...

journal_title：Neurochemical research

authors： Chen XP,Hu XH,Wu SH,Zhang YW,Xiao B,Shang HF

更新日期：2010-08-01 00:00:00

abstract：:Acute tryptophan depletion (ATD) is extensively used to investigate the role of central serotonin (5-HT). However, several studies reported that ATD had no significant effect on central 5-HT concentration and some ATD-induced changes was independent of 5-HT in the rodent brain. Therefore, the potential mechanism of AT...

journal_title：Neurochemical research

authors： Liu H,Zhou J,Fang L,Liu Z,Fan S,Xie P

更新日期：2013-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a degenerative disorder caused by motor neuron loss. T-cell intracellular antigen-1 (TIA-1), a cytotoxic T lymphocyte granule-associated RNA binding protein, is a key component of stress granules. However, it remains uncertain whether ALS-causing superoxide dismutase-1 (SOD1) tox...

journal_title：Neurochemical research

authors： Lee DY,Jeon GS,Sung JJ

更新日期：2020-12-01 00:00:00

abstract：:Memory impairment is a major problem afflicting mankind. The association between memory functions and neurotransmitter functions is of great interest for understanding brain function. Serotonergic pathways play an important role in the modulation of memory functions but the importance of its receptor types and subtype...

journal_title：Neurochemical research

authors： Haider S,Khaliq S,Tabassum S,Haleem DJ

更新日期：2012-10-01 00:00:00

abstract：:Lesions of the nigrostriatal pathway are known to induce a compensatory up-regulation of various neurotrophic factors. In this study we examined protein content of basic fibroblast growth factor (FGF-2) in tissue samples taken from the ventral midbrain and striatum at two different time points following a neurotoxic l...

journal_title：Neurochemical research

authors： Yurek DM,Fletcher AM,Peters LE,Cass WA

更新日期：2010-04-01 00:00:00

abstract：:The interactions of S-nitrosoglutathione (GSNO) with the ionotropic glutamate receptors were studied on synaptic membranes isolated from the pig cerebral cortex. GSNO displaced the binding of [3H]glutamate, 3-[(R)-2-carboxypiperazin-4-yl] [3H]propyl-1-phosphonate ([3H]CPP), a competitive N-methyl-D-aspartate (NMDA) an...

journal_title：Neurochemical research

authors： Hermann A,Varga V,Janáky R,Dohovics R,Saransaari P,Oja SS

更新日期：2000-08-01 00:00:00

abstract：:Lipid peroxides, quantitated as lipid conjugated dienes, and (Na+, K+)-ATPase activity were assayed concurrently in brains of control rats and in three groups subjected to 30 min of reversible forebrain ischemia followed by 0, 1, and 4 hr of recirculation. Multiple small samples were taken from lateral, dorsolateral a...

journal_title：Neurochemical research

authors： Goldberg WJ,Watson BD,Busto R,Kurchner H,Santiso M,Ginsberg MD

更新日期：1984-12-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) inhibits carbachol-stimulated phosphoinositide breakdown in rat brain cortical slices but not in isolated membranes (1). To gain insight into the mechanisms, we examined the effects of NMDA on carbachol-stimulated [3H]inositol phosphate and intermediates of phosphatidylinositol cycle accumu...

journal_title：Neurochemical research

authors： Lee HM,Huang CL

更新日期：1997-05-01 00:00:00

abstract：:Selective blockade of a subset of GABA(A) receptors may be involved in the antipsychotic effects of Clozapine and several other antipsychotic drugs. Seven antipsychotic drugs, and 11 drugs classified as antidepressants that only partially reverse the inhibitory effect of 1 microM GABA on [35S]TBPS binding, do not yiel...

journal_title：Neurochemical research

authors： Squires RF,Saederup E

更新日期：1997-02-01 00:00:00

abstract：:Experimental allergic encephalomyelitis (EAE) is an experimentally induced autoallergic demyelinating disease which is caused by immunization with a particular neuroantigen, such as myelin basic protein (MBP). Results have suggested that protease inhibitors might be useful therapeutically. Leupeptin (acetyl-L-leucyl-L...

journal_title：Neurochemical research

authors： Osanai T,Nagai Y

更新日期：1984-10-01 00:00:00

abstract：:Subunit-specific antibodies to all the gamma subunit isoforms described in mammalian brain (gamma(1), gamma(2S), gamma(2L), and gamma(3) have been made. The proportion of GABA(A) receptors containing each gamma subunit isoform in various brain regions has been determined by quantitative immunoprecipitation. In all tes...

journal_title：Neurochemical research

authors： Khan ZU,Gutiérrez A,Miralles CP,De Blas AL

更新日期：1996-02-01 00:00:00

abstract：:Metal ions are often used to block calcium channels in various tissues, including synaptosomes. In the present study, Fura-2 was used to determine the effectiveness of various metal ions as calcium channel blockers in rat brain synaptosomes in vitro. In buffer solutions, La3+ and Cd2+ increased the Fura-2 fluorescence...

journal_title：Neurochemical research

authors： Sun YD,Benishin CG

更新日期：1989-11-01 00:00:00

abstract：:A previously described inhibitor of the UDP-N-acetylgalactosamine: GM3, N-acetylgalactosaminyltransferase (GalNAc-T) (Quiroga et al., 1, 2), was purified from chicken blood serum by a new procedure. When subjected to SDS-PAGE, two major polypeptides of 27 and 70 kDa were observed. When tested in vitro, only the 27 kDa...

journal_title：Neurochemical research

authors： Conde CB,Grabois VR,Deza SN,Caputto BL

更新日期：1997-04-01 00:00:00

abstract：:We examined the effects of small unilamellar vesicles composed of dipalmitoylphosphatidylcholine on rat cerebral cortical [3H]acetylcholine release. Synaptosomes from this region were loaded with the labeled transmitter, and then incubated with the lipid (0-6 mg/ml) for specified intervals before adding various secret...

journal_title：Neurochemical research

authors： Bottiglieri DF,Meyer EM

更新日期：1987-08-01 00:00:00