Effects of NMDA on carbachol-stimulated phosphatidylinositol resynthesis in rat brain cortical slices.

abstract：:As is known to all, neuroinflammation plays a vital role in early brain injury pathogenesis following subarachnoid hemorrhage (SAH). It has been shown that rutin have a property of inhibiting inflammation in many kinds of animal models. However, the effect of rutin on neuroinflammation after SAH remains uninvestigated...

journal_title：Neurochemical research

authors： Hao G,Dong Y,Huo R,Wen K,Zhang Y,Liang G

更新日期：2016-06-01 00:00:00

abstract：:Protein kinase C has recently attracted considerable attention because of its importance in the control of cell division, cell differentiation, and signal transduction across the cell membrane. The activity of this enzyme is altered by several lipids such as diacylglycerol, free fatty acids, lipoxins, gangliosides, an...

journal_title：Neurochemical research

authors： Farooqui AA,Farooqui T,Yates AJ,Horrocks LA

更新日期：1988-06-01 00:00:00

abstract：:Shape-shifting, a phenomenon wide-spread in folklore, refers to the ability to physically change from one identity to another, typically from an innocuous entity to a destructive one. The amino acid D-serine over the last 25 years has "shape-shifted" into several identities: a purported glial transmitter activating N-...

journal_title：Neurochemical research

authors： Coyle JT,Balu D,Wolosker H

更新日期：2020-06-01 00:00:00

abstract：:Mammalian MTH1 protein, a MutT-related protein, catalyzes the hydrolysis of 8-oxo-7,8-dihydroguanosine triphosphate (8-oxoGTP) to monophosphate, thereby preventing incorporation of 8-oxo-7,8-dihydroguanine (8-oxoguanine) into RNA. In this study, we applied immunohistochemistry to follow the expression of MTH1 and the ...

journal_title：Neurochemical research

authors： Song XN,Zhang LQ,Liu DG,Lin J,Zheng JD,Dai DP,Hei AL,Hayakawa H,Sekiguchi M,Cai JP

更新日期：2011-08-01 00:00:00

abstract：:Ménière's disease (MD) is characterized by the triad of fluctuating hearing loss, episodic vertigo and tinnitus, and by endolymphatic hydrops found on post-mortem examination. Increasing evidence suggests that oxidative stress is involved in the development of endolymphatic hydrops and that cellular damage and apoptot...

journal_title：Neurochemical research

authors： Calabrese V,Cornelius C,Maiolino L,Luca M,Chiaramonte R,Toscano MA,Serra A

更新日期：2010-12-01 00:00:00

abstract：:Hypoglycemia is the major problem to blood glucose homeostasis in treatment of diabetes and is associated with severe irreversible consequences including seizures, coma and death. GABAergic inhibitory function in the cerebral cortex plays an important role in controlling the excitability and responsiveness of cortical...

journal_title：Neurochemical research

authors： Antony S,Kumar TP,Kuruvilla KP,George N,Paulose CS

更新日期：2010-10-01 00:00:00

abstract：:The phospholipid requirement for Ca2+-stimulated, Mg2+-dependent ATP hydrolysis (Ca2+/Mg2+-ATPase) and Mg2+-stimulated ATP hydrolysis (Mg2+-ATPase) in rat brain synaptosomal membranes was studied employing partial delipidation of the membranes with phospholipase A2 (Hog pancreas), phospholipase C (Bacillus cereus) and...

journal_title：Neurochemical research

authors： Gandhi CR,Ross DH

更新日期：1986-10-01 00:00:00

abstract：:MicroRNAs (miRNAs), an abundant class of small noncoding RNA molecules, which regulate gene expression by functioning as post-transcriptional regulatory factors, have been identified as key components of traumatic brain injury (TBI) progression. MicroRNA-21 (miR-21) is a recently identified typical miRNA that is invol...

journal_title：Neurochemical research

authors： Ji W,Jiao J,Cheng C,Shao J

更新日期：2018-10-01 00:00:00

abstract：:The characteristics of endogenous Ca2+/calmodulin (CaM)- and Ca2+/phosphatidylserine (PS)-stimulated phosphorylated proteins in the striatum of rat were partially determined and compared in this study. The Ca2+/CaM-dependent phosphoproteins were associated with serine and threonine residues. The sensitivity of these p...

journal_title：Neurochemical research

authors： Lau YS

更新日期：1990-03-01 00:00:00

abstract：:Systemic inflammation triggered by lipopolysaccharide (LPS) administration disrupts blood-brain barrier (BBB) homeostasis in animal models. This event leads to increased susceptibility of several encephalic structures to potential neurotoxicants present in the bloodstream. In this study, we investigated the effects of...

journal_title：Neurochemical research

authors： Gonçalves C,Dos Santos DB,Portilho SS,Lopes MW,Ghizoni H,de Souza V,Mack JM,Naime AA,Dafre AL,de Souza Brocardo P,Prediger RD,Farina M

更新日期：2018-03-01 00:00:00

abstract：:Suspensions of rat brain microsomes, synaptosomes, and synaptic vesicles were able to convert adenosine to inosine by means of adenosine deaminase. Isosbestic points of this transformation, at 222, 250 and 281 nm, remained unchanged with time-course. This fact suggests that adenosine deaminase (ADA, E.C. 3.5.4.4) is l...

journal_title：Neurochemical research

authors： Centelles JJ,Franco R,Canela EI,Bozal J

更新日期：1986-04-01 00:00:00

abstract：:The selective vulnerability of specific neuronal subpopulations to trimethyltin (TMT), an organotin compound with neurotoxicant effects selectively involving the limbic system and especially marked in the hippocampus, makes it useful to obtain in vivo models of neurodegeneration associated with behavioural alterations...

journal_title：Neurochemical research

authors： Corvino V,Marchese E,Michetti F,Geloso MC

更新日期：2013-02-01 00:00:00

abstract：:During neural activity, neurotransmitters released at synapses reach neighbouring cells, such as astrocytes. These get excited via numerous mechanisms, including the G protein coupled receptors that regulate the cytosolic concentration of second messengers, such as Ca(2+) and cAMP. The stimulation of these pathways le...

journal_title：Neurochemical research

authors： Vardjan N,Zorec R

更新日期：2015-12-01 00:00:00

abstract：:Altered proteostasis induced by amyloid peptide aggregation and hyperphosphorylation of tau protein, is a prominent feature of Alzheimer's disease, which highlights the occurrence of endoplasmic reticulum stress and triggers the activation of the unfolded protein response (UPR), a signaling pathway that enforces adapt...

journal_title：Neurochemical research

authors： Cui H,Deng M,Zhang Y,Yin F,Liu J

更新日期：2018-03-01 00:00:00

abstract：:Glutamine synthetase (GS) from the chick brain was purified to apparent homogeneity by ammonium sulfate fractionation followed by affinity chromatography, electrofocusing and Sephadex G-150 chromatography. The purified enzyme showed a single band on sodium dodecyl sulfate analysis in polyacrylamide gel. By sedimentati...

journal_title：Neurochemical research

authors： Tholey G,Bloch S,Ledig M,Mandel P,Wedler F

更新日期：1987-11-01 00:00:00

abstract：:Alcohol abuse affects several neurological pathways and causes significant alterations in the brain. Abstention from alcohol causes only a marginal decrease in oxidative stress and neuro inflammation. Our previous studies had shown that an active metabolite of vitamin A, all trans retinoic acid (ATRA), ameliorates alc...

journal_title：Neurochemical research

authors： Priyanka SH,Syam Das S,Thushara AJ,Rauf AA,Indira M

更新日期：2018-09-01 00:00:00

abstract：:The present study reports inhibition of taurine uptake in the rat retina in vitro to 49% of control by 1 mM guanidinoethyl sulfonate. No efflux of preloaded [14C]taurine was observed by incubation in the presence of guanidinoethyl sulfonate. The in vivo depletion of retinal taurine by guanidinoethyl sulfonate treatmen...

journal_title：Neurochemical research

authors： Lake N,Cocker SE

更新日期：1983-12-01 00:00:00

abstract：:We observed a spot on two-dimensional (2-D) gel in the epileptic mutant strain E1 mice with a similar molecular weight but with a different isoelectric point of approximately 0.2, compared with its mother strain ddY mice. The collected protein from the E1 mice was identified as cytosolic NADP+-dependent isocitrate deh...

journal_title：Neurochemical research

authors： Ohmori O,Hirano H,Mita T

更新日期：1999-03-01 00:00:00

abstract：:The present study investigated the expression patterns of glial cells and interleukin-1beta (IL-1beta) in the rat spinal cord after a surgical incision, which is closely related with clinical postoperative pain. Microglia and astrocytes became activated in the spinal cord following incision. Real-time polymerase chain...

journal_title：Neurochemical research

authors： Fu D,Guo Q,Ai Y,Cai H,Yan J,Dai R

更新日期：2006-03-01 00:00:00

abstract：:Convection enhanced delivery of 6-hydroxydopamine (6-OHDA) to the rat striatum results in a model of Parkinson's disease. An important feature of this unilateral model is the progressive loss of dopaminergic (DA) neurons over the course of several weeks. To improve the understanding of this model, gene expression chan...

journal_title：Neurochemical research

authors： Na SJ,DiLella AG,Lis EV,Jones K,Levine DM,Stone DJ,Hess JF

更新日期：2010-05-01 00:00:00

abstract：:The changes in both the levels of some free amino acids and their metabolism in the rat brain during the first 24 hr of postnatal life were studied. The content of glutamic acid decreased for the first 2 hr; it remained at the lowest level for the next 4 hr, when it began to increase. The content of alanine decreased ...

journal_title：Neurochemical research

authors： Noguchi T,Nomura M,Tsukada Y

更新日期：1980-10-01 00:00:00

abstract：:Agonist occupancy of muscarinic cholinergic receptors in human SH-SY-5Y neuroblastoma cells elicited two kinetically distinct phases of phosphoinositide hydrolysis when monitored by either an increased mass of inositol 1,4,5-trisphosphate, or the accumulation of a total inositol phosphate fraction. Within 5s of the ad...

journal_title：Neurochemical research

authors： Fisher SK,Slowiejko DM,McEwen EL

更新日期：1994-05-01 00:00:00

abstract：:The subcellular distribution of Ca2+/calmodulin-stimulated adenylate cyclase activity was studied in comparison with that of guanine nucleotide-stimulated cyclase activity. The distributions of these activities were similar among the crude fractions but differed among the purified subsynaptosomal fractions. The specif...

journal_title：Neurochemical research

authors： Bissen ST,Ueda T

更新日期：1986-03-01 00:00:00

abstract：:Glutamate and its receptors are expressed very early during development and may play important roles in neurogenesis, synapse formation and brain wiring. The levels of glutamate and activity of its receptors can be influenced by exogenous factors, leading to neurodevelopmental disorders. To investigate the role of NMD...

journal_title：Neurochemical research

authors： Ghiani CA,Beltran-Parrazal L,Sforza DM,Malvar JS,Seksenyan A,Cole R,Smith DJ,Charles A,Ferchmin PA,de Vellis J

更新日期：2007-02-01 00:00:00

abstract：:6-Hydroxydopamine (6-OHDA) induces the production of reactive oxygen species (ROS) that are associated with various neurodegenerative diseases such as Parkinson's disease. 3,3',4',7-Tetrahydroxyflavone (fisetin), a plant flavonoid has a variety of physiological effects such as antioxidant activity. In this study, we i...

journal_title：Neurochemical research

authors： Watanabe R,Kurose T,Morishige Y,Fujimori K

更新日期：2018-02-01 00:00:00

abstract：:Previous studies suggest that alterations of brain glutamate synthesis and release occur in experimental thiamine deficiency. In order to assess the integrity of post-synaptic glutamatergic receptors in thiamine deficiency, binding sites for [3H]glutamate (displaced by NMDA), [3H]-kainate, and [3H]quisqualate (AMPA si...

journal_title：Neurochemical research

authors： Peterson C,Héroux M,Lavoie J,Butterworth RF

更新日期：1995-10-01 00:00:00

abstract：:The exposure to hypobaric hypoxia increased lipid peroxidation as indicated by thiobarbituric acid-reactive substances [TBARS] in rat brain. Plasma lactate/pyruvate ratio was used as a marker of hypoxia. We compared the protective effect of alpha-tocopherol with the effect of L-carnitine or phosphocreatine. Rats pretr...

journal_title：Neurochemical research

authors： Rauchová H,Koudelová J,Drahota Z,Mourek J

更新日期：2002-09-01 00:00:00

abstract：:Precise control of the proliferation and differentiation of multipotent neural stem cells (NSCs) is crucial for the proper development of the nervous system. Although cyclinD1 has been implicated as a cause of cancer in many studies, its roles in NSCs remain elusive. In this study, we examined the over-expression of c...

journal_title：Neurochemical research

authors： Ma J,Cui B,Ding X,Wei J,Cui L

更新日期：2015-08-01 00:00:00

abstract：:Exercise increases both the consumption of oxygen and the production of reactive species in biological tissues, and this is counterbalanced by antioxidant adaptations to regular physical training. When the intensity of exercise fluctuates between mild and moderate, it improves the status of reduction-oxidation balance...

journal_title：Neurochemical research

authors： Speck AE,Tromm CB,Pozzi BG,Paganini CS,Tuon T,Silveira PC,Aguiar AS Jr,Pinho RA

更新日期：2014-08-01 00:00:00

abstract：:Isorhynchophylline (IRN), an oxindole alkaloid, has been identified as the main active ingredient responsible for the biological activities of Uncaria rhynchophylla (Miq) Miq ex Havil. (Rubiaceae). Previous studies in our laboratory have revealed that IRN possesses potent neuroprotective effects in different models of...

journal_title：Neurochemical research

authors： Xian YF,Fan D,Ip SP,Mao QQ,Lin ZX

更新日期：2017-02-01 00:00:00