Abstract：
:The study aimed to directly measure in vivo superoxide radical (O*2) a direct indicator of oxidative stress, in the brain of rats with experimentally induced obstructive jaundice by employing a new quantitative ultrasensitive fluorescent assay requiring minimum sample. O*2 anion is specific for dihydroethidine (DHE) and upon reaction gives a characteristic product, namely 2-OH-ethidium. Ten male rats underwent laparotomy and were divided into two groups: I, sham operated and II bile duct ligation. Ten days later, following injection with DHE (a O*2 trap), all animals were killed and samples from cerebral cortex, midbrain and cerebellum were removed for analysis. It was shown that compared to group I, in group II the O*2 was increased by 67% in the cerebral cortex and by 37% in the midbrain as a consequence of experimental obstructive jaundice, while its levels were unaffected in the cerebellum. The data in this experimental obstructive jaundice model imply a region-specific increase of O*2 formation rate, being higher in cerebral cortex, less so in the midbrain and not at all in cerebellum.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Konstantinou D,Mavrakis A,Grintzalis K,Papapostolou I,Assimakopoulos SF,Chroni E,Georgiou Cdoi
10.1007/s11064-007-9556-xsubject
Has Abstractpub_date
2008-06-01 00:00:00pages
1101-5issue
6eissn
0364-3190issn
1573-6903journal_volume
33pub_type
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