Abstract：
:More than a decade has passed since Zic family zinc finger proteins were discovered to be transcription factors controlling neuroectodermal differentiation (neural induction) in Xenopus laevis embryos. Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation, recent studies have revealed that FGF signaling and intracellular calcium elevation are also involved in regulating the expression of Zic genes. Different regulatory mechanisms have been found for the Zic1 and Zic3 genes, raising the possibility that functional synergism between them partly accounts for the integration of BMP-signal blocking and FGF signaling in neuroectodermal differentiation. Furthermore, mammalian Zic1 and Zic3 have been found to be neural-cell-fate-inducing and pluripotency-maintaining factors, respectively, leading us to the intriguing question of whether the mechanism underlying amphibian neuroectodermal differentiation is applicable to mammals. Comprehensive understanding of the Zic family genes is therefore essential for the study of the neuroectodermal differentiation and stem cell biology.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Aruga J,Mikoshiba Kdoi
10.1007/s11064-011-0422-5subject
Has Abstractpub_date
2011-07-01 00:00:00pages
1286-92issue
7eissn
0364-3190issn
1573-6903journal_volume
36pub_type
杂志文章,评审abstract：:Since 1973, multiple effects of basic fibroblast growth factor have been described in a large number of cells. These effects include proliferation, survival and differentiation. The aim of this work was to study the intracellular pathways involved in the basic fibroblast growth factor (FGF2) effect on rat retinal cell...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9491-x
更新日期：2008-05-01 00:00:00
abstract：:The abnormal production of short chain fatty acid (SCFAs) caused by gut microbial dysbiosis plays an important role in the pathogenesis and progression of Parkinson's disease (PD). This study sought to evaluate how butyrate, one of SCFAs, affect the pathology in a subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03074-3
更新日期：2020-09-01 00:00:00
abstract：:TRH-like immunoreactivity distinct from TRH is present in various tissues and fluids. In order to determine whether TRH-like molecules are secreted by the hypothalamus, we analyzed tissues and media from hypothalamic slices incubated in Krebs Ringer bicarbonate. Media from basal or high KCl conditions contained 3 TRH-...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020993527602
更新日期：1999-07-01 00:00:00
abstract：:Uridine, a pyrimidine nucleoside, has been proposed to be a potential signaling molecule in the central nervous system. The understanding of uridine release in the brain is therefore of fundamental importance. The present study was performed to determine the characteristics of basal and morphine-induced uridine releas...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0903-1
更新日期：2013-01-01 00:00:00
abstract：:It is known that the NMDA-R NR1 subunit is needed for the receptor activity and that under hypoxia the evolution toward apoptosis or neuronal survival depends on the balance NR2A/NR2B subunits. This paper analyzes the effect of acute hypoxia on the above mentioned subunits mRNAs during development. The mean percentage...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0221-4
更新日期：2010-10-01 00:00:00
abstract：:NMDA, the specific agonist of glutamate gated ion channels permeable to calcium, is implicated as a causal factor in the pathogenesis of several neurobiological disorders such as stroke, seizures, ischemia, and chronic neurodegenerative diseases. On the other hand, evidence on the roles of oxidative mechanisms involve...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02533102
更新日期：1996-12-01 00:00:00
abstract：:The primary objective of this investigation was to assess the neuroprotective efficacy of spice active principles namely Eugenol (Eug) and isoeugenol (IE) in an acrylamide (ACR) neuropathy model in rats. In the present study, ACR administration (50 mg/kg bw, i.p. 3 times/week) for 5 weeks to growing rats caused typica...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0924-9
更新日期：2013-02-01 00:00:00
abstract：:The phospholipid requirement for Ca2+-stimulated, Mg2+-dependent ATP hydrolysis (Ca2+/Mg2+-ATPase) and Mg2+-stimulated ATP hydrolysis (Mg2+-ATPase) in rat brain synaptosomal membranes was studied employing partial delipidation of the membranes with phospholipase A2 (Hog pancreas), phospholipase C (Bacillus cereus) and...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966224
更新日期：1986-10-01 00:00:00
abstract：:A study of separate and combined actions of cobra venom (CV) and a new hypothalamic proline-rich polypeptide (PRP) isolated from magnocellular cells (NPV and NSO) on intoxication- and trauma-induced neuronal injury (during 3-4 weeks after hemisection with and without PRP treatment) was carried out. The registration of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1012353005489
更新日期：2001-09-01 00:00:00
abstract：:Nitric oxide has been strongly implicated in the development of tissue infarction in response to focal cerebral ischemia. Nitric oxide and its derivatives can inhibit components of the electron transport chain, providing a likely target for these substances in ischemic and post-ischemic brain. Lactate content is incre...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9160-5
更新日期：2007-04-01 00:00:00
abstract：:This study was designed to investigate the protective effects of extracellular superoxide dismutase (SOD3) against hydrogen peroxide (H2O2) induced damage in human neuroblastoma SH-SY5Y cells and to elucidate the mechanisms responsible for this beneficial effect. SOD3-overexpressing SH-SY5Y cells were generated by ade...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1897-x
更新日期：2016-07-01 00:00:00
abstract：:Protein misfolding and deposition in the brain are implicated in the etiology of numerous neurodegenerative disorders. Here, organic solutes characteristic of microorganisms adapted to hot environments, were tested on experimental cell models of Huntington's and Parkinson's diseases. Diglycerol phosphate, di-myo-inosi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0440-3
更新日期：2011-06-01 00:00:00
abstract：:Abnormal myo-[2-3H]inositol incorporation into phosphatidylinositol has been found in phentolamine-treated synaptosomes that were isolated from the cerebral hemispheres of galactose toxic rats and incubated with [33P]Pi and myo-[2-3H] inositol. In galactose toxic rats phentolamine-stimulated myo-[2-3H]inositol labelin...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965068
更新日期：1982-01-01 00:00:00
abstract：:The effects of a number of drugs that deplete catecholamines or block their receptors were investigated on the levels of free amino acids and glutamate decarboxylase activity in rat striatum and substantia nigra, in an attempt to clarify the possible links between catecholamine and amino acid transmitter function. Whi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966009
更新日期：1977-10-01 00:00:00
abstract：:The folate cycle, which has a close correlation with nucleic acid synthesis as well as with sulfur amino acid metabolism, may have some bearing on the pathogenesis of amyotrophic lateral sclerosis. The folate cycle hypothesis offers a unified explanation of the reduction of RNA and the elevation of taurine in nervous ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963985
更新日期：1984-03-01 00:00:00
abstract：:Carp (Cyprinus carpio L.) whole brain was used to investigate the thermal acclimation changes under normoxic conditions of three-subclasses (alkenylacyl-, alkylacyl- and diacyl-subclasses) of choline glycerophospholipids (CGP), ethanolamine glycerophospholipids (EGP) and inositol glycerophospholipids (IGP) as well as ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021937114401
更新日期：1997-10-01 00:00:00
abstract：:Using the mouse maximal electroshock test, the reference model of tonic-clonic seizures, the aim of the present study was to determine the type of interaction between mexiletine (a class IB antiarrhythmic drug) and classical antiepileptics: valproate, carbamazepine, phenytoin, and phenobarbital. Isobolographic analysi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1812-x
更新日期：2016-05-01 00:00:00
abstract：:Neuroglycan C (NGC) is a transmembrane-type chondroitin sulfate proteoglycan that promotes neurite outgrowth. To identify the ligand of NGC, we applied a detergent-solubilized membrane fraction of fetal rat brains to an NGC-immobilized affinity column. Several proteins were eluted from the column including an 18 kDa-b...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0164-9
更新日期：2010-08-01 00:00:00
abstract：:Mycobacterium leprae, the causative agent of leprosy, specifically invades and destroys the peripheral nerve, which results in the main clinical manifestation of the disease. Little is known about the bacteria-nerve protein interaction. We show in the present work that M leprae binds to a 25 kDa glycoprotein from huma...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022471331168
更新日期：1998-06-01 00:00:00
abstract：:The effects of the following drugs: nimodipine (1 mg/kg b.w., i.p.), 2-amino-5-phosphonovaleric acid (4 mg/kg b.w., i.p.) and propentofylline (25 mg/kg b.w., i.p.), administered (alone or in combination) at the end of 15 min bilateral ischemia in gerbils were evaluated on mitochondrial superoxide dismutase (SOD), glut...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966815
更新日期：1994-02-01 00:00:00
abstract：:Mitochondrial division inhibitor 1 (Mdivi-1) is the most effective pharmacological inhibitor of mitochondrial fission. Spinal cord injury (SCI) is a common and serious trauma, which lacks efficient treatment. This study aimed to detect the role of Mdivi-1 in neuronal injury and its underlying mechanism after acute SCI...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1604-3
更新日期：2015-07-01 00:00:00
abstract：:Changes in serotonin (5-HT) and 5-hydroxy indole acetic acid (5-HIAA), its major metabolite, in cerebral cortex, corpus striatum and hippocampus were investigated at 10th and 21st days of chronic ethanol ingestion in Wistar rats. Ethanol (7.2% v/v) was given to rats in a modified liquid diet. Biochemical analysis was ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1007579705230
更新日期：2000-02-01 00:00:00
abstract：:Intracerebral folate injections produce convulsions and brain lesions, folic acid itself and tetrahydrofolate being more potent toxins than 5-methyltetrahydrofolate, the primary folate of mammalian extracellular fluids. Folates are known to excite neurons, by unknown mechanisms Folates stimulate GTP binding and GTPase...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973648
更新日期：1990-07-01 00:00:00
abstract：:The role of repulsive guidance molecule A (RGMa) in cerebral ischemia remains unclear. In the study, we examined the expression of RGMa in ischemic brain tissues following focal cerebral ischemia/reperfusion (IR) in rats. An established middle cerebral artery suture occlusion model was employed. A dipolar electrode wa...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0809-y
更新日期：2012-09-01 00:00:00
abstract：:The present study was designed to evaluate the potential role of miR-93 in cerebral ischemic/reperfusion (I/R) injury in mice. The stroke model was produced in C57BL/6 J mice via middle cerebral artery occlusion (MCAO) for 1 h followed by reperfusion. And miR-93 antagomir was transfected to down-regulate the miR-93 le...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1975-0
更新日期：2016-10-01 00:00:00
abstract：:Paclitaxel (PTX) is an antineoplastic agent commonly used in the treatment of solid tumors and is known to cause dose-limiting peripheral neurotoxicity. This study was performed to evaluate the protective effect of curcumin (CUR) against PTX-induced spinal cord and sciatic nerve injuries in rats. The rats were adminis...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03174-0
更新日期：2020-11-17 00:00:00
abstract：:Serotonin (5HT) synthesis in brain is influenced by precursor (tryptophan (TRP)) concentrations, which are modified by food ingestion. Hence, in rats, a carbohydrate meal raises brain TRP and 5HT; a protein-containing meal does not, but little attention has focused on differences among dietary proteins. Recently, sing...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0382-1
更新日期：2011-03-01 00:00:00
abstract：:Dual-specificity tyrosine-regulated kinase 2 (DYRK2), a protein kinase that phosphorylates its substrates on serine/threonine, is expressed in numerous human tumors, but little is known about its role in the pathophysiology of glioma. In this study, we made an effort to explore the expression and function in human gli...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-017-2345-2
更新日期：2017-11-01 00:00:00
abstract：:Acute tryptophan depletion (ATD) is extensively used to investigate the role of central serotonin (5-HT). However, several studies reported that ATD had no significant effect on central 5-HT concentration and some ATD-induced changes was independent of 5-HT in the rodent brain. Therefore, the potential mechanism of AT...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1177-y
更新日期：2013-12-01 00:00:00
abstract：:Menadione (2-methyl-1,4-naphthoquinone) is a synthetic derivative of vitamin K that allows rapid redox cycling in cells and thereby generates reactive oxygen species (ROS). To test for the consequences of a treatment of brain astrocytes with menadione, we incubated primary astrocyte cultures with this compound. Incuba...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02760-1
更新日期：2019-05-01 00:00:00
