Abstract:
:Mycobacterium leprae, the causative agent of leprosy, specifically invades and destroys the peripheral nerve, which results in the main clinical manifestation of the disease. Little is known about the bacteria-nerve protein interaction. We show in the present work that M leprae binds to a 25 kDa glycoprotein from human peripheral nerve. This protein is phosphorylatable and it binds to lectins which have alpha-mannose specificity. This M leprae-protein interaction could be of importance in the pathogenesis of leprosy.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Suneetha LM,Satish PR,Korula RJ,Suneetha SK,Job CK,Balasubramanian ASdoi
10.1023/a:1022471331168subject
Has Abstractpub_date
1998-06-01 00:00:00pages
907-11issue
6eissn
0364-3190issn
1573-6903journal_volume
23pub_type
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journal_title:Neurochemical research
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abstract::Neuroprotectin D1 (NPD1), a docosahexaenoic acid (DHA)-derived lipid mediator, promotes survival in cells exposed to oxidative stress by inducing the activity of anti-inflammatory mediators and suppressing the expression of pro-inflammatory genes. Though retinal pigment epithelial (RPE) cells naturally produce NPD1 fr...
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更新日期:1996-07-01 00:00:00
abstract::Implication of protein phosphatases in Alzheimer disease led us to a systemic investigation of the identification of these enzyme activities in human brain. Human brain phosphatases eluted from DEAE-Sephacel with 0.22 M NaCl were resolved into two main groups by affi-gel blue chromatography, namely affi-gel blue-bindi...
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更新日期:2000-01-01 00:00:00
abstract::cDNA microarray analysis of 1-methyl-4-phenyl-pyridinium (MPP+) toxicity (1 mM, 72 h) in undifferentiated SH-SY5Y cells identified 48 genes that displayed a signal intensity greater than the mean of all differentially expressed genes and a two-fold or greater difference in normalized expression. RT-PCR analysis of a s...
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更新日期:2003-12-01 00:00:00
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journal_title:Neurochemical research
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更新日期:2016-06-01 00:00:00
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更新日期:2019-02-01 00:00:00
abstract::The protein composition of myelin isolated from the CNS of four different fish species (trout, goldfish), eel, Tilapia) was analysed by SDS-polyacrylamide gel electrophoresis and compared with that of pig and rat brain. Thereby the following features were found typical to the myelin of fish: (1) a basic protein of par...
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pub_type: 杂志文章
doi:10.1007/BF00998271
更新日期:1993-08-01 00:00:00