Abstract：
:The hypothalamic paraventricular nucleus (PVN) is a key site for regulating neuroendocrine functions in the magnocellular part and autonomic activities in the parvocellular part. Its anatomical proximity to the third ventricle could be a good target for intrathecal injection of baclofen. We investigated the correlation of intrathecal application of baclofen (a specific GABAB receptor agonist) and the release of epinephrine, norepinephrine, dopac, homovanillinic acid (HVA), glutamate and aspartate from the PVN. The decomposition products HVA, dopa and dopac of norepinephrine, epinephrine and dopamine, respectively, were used as parameters for the secretion of dopamine. We implanted a microdialysis probe in the PVN of 25 Wistar rats. In 13 rats, 1.5 μg baclofen was injected in the lateral ventricle and the equivalent quantity of Ringer's lactate solution injected in the remaining 12 rats as a control group. Neurotransmitters and amino acids were quantified by high-performance liquid chromatography. There was a conspicuous but not significant effect of baclofen concerning the secretion of epinephrine, norepinephrine, dopac, glutamate and aspartate from the PVN. A significant increase in HVA concentration was observed only in rats treated with baclofen compared with the control group. These findings suggest that baclofen influences the secretion of neurotransmitters and amino acids involved in autonomic activities mediated by GABAB receptors.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Czell D,Efe T,Preuss M,Schofer MD,Becker Rdoi
10.1007/s11064-011-0621-0subject
Has Abstractpub_date
2012-02-01 00:00:00pages
381-6issue
2eissn
0364-3190issn
1573-6903journal_volume
37pub_type
杂志文章abstract：:We observed a spot on two-dimensional (2-D) gel in the epileptic mutant strain E1 mice with a similar molecular weight but with a different isoelectric point of approximately 0.2, compared with its mother strain ddY mice. The collected protein from the E1 mice was identified as cytosolic NADP+-dependent isocitrate deh...
journal_title：Neurochemical research
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doi：10.1023/a:1020981532281
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abstract：:In human pathology little is known about the activating enzymes for fatty acids of different carbon chain length. In order to have a better insight into disorders of lipid metabolism in human skeletal muscle, we studied the distribution of acyl-CoA synthetases in muscular subcellular fractions. We find that in muscle ...
journal_title：Neurochemical research
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doi：10.1007/BF00964696
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964355
更新日期：1981-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1023/a:1020788031720
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更新日期：1987-01-01 00:00:00
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更新日期：2015-08-01 00:00:00
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doi：10.1007/s11064-019-02747-y
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更新日期：2014-07-01 00:00:00
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doi：10.1007/BF00973280
更新日期：1988-07-01 00:00:00
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更新日期：1987-10-01 00:00:00
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journal_title：Neurochemical research
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更新日期：1994-03-01 00:00:00
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journal_title：Neurochemical research
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更新日期：1983-02-01 00:00:00
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doi：10.1007/BF00964417
更新日期：1981-10-01 00:00:00
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journal_title：Neurochemical research
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更新日期：2017-03-01 00:00:00
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更新日期：2016-05-01 00:00:00
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更新日期：2020-04-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964363
更新日期：1978-02-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
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