Abstract:
:The effect of optic nerve transsection on proteolytic degradation of axonally transported proteins in the superior colliculus of the rabbit was studied. Proteolysis of labeled proteins was determined in vitro in small pieces of the superior colliculus. Within 2 hours after sectioning the optic nerve there was a decreased degradation of slowly transported labeled proteins in the nerve terminals in the superior colliculus.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Gustavsson S,Karlsson JOdoi
10.1007/BF00973280subject
Has Abstractpub_date
1988-07-01 00:00:00pages
633-5issue
7eissn
0364-3190issn
1573-6903journal_volume
13pub_type
杂志文章abstract::The mechanism of focal demyelination in multiple sclerosis has been a long-standing enigma of this disorder. Cytokines, a diverse family of signalling molecules, are viewed as potential mediators of the process based on clinical observations and studies with animal models and tissue/cell culture systems. Myelin and ol...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1022493013904
更新日期:1998-03-01 00:00:00
abstract::A simple, rapid method for determining depolarization-induced 45Ca influx into synaptosomes is described. Synaptosomes which had been depolarized in the presence of 45Ca were applied to a small column of Chelex-100 resin to separate free Ca2+ from that taken up by the tissue. Approximately 70% of the synaptosomal prot...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965062
更新日期:1982-02-01 00:00:00
abstract::The binding of the enkephalin dimer [D-Ala2, Leu5-NH-CH2-]2 (DPE2) is characterized by its high affinity for receptors on NG108-15 hybrid cells, the affinity constant K = 4.7 X 10(9) M-1 is up to 8-fold that of monomers (0.6 to 1.0 X 10(9) M-1), and a maximal binding capacity equal to one half that of the monomers. Ki...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965208
更新日期:1986-06-01 00:00:00
abstract::The pineal gland is a neuroendocrine gland responsible for nocturnal synthesis of melatonin. During early development of the rodent pineal gland from the roof of the diencephalon, homeobox genes of the orthodenticle homeobox (Otx)- and paired box (Pax)-families are expressed and are essential for normal pineal develop...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-012-0906-y
更新日期:2013-06-01 00:00:00
abstract::The effect of phenobarbital (100 mg/kg i.p.) and 6-aminonicotinamide (6AN) (35 mg/kg i.p.) on enzyme activities related to energy transduction was investigated on the homogenate "in toto", non-synaptic mitochondrial fraction and synaptosomal fraction isolated from different rat brain areas (cerebral cortex, hippocampu...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00971361
更新日期:1987-01-01 00:00:00
abstract::A phosphoinositide-linked peptide response in cultured rat astrocytes was studied by measuring the accumulation of [3H]inositol phosphates in the presence of lithium. Cultures derived from cortex, cerebellum and spinal cord each showed a unique pattern or degree of stimulation to a panel of neuropeptides. Cortical and...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00972490
更新日期:1988-04-01 00:00:00
abstract::The real-time iontophoretic method has measured volume fraction and tortuosity of the interstitial component of extracellular space in many regions and under different conditions. To interpret these data computer models of the interstitial space (ISS) of the brain are constructed by representing cells as Basic Cellula...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02793-6
更新日期:2020-01-01 00:00:00
abstract::Addiction is a debilitating, chronic psychiatric disorder that is difficult to cure completely owing to the high rate of relapse. Behavioral sensitization is considered to may underlie behavioral changes, such as relapse, caused by chronic abuse of psychomotor stimulants. Thus, its animal models have been widely used ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1976-z
更新日期:2016-10-01 00:00:00
abstract::The effects of 1 min of acute hypoxic treatment (1% O2 in N2) on incorporation of [1-14C]arachidonic acid into brain lipids of 16-day-old rats were investigated at 3, 6, and 12 min after intracerebral injection of the labeled fatty acid. The hypoxic-hypoxia condition associated with convulsive seizures caused a decrea...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965474
更新日期:1981-07-01 00:00:00
abstract::Evidence has suggested that cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) is correlated with the development and recurrence of pain. A recent research showed that the CSF-contacting nucleus acts as a component of the descending 5-hydroxytryptamine (5-HT) system and plays a role in descending pain inh...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1880-6
更新日期:2016-07-01 00:00:00
abstract::This study investigated the effects of aging on the actions of a specific glutamate reuptake blocker, L-trans-pyrrolidine-2, 4-dicarboxylic acid (PDC), in extracellular glutamate and glutamine in striatum of the awake rat. Microdialysis experiments were performed on young (2-3 months), middle-aged (12-14 months), aged...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1007624531077
更新日期:2001-01-01 00:00:00
abstract::Rat posterior eyecups containing the retina were prepared, loaded with [(3)H]glycine and superfused in order to determine its release originated from glycinergic amacrine cells and/or glial cells. Deprivation of oxygen and glucose from the Krebs-bicarbonate buffer used for superfusion evoked a marked increase of [(3)H...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1713-z
更新日期:2016-02-01 00:00:00
abstract::A number of recent findings support the notion of mechanistic parallels between Alzheimer disease (AD) and oncogenic processes, specifically, that neurons in AD, like cancer cells, display aberrant mitotic cell cycle re-entry. However, the mechanism that drives postmitotic neurons to reenter cell cycle remains elusive...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9146-3
更新日期:2007-04-01 00:00:00
abstract::Cholinesterase activities in rat forebrain, erythrocytes, and plasma were assessed after a single oral administration of metrifonate or dichlorvos. In 3-month-old rats, the dichlorvos (10 mg/kg p.o.)induced inhibition of cholinesterase reached its peak in brain after l5-45 min and after 10-30 min in erythrocytes and p...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF02531650
更新日期:1996-03-01 00:00:00
abstract::Treatment of neural membranes from rat cerebral cortex with phospholipase C (phosphatidylcholine cholinephosphohydrolase) inhibited the binding of radiolabelled antagonists to muscarinic acetylcholine receptors. This inhibition was incomplete, was not competitive, and did not appear to be related to the production of ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964517
更新日期:1984-05-01 00:00:00
abstract::Regional cerebral glucose utilization (RCGU) and behavior were studied during naloxone-precipitated withdrawal in rats after chronic intravenous (IV) or intracerebroventricular (ICV) administration of sufentanil citrate, a potent, highly selective mu opiate agonist. Changes in RCGU were indistinguishable between the t...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF01006813
更新日期:1994-10-01 00:00:00
abstract::Convulsant doses of penicillin and elevated ambient pressure of 41 bar enhance the excitability of neurons. Their effects have been studied in neostriatal tissue with methods allowing differentiation between transmitter and metabolic glutamate pools. Levels of glutamate (Glu), glutamine (Gln), aspartate (Asp); gamma-a...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965621
更新日期:1989-11-01 00:00:00
abstract::In this report data are summarized on changes in the quantity of proteolipid protein (PLP), its amino acid composition, and the lipid moiety of these lipid-protein complexes in rat brain during postnatal development. In all three parts of the central nervous system (CNS) studied (cerebral hemispheres, medulla oblongat...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:
更新日期:1985-11-01 00:00:00
abstract::In the present paper we describe the presence in avian CNS of an endogenous inhibitor of [3H]flunitrazepam binding. This compound was extracted from a synaptic membrane fraction isolated from chick optic lobe and brain using an exhaustive aqueous washing procedure, then purified by means of solid-phase extraction with...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020702823600
更新日期:1998-11-01 00:00:00
abstract::We investigated the ability of hydrogen peroxide (H2O2) to cause apoptotic cell death in cultured rat forebrain neurons and the potential mechanisms by which oxidative stress triggers delayed neuronal death. H2O2 (25 microM for 5 min) reduced cell viability to 34.5 +/- 8.3% of untreated controls 20 h after exposure, a...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022403224901
更新日期:1997-03-01 00:00:00
abstract::Curcumin (diferuloyl), from the Indian spice turmeric, reduces oxidative damage and induces apoptosis. Utilizing DNA microarrays, we have demonstrated that a low (5 microM) dose of curcumin added to a mixture of astrocytes and oligodendrocytes (C6 rat glioma cells) in culture for 24 and 48 h significantly modulates ge...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9608-x
更新日期:2008-09-01 00:00:00
abstract::The concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites were determined in 5 brain areas of non-pregnant, 15 and 20 day pregnant and 4 day post-partum rats. Striatal 5-HT content was significantly lower in 15 and 20 day pregnant rats than in estrous controls. A significant decr...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965738
更新日期:1990-10-01 00:00:00
abstract::Incubation of membranes derived from sarcotubular system of rabbit skeletal muscle with increasing concentrations of Triton X-100 produced both stimulation of the AChE activity and solubilization of this enzyme. Mild proteolytic treatment of microsomal membranes produced a several fold activation of the still membrane...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00969639
更新日期:1989-02-01 00:00:00
abstract::Planarians are rapidly developing into very useful research subjects in pharmacology and neuroscience research. Here we report that curare, a cholinergic nicotinic receptor antagonist, alleviates the nicotine-induced planarian seizure-like movements (pSLM) by up to 50 % at equimolar concentrations of nicotine and cura...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1512-6
更新日期:2015-10-01 00:00:00
abstract::Brofaromine, a selective and reversible inhibitor of monoamine oxidase-A (MAO-A) was given to 19 women while 17 received placebo for 8 weeks. All met DSM III-R criteria for bulimia nervosa, a psychiatric disorder in which uncontrolled overeating episodes are accompanied by purging activities and extreme concerns about...
journal_title:Neurochemical research
pub_type: 临床试验,杂志文章
doi:10.1007/BF00975048
更新日期:1993-12-01 00:00:00
abstract::The composition of retrogradely transported axonal proteins was examined by acrylamide gel electrophoresis and gel autoradiography in the experimental neuropathy induced in rats by p-bromophenylacetylurea (BPAU). Protein composition was normal during the early phase of retrograde transport but showed significant abnor...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966781
更新日期:1993-06-01 00:00:00
abstract::Since 1973, multiple effects of basic fibroblast growth factor have been described in a large number of cells. These effects include proliferation, survival and differentiation. The aim of this work was to study the intracellular pathways involved in the basic fibroblast growth factor (FGF2) effect on rat retinal cell...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9491-x
更新日期:2008-05-01 00:00:00
abstract::Isoleucine, together with leucine and valine, constitutes the group of branched-chain amino acids (BCAAs). BCAAs are transported from the blood into the brain parenchyma, where they can serve several distinct functions. Since brain tissue is known to oxidatively metabolize BCAAs to CO(2), they are considered as fuel m...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9840-4
更新日期:2009-01-01 00:00:00
abstract::N-methyl-D-aspartate (NMDA) inhibits carbachol-stimulated phosphoinositide breakdown in rat brain cortical slices but not in isolated membranes (1). To gain insight into the mechanisms, we examined the effects of NMDA on carbachol-stimulated [3H]inositol phosphate and intermediates of phosphatidylinositol cycle accumu...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022426204583
更新日期:1997-05-01 00:00:00
abstract::As is known to all, neuroinflammation plays a vital role in early brain injury pathogenesis following subarachnoid hemorrhage (SAH). It has been shown that rutin have a property of inhibiting inflammation in many kinds of animal models. However, the effect of rutin on neuroinflammation after SAH remains uninvestigated...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1863-7
更新日期:2016-06-01 00:00:00