Rat brain monoamine and Serotonin S2 receptor changes during pregnancy.

abstract：:Pyroptosis is a newly identified lytic form of programmed cell death which is characterized by plasma membrane blebbing and rupture. Pyroptosis occurs in cerebral ischemia injury, and contributes to the activation and secretion of the inflammatory cytokines interleukin (IL)-1β, IL-18, and IL-6. Previous reports have f...

journal_title：Neurochemical research

authors： Liu D,Dong Z,Xiang F,Liu H,Wang Y,Wang Q,Rao J

更新日期：2020-02-01 00:00:00

abstract：:The present studies examined the inhibitory effect of veratridine (a Na+ channel activator) on carbachol (a cholinergic agonist) stimulated inositol 1,3,4,5-tetrakisphosphate accumulation in rat brain cortical slices. Veratridine inhibited carbachol stimulation of inositol 1,3,4,5-tetrakisphosphate formation (after a ...

journal_title：Neurochemical research

authors： Myles ME,Gokmen-Polar Y,Fain JN

更新日期：1995-09-01 00:00:00

abstract：:Parkinson's disease (PD) is a common progressive neurodegenerative disorder, for which at present no causal treatment is available. On the understanding that the causes of PD are mainly oxidative stress and mitochondrial dysfunction, antioxidants and other drugs are expected to be used. In the present study, we demons...

journal_title：Neurochemical research

authors： Jimenez-Del-Rio M,Guzman-Martinez C,Velez-Pardo C

更新日期：2010-02-01 00:00:00

abstract：:Sandhoff disease is an incurable neurodegenerative disorder caused by mutations in the lysosomal hydrolase β-hexosaminidase. Deficiency in this enzyme leads to excessive accumulation of ganglioside GM2 and its asialo derivative, GA2, in brain and visceral tissues. Small molecule inhibitors of ceramide-specific glucosy...

journal_title：Neurochemical research

authors： Arthur JR,Wilson MW,Larsen SD,Rockwell HE,Shayman JA,Seyfried TN

更新日期：2013-04-01 00:00:00

abstract：:Incomplete ischemia of the spinal cord was produced in dogs by 40 min occlusion of the abdominal aorta that was followed by 5-40 min of recirculation. Amino acid incorporation into ribosomes in vitro in the presence of venous blood sera was estimated. The most significant reduction in incorporation was produced by ser...

journal_title：Neurochemical research

authors： Chavko M,Burda J,Marsala J

更新日期：1986-06-01 00:00:00

abstract：:The present study investigated the expression patterns of glial cells and interleukin-1beta (IL-1beta) in the rat spinal cord after a surgical incision, which is closely related with clinical postoperative pain. Microglia and astrocytes became activated in the spinal cord following incision. Real-time polymerase chain...

journal_title：Neurochemical research

authors： Fu D,Guo Q,Ai Y,Cai H,Yan J,Dai R

更新日期：2006-03-01 00:00:00

abstract：:Ingestion of ammonium induces hyperammonemia which increases tubulin content in cerebrum but not in cerebellum. We have dissected 11 discrete areas of cerebrum and quantified the tubulin content in control and hyperammonemic rats. An heterogeneity in the induction of tubulin is shown. The areas more affected are ventr...

journal_title：Neurochemical research

authors： Miñana MD,Felipo V,Quel A,Pallardó F,Grisolía S

更新日期：1989-12-01 00:00:00

abstract：:The acetylcholinesterase from synaptosomal membranes is inhibited by anesthetics: Nembutal, brietal, and thiopental. Nembutal and brietal decrease the Km for acetylthiocholine, without changes in Vmas. A noncompetitive type of inhibition is produced by thiopental. This anesthetic decreases Arrhenius plot discontinuity...

journal_title：Neurochemical research

authors： Pastuszko A

更新日期：1980-07-01 00:00:00

abstract：:Primary malignant brain cancer, one of the most deadly diseases, has a high rate of recurrence after treatment. Studies in the past several years have led to the hypothesis that the root of the recurrence may be brain tumor stem cells (BTSCs), stem-like subpopulation of cells that are responsible for propagating the t...

journal_title：Neurochemical research

authors： Xie Z

更新日期：2009-12-01 00:00:00

abstract：:The Src family kinases are a family of intracellular, non-receptor tyrosine kinases that are involved in a variety of cellular functions including the regulation of inflammation and apoptosis after brain hypoxia. Caspase-1 (C1) activates IL-1β through the formation of complex structures, the inflammasomes, while caspa...

journal_title：Neurochemical research

authors： Angelis D,Fontánez Nieves TD,Delivoria-Papadopoulos M

更新日期：2015-11-01 00:00:00

abstract：:A set of synaptic membrane antigens has been investigated in a number of tissues by indirect immunofluorescence histochemistry, using an antiserum (SPM-I) raised against a purified synaptosomal plasma membrane fraction prepared from day-old chick forebrain. The antigens were found to be present in both the central and...

journal_title：Neurochemical research

authors： Rostas JA,Jeffrey PL

更新日期：1977-02-01 00:00:00

abstract：:The wobbler mouse suffers an autosomal recessive mutation producing severe neurodegeneration and astrogliosis in spinal cord. It has been considered a model for amyotrophic lateral sclerosis. We have studied in these animals the expression of two proteins, the growth-associated protein (GAP-43) and the NADPH-diaphoras...

journal_title：Neurochemical research

authors： González Deniselle MC,González SL,Lima AE,Wilkin G,De Nicola AF

更新日期：1999-01-01 00:00:00

abstract：:The cyclic GMP analog 8-bromo-cyclic GMP (8-Br-cGMP) protects differentiated murine oligodendrocytes (OLs) from caspase-mediated death initiated by staurosporine, thapsigargin or kainate. Caspase-independent death caused by high levels of NO is also partially prevented by 8-Br-cGMP. Inhibitors of protein kinase G (cGM...

journal_title：Neurochemical research

authors： Benjamins JA,Nedelkoska L

更新日期：2007-02-01 00:00:00

abstract：:Brief limb ischemia was reported to protect neurons against injury induced by subsequent cerebral ischemia-reperfusion, and this phenomenon is known as limb ischemic preconditioning (LIP). To explore the role of nitric oxide (NO) in neuroprotection of LIP in rats, we observed changes in the content of nitric oxide (NO...

journal_title：Neurochemical research

authors： Zhao HG,Sun XC,Xian XH,Li WB,Zhang M,Li QJ

更新日期：2007-11-01 00:00:00

abstract：:The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental brain ischemia-reperfusion in rats. Present study was performed on the 34 male Wistar-albino rats, weigth 350-400 g. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; animal we...

journal_title：Neurochemical research

authors： Caliskan M,Mogulkoc R,Baltaci AK,Menevse E

更新日期：2016-07-01 00:00:00

abstract：:Mitochondrially bound brain hexokinase is solubilized by anesthetics and this effect has been suggested to contribute to anesthesia. In the present investigation the influence of the metabolic inhibitor 2-deoxy-D-glucose (2-DOG) was studied. An isolated rat brain preparation was used to avoid the contribution of perip...

journal_title：Neurochemical research

authors： Krieglstein J,Sperling G,Stock R

更新日期：1982-06-01 00:00:00

abstract：:Deciphering what governs inflammation and its effects on tissues is vital for understanding many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes inflammation reveals a new component of its well-documented actions in several prevalent diseases which involve inflammation, including mood...

journal_title：Neurochemical research

authors： Jope RS,Yuskaitis CJ,Beurel E

更新日期：2007-04-01 00:00:00

abstract：:Using a model of middle cerebral artery occlusion (MCAO), we have previously demonstrated that treadmill exercise promotes angiogenesis in the ischemic penumbra through caveolin-1/VEGF signaling pathways. However, the function of caveolin-1/VEGF signaling in neurogenesis after MCAO has not been determined. In this stu...

journal_title：Neurochemical research

authors： Zhao Y,Pang Q,Liu M,Pan J,Xiang B,Huang T,Tu F,Liu C,Chen X

更新日期：2017-02-01 00:00:00

abstract：:The current study demonstrates that in hippocampal neurons mitochondrial Ca(2+) processing supports Ca(2+) influx via ionotropic glutamate (Glu) receptors. We define mitochondrial Ca(2+) processing as Ca(2+) uptake via mitochondrial Ca(2+) uniporter (MCU) combined with subsequent Ca(2+) release via mitochondrial Na(+)...

journal_title：Neurochemical research

authors： Strokin M,Reiser G

更新日期：2016-06-01 00:00:00

abstract：:It is reported that chitinase1 increases in Alzheimer's disease (AD). However, the alteration of chitinase1 in the progress of AD is still unclear. Thus, we designed the present study to detect chitinase1 level in different stages of APP/PS1 double transgenic mice. Experimental models were APP/PS1 double transgenic mi...

journal_title：Neurochemical research

authors： Xiao Q,Shi R,Yang W,Zou Y,Du Y,Zhang M,Yu W,Lü Y

更新日期：2016-07-01 00:00:00

abstract：:Recently we have demonstrated that extracellular ATP acts as an excitatory neurotransmitter and enhances cell death in the presence of ferrous ions. By using a newly developed cis-parinaric acid fluorescence technique, we demonstrated that ATP, in a dose dependent manner, enhanced the increased membrane lipid peroxida...

journal_title：Neurochemical research

authors： Cheng Y,Chen M,James-Kracke M,Wixom P,Sun AY

更新日期：1996-01-01 00:00:00

abstract：:The effects of acute lorazepam challenges on plasma (p) HVA, MHPG, and 5-HIAA, and their relationship to drug-induced cognitive and motor deficits and the apolipoprotein (APOE)-epsilon4 allele were examined. Eighteen healthy elderly (8 epsilon4 carriers) received placebo or acute oral lorazepam doses (0.5 mg or 1 mg) ...

journal_title：Neurochemical research

authors： Pomara N,Willoughby LM,Hashim A,Sershen H,Sidtis JJ,Wesnes K,Greenblatt DJ,Lajtha A

更新日期：2004-07-01 00:00:00

abstract：:The lysosomal degradation of several sphingolipids requires the presence of four small glycoproteins called saposins, generated by proteolytic processing of a common precursor, prosaposin. Saposins share several structural properties, including six similarly located cysteines forming three disulfide bridges with the s...

journal_title：Neurochemical research

authors： Vaccaro AM,Salvioli R,Tatti M,Ciaffoni F

更新日期：1999-02-01 00:00:00

abstract：:The microdialysis technique was utilized to study the local effects of D1 and D2 family type dopamine (DA) receptor (R) ligands on the in vivo release of endogenous glutamate (GLU) and aspartate (ASP) from rat substantia nigra (SN). Addition to the dialysis perfusion solution of either D1-R and D2-R agonists, such as ...

journal_title：Neurochemical research

authors： Abarca J,Gysling K,Roth RH,Bustos G

更新日期：1995-02-01 00:00:00

abstract：:The aim of this study is to investigate differences in thyroid-stimulating hormone (TSH) level in patients with acute schizophrenia, unipolar depression, bipolar depression and bipolar mania. Serum level of TSH was measured in 1,685 Caucasian patients (1,064 women, 63.1%; mean age 46.4). Mean serum TSH concentration w...

journal_title：Neurochemical research

authors： Wysokiński A,Kłoszewska I

更新日期：2014-07-01 00:00:00

abstract：:Myelinating cells of both the peripheral and central nervous systems (CNSs) undergo dramatic cytoskeletal reorganization in order to differentiate and produce myelin. Myelinating oligodendrocytes in the CNS show a periodic actin pattern, demonstrating tight regulation of actin. Furthermore, recent data demonstrate tha...

journal_title：Neurochemical research

authors： Brown TL,Macklin WB

更新日期：2020-03-01 00:00:00

abstract：:Subacute exposure to manganese (Mn) produced Parkinson's disease-like syndrome called Manganism. Chronic onset and progression are characteristics of Manganism, therefore, this study aimed to examine Mn toxicity following chronic exposures. Male Sprague-Dawley rats were injected Mn2+ 1 and 5 mg/kg, every 10 days for 1...

journal_title：Neurochemical research

authors： Fan XM,Luo Y,Cao YM,Xiong TW,Song S,Liu J,Fan QY

更新日期：2020-08-01 00:00:00

abstract：:This study evaluates whether physiological variables differentially affect the local synthesis of protein constituents of synapses in subcellular fractions containing pinched-off dendrites (synaptodendrosomes). Synaptodendrosomes were pulse-labeled in a medium containing 35S-methionine with 3 or 25 mM KCl and in the p...

journal_title：Neurochemical research

authors： Leski ML,Steward O

更新日期：1996-06-01 00:00:00

abstract：:In our previous study vesamicol, an inhibitor of the acetylcholine transporter of the cholinergic vesicles, inhibited veratridine-evoked external Ca(2+)-dependent acetylcholine release from striatal slices but did not influence acetylcholine release observed in Ca(2+)-free medium (4). Here we examined if the effect of...

journal_title：Neurochemical research

authors： Deri Z,Adam-Vizi V

更新日期：1992-06-01 00:00:00

abstract：:The effects of mu, delta, and kappa receptor-agonists on forskolin stimulated cyclic adenosine-3',5'-monophosphate (cAMP) formation were examined in astroglial enriched primary cultures from the cerebral cortex of newborn rats. Intracellular cAMP accumulation was quantified by radioimmunoassay. Morphine was used as a ...

journal_title：Neurochemical research

authors： Eriksson PS,Hansson E,Rönnbäck L

更新日期：1990-11-01 00:00:00