The role of nitric oxide in the neuroprotection of limb ischemic preconditioning in rats.

abstract：:Neuronal excitation leads to an increase of the extracellular K(+) concentration ([K(+)]o) in brain. This increase has at least two energy-consuming consequences: (1) a depolarization-mediated change in intracellular pH (pHi) in astrocytes due to depolarization-mediated increased activity of the acid-extruding Na(+)/b...

journal_title：Neurochemical research

authors： Song D,Man Y,Li B,Xu J,Hertz L,Peng L

更新日期：2013-11-01 00:00:00

abstract：:Turmeric has been in use since ancient times as a condiment and due to its medicinal properties. Curcumin, the yellow colouring principle in turmeric, is polyphenolic and major active constituent. Besides anti-inflammatory, thrombolytic and anticarcinogenic activities, curcumin also possesses strong antioxidant proper...

journal_title：Neurochemical research

authors： Shukla PK,Khanna VK,Ali MM,Khan MY,Srimal RC

更新日期：2008-06-01 00:00:00

abstract：:Metabotropic glutamate receptors (mGluR) play a role in synaptic transmission, neuronal modulation and plasticity but their action in epileptic activity is still controversial. On the other hand adenosine acts as a neuromodulator with endogenous anticonvulsive properties. Since cerebellum from epileptic patients has s...

journal_title：Neurochemical research

authors： Girardi ES,Canitrot J,Antonelli M,González NN,Coirini H

更新日期：2007-07-01 00:00:00

abstract：:In this paper, we show that caveolin-1 is abundantly present in a cell line of immortalized gonadotropin-releasing hormone-expressing neurons (GN11). In contrast to GN11, caveolin is undetectable in a cognate cell line of immortalized gonadotropin-releasing hormone-secreting neurons (GT1-7). These two cell lines are c...

journal_title：Neurochemical research

authors： Prioni S,Loberto N,Prinetti A,Chigorno V,Guzzi F,Maggi R,Parenti M,Sonnino S

更新日期：2002-08-01 00:00:00

abstract：:Hydroxysafflor yellow A (HSYA) is a component of the flower Carthamus tinctorius L. that elicits neuroprotective effects in vivo and in vitro. The purpose of this study was to investigate pharmacological properties of HSYA on neurotoxicity of glutamate in primary cultured rat cortical neurons along with its possible m...

journal_title：Neurochemical research

authors： Yang Q,Yang ZF,Liu SB,Zhang XN,Hou Y,Li XQ,Wu YM,Wen AD,Zhao MG

更新日期：2010-09-01 00:00:00

abstract：:Memory impairment is the most common symptom in patients with Alzheimer's disease. The purpose of this study is to evaluate the memory enhancing effects of P7C3, a recently identified compound with robust proneurogenic and neuroprotective effects, on the cognitive impairment induced by scopolamine, a muscarinic acetyl...

journal_title：Neurochemical research

authors： Jiang B,Song L,Huang C,Zhang W

更新日期：2016-05-01 00:00:00

abstract：:Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. The glycolytic inhibitor 2-deoxy-D-glucose (2-DG) has been reported to exert antiepileptic effects by upregulating KATP subunits (kir6.1 and kir6.2). We evaluated whether 2-DG exhibits anti-seizure effect by...

journal_title：Neurochemical research

authors： Long Y,Zhuang K,Ji Z,Han Y,Fei Y,Zheng W,Song Z,Yang H

更新日期：2019-04-01 00:00:00

abstract：:Development of the central somatosensory system is profoundly modulated by the sensory periphery. Cauterization of facial whiskers alters the segregation pattern of barrels in rodents only during a few days just after birth (critical period). Although a molecular basis of the segregation of barrel neurons and the crit...

journal_title：Neurochemical research

authors： Singh TD,Mizuno K,Kohno T,Nakamura S

更新日期：1997-07-01 00:00:00

abstract：:Cerebral deposition of amyloid β-peptide (Aβ), a fundamental feature of Alzheimer's disease (AD), damages the neurocytes and impairs the cognition functions and associative learning memory of AD patients. A series of novel 2-arylethenylquinoline derivatives were synthesized and evaluated in our previous study, which i...

journal_title：Neurochemical research

authors： He Q,Huang G,Chen Y,Wang X,Huang Z,Chen Z

更新日期：2017-11-01 00:00:00

abstract：:Rat posterior eyecups containing the retina were prepared, loaded with [(3)H]glycine and superfused in order to determine its release originated from glycinergic amacrine cells and/or glial cells. Deprivation of oxygen and glucose from the Krebs-bicarbonate buffer used for superfusion evoked a marked increase of [(3)H...

journal_title：Neurochemical research

authors： Hanuska A,Szénási G,Albert M,Koles L,Varga A,Szabo A,Matyus P,Harsing LG Jr

更新日期：2016-02-01 00:00:00

abstract：:Acupuncture and moxibustion are traditional medical treatments that have come to play important roles in complementary and alternative medicines. Moxibustion also has a long history as a folk remedy in Japan, particularly due to the technical simplicity and selective efficacy on certain types of disease and distress. ...

journal_title：Neurochemical research

authors： Fukuda F,Shinbara H,Yoshimoto K,Yano T,Kuriyama K

更新日期：2005-12-01 00:00:00

abstract：:The spontaneously hypertensive rat (SHR) has been proposed as an animal model for attention-deficit hyperactivity disorder (ADHD). The behavioural problems have been suggested to be secondary to altered reinforcement mechanisms in which nucleus accumbens dopaminergic activity plays an important role. Interaction betwe...

journal_title：Neurochemical research

authors： de Villiers AS,Russell VA,Sagvolden T,Searson A,Jaffer A,Taljaard JJ

更新日期：1995-04-01 00:00:00

abstract：:Cholinesterase activities in rat forebrain, erythrocytes, and plasma were assessed after a single oral administration of metrifonate or dichlorvos. In 3-month-old rats, the dichlorvos (10 mg/kg p.o.)induced inhibition of cholinesterase reached its peak in brain after l5-45 min and after 10-30 min in erythrocytes and p...

journal_title：Neurochemical research

authors： Hinz V,Grewig S,Schmidt BH

更新日期：1996-03-01 00:00:00

abstract：:Spinal cord injury (SCI), a severe health problem in worldwide, was commonly associated with functional disability and reduced quality of life. As the expression of brain-derived neurotrophic factor (BDNF) was substantial event in injured spinal cord, we hypothesized whether BDNF-overexpression could be in favor of th...

journal_title：Neurochemical research

authors： Chen MR,Dai P,Wang SF,Song SH,Wang HP,Zhao Y,Wang TH,Liu J

更新日期：2016-10-01 00:00:00

abstract：:Secretases degrade amyloid precursor protein (APP) releasing fragments (beta-peptides A beta, A beta x) that assemble to form hallmark extracellular deposits in Alzheimer's disease (AD) correlating with disease severity. As such, secretases supply targets for therapeutic intervention and form the focus of this overvie...

journal_title：Neurochemical research

authors： Marks N,Berg MJ

更新日期：2003-07-01 00:00:00

abstract：:The Fatty Acid method was used to determine whether incorporation of plasma radiolabeled arachidonic acid into brain phospholipids is controlled by phospholipase A2. Awake rats received an i.v. injection of a phospholipase A2 inhibitor, manoalide (10 mg/kg), and then were infused i.v. with [1-(14)C]arachidonate or [3H...

journal_title：Neurochemical research

authors： Grange E,Rabin O,Bell J,Chang MC

更新日期：1998-10-01 00:00:00

abstract：:Gelsolin is an actin regulatory protein that generally distributed in a wide variety of body tissues, especially the brain tissues and cerebrospinal fluid. In this study we found that lumbar CSF-gelsolin concentrations markedly decreased in epileptic patients by enzyme linked immunosorbent assay. In order to help judg...

journal_title：Neurochemical research

authors： Peng X,Zhang X,Wang L,Zhu Q,Luo J,Wang W,Wang X

更新日期：2011-12-01 00:00:00

abstract：:The maximal rate of some cerebral enzymatic activities related to energy transduction (hexokinase; phosphofructokinase; lactate dehydrogenase; citrate synthase; malate dehydrogenase; total NADH-cytochrome c reductase; cytochrome oxidase), amino acid metabolism (glutamate decarboxylase; glutamate dehydrogenase) and cho...

journal_title：Neurochemical research

authors： Villa RF,Marzatico F,Benzi G

更新日期：1983-02-01 00:00:00

abstract：:Somatostatin contents of striatum, hippocampus, and pons medulla have been followed in two inbred strains of mice (C57B1/6J and Balb/cJ) with aging and long term alcohol exposure (over a 25 month period of intoxication). Marked strain dependent differences in basic levels of somatostatin and genotypic variations in re...

journal_title：Neurochemical research

authors： Fuhrmann G,Strosser MT,Besnard F,Kempf E,Kempf J,Ebel A

更新日期：1986-05-01 00:00:00

abstract：:Single exposure of adult male rats to low environmental temperature (LET, 12 +/- 0.5 degrees C) for 2 h significantly increased the hypothalamic and striatal GABA levels without affecting those in other regions of brain. The activity of glutamate decarboxylase (GAD) was elevated in hypothalamus (H) and corpus striatum...

journal_title：Neurochemical research

authors： Biswas S,Poddar MK

更新日期：1990-08-01 00:00:00

abstract：:The cellular effects of eleven compounds including chalcone glycosides isolated from Brassica rapa L. 'hidabeni' and their synthetic derivatives were studied in rat pheochromocytoma PC12 cells. Of the compounds tested, 4'-O-β-D-glucopyranosyl-3',4-dimethoxychalcone (A2) significantly increased the levels of the phosph...

journal_title：Neurochemical research

authors： Nishina A,Kimura H,Tsukagoshi H,Kozawa K,Koketsu M,Ninomiya M,Sato D,Obara Y,Furukawa S

更新日期：2013-11-01 00:00:00

abstract：:In vitro aggregation and fibrillization of synthetic amyloid beta-protein Abeta 1-40 was assessed in the conditioned media from rhabdomyosarcoma (CRL 1598, HTB 82, HTB 153, CCL 136), adenocarcinoma (CCL 218), neuroblastoma (SY5Y), and COS cells cultured in the absence and presence of 10% heat-inactivated fetal bovine ...

journal_title：Neurochemical research

authors： Chauhan A,Chauhan VP,Rubenstein R,Wegiel J,Wisniewski HM

更新日期：1997-02-01 00:00:00

abstract：:N-terminal protein arginylation has been demonstrated in vitro and in situ and has been reported to increase following injury to sciatic nerves of rats. The present study attempts to demonstrate these reactions in vivo by applying [3H]Arg to the cut end of sciatic nerves in anesthetized rats and assaying for N-termina...

journal_title：Neurochemical research

authors： Wang YM,Ingoglia NA

更新日期：1997-12-01 00:00:00

abstract：:Overactivation of glutamate receptors results in neurodegeneration in a variety of brain pathologies, including ischemia, epilepsy, traumatic brain injury and slow-progressing neurodegenerative disorders. In all these pathologies, it is well accepted that the calcium-dependent cysteine proteases calpains are key playe...

journal_title：Neurochemical research

authors： Araújo IM,Carreira BP,Carvalho CM,Carvalho AP

更新日期：2010-12-01 00:00:00

abstract：:Activation of glial cells has been observed in neurodegenerative diseases including Alzheimer's disease (AD). Aggregation of amyloid β (Aβ) is profusely observed as characteristic pathology in AD brain. In our previous study using microglial cell line BV-2, tissue-type transglutaminase (TG2) was found to be involved i...

journal_title：Neurochemical research

authors： Kawabe K,Takano K,Moriyama M,Nakamura Y

更新日期：2018-01-01 00:00:00

abstract：:We have developed a coupled Xenopus oocyte expression system for evaluating the functional effects of mutations in known or suspected adhesion molecules, which allows for a very rapid assessment of intercellular adhesion. As a model protein, we first used Protein zero (Po), an adhesion molecule that mediates self-adhe...

journal_title：Neurochemical research

authors： Yoshida M,Colma DR

更新日期：2001-06-01 00:00:00

abstract：:The pathophysiological mechanism(s) underlying Alzheimer's disease (AD) still remain unclear, and no disease-modifying or prophylactic therapies are currently available. Unraveling the fundamental neuropathogenesis of AD is an important challenge. Several studies on AD have suggested lesions in a number of CNS areas i...

journal_title：Neurochemical research

authors： Daulatzai MA

更新日期：2012-04-01 00:00:00

abstract：:This study was undertaken to evaluate whether chemical hypoxia-induced cell injury is a result of reactive oxygen species (ROS) generation, ATP depletion, mitochondrial permeability transition, and an increase in intracellular Ca2+, in A172 cells, a human glioma cell line. Chemical hypoxia was induced by incubating ce...

journal_title：Neurochemical research

authors： Jeong JI,Lee YW,Kim YK

更新日期：2003-08-01 00:00:00

abstract：:Three peptides overlapping the tryptophan region of bovine CNS myelin basic protein were synthesized by the solid phase procedure of Merrifield. These were the nonapeptide H-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Lys-OH, the octapeptide H-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Lys-OH, and the heptapeptide H-Trp-Gly-Ala-Glu-Gly-Gln-Lys-...

journal_title：Neurochemical research

authors： Levit S,Powers JM,Milek D,Brostoff SW

更新日期：1980-01-01 00:00:00

abstract：:Brain development is a highly orchestrated complex process. The developing brain utilizes many substrates including glucose, ketone bodies, lactate, fatty acids and amino acids for energy, cell division and the biosynthesis of nucleotides, proteins and lipids. Metabolism is crucial to provide energy for all cellular p...

journal_title：Neurochemical research

authors： McKenna MC,Scafidi S,Robertson CL

更新日期：2015-12-01 00:00:00