APP processing enzymes (secretases) as therapeutic targets: insights from the use of transgenics (Tgs) and transfected cells.

abstract：:The present study investigated the expression patterns of glial cells and interleukin-1beta (IL-1beta) in the rat spinal cord after a surgical incision, which is closely related with clinical postoperative pain. Microglia and astrocytes became activated in the spinal cord following incision. Real-time polymerase chain...

journal_title：Neurochemical research

authors： Fu D,Guo Q,Ai Y,Cai H,Yan J,Dai R

更新日期：2006-03-01 00:00:00

abstract：:Changes in serotonin (5-HT) and 5-hydroxy indole acetic acid (5-HIAA), its major metabolite, in cerebral cortex, corpus striatum and hippocampus were investigated at 10th and 21st days of chronic ethanol ingestion in Wistar rats. Ethanol (7.2% v/v) was given to rats in a modified liquid diet. Biochemical analysis was ...

journal_title：Neurochemical research

authors： Uzbay IT,Usanmaz SE,Akarsu ES

更新日期：2000-02-01 00:00:00

abstract：:This study examined the relationship between the distance of axotomy and the death of injured retinal ganglion cells (RGCs) in adult hamsters and the relationship of cytochrome c and caspase-3 on the death pathway of RGCs. The left optic nerve (ON) of adult hamsters was transected either at 1 or 3 mm away from the opt...

journal_title：Neurochemical research

authors： He MH,Cheung ZH,Yu EH,Tay DK,So KF

更新日期：2004-11-01 00:00:00

abstract：:The study examined (a) whether there is sex difference in spinal cord and plasma oxidative stress profiles in Dark Agouti rats immunised for experimental autoimmune encephalomyelitis (EAE), the principal experimental model of multiple sclerosis, and (b) whether there is correlation between the oxidative stress in spin...

journal_title：Neurochemical research

authors： Dimitrijević M,Kotur-Stevuljević J,Stojić-Vukanić Z,Vujnović I,Pilipović I,Nacka-Aleksić M,Leposavić G

更新日期：2017-02-01 00:00:00

abstract：:Glycogen is the main storage form of glucose in the brain. In contrast with previous beliefs, brain glycogen has recently been shown to play important roles in several brain functions. A fraction of metabolized glucose molecules are being shunted through glycogen before reentering the glycolytic pathway, a phenomenon ...

journal_title：Neurochemical research

authors： Jakobsen E,Bak LK,Walls AB,Reuschlein AK,Schousboe A,Waagepetersen HS

更新日期：2017-09-01 00:00:00

abstract：:Tetrahydrobiopterin and the folate coenzymes can reciprocally interact in ways that would be useful to the metabolic pathways subserved by both of these coenzymes. Thus, through one of the reactions catalyzed by methylene tetrahydrofolate reductase, 5-CH3-H4-folate can regenerate BH4 from q-BH2 and q-BH2 can provide a...

journal_title：Neurochemical research

authors： Kaufman S

更新日期：1991-09-01 00:00:00

abstract：:We measured the activity of several acid hydrolases in oligodendrocyte and mixed glial (predominantly astrocytic) cell cultures prepared from neonatal rat cerebra. When compared with the mixed glial cultures, the cultured oligodendrocytes exhibited higher levels for all the hydrolases when activities were normalized t...

journal_title：Neurochemical research

authors： Bradel EJ,Sloan HR

更新日期：1988-10-01 00:00:00

abstract：:Ethyl pyruvate (EP) has recently been reported to afford protection against neurodegenerative disorders. However, the mechanism underlying EP-mediated neuroprotection remains to be elucidated. Because peroxynitrite has been extensively implicated in the pathogenesis of various forms of neurodegenerative disorders via ...

journal_title：Neurochemical research

authors： Chen W,Jia Z,Zhu H,Zhou K,Li Y,Misra HP

更新日期：2010-02-01 00:00:00

abstract：:A double ligand enzyme-linked immunosorbent assay (ELISA) has been developed to detect antibodies against brain tissue antigens in the sera of patients with neurological diseases. The sera were tested on human white matter homogenate. The technique consists of successive incubations with the human serum to be tested, ...

journal_title：Neurochemical research

authors： Bologa L,Hofstetter W,Schonenberger K,Jacque C,Herschkowitz N

更新日期：1985-04-01 00:00:00

abstract：:Sonic hedgehog (Shh), a secreted glycoprotein factor, can activate the Shh pathway, which has been implicated in neuronal polarization involving neurite outgrowth. However, little evidence is available about the effect of Shh on neurite outgrowth in primary cortical neurons and its potential mechanism. Here, we reveal...

journal_title：Neurochemical research

authors： He W,Cui L,Zhang C,Zhang X,He J,Xie Y

更新日期：2016-04-01 00:00:00

abstract：:Using the replication-defective adenovirus vector, we overexpressed rat glia maturation factor (GMF) in primary astrocyte cultures derived from embryonic rat brains. Among the three isoforms of MAP kinase, there was a big increase in the phosphorylation of p38, as detected with Western blotting using the phosphospecif...

journal_title：Neurochemical research

authors： Zaheer A,Yorek MA,Lim R

更新日期：2001-12-01 00:00:00

abstract：:Discrete populations of anti-S49 antibodies were found in the antisera of Lewis rats recovered from S49-induced experimental allergic encephalomyelitis (EAE). A potent inducer of EAE in Lewis rats, S49 is a synthetic peptide representing residues 69-84 of bovine myelin basic protein but with deletions at Gly-77 and Hi...

journal_title：Neurochemical research

authors： Day ED,Hashim GA,Potter NT,Lazarus KJ

更新日期：1985-12-01 00:00:00

abstract：:Presenilins (PSs) are catalytic components of the γ-secretase complex that produces Aβ peptides. Substrates of γ-secretase are membrane-bound protein fragments deriving from the cleavage of extracellular sequence of cell surface proteins. APP-derived γ-secretase substrates are cleaved at gamma (γ) sites to produce Aβ ...

journal_title：Neurochemical research

authors： Robakis NK

更新日期：2014-01-01 00:00:00

abstract：:During neural activity, neurotransmitters released at synapses reach neighbouring cells, such as astrocytes. These get excited via numerous mechanisms, including the G protein coupled receptors that regulate the cytosolic concentration of second messengers, such as Ca(2+) and cAMP. The stimulation of these pathways le...

journal_title：Neurochemical research

authors： Vardjan N,Zorec R

更新日期：2015-12-01 00:00:00

abstract：:Excitatory and inhibitory neurotransmission in the central nervous system can be modulated by neurosteroids. We previously found that in rat hippocampal slices allopregnanolone (3α-hydroxy-5α-pregnan-20-one), a positive GABA(A) receptor modulator, suppresses the epileptic discharges induced by 4-aminopyridine (4-AP), ...

journal_title：Neurochemical research

authors： Salazar P,Tapia R

更新日期：2012-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia that progressively disrupts neurocognitive function, which has neither cure nor effective treatment. Hypercholesterolemia might be involved in brain alterations that could evolve into AD. The present study aims to evaluate the potential of omega-3, Co-enzyme...

journal_title：Neurochemical research

authors： Ibrahim Fouad G

更新日期：2020-05-01 00:00:00

abstract：:Two models of perturbed cerebellar ontogenesis were obtained by a single administration of methylazoxymethanol (MAM), a potent antimitotic agent, to mouse pups either on the day of birth (MAM0 mice) or at postnatal day 5 (MAM5 mice). The alterations of the cerebellar GABAergic system were studied by measuring glutamic...

journal_title：Neurochemical research

authors： Bacon E,Girard C,de Barry J,Gombos G

更新日期：1992-07-01 00:00:00

abstract：:This study aimed at comparing the binding characteristics of [3H]ketanserin, a high-affinity serotonin 2A (5-HT2A) receptor antagonist, in the prefrontal cortex, hippocampus and striatum of human brain post-mortem. The results indicated the presence of a single population of binding sites in all the regions investigat...

journal_title：Neurochemical research

authors： Marazziti D,Rossi A,Palego L,Giannaccini G,Naccarato A,Lucacchini A,Cassano GB

更新日期：1997-06-01 00:00:00

abstract：:Using a model of middle cerebral artery occlusion (MCAO), we have previously demonstrated that treadmill exercise promotes angiogenesis in the ischemic penumbra through caveolin-1/VEGF signaling pathways. However, the function of caveolin-1/VEGF signaling in neurogenesis after MCAO has not been determined. In this stu...

journal_title：Neurochemical research

authors： Zhao Y,Pang Q,Liu M,Pan J,Xiang B,Huang T,Tu F,Liu C,Chen X

更新日期：2017-02-01 00:00:00

abstract：:Most inborn errors of tyrosine catabolism produce hypertyrosinemia. Neurological manifestations are variable and some patients are developmentally normal, while others show different degrees of developmental retardation. Considering that current data do not eliminate the possibility that elevated levels of tyrosine an...

journal_title：Neurochemical research

authors： Ferreira GK,Jeremias IC,Scaini G,Carvalho-Silva M,Gomes LM,Furlanetto CB,Morais MO,Schuck PF,Ferreira GC,Streck EL

更新日期：2013-08-01 00:00:00

abstract：:1-Methyl-4-phenylpyridinium (MPP(+)) or 6-hydroxydopamine (6-OHDA) caused a nuclear damage, the mitochondrial membrane permeability changes, leading to the cytochrome c release and caspase-3 activation, the formation of reactive oxygen species and the depletion of GSH in PC12 cells. Nicardipine (a calcium channel bloc...

journal_title：Neurochemical research

authors： Lee DH,Han YS,Han ES,Bang H,Lee CS

更新日期：2006-07-01 00:00:00

abstract：:Metabolic turnover of axonally transported glycoproteins has been examined in membranous and soluble subfractions of goldfish optic tectum following intraocular injection of [3H]fucose. Radioactivity in total transported glycoproteins reached a maximum in the tectum after 24-30 hr, then declined with a half-life of ap...

journal_title：Neurochemical research

authors： Ripellino JA,Elam JS

更新日期：1980-04-01 00:00:00

abstract：:Antiretroviral protease inhibitors are a class of important drugs that are used for the treatment of human immunodeficiency virus infections. Among those compounds, ritonavir is applied frequently in combination with other antiretroviral protease inhibitors, as it has been reported to boost their therapeutic efficienc...

journal_title：Neurochemical research

authors： Arend C,Brandmann M,Dringen R

更新日期：2013-04-01 00:00:00

abstract：:The acetylcholinesterase from synaptosomal membranes is inhibited by anesthetics: Nembutal, brietal, and thiopental. Nembutal and brietal decrease the Km for acetylthiocholine, without changes in Vmas. A noncompetitive type of inhibition is produced by thiopental. This anesthetic decreases Arrhenius plot discontinuity...

journal_title：Neurochemical research

authors： Pastuszko A

更新日期：1980-07-01 00:00:00

abstract：:Apoptosis is a highly complex form of cell death that can be triggered by alterations in Ca(2+) homeostasis. Members of the Bcl-2 family may regulate apoptosis and modulate Ca(2+) distribution within intracellular compartments. Bax, a proapoptotic member of the family, is constitutively expressed and soluble in the cy...

journal_title：Neurochemical research

authors： Morales AP,Carvalho AC,Monteforte PT,Hirata H,Han SW,Hsu YT,Smaili SS

更新日期：2011-05-01 00:00:00

abstract：:Chemokines are small secreted proteins that are essential for the recruitment and activation of specific leukocyte subsets at sites of inflammation and for the development and homeostasis of lymphoid and nonlymphoid tissues. During the past decade, chemokines and their receptors have also emerged as key signaling mole...

journal_title：Neurochemical research

authors： Ambrosini E,Aloisi F

更新日期：2004-05-01 00:00:00

abstract：:Rhesus macaque monkey brain microvessel endothelial cells (BMECs) were isolated and grown in culture in an effort to establish an appropriate primate in vitro model of the endothelial component of the blood-brain barrier. The presence of Factor VIII antigen, alkaline phosphatase, gamma-glutamyl transpeptidase, lactate...

journal_title：Neurochemical research

authors： Shi F,Audus KL

更新日期：1994-04-01 00:00:00

abstract：:An in vitro procedure for labeling of RNA in the excised rat nodose ganglion was used to evaluate the changes in incorporation of [3H]uridine into ganglionic RNA following transection of the abdominal vagus nerves. Significant increases in the incorporation into 28S, 18S and 4S RNA were observed at 1 day after injury,...

journal_title：Neurochemical research

authors： Bates DJ,Sirkos S,Moses EK,Austin L

更新日期：1983-03-01 00:00:00

abstract：:Experimentalists would like to perform large-scale expression analysis on samples drawn from small cell populations and even single cells. Amplification of the source material is required to assay such small samples under all existing array technologies. In this report we consider the very different theoretical proper...

journal_title：Neurochemical research

authors： Shaw CA

更新日期：2002-10-01 00:00:00

abstract：:We observed a spot on two-dimensional (2-D) gel in the epileptic mutant strain E1 mice with a similar molecular weight but with a different isoelectric point of approximately 0.2, compared with its mother strain ddY mice. The collected protein from the E1 mice was identified as cytosolic NADP+-dependent isocitrate deh...

journal_title：Neurochemical research

authors： Ohmori O,Hirano H,Mita T

更新日期：1999-03-01 00:00:00