Abstract：
:Most inborn errors of tyrosine catabolism produce hypertyrosinemia. Neurological manifestations are variable and some patients are developmentally normal, while others show different degrees of developmental retardation. Considering that current data do not eliminate the possibility that elevated levels of tyrosine and/or its derivatives may have noxious effects on central nervous system development in some patients, the present study evaluated nerve growth factor (NGF) levels in hippocampus, striatum and posterior cortex of young rats. In our acute protocol, Wistar rats (10 and 30 days old) were killed 1 h after a single intraperitoneal administration of L-tyrosine (500 mg/kg) or saline. Chronic administration consisted of L-tyrosine (500 mg/kg) or saline injections 12 h apart for 24 days in Wistar rats (7 days old); the rats were killed 12 h after the last injection. NGF levels were then evaluated. Our findings showed that acute administration of L-tyrosine decreased NGF levels in striatum of 10-day-old rats. In the 30-day-old rats, NGF levels were decreased in hippocampus and posterior cortex. On the other hand, chronic administration of L-tyrosine increased NGF levels in posterior cortex. Decreased NGF may impair growth, differentiation, survival and maintenance of neurons.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Ferreira GK,Jeremias IC,Scaini G,Carvalho-Silva M,Gomes LM,Furlanetto CB,Morais MO,Schuck PF,Ferreira GC,Streck ELdoi
10.1007/s11064-013-1078-0subject
Has Abstractpub_date
2013-08-01 00:00:00pages
1742-6issue
8eissn
0364-3190issn
1573-6903journal_volume
38pub_type
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