Abstract：
:S100beta is a soluble protein released by glial cells mainly under the activation of the 5-HT1A receptor. It has been reported as a neuro-trophic and -tropic factor that promotes neurite maturation and outgrowth during development. This protein also plays a role in axonal stability and the plasticity underlying long-term potentiation in adult brains. The ability of S100beta to rapidly regulate neuronal morphology raises the interesting point of whether there are daily rhythm or gender differences in S100beta level in the brain. To answer this question, the S100beta expression in adult female and male rats, as well as in adult female CD-21 and S100beta -/- female mice, were investigated. Scintillation counting and morphometric analysis of the immunoreactivity of S100beta, showed rhythmic daily expression. The female and male rats showed opposite cycles. Females presented the highest value at the beginning of the rest phase (5:00 h), while in males the maximum value appeared in the beginning of the motor activity period (21:00 h). These results confirm previous S100beta evaluations in human serum and cerebrospinal fluid reporting the protein's function as a biomarker for brain damage (Gazzolo et al. in Clin Chem 49:967-970, 2003; Clin Chim Acta 330:131-133, 2003; Pediatr Res 58:1170-1174, 2005), similar behavior was also observed for GFAP in relation to Alzheimer Disease (Fukuyama et al. in Eur Neurol 46:35-38, 2001). The data should be taken into account when considering S100beta as a biomarker of health condition. In addition, the results raise questions on which structure or condition imposes these rhythms as well as on the physiological meaning of the observed gender differences.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Nogueira MI,Abbas SY,Campos LG,Allemandi W,Lawson P,Takada SH,Azmitia ECdoi
10.1007/s11064-009-9915-xsubject
Has Abstractpub_date
2009-08-01 00:00:00pages
1355-62issue
8eissn
0364-3190issn
1573-6903journal_volume
34pub_type
杂志文章abstract：:The SAM strains, a group of related inbred strains consisting of senescence-prone inbred strains (SAMP) and senescence-resistant inbred strains (SAMR), have been successfully developed by selective inbreeding of the AKR/J strain of mice donated by the Jackson laboratory in 1968. The characteristic feature of aging com...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-009-9922-y
更新日期：2009-04-01 00:00:00
abstract：:Olfactory ensheathing cells (OECs) and Schwann cells (SCs) are closely-related cell types with regeneration-promoting properties. Comparative gene expression analysis is particularly relevant since it may explain cell type-specific effects and guide the use of each cell type into special clinical applications. In the ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1006-3
更新日期：2013-05-01 00:00:00
abstract：:The copper-transporting ATPases Atp7A and Atp7B play a major role in controlling intracellular copper levels. In addition, they are believed to deliver copper to the copper-requiring proteins destined for the secretory vesicles. One cuproprotein, dopamine beta-hydroxylase (DBH) functions in the biosynthesis of norepin...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1023219308890
更新日期：2003-06-01 00:00:00
abstract：:Using the immunoblot technique, we found that an incubation of purified human myelin in 10 mM Tris-HCl buffer at pH 7.5 resulted in the conversion of the myelin-associated glycoprotein (MAG) to a smaller derivative (dMAG). Exogenously added 5 mM CaCl2 accelerated the conversion of MAG. In buffer containing more than 1...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964509
更新日期：1984-05-01 00:00:00
abstract：:Neuroprotectin D1 (NPD1), a docosahexaenoic acid (DHA)-derived lipid mediator, promotes survival in cells exposed to oxidative stress by inducing the activity of anti-inflammatory mediators and suppressing the expression of pro-inflammatory genes. Though retinal pigment epithelial (RPE) cells naturally produce NPD1 fr...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0351-8
更新日期：2010-12-01 00:00:00
abstract：:The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental brain ischemia-reperfusion in rats. Present study was performed on the 34 male Wistar-albino rats, weigth 350-400 g. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; animal we...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1889-x
更新日期：2016-07-01 00:00:00
abstract：:Guanine nucleotides (GN) have been implicated in many intracellular mechanisms. Extracellular actions, probably as glutamate receptor antagonists, have also been recently attributed to these compounds. GN may have a neuroprotective role by inhibiting excitotoxic events evoked by glutamate. Effects of extracellular GN ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1007557600687
更新日期：2000-02-01 00:00:00
abstract：:These studies were designed to compare the effects of nitric oxide (NO) generating compounds with those of several iron containing compounds which do not generate NO on glutamate receptor function. Stimulation of primary cultures of cerebellar granule cells with N-methyl-D-aspartate (NMDA) or kainate results in the el...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969689
更新日期：1995-07-01 00:00:00
abstract：:Schwann cell biosynthesis of glycolipids was studied by in vitro incorporation of [3H]galactose into neonatal rat sciatic nerves before and after endoneurial explant culture and in culture of purified Schwann cells. In neonatal nerves prior to culture, [3H]galactose was actively incorporated into galactocerebrosides (...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00968672
更新日期：1990-03-01 00:00:00
abstract：:Docosahexaenoic acid (DHA) can alleviate cerebral ischemia/reperfusion injury by reducing blood-brain barrier permeability and maintaining its integrity, accompanied by an increased Ang-1/Ang-2 ratio; however, the underlying mechanisms of these effects remain unclear. Src-suppressed C kinase substrates (SSeCKS), a sub...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02915-0
更新日期：2020-02-01 00:00:00
abstract：:Adaptive changes in serotonergic 5HT1 receptor signalling are believed to underlie the therapeutic effectiveness of antidepressant drugs. Since cells are continuously exposed to neurotransmitters/neuromodulators, spatially and temporally integrated, the responsiveness of a receptor system is dependent upon the physio-...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9582-8
更新日期：2008-07-01 00:00:00
abstract：:Detergents Triton X-100, sodium deoxycholate, and octyl-beta-D-glucopyranoside, and proteinase papain proved to be excellent agents solubilizing the gamma-glutamyltransferase (gamma-GT) from human brain cortex microvessels. Ficin also solubilized gamma-GT but to a lesser extent than papain. The relative molecular mass...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964524
更新日期：1984-07-01 00:00:00
abstract：:Traumatic brain injury (TBI) initiates a series of neurochemical and signaling changes that could eventually lead to neuronal apoptosis. Recent studies indicated that mature neurons cell cycle re-enter played a crucial role in neuronal apoptosis. In this study, we identified that the chaperonin containing TCP-1, subun...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1683-1
更新日期：2015-09-01 00:00:00
abstract：:The decline in neuronal function during aging may result from increases in extracellular glutamate (Glu), Glu-induced neurotoxicity, and altered mitochondrial metabolism. To study metabolic responses to persistently high levels of Glu at synapses during aging, we used transgenic (Tg) mice that over-express the enzyme ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1239-9
更新日期：2014-01-01 00:00:00
abstract：:In this study, we investigated if subunit displacement and/or alterations in proteasome biosynthesis are responsible for the changes in the levels of constitutive proteasomes (c-20S), immunoproteasomes (i-20S) and the activators PA28 and PA700 in neurons and astrocytes cultured with a cytokine mixture (IFN-γ/TNF-α/IL-...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-02958-8
更新日期：2020-04-01 00:00:00
abstract：:In the present study, we aimed to investigate the effects of pinealectomy and chronic melatonin administration on focal epileptiform activity induced by penicillin in the rat cortex and to determine the relation between melatonin levels and electrocorticogram (ECoG) power spectrum. For this purpose, male Sprague-Dawle...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1069-1
更新日期：2013-08-01 00:00:00
abstract：:It is known that the NMDA-R NR1 subunit is needed for the receptor activity and that under hypoxia the evolution toward apoptosis or neuronal survival depends on the balance NR2A/NR2B subunits. This paper analyzes the effect of acute hypoxia on the above mentioned subunits mRNAs during development. The mean percentage...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0221-4
更新日期：2010-10-01 00:00:00
abstract：:Status epilepticus (SE) is a severe clinical manifestation of epilepsy associated with intense neuronal loss and inflammation, two key factors involved in the pathophysiology of temporal lobe epilepsy. Bone marrow mononuclear cells (BMMC) attenuated the consequences of pilocarpine-induced SE, including neuronal loss, ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1217-7
更新日期：2014-02-01 00:00:00
abstract：:Interleukin (IL)-18, a member of the IL-1 cytokine family, is an important mediator of peripheral inflammation and host defence responses. However, although IL-1 is a key proinflammatory cytokine in the brain, little is known about IL-18 changes in glial cells under excitotoxic neurodegeneration. In this study, we cha...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9434-6
更新日期：2008-01-01 00:00:00
abstract：:The incubation of neuronal nitric oxide synthase with the five amyloid peptide fragments [Aβ17-21; Aβ25-29; Aβ29-33; Aβ33-37; Aβ25-37] catalyzed the formation of fibrils. The role of neuronal isomer (nNOS) involved the entrapment of free monomers and seed aggregates to initiate the events of nucleation and elongation,...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1206-x
更新日期：2014-01-01 00:00:00
abstract：:Somatostatin (SS) is an inhibitory regulator of secretory and proliferative responses that activates a group of receptors in the plasma membrane termed SSR1-5. SSR2 is one of the most abundant SSR, which also is expressed in high numbers in many neuroendocrine tumor types. Here, we describe a study of the presence and...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022848718109
更新日期：2003-04-01 00:00:00
abstract：:Altered proteostasis induced by amyloid peptide aggregation and hyperphosphorylation of tau protein, is a prominent feature of Alzheimer's disease, which highlights the occurrence of endoplasmic reticulum stress and triggers the activation of the unfolded protein response (UPR), a signaling pathway that enforces adapt...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2469-z
更新日期：2018-03-01 00:00:00
abstract：:Alzheimer's disease (AD) is the most common form of dementia in the aged population. Early-onset familial AD (FAD) involves mutations in a gene on chromosome 21 encoding the amyloid protein precursor or on chromosomes 14 or 1 encoding genes known as presenilins. All mutations examined have been found to increase the p...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1022471729291
更新日期：1998-05-01 00:00:00
abstract：:The search for neuronotrophic factors addressing CNS neurons requires CNS neuronal cell cultures to quantitate putative effects on neuronal survival. Investigation of neurons dissociated from several embryonic CNS tissues have shown that their short-term survival requires supplementation of the culture medium with eit...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973276
更新日期：1988-07-01 00:00:00
abstract：:Cholinergic muscarinic receptors, when stimulated by arecoline, can activate cytosolic phospholipase A(2) (cPLA(2)) to release arachidonic acid (AA) from membrane phospholipid. This signal can be imaged in the brain in vivo using quantitative autoradiography following the intravenous injection of radiolabeled AA, as a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9372-3
更新日期：2007-11-01 00:00:00
abstract：:The influence of hypothyroidism (HO) induced by treatment with propylthiouracil on lipid composition, receptor responsiveness of M1-muscarinic receptors (M1AChRs) and metabotropic glutamate receptors (mGluRs) as well as on protein kinase C (PKC) activity was investigated in the cerebral cortex of Lewis rats. HO did no...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02527750
更新日期：1996-05-01 00:00:00
abstract：:The study provides detailed biochemical correlates to the common histopathological diagnoses in epilepsy. A dot immunobinding procedure was used for quantification of NSE, GFA, S-100, NCAM, NF 68 and NF 200. The material consisted of samples from 48 patients either selected for surgical treatment of partial epilepsy o...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967255
更新日期：1993-04-01 00:00:00
abstract：:In a study of the role of taurine in the genesis of epilepsy the effects of metrazol-induced convulsions on the uptake and distribution of taurine in the brain were measured. In vivo we found no significant uptake of taurine in the mouse brain; in rabbit brain in most areas significant taurine uptake was found. The ph...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964640
更新日期：1979-08-01 00:00:00
abstract：:The central control of growth hormone (GH) secretion from the pituitary gland is ultimately achieved by the interaction between two hypothalamic neurohormones, somatostatin which inhibits and growth hormone-releasing hormone (GHRH) which stimulates GH release. The regulation of the somatostatin and GHRH release from t...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-005-9017-3
更新日期：2006-02-01 00:00:00
abstract：:Synaptosomes isolated from mouse brain were incubated with [14C]glutamate and [3H]gamma-amino-butyric acid ([3H]GABA), and then [14C]GABA (newly synthesized GABA) and [3H]GABA (newly captured GABA) in the synaptosomes were analysed. (1) the [3H]GABA was rapidly degraded in the synaptosomes, (2) when the synaptosomes w...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00968675
更新日期：1990-03-01 00:00:00
