Abstract:
:The acetylcholinesterase from synaptosomal membranes is inhibited by anesthetics: Nembutal, brietal, and thiopental. Nembutal and brietal decrease the Km for acetylthiocholine, without changes in Vmas. A noncompetitive type of inhibition is produced by thiopental. This anesthetic decreases Arrhenius plot discontinuity by about 4 degrees C and increases activation energies. Nembutal and brietal do not change Arrhenius plot discontinuities, but they increase activation energies. These results suggest that barbiturates change lipid-protein interactions in synaptosomal membranes.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Pastuszko Adoi
10.1007/BF00964714subject
Has Abstractpub_date
1980-07-01 00:00:00pages
769-76issue
7eissn
0364-3190issn
1573-6903journal_volume
5pub_type
杂志文章abstract::Incomplete ischemia of the spinal cord was produced in dogs by 40 min occlusion of the abdominal aorta that was followed by 5-40 min of recirculation. Amino acid incorporation into ribosomes in vitro in the presence of venous blood sera was estimated. The most significant reduction in incorporation was produced by ser...
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