Abstract:
:Ellagic acid (EA, 2,3,7,8-tetrahydroxy-chromeno; C14H6O8) is a polyphenol derived from fruits (pomegranates, berries) and nuts. EA exhibits antioxidant capacity and induces anti-inflammatory actions in several mammalian tissues. EA has been characterized as a possible neuroprotective agent, but the number of reports is still limited to conclude whether and how EA exerts neuroprotection in humans. In this regard, performing additional studies considering the potential beneficial and/or toxicological roles for EA on brain cells would be an important step towards fully understanding of when and how EA may be securely utilized by humans as a neuroprotective agent. The aim of the present work is to discuss data related to the neuronal and glial effects of EA and the mechanisms underlying such events. Moreover, future directions are suggested as a potential guide to be utilized by researchers interested in investigating the neuronal and glial actions of EA hereafter.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
de Oliveira MRdoi
10.1007/s11064-016-1853-9subject
Has Abstractpub_date
2016-06-01 00:00:00pages
1219-28issue
6eissn
0364-3190issn
1573-6903pii
10.1007/s11064-016-1853-9journal_volume
41pub_type
杂志文章,评审abstract::This study examined the relationship between the distance of axotomy and the death of injured retinal ganglion cells (RGCs) in adult hamsters and the relationship of cytochrome c and caspase-3 on the death pathway of RGCs. The left optic nerve (ON) of adult hamsters was transected either at 1 or 3 mm away from the opt...
journal_title:Neurochemical research
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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