Abstract：
:We have previously shown that 5-methyltetrahydrofolate influences neuro-secretion. The present study more precisely characterises the processes involved and considers one probable site of action. Focusing on the tyrosine-noradrenalin axis in cerebellum we showed 5-methyltetrahydrofolate causes a significant reduction in the apparent K+ evoked secretion of noradrenalin to only 12.9% of control release. Evidence supports the idea that this could actually be due to increased synthesis leading to; depletion of reserves, possibly through leakage, exocytotic inhibition via activation of presynaptic receptors or end product inhibition by noradrenalin at the pteridine cofactor level of tyrosine hydroxylase: a) concomitant decreased measurement of perfusate and intracellular tyrosine with released noradrenalin following 5-methyltetrahydrofolate treatment supports the idea of increased transmitter turn over; b) kinetic studies indicate that at saturating concentrations of tyrosine and in the presence of an inhibitor of L-DOPA decarboxylase, 5-methyltetrahydrofolate partially duplicates the rate limiting behaviour of a synthetic pteridine cofactor--DL,2-amino-4-hydroxy-6,7,dimethyltetrahydropteridine. We debate whether, in vivo, CSF 5-methyltetrahydrofolate might interact at the tetrahydrobiopterin cofactor level of tyrosine hydroxylase and other aromatic amino-acid hydroxylases.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Lucock MD,Green M,Levene MIdoi
10.1007/BF01705542subject
Has Abstractpub_date
1995-06-01 00:00:00pages
727-36issue
6eissn
0364-3190issn
1573-6903journal_volume
20pub_type
杂志文章abstract：:The copper-transporting ATPases Atp7A and Atp7B play a major role in controlling intracellular copper levels. In addition, they are believed to deliver copper to the copper-requiring proteins destined for the secretory vesicles. One cuproprotein, dopamine beta-hydroxylase (DBH) functions in the biosynthesis of norepin...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1023219308890
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964414
更新日期：1981-10-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-004-6879-8
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00968402
更新日期：1992-12-01 00:00:00
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journal_title：Neurochemical research
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abstract：:Paclitaxel (PTX) is an antineoplastic agent commonly used in the treatment of solid tumors and is known to cause dose-limiting peripheral neurotoxicity. This study was performed to evaluate the protective effect of curcumin (CUR) against PTX-induced spinal cord and sciatic nerve injuries in rats. The rats were adminis...
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doi：10.1007/s11064-020-03174-0
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journal_title：Neurochemical research
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doi：10.1007/BF00967701
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更新日期：2013-02-01 00:00:00
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更新日期：1976-04-01 00:00:00
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journal_title：Neurochemical research
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更新日期：1981-01-01 00:00:00
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更新日期：2013-12-01 00:00:00
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更新日期：1987-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-02-01 00:00:00
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更新日期：2009-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/BF00970775
更新日期：1988-10-01 00:00:00
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journal_title：Neurochemical research
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更新日期：2006-02-01 00:00:00
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更新日期：2012-03-01 00:00:00
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journal_title：Neurochemical research
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更新日期：2008-03-01 00:00:00
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journal_title：Neurochemical research
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更新日期：1998-06-01 00:00:00
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journal_title：Neurochemical research
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更新日期：2008-03-01 00:00:00
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更新日期：2020-09-01 00:00:00
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journal_title：Neurochemical research
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doi：10.1007/s11064-020-02976-6
更新日期：2020-04-01 00:00:00
