Abstract:
:The influence of hypothyroidism (HO) induced by treatment with propylthiouracil on lipid composition, receptor responsiveness of M1-muscarinic receptors (M1AChRs) and metabotropic glutamate receptors (mGluRs) as well as on protein kinase C (PKC) activity was investigated in the cerebral cortex of Lewis rats. HO did not influence the lipid composition. There was a significant 2-fold increase of efficacy and 6-fold decrease of potency of carbachol-induced inositol phosphate (IP) accumulation in HO, with respect to control rats. The efficacy of trans-(1S,3R)-1-amino-1,3-cyclopentanedicarboxylic acid (ACPD)-induced IP accumulation was also higher in HO (by 50%), without differences in EC50 values. The activities of soluble calcium-dependent and calcium-independent PKC were higher in HO than in control rats (both roughly 30%); membrane-associated PKCs were not modified. The data indicate that HO induces an increased responsiveness of M1AChRs and mGluRs and a rise in the soluble PKC activity that could be available and ready for translocation.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Pintor A,Fortuna S,Lorenzini P,Pascale A,Battaini F,Avellino C,Malvezzi Campeggi L,Salvati Sdoi
10.1007/BF02527750subject
Has Abstractpub_date
1996-05-01 00:00:00pages
541-5issue
5eissn
0364-3190issn
1573-6903journal_volume
21pub_type
杂志文章abstract::The effects of chronic pentobarbital (PB) treatment on the binding characteristics of [3H]flunitrazepam (FLU) in rat brain were examined. Saline or sodium PB (500 micrograms/10 microliters/hr) was infused into the lateral cerebral ventricles of rats for 6 days using osmotic pumps. Immediately before withdrawal, there ...
journal_title:Neurochemical research
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更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Neurochemical research
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更新日期:1995-02-01 00:00:00
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journal_title:Neurochemical research
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