Abstract：
:Malignant peripheral nerve sheath (MPNST) cell lines derived from patients with neurofibromatosis type 1 (NF!) were found to have basal cAMP levels which are two-fold higher than cAMP levels in normal human adult Schwann cells (nHSC). PCR analysis also revealed that normal adult human Schwann cells express mRNA for types Ill, IV, and IX adenylyl cyclase (AC) while NF1 MPNST cells express AC mRNA of types II, V, and VIII in addition to expressing all the isoforms of normal adult human Schwann cells. Further PCR analysis revealed that NF1 MPNST lines express mRNA for EP2 and EP4 prostaglandin receptors whereas nHSC only express mRNA for the EP2 receptor. Exogenous prostaglandins alone or in combination with PDGF BB induced greater increases in cAMP levels and proliferation of NF1 MPNST cells compared to nHSC. We conclude that aberrant cAMP signaling in NF1 MPNST cells contributes to tumor formation in NF1 patients.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Dang I,De Vries GHdoi
10.1007/s11064-011-0433-2subject
Has Abstractpub_date
2011-09-01 00:00:00pages
1697-705issue
9eissn
0364-3190issn
1573-6903journal_volume
36pub_type
杂志文章abstract：:The endogenous opioid peptide dynorphin A elicits non-opioid receptor-mediated neurotoxic effects. These effects are blocked by pretreatment with N-methyl-D-aspartate (NMDA) receptor antagonists. Herein, the mechanism for the non-opioid effects of dynorphin and related peptides was studied by matrix-assisted laser des...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1010903215566
更新日期：2001-04-01 00:00:00
abstract：:The aim of this study was to determine the anticancer potential of Leonurus sibiricus extract derived from in vitro transgenic roots transformed by Agrobacetrium rhizogenes with AtPAP1 transcriptional factor, and that of transformed roots without construct, on grade IV human glioma cells and the U87MG cell line, and a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2551-6
更新日期：2018-07-01 00:00:00
abstract：:Alterations in lysosomal proteases have been implicated in many neurodegenerative diseases. The current study demonstrates a concentration-dependent decrease in PC12 cell viability and transient changes in cystatin C (CYSC), cathepsin B (CATB), cathepsin D (CATD) and caspase-3 following exposure to H2O2. Furthermore, ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9338-5
更新日期：2007-09-01 00:00:00
abstract：:Although nitric oxide (NO) plays key signaling roles in the nervous systems, excess NO leads to cell death. In this study, the involvement of p38 mitogen-activated protein kinase (p38 MAPK) and apoptosis signal-regulating kinase-1 (ASK1) in NO-induced cell death was investigated in PC12 cells. NO donor transiently act...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1010917129951
更新日期：2001-05-01 00:00:00
abstract：:Uridine, a pyrimidine nucleoside, has been proposed to be a potential signaling molecule in the central nervous system. The understanding of uridine release in the brain is therefore of fundamental importance. The present study was performed to determine the characteristics of basal and morphine-induced uridine releas...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0903-1
更新日期：2013-01-01 00:00:00
abstract：:The first mentioning of the word "receptor" for the structure with which a bioactive compound should react for obtaining its specific influence on a physiological system goes back to the years around 1900. The receptor concept was adapted from the lock and key theory for the enzyme substrate and blockers interactions....
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-014-1398-8
更新日期：2014-10-01 00:00:00
abstract：:Parecoxib is a recently described novel COX-2 inhibitor whose functional significance and neuroprotective mechanisms remain elusive. Therefore, in this study, we aimed to investigate whether delayed administration of parecoxib inhibited mitochondria-mediated neuronal apoptosis induced by ischemic reperfusion injury vi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0615-y
更新日期：2012-02-01 00:00:00
abstract：:The ability of Sendai virosomes or Lipofectin to introduce an AAV vector into primary rat brain astroglial cultures was characterized. The pJDT95npy vector was constructed by inserting rat NPY cDNA downstream from the indigenous AAV p5, p19 and p40 promoters in pJDT95. Lipofectin-mediated transfection with pJDT95npy (...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967701
更新日期：1994-06-01 00:00:00
abstract：:The decline in neuronal function during aging may result from increases in extracellular glutamate (Glu), Glu-induced neurotoxicity, and altered mitochondrial metabolism. To study metabolic responses to persistently high levels of Glu at synapses during aging, we used transgenic (Tg) mice that over-express the enzyme ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1239-9
更新日期：2014-01-01 00:00:00
abstract：:Any spinal cord injury carries the potential for persistent disability affecting motor, sensory and autonomic functions. To prevent this outcome, it is highly desirable to block a chain of deleterious reactions developing in the spinal areas immediately around the primary lesion. Thus, early timing of pharmacological ...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-017-2459-6
更新日期：2019-01-01 00:00:00
abstract：:Microglia can exacerbate central nervous system disorders, including stroke and chronic progressive neurodegenerative diseases such as Alzheimer disease. Mounting evidence points to ion channels expressed by microglia as contributing to these neuropathologies. The Chloride Intracellular Channel (CLIC) family represent...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1084-2
更新日期：2013-09-01 00:00:00
abstract：:As is known to all, neuroinflammation plays a vital role in early brain injury pathogenesis following subarachnoid hemorrhage (SAH). It has been shown that rutin have a property of inhibiting inflammation in many kinds of animal models. However, the effect of rutin on neuroinflammation after SAH remains uninvestigated...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1863-7
更新日期：2016-06-01 00:00:00
abstract：:Cloned fragments of members of the Drosophila and mouse major heat shock (hsp70) gene family were used to demonstrate that homologous sequences are present in the rabbit genome. After a physiologically relevant increase in body temperature of 3 degrees C, transcription of inducible hsp70 genes is detected in both the ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964846
更新日期：1985-09-01 00:00:00
abstract：:The preventive effect of dietary taurine supplementation on glial alterations in retina of streptozotocin-induced diabetic rats was examined in this study. Blood glucose content, content of taurine, glutamate and
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9763-0
更新日期：2009-02-01 00:00:00
abstract：:Repeated electroconvulsive shock is an effective treatment for affective disorders. Striatum, hippocampus and brainstem are involved in affective disorders. Sodium-potassium/ATPase is of paramount importance for the proper functioning of the brain and its involvement in the affective disorders has been claimed for a l...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9046-6
更新日期：2006-04-01 00:00:00
abstract：:Enolase is a glycolytic enzyme whose amino acid sequence is highly conserved across a wide range of animal species. In mammals, enolase is known to be a dimeric protein composed of distinct but closely related subunits: alpha (non-neuronal), beta (muscle-specific), and gamma (neuron-specific). However, little informat...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00970738
更新日期：1995-08-01 00:00:00
abstract：:DNase I sensitivity experiments were performed utilizing DNA probes to genes which are either transcribed in rat cortical neurons (the 68 kDa neurofilament gene and the neuron-specific enolase gene) or are transcriptionally silent (albumin). Results suggest that unlike liver, in which a hierarchy in chromatin conforma...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969627
更新日期：1989-02-01 00:00:00
abstract：:We have investigated gene expression changes produced by acute and chronic daily treatment with a prototypical antidepressant, imipramine, using DNA microarrays. The analysis of similarities in gene expression patterns among functionally related genes revealed four expression profile cluster areas that showed a highly...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/b:nere.0000023610.89631.d6
更新日期：2004-06-01 00:00:00
abstract：:The hippocampus-derived neuroestradiol plays a major role in neuroplasticity, independent of circulating estradiol that originates from gonads. The response of hypothalamus-pituitary regions towards the synthesis of neuroestradiol in the hippocampus is an emerging scientific concept in cognitive neuroscience. Hippocam...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-019-02833-1
更新日期：2019-08-01 00:00:00
abstract：:One of the main pathological symptoms of early diabetic retinal neuropathy is retina neuronal apoptosis. In the present work we investigated the effects of indoleamine hormone melatonin, a powerful free radical scavenger, on streptozotocin-induced retina neuronal cell apoptosis in high blood glucose rat. After melaton...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0966-z
更新日期：2013-03-01 00:00:00
abstract：:We estimated catecholamine levels in CSF of 15 epileptics and 75 non-neurological patients utilizing a high performance liquid chromatograph with a highly sensitive fluorometer and found the following results: The dopamine (DA) levels in males were significantly higher than those in females, while norepinephrine (NE) ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965900
更新日期：1982-10-01 00:00:00
abstract：:Autoantibodies to three eukaryotic 60S ribosomal phosphoproteins P0, P1 and P2 have been found in the sera of 10-20% of patients with systemic lupus erythematosus (SLE). These antibodies inhibit protein synthesis in vitro and when microinjected into cultured human fibroblasts. The three proteins share a common epitope...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969925
更新日期：1990-04-01 00:00:00
abstract：:Evidence is presented that multiple forms of cyclic nucleotide phophodiesterase (PDE) activity chromatographically separated from the soluble fraction of bovine hypothalamus are co-eluted with multiple forms of 5'-nucleotidase (5'N) activity. The enzymes could not be resolved from each other by anion-exchange chromato...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965512
更新日期：1989-12-01 00:00:00
abstract：:The inflammatory response mediated by microglia in the central nervous system is closely related to epilepsy. Notch signaling plays an important role in the microglial activation during hypoxia. This study aimed to investigate whether Notch signaling is involved in microglial activation and subsequent inflammation-rel...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2544-5
更新日期：2018-06-01 00:00:00
abstract：:The effect of postdecapitative ischemia (5 min at 37 degrees) and hypoxia (5% O2, 95% N2, 30 min) on the distribution of protein radioactivity in the cellular fractions of guinea pig cerebral cortex was studied. Ischemic conditions resulted in the increase of total radioactivity level and protein content in the mitoch...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963828
更新日期：1979-02-01 00:00:00
abstract：:Remyelination promoting human IgMs effectively increase the number of myelinated axons in animal models of multiple sclerosis. Hence, they ultimately stimulate myelin production by oligodendrocytes (OLs); however, their exact mechanism of action remains to be elucidated, and in particular, it remains unclear whether t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2701-x
更新日期：2019-06-01 00:00:00
abstract：:(4S)-4-Amino-5,6-heptadienoic acid [S)-gamma-allenyl-GABA; MDL 72483) is a potent inactivator of brain GABA-T in mice; (ED50 (i.p.) = 60 mg.kg-1; ED50 (oral) = 70 mg.kg-1). Its anticonvulsant effects against 3-mercaptopropionic acid (MPA)-induced seizures in mice is related to the elevation of whole brain GABA concent...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966092
更新日期：1991-03-01 00:00:00
abstract：:Calcium-naive synaptosomes were used to assess the effects of divalent cations on [3H]acetylcholine release from rat hippocampal homogenates. Following equilibration with calcium-free buffer (containing 10 microM EGTA), calcium reversibly increased [3H]acetylcholine efflux (up to five-fold) while causing no measurable...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966598
更新日期：1991-10-01 00:00:00
abstract：:Transferrin (Tf), the iron-transport protein of vertebrate serum, is mainly synthesized in hepatocytes but is also found in other cell-types including oligodendrocytes. Our laboratory has characterized in a human oligodendrial cell line the presence of a new Tf transcript containing an alternative exon 1b replacing th...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021692220482
更新日期：2002-11-01 00:00:00
abstract：:The activity, properties, and developmental pattern of cysteine sulfinate transaminase (CSA-T) were studied in chick retina and compared with the activity, properties, and developmental pattern of glutamate oxaloacetate transaminase (GOT). Their optimum pH is identical whereas the effect of pyridoxal phosphate seems t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964358
更新日期：1978-02-01 00:00:00
