Abstract：
:Autoantibodies to three eukaryotic 60S ribosomal phosphoproteins P0, P1 and P2 have been found in the sera of 10-20% of patients with systemic lupus erythematosus (SLE). These antibodies inhibit protein synthesis in vitro and when microinjected into cultured human fibroblasts. The three proteins share a common epitope contained within the carboxyl terminal 22 amino acids of each protein. Because a significant number of SLE patients have central nervous system disturbances with major behavioral disorders, the antiribosomal protein autoantibodies were measured in this subset of SLE individuals to determine whether or not there was an association. These antibodies are present in 90% of SLE patients who were diagnosed as having psychosis, secondary to the disease.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Elkon K,Weissbach H,Brot Ndoi
10.1007/BF00969925subject
Has Abstractpub_date
1990-04-01 00:00:00pages
401-6issue
4eissn
0364-3190issn
1573-6903journal_volume
15pub_type
杂志文章abstract：:Seizures are accompanied by an exacerbated activation of cerebral ion channels. 4-aminopyridine (4-AP) is a pro-convulsive agent which mechanism of action involves activation of Na(+) and Ca(2+) channels, and several antiepileptic drugs control seizures by reducing these channels permeability. The antidepressant, sert...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1840-1
更新日期：2016-06-01 00:00:00
abstract：:In the present paper we describe the presence in avian CNS of an endogenous inhibitor of [3H]flunitrazepam binding. This compound was extracted from a synaptic membrane fraction isolated from chick optic lobe and brain using an exhaustive aqueous washing procedure, then purified by means of solid-phase extraction with...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020702823600
更新日期：1998-11-01 00:00:00
abstract：:The phospholipid requirement for Ca2+-stimulated, Mg2+-dependent ATP hydrolysis (Ca2+/Mg2+-ATPase) and Mg2+-stimulated ATP hydrolysis (Mg2+-ATPase) in rat brain synaptosomal membranes was studied employing partial delipidation of the membranes with phospholipase A2 (Hog pancreas), phospholipase C (Bacillus cereus) and...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966224
更新日期：1986-10-01 00:00:00
abstract：:The original version of this article unfortunately contained a mistake. The spelling of the author Tommaso Ianniti was incorrect and has been corrected as Tommaso Iannitti. The original article has been corrected. ...
journal_title：Neurochemical research
pub_type： 杂志文章,已发布勘误
doi：10.1007/s11064-018-2468-0
更新日期：2018-02-01 00:00:00
abstract：:Charge microheterogeneity of myelin basic protein is known to affect its conformation and function. Here, the citrullinated myelin basic protein charge isomer, component-8, was shown to be more susceptible to stromelysin-1 cleavage than myelin basic protein component-1. Since levels of component-8 are increased in mul...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9116-9
更新日期：2006-08-01 00:00:00
abstract：:Estrogen action is necessary for evidencing the stimulatory action of mifepristone and naloxone on prolactin (PRL) secretion during late pregnancy. Our aim is to determine the mechanism mediating this facilitator action of estrogens. To investigate the hypothalamic mechanisms involved in estrogen actions in PRL secret...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-2067-x
更新日期：2016-12-01 00:00:00
abstract：:Overactivation of glutamate receptors results in neurodegeneration in a variety of brain pathologies, including ischemia, epilepsy, traumatic brain injury and slow-progressing neurodegenerative disorders. In all these pathologies, it is well accepted that the calcium-dependent cysteine proteases calpains are key playe...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0323-z
更新日期：2010-12-01 00:00:00
abstract：:Cell surface β-Amyloid precursor protein (APP) is known to have a functional role in iron homeostasis through stabilising the iron export protein ferroportin (FPN). Mechanistic evidence of this role has previously only been provided through transcriptional or translational depletion of total APP levels. However, numer...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02747-y
更新日期：2019-06-01 00:00:00
abstract：:Rabbits were immunized with the myelin-associated glycoprotein (MAG) that had been purified from isolated rat brain myelin by selective extraction with lithium diiodosalicylate (LIS) and phenol followed by preparative SDS gel electrophoresis. Antibodies to MAG were detected qualitatively by immunodiffusion and quantit...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964417
更新日期：1981-10-01 00:00:00
abstract：:In an effort to develop an animal model of hyperpipecolatemia, the uptake of pipecolic acid (PA) in the brain and changes of PA levels in serum following administration of D,L-PA were studied in the mouse using a new sensitive HPLC-EC method. Following i.p. injections (250 mg/kg) to adult male mice, the brain concentr...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964981
更新日期：1985-10-01 00:00:00
abstract：:This study investigated the effects of aging on the actions of a specific glutamate reuptake blocker, L-trans-pyrrolidine-2, 4-dicarboxylic acid (PDC), in extracellular glutamate and glutamine in striatum of the awake rat. Microdialysis experiments were performed on young (2-3 months), middle-aged (12-14 months), aged...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1007624531077
更新日期：2001-01-01 00:00:00
abstract：:Remyelination promoting human IgMs effectively increase the number of myelinated axons in animal models of multiple sclerosis. Hence, they ultimately stimulate myelin production by oligodendrocytes (OLs); however, their exact mechanism of action remains to be elucidated, and in particular, it remains unclear whether t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2701-x
更新日期：2019-06-01 00:00:00
abstract：:Human amniotic membrane mesenchymal stem cells (hAMSCs) are considered ideal candidate stem cells for cell-based therapy. In this study, we assessed whether hAMSCs transplantation promotes neurological functional recovery in rats after traumatic spinal cord injury (SCI). In addition, the potential mechanisms underlyin...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1987-9
更新日期：2016-10-01 00:00:00
abstract：:Pig brain extracts from both soluble and membrane fractions were found to contain potent inhibitors for GABA synthesizing enzyme, GAD, referred to as endogenous GAD inhibitors (EGIs) and for the binding of GABA agonist, muscimol, referred to as muscimol binding inhibitors (MBIs). EGIs and MBIs were first purified thro...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966871
更新日期：1992-01-01 00:00:00
abstract：:Deprenyl has been discovered by Knoll and co-workers. The R-enantiomer of deprenyl (selegiline) is a selective and irreversible inhibitor of the B-isoform of monoamine oxidase (MAO-B) enzyme. Due to its dopamine potentiating and possible neuroprotective properties it has an established role in the treatment of parkins...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0238-8
更新日期：2010-12-01 00:00:00
abstract：:Parkinson's disease (PD) is a neurodegenerative disorder of dopaminergic, noradrenergic, and serotonergic systems, in which dopamine, noradrenaline, and serotonin levels are depleted and lead to the development of motor and non-motor symptoms such as tremor, bradykinesia, weight changes, fatigue, depression, and visua...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03130-y
更新日期：2020-11-01 00:00:00
abstract：:We have previously reported that angiotensin receptor blockade reduces reperfusion hemorrhage in a suture occlusion model of stroke, despite increasing matrix metalloproteinase (MMP-9) activity. We hypothesized that candesartan will also decrease hemorrhage associated with delayed (6 h) tissue plasminogen activator (t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1185-y
更新日期：2013-12-01 00:00:00
abstract：:Using the replication-defective adenovirus vector, we overexpressed rat glia maturation factor (GMF) in primary astrocyte cultures derived from embryonic rat brains. Among the three isoforms of MAP kinase, there was a big increase in the phosphorylation of p38, as detected with Western blotting using the phosphospecif...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1014241300179
更新日期：2001-12-01 00:00:00
abstract：:There is a growing body of evidence confirming the involvement of oxidative stress and inflammation in pathogenesis of schizophrenia. Inter-individual variation in antioxidant capacity caused by different genetic profile could potentially influence patient's susceptibility to oxidative damage. In this study we evaluat...
journal_title：Neurochemical research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s11064-012-0937-4
更新日期：2013-02-01 00:00:00
abstract：:In the present study, we aimed to investigate the effects of pinealectomy and chronic melatonin administration on focal epileptiform activity induced by penicillin in the rat cortex and to determine the relation between melatonin levels and electrocorticogram (ECoG) power spectrum. For this purpose, male Sprague-Dawle...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1069-1
更新日期：2013-08-01 00:00:00
abstract：:The mechanism of focal demyelination in multiple sclerosis has been a long-standing enigma of this disorder. Cytokines, a diverse family of signalling molecules, are viewed as potential mediators of the process based on clinical observations and studies with animal models and tissue/cell culture systems. Myelin and ol...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1022493013904
更新日期：1998-03-01 00:00:00
abstract：:Uridine, a pyrimidine nucleoside, has been proposed to be a potential signaling molecule in the central nervous system. The understanding of uridine release in the brain is therefore of fundamental importance. The present study was performed to determine the characteristics of basal and morphine-induced uridine releas...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0903-1
更新日期：2013-01-01 00:00:00
abstract：:We investigated the action of the new hypothalamic proline-rich peptide (PRP-1), normally produced by neurosecretory cells of hypothalamic nuclei (NPV and NSO), 3 and 4 weeks following rat sciatic nerve transection. The impulse activity flow of interneurons (IN) and motoneurons (MN) on stimulation of mixed (n. ischiad...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-2685-1
更新日期：2005-04-01 00:00:00
abstract：:The serotoninergic system modulates nociceptive and locomotor spinal cord circuits. Exercise improves motor function and changes dopaminergic, noradrenergic, and serotonergic central systems. However, the direct relationship between serotonin, peripheral nerve lesion and aerobic treadmill exercise has not been studied...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-0066-x
更新日期：2010-03-01 00:00:00
abstract：:We observed a spot on two-dimensional (2-D) gel in the epileptic mutant strain E1 mice with a similar molecular weight but with a different isoelectric point of approximately 0.2, compared with its mother strain ddY mice. The collected protein from the E1 mice was identified as cytosolic NADP+-dependent isocitrate deh...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020981532281
更新日期：1999-03-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) is a promising biological marker and prognostic indicator in many neurological diseases. Although VEGF concentrations in plasma and cerebrospinal fluid (CSF) are increasingly reported, CSF-VEGF stability pre- and during-assay procedures is seldom evaluated. In the current stud...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0517-z
更新日期：2011-11-01 00:00:00
abstract：:Association of the candidate gene DLST with late-onset Alzheimer's disease (LOAD) risk has been suggested on the basis of case-control studies. This gene, located on chromosome 14q24.3, encodes a subunit of a mitochondrial component known to be defective in AD, the alpha-ketoglutarate dehydrogenase complex. Positive r...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/b:nere.0000014833.54481.1d
更新日期：2004-03-01 00:00:00
abstract：:Salsolinol, an endogenous neurotoxin, is known to be involved in the pathogenesis of Parkinson's disease (PD). In the present study, we have investigated the effects of salsolinol on the activation of two different signaling pathways that involve c-Jun N-terminal kinase (JNK), and nuclear factor-kappaB, (NF-kappaB) in...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9246-0
更新日期：2007-03-01 00:00:00
abstract：:Tamoxifen and toremifene are antiestrogenic drugs successfully used in the therapy of breast cancer. Rheumatoid arthritis and malaria have been treated with chloroquine for decades. Unfortunately, tamoxifen and chloroquine are reported to induce retinal changes as a side effect. We now studied the effects of tamoxifen...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/b:nere.0000010459.48656.4a
更新日期：2004-01-01 00:00:00
abstract：:Oligodendrocytes (OL) are the only myelinating cells of the central nervous system thus interferences, either environmental or genetic, with their maturation or function have devastating consequences. Albeit so far neglected, one of the less appreciated, nevertheless possible, regulators of OL maturation and function ...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-019-02778-5
更新日期：2020-03-01 00:00:00
