Abstract：
:Charge microheterogeneity of myelin basic protein is known to affect its conformation and function. Here, the citrullinated myelin basic protein charge isomer, component-8, was shown to be more susceptible to stromelysin-1 cleavage than myelin basic protein component-1. Since levels of component-8 are increased in multiple sclerosis brain, the increased susceptibility of component-8 to proteolytic digestion may play a role in the pathogenesis of multiple sclerosis. Interestingly, component-1 isolated from multiple sclerosis patients was digested at a faster rate by stromelysin-1 than component-1 isolated from normal individuals. The reason for this difference is not clear, but likely reflects conformational differences between the two proteins as a result of post-translational modifications. Stromelysin-1 was able to cleave myelin basic protein in the presence of lipids and within the context of myelin and released several peptides including peptides containing the immunodominant epitope.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
D'Souza CA,Moscarello MAdoi
10.1007/s11064-006-9116-9subject
Has Abstractpub_date
2006-08-01 00:00:00pages
1045-54issue
8eissn
0364-3190issn
1573-6903journal_volume
31pub_type
杂志文章abstract：:Lewy bodies and Lewy neurites in the brain constitute the main histopathological features of Parkinson's disease (PD) and dementia with Lewy bodies. They comprise amyloid-like fibrils composed of α-synuclein (αS), a small protein (~14 kDa). Because the aggregation of αS in the brain has been implicated as a critical s...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-017-2382-x
更新日期：2017-12-01 00:00:00
abstract：:We identify and characterize two classes of immediate-early genes: (i) genes, induced by depolarization in neurons, that play a role in depolarization-induced neuronal plasticity and (ii) genes, induced in neuronal precursors by neurotrophins, that play a causal role in neurotrophin-directed neuronal differentiation. ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1007546600535
更新日期：2000-05-01 00:00:00
abstract：:The effect of 4-aminopyridine on [3H]acetylcholine release was studied in rat cerebral cortical synaptosomes in the presence of a several secretagogues that have different mechanisms of action. As found previously, 4-aminopyridine increased [3H]acetylcholine release in a concentration-dependent manner (5-10 mM); a hig...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969632
更新日期：1989-02-01 00:00:00
abstract：:An efficient exchange of lactate between different cell types (such as astrocytes and neurones) would require that lactate transporters are expressed in contiguous parts of the respective plasma membranes. To settle this issue we explored the subcellular expression pattern of monocarboxylate transporters (MCTs) by use...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1014806723147
更新日期：2002-02-01 00:00:00
abstract：:Rats fed a vitamin E-deficient diet for 7--8 weeks postweaning showed no change in brain weight or the activity in brain of various enzymes involved in neurotransmitter synthesis and metabolism. Body and muscle weights were markedly reduced. Muscle choline acetyltransferase and acetylcholinesterase activities were sig...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966003
更新日期：1978-12-01 00:00:00
abstract：:The tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) is not only a protein, but also a lipid phosphatase that can negatively regulate the serine/threonine kinase Akt. It has been reported that PTEN can be regulated by means of phosphorylation. However, whether PTEN can be regulated by an...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-9938-3
更新日期：2009-08-01 00:00:00
abstract：:To evaluate the influence of light and darkness on brain pyroglutamyl-peptidase I (pGluPI) activity, four experimental groups of rats were compared at the same time-point (10.00 h). Two groups were designed with a standard 12-12 h light-dark cycle: In group A, the lights were on from 7.00 h to 19.00 h, and the experim...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1010996425408
更新日期：2001-05-01 00:00:00
abstract：:Consumption of fifteen percent alcohol, during gestation did not cause any decrease in the total calorie or fluid intake of the rats maintained on normal dietary regimen. However, the alcohol consumption by gestating mothers resulted in a decreased contents of both DNA and protein in the CNS of the in utero alcohol ex...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965614
更新日期：1989-11-01 00:00:00
abstract：:Metabolism of triacylglycerol (TAG) in developing brain has been examined. TAG is a relatively minor fraction of brain lipid in both suckling and adult rats and cannot be accounted for as entrapped blood. When glycerol tri[1-14C]oleate and [2-3H]glycerol trioleate were simultaneously injected intracerebrally into suck...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966679
更新日期：1981-11-01 00:00:00
abstract：:The aim of this study was to determine whether neurotrophin-4/5 (NT-4/5) treatment alters infarction volume following permanent focal cerebral ischemia in the rat. Permanent focal cerebral ischemia was produced in adult male rats by intraluminal occlusion of the right middle cerebral artery. NT-4/5 was administered in...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02532298
更新日期：1996-07-01 00:00:00
abstract：:Memory impairment is the most common symptom in patients with Alzheimer's disease. The purpose of this study is to evaluate the memory enhancing effects of P7C3, a recently identified compound with robust proneurogenic and neuroprotective effects, on the cognitive impairment induced by scopolamine, a muscarinic acetyl...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1783-y
更新日期：2016-05-01 00:00:00
abstract：:This review presents data on metabotropic uridine nucleotide receptor subtypes (P2UR) activated by UTP, sometimes also by UDP and/or ATP. Some chemical details of receptor subtypes and ligand interactions are described. Ligand-activated P2UR subtypes may couple to different second messengers, yet little is known about...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1022487128766
更新日期：1997-08-01 00:00:00
abstract：:Radioactive azide derivatives of tetrodotoxin (TTX) were synthesized using 2-nitro-4-azidephenyl-[3H]beta alanine for the purpose of photolabeling of the Na channel. Three azide derivatives, N1, N2 and N3, were separated by ion exchange chromatography on Bio-Rex 70 resin and reversed phase high performance liquid chro...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965886
更新日期：1985-08-01 00:00:00
abstract：:The hypothalamic paraventricular nucleus (PVN) is a key site for regulating neuroendocrine functions in the magnocellular part and autonomic activities in the parvocellular part. Its anatomical proximity to the third ventricle could be a good target for intrathecal injection of baclofen. We investigated the correlatio...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0621-0
更新日期：2012-02-01 00:00:00
abstract：:The 12/15-lipoxygenase(s) (LOX), poly(ADP-ribose) polymerase (PARP-1) activity and mitochondrial apoptosis inducing factor (AIF) protein in the amyloid β (Aβ) toxicity were investigated in PC12 cells that express either wild-type (APPwt) or double Swedish mutation (APPsw) forms of human Aβ precursor protein. Different...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0412-7
更新日期：2011-05-01 00:00:00
abstract：:Experimental evidence has suggested that the high endogenous levels of taurine found in the rat heart and retina are maintained to a large extent by transport processes out of the blood, rather than by endogenous biosynthesis. When these high levels are depleted, dysfunction ensues. In vitro studies have shown that be...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00970775
更新日期：1988-10-01 00:00:00
abstract：:Single exposure of adult male rats to low environmental temperature (LET, 12 +/- 0.5 degrees C) for 2 h significantly increased the hypothalamic and striatal GABA levels without affecting those in other regions of brain. The activity of glutamate decarboxylase (GAD) was elevated in hypothalamus (H) and corpus striatum...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00968559
更新日期：1990-08-01 00:00:00
abstract：:Mice with a heterozygous knock-out of the myelin protein P0 gene (P0+/-) develop a neuropathy similar to human Charcot-Marie-Tooth disease. They are indistinguishable from wild-types (WT) at birth and develop a slowly progressing demyelinating neuropathy. The aim of this study was to investigate whether the regenerati...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1030-3
更新日期：2013-06-01 00:00:00
abstract：:Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor. However, therapeutic strategies against malignant gliomas have not been completely established. Runt-related transcription factor 2 (Runx2) is an essential gene for skeletal development but its regulatory role in the malignant progression of gli...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2626-4
更新日期：2018-11-01 00:00:00
abstract：:Quantitative measurements were made of choline acetyltransferase (CAT) activity, acetylcholinesterase (AChE) activity and cholinergic muscarinic receptor binding ([3H]QNB) in eight areas of a cross-section of the rat medulla oblongata. A fourth cholinergic parameter, high-affinity choline uptake, was measured in three...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964389
更新日期：1981-05-01 00:00:00
abstract：:Neurovascular injury comprises a wide spectrum of pathophysiology that underlies the progression of brain injury after cerebral ischemia. Recently, it has been shown that activation of the integrin-associated protein CD47 mediates the development of blood-brain barrier injury and edema after cerebral ischemia. However...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0159-6
更新日期：2010-07-01 00:00:00
abstract：:The pineal gland is a neuroendocrine gland responsible for nocturnal synthesis of melatonin. During early development of the rodent pineal gland from the roof of the diencephalon, homeobox genes of the orthodenticle homeobox (Otx)- and paired box (Pax)-families are expressed and are essential for normal pineal develop...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-012-0906-y
更新日期：2013-06-01 00:00:00
abstract：:The effect of hydrogen peroxide (H2O2) on cytosolic free calcium concentration ([Ca2+]c) as well as its effect on glutamate secretion in rat hippocampal astrocytes have been the aim of the present research. Our results show that 100 microM H2O2 induces an increase in [Ca2+]c, that remains at an elevated level while th...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9078-y
更新日期：2006-06-01 00:00:00
abstract：:Intracerebral folate injections produce convulsions and brain lesions, folic acid itself and tetrahydrofolate being more potent toxins than 5-methyltetrahydrofolate, the primary folate of mammalian extracellular fluids. Folates are known to excite neurons, by unknown mechanisms Folates stimulate GTP binding and GTPase...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973648
更新日期：1990-07-01 00:00:00
abstract：:Several lines of evidence suggest that the mechanism underlying drug-induced neuronal apoptosis is initiated by the increased production of reactive oxygen species (ROS). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxin, has been shown to initiate an apoptotic cascade by increasing ROS in the dopamine...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1208-8
更新日期：2014-02-01 00:00:00
abstract：:Levels of free amino acids were determined quantitatively in whole ocular tissues of the rat eye with aid of a sensitive amino acid analyzer. The tissues studied were the retina, vitreous, lens, iris-ciliary body, and cornea. The retina and lens contained a more concentrated free amino acid pool than other tissues. Th...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965323
更新日期：1986-04-01 00:00:00
abstract：:It has been reported that electrical stimulation (ES) can promote nerve regeneration. One of the key factors leading to the promotion is calcium, which plays a vital role in the regulation on electrical activity of neurons, but the detailed mechanism is still an open question. In this study, ES was used to stimulate c...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1197-7
更新日期：2014-01-01 00:00:00
abstract：:Postnatal developmental patterns of activity for acid and alkaline deoxyribonuclease (DNase) were determined in the cerebellum of the androgenized female rat. Littermates were injected s.c. with either 1.25 mg testosterone propionate (TP) or vehicle 48 hours after birth. The enzymes and DNA content were measured in th...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964659
更新日期：1985-04-01 00:00:00
abstract：:Epileptogenesis, induced by status epilepticus (SE), is a chronic process, and intervention in this progress may prevent chronic epilepsy. It has been proposed that DNA methylation might be related with epileptogenesis. RASgrf1 has a differentially methylated region at the promoter which can silence gene expression. W...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2621-9
更新日期：2018-10-01 00:00:00
abstract：:We review some of the older literature concerning metabolic turnover of cholesterol in the nervous system. The overall picture is that incorporation of radioactive precursors into brain cholesterol is roughly proportional to the rate of myelination and that, once incorporated, radioactive cholesterol is relatively sta...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/BF02527711
更新日期：1996-04-01 00:00:00
