Abstract：
:The pineal gland is a neuroendocrine gland responsible for nocturnal synthesis of melatonin. During early development of the rodent pineal gland from the roof of the diencephalon, homeobox genes of the orthodenticle homeobox (Otx)- and paired box (Pax)-families are expressed and are essential for normal pineal development consistent with the well-established role that homeobox genes play in developmental processes. However, the pineal gland appears to be unusual because strong homeobox gene expression persists in the pineal gland of the adult brain. Accordingly, in addition to developmental functions, homeobox genes appear to be key regulators in postnatal phenotype maintenance in this tissue. In this paper, we review ontogenetic and phylogenetic aspects of pineal development and recent progress in understanding the involvement of homebox genes in rodent pineal development and adult function. A working model is proposed for understanding the sequential action of homeobox genes in controlling development and mature circadian function of the mammalian pinealocyte based on knowledge from detailed developmental and daily gene expression analyses in rats, the pineal phenotypes of homebox gene-deficient mice and studies on development of the retinal photoreceptor; the pinealocyte and retinal photoreceptor share features not seen in other tissues and are likely to have evolved from the same ancestral photodetector cell.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Rath MF,Rohde K,Klein DC,Møller Mdoi
10.1007/s11064-012-0906-ysubject
Has Abstractpub_date
2013-06-01 00:00:00pages
1100-12issue
6eissn
0364-3190issn
1573-6903journal_volume
38pub_type
杂志文章,评审abstract：:Tyrosine hydroxylase (TH) activity and levels of tyrosine were measured in whole brains from mice subjected to brief electric foot shock or to single or multiple injections of hydrocortisone acetate (HCA; 20 mg/kg). Adult brain tyrosine levels showed a rapid increase after either foot shock or a single injection of HC...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964094
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journal_title：Neurochemical research
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journal_title：Neurochemical research
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doi：10.1007/BF00970738
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journal_title：Neurochemical research
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更新日期：2013-12-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
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更新日期：1989-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-11-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020217309987
更新日期：2002-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11064-020-03059-2
更新日期：2020-08-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965474
更新日期：1981-07-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-007-9356-3
更新日期：2007-12-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9287-z
更新日期：2007-07-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00970543
更新日期：1995-02-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973296
更新日期：1988-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-09-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2010-12-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0788-z
更新日期：2012-08-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02527750
更新日期：1996-05-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1400-5
更新日期：2014-11-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
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更新日期：2017-02-01 00:00:00
abstract：:The effects of neuroleptic treatments on dopamine transporters and on dopamine receptors was investigated in the forebrain of adult rats treated for 21 days with either haloperidol, clozapine or saline. The dopamine D1 receptors, labeled with [3H]SCH23390, increased in nucleus accumbens, latero-dorsal rostral neostria...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022405621365
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abstract：:Level of adenosine, an endogenous astrocyte-based neuromodulator, is primarily regulated by adenosine P1 receptors. This study assessed expression of adenosine P1 receptors, ADORA1 (adenosine A1 receptor) and ADORA2A (adenosine A2a receptor) and their association with glioma development and epilepsy in glioma patients...
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pub_type： 杂志文章
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更新日期：2016-07-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
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更新日期：2016-05-01 00:00:00
abstract：:Metabolic turnover of axonally transported glycoproteins has been examined in membranous and soluble subfractions of goldfish optic tectum following intraocular injection of [3H]fucose. Radioactivity in total transported glycoproteins reached a maximum in the tectum after 24-30 hr, then declined with a half-life of ap...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964224
更新日期：1980-04-01 00:00:00
abstract：:The aim of this study was to explore effects of hypoxia, glucose deprivation (HGD) and recovery on expression and activities of equilibrative nucleoside transporters (rENT) and concentrative nucleoside transporters (rCNT) in rat astrocytes in primary culture. Amounts of cellular ATP in the control group (CG, 5% CO(2) ...
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pub_type： 杂志文章
doi：10.1007/s11064-010-0203-6
更新日期：2010-09-01 00:00:00
